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The map label for this gene is thiD [H]

Identifier: 126445131

GI number: 126445131

Start: 1495388

End: 1496395

Strand: Reverse

Name: thiD [H]

Synonym: BURPS668_A1561

Alternate gene names: 126445131

Gene position: 1496395-1495388 (Counterclockwise)

Preceding gene: 126442358

Following gene: 126442569

Centisome position: 47.85

GC content: 72.62

Gene sequence:

>1008_bases
ATGGCGGCTCGAACGCCGCCGCCGCGCGCGCACGCCCGCACGGGCCGAGGTCGCCCGACGACGGGCGCGAGCCGGCCGCC
GACGCCGCGGCGGCCGGCCCGACCGACGGCCCACCGACGACGTGACGCGCGGCGCCGCCCGCGCGGCTCGCCGACGGCGC
AGCGGCACAATCACAACACGACGCAACATAACGAAACACGAGGGAACATGATCGCGAACGTACTGACGATCGCCGGCACC
GACCCGACGGGCGGAGCGGGCATTCAGGCCGATCTCAAGGCATTTTCGGCAATGCGCGCATACGGGATGGCGGCGATCAC
CGCGGTCGTCGCGCAGAACACCACCGGCGTGCGCAGCTTCCGCGCGCTCGATCCGGCGTTCGTCGCCGATCAGATCGACG
CGGTGTTCGACGACGTCGCCGTGCACGCGGTGAAGATCGGCATGATCGCGACGGCCGCGATCGCCGAGGCGGTCGCCGCG
GCGCTCGTCAGGCATCGCGCGGCGCCCGTCGTGCTCGATCCGGTGATGGTCGCGAAAAGCGGCGACCGGCTGCTCGATCC
GGACGCCGTCGACGCGATCCGCGACAAGCTCGTGCCGATCTCCACGCTGATCACGCCGAACCTGCCGGAAGCGGGCGTGC
TGCTCGGCCGAAGCGAGCCGCGCACGCTCGCCGAGATGCACGCGGCGGCCGCCGAGCTGCACGCGCTCGGTTCGCGCTGG
GTGCTGCTCAAGGGCGGGCATCTGGCGGGCGAGCGCAGCGTCGACGTGCTGCGCGGCCCGGCCGCCGCGACGGTCGAGCT
CTCCGCGCCGCGCGTCGCGACGAACAACGATCACGGCACCGGCTGCACGCTGTCGGCCGCGATCGCGGCGCTGCTGCCGA
GCCATTCGGTCGAGGACAGCGTCTGCCAAGCCAAGGCTTACCTGAGCGACGCGCTCGCCGCGTCGGGCGAGCTCGAGGTC
GGTCGCGGGCACGGCCCGGTCCATCATTTCCACGCGCTATGGAACTGA

Upstream 100 bases:

>100_bases
GCCCATGCGGACGCCGACGGCAGCAAGCCGTTCGTGCTGTTCAAGGCAACCAGGCCGCCGCGCTGACGCGCGCGCCGCGG
CGCATGCGCGGTGCGCCGGC

Downstream 100 bases:

>100_bases
CGCCCGCGCCGCGCGCCGGCATGCGCGCGCATCGACAAACACCAAGACAAGCGCATCGTTTCGCACGCGTCATTCGACAA
GGAACCATCATGCGTCGCCT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MAARTPPPRAHARTGRGRPTTGASRPPTPRRPARPTAHRRRDARRRPRGSPTAQRHNHNTTQHNETRGNMIANVLTIAGT
DPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSFRALDPAFVADQIDAVFDDVAVHAVKIGMIATAAIAEAVAA
ALVRHRAAPVVLDPVMVAKSGDRLLDPDAVDAIRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAAAAELHALGSRW
VLLKGGHLAGERSVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSHSVEDSVCQAKAYLSDALAASGELEV
GRGHGPVHHFHALWN

Sequences:

>Translated_335_residues
MAARTPPPRAHARTGRGRPTTGASRPPTPRRPARPTAHRRRDARRRPRGSPTAQRHNHNTTQHNETRGNMIANVLTIAGT
DPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSFRALDPAFVADQIDAVFDDVAVHAVKIGMIATAAIAEAVAA
ALVRHRAAPVVLDPVMVAKSGDRLLDPDAVDAIRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAAAAELHALGSRW
VLLKGGHLAGERSVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSHSVEDSVCQAKAYLSDALAASGELEV
GRGHGPVHHFHALWN
>Mature_334_residues
AARTPPPRAHARTGRGRPTTGASRPPTPRRPARPTAHRRRDARRRPRGSPTAQRHNHNTTQHNETRGNMIANVLTIAGTD
PTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSFRALDPAFVADQIDAVFDDVAVHAVKIGMIATAAIAEAVAAA
LVRHRAAPVVLDPVMVAKSGDRLLDPDAVDAIRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAAAAELHALGSRWV
LLKGGHLAGERSVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSHSVEDSVCQAKAYLSDALAASGELEVG
RGHGPVHHFHALWN

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=263, Percent_Identity=56.6539923954373, Blast_Score=270, Evalue=7e-74,
Organism=Saccharomyces cerevisiae, GI6324997, Length=275, Percent_Identity=35.6363636363636, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6324517, Length=273, Percent_Identity=35.1648351648352, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6325378, Length=272, Percent_Identity=30.8823529411765, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 35071; Mature: 34940

Theoretical pI: Translated: 10.93; Mature: 10.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARTPPPRAHARTGRGRPTTGASRPPTPRRPARPTAHRRRDARRRPRGSPTAQRHNHNT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCC
TQHNETRGNMIANVLTIAGTDPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSF
CCCCCHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RALDPAFVADQIDAVFDDVAVHAVKIGMIATAAIAEAVAAALVRHRAAPVVLDPVMVAKS
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEECC
GDRLLDPDAVDAIRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAAAAELHALGSRW
CCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCE
VLLKGGHLAGERSVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSHSVEDS
EEEECCCCCCCCCHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHHHHHCCCCCHHH
VCQAKAYLSDALAASGELEVGRGHGPVHHFHALWN
HHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHCC
>Mature Secondary Structure 
AARTPPPRAHARTGRGRPTTGASRPPTPRRPARPTAHRRRDARRRPRGSPTAQRHNHNT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCC
TQHNETRGNMIANVLTIAGTDPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSF
CCCCCHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RALDPAFVADQIDAVFDDVAVHAVKIGMIATAAIAEAVAAALVRHRAAPVVLDPVMVAKS
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEECC
GDRLLDPDAVDAIRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAAAAELHALGSRW
CCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCE
VLLKGGHLAGERSVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSHSVEDS
EEEECCCCCCCCCHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHHHHHCCCCCHHH
VCQAKAYLSDALAASGELEVGRGHGPVHHFHALWN
HHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]