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The map label for this gene is macA [H]

Identifier: 126444539

GI number: 126444539

Start: 909493

End: 910692

Strand: Reverse

Name: macA [H]

Synonym: BURPS668_A0927

Alternate gene names: 126444539

Gene position: 910692-909493 (Counterclockwise)

Preceding gene: 126442833

Following gene: 126443590

Centisome position: 29.12

GC content: 68.58

Gene sequence:

>1200_bases
ATGAAAAAATCCCAACGCCGCTGGATCGCCGTAGCGGCCGGCGGCGTCGTGCTCGTCTCGCTCGCCTTGCTCTATCACCG
CTTCGTGTCGAAAGACAAGGCGCCGCATTACCTCACCGCGAACGTCGCCCGCGCCGATCTCGAGAACGCGGTGCTCGCCA
CCGGCACGCTGCACGCGTTCAAGCAGGTCGACGTCGGCGCGCAGGTGTCCGGCCAGTTGAAATCGCTGAAGGTGAAGCTC
GGCGACAAGGTGACGAAGGATCAATGGCTCGCCGAGATCGATCCGGTGATCTCGCGAAACGAGCTGCGCCAGGCCGAGGC
GAACGTCGAGAACCTCGTCGCGCAGAAGCGCTCGAGCTCCGCGCAGTTCAAGCAGGCCGAGCTCGCGTTCAGGCGGCAGC
AGCAGATGCTGCCCGACGACGCGACCTCGCGCCAGGACTACGAGGCCGCGGCCGCGTCGCTCGACGTGCAGCGCGCGAGC
CTCGCCGCGCTCGACGCGCAGATCCGCGCGGCGCGCATCAAGATCGAGACCGCGCGCGCGAACCTCGGCTATACGCGGAT
CGTCGCGCCGATGGACGGCGAAGTGGTCGCGATCGTCACGCAGGAAGGCCAGACGGTGATCGCGCAGCAGCAGGCGCCCG
TGATCCTGAAGCTCGCGCAGCTCGACACGATGACGGTCAAGGCGCAGGTGTCGGAGGCGGACGTGATCCGCATCCATCCC
GAGCAGGCCGCGTACTTCACGATCCTCGGCGAGCCCGACAAGCGCTACTACGGCAAGCTGCGCGCGATCGAGCCCGCGCC
GCAGAACTTCCTCGACACGCAGGGCGGCATGGGCGGCGCGGGCGGCGGCTCCGCGAAGACGAACACGGCGGTGTTCTACA
ACGCGCTCTTCGAAGTGCCGAATCCCGGCCACCGGCTACGCATCTCGATGACCGCGCAGGTAAACATCCTGCTCGGCACC
GCGCGCAACGCGCTCAACATTCCCGTCGCCGCGCTCGGCGCGAAGGGCAAGGACGGCGCATACGCGGTGCGCGTCGTCGG
CGCCGATGGCAAGGTGGCCACGCGCCAGGTGCGCACCGGCATCAACAACAACGTGAAGGTCGAGGTGCTGTCGGGCCTCA
CCGAGGGCGAGCGCGTGATCATCGGCGATGCGGCCGAGCCCGCCGGCGCCGGCGCGGCCGCGTCCGACGCGAGGAACTGA

Upstream 100 bases:

>100_bases
GAAATCTGTCGCTGAATTGAACCCGGCGACCTTTTCGCATTCCAATATCCGGTTTCATTTTCATTACAATTGCCTGCCAC
GCGTTACCGTCCCGTCTCCC

Downstream 100 bases:

>100_bases
CGATGACCGGGCCGCTGCTTCAGCTCACGCGCGTCACGCGCCGCTTTCCGGCGGGCGAGAAGGACGTCGTCGTGCTCGAC
GACGTGAGCCTGTCGATCGA

Product: macrolide efflux protein MacA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKKSQRRWIAVAAGGVVLVSLALLYHRFVSKDKAPHYLTANVARADLENAVLATGTLHAFKQVDVGAQVSGQLKSLKVKL
GDKVTKDQWLAEIDPVISRNELRQAEANVENLVAQKRSSSAQFKQAELAFRRQQQMLPDDATSRQDYEAAAASLDVQRAS
LAALDAQIRAARIKIETARANLGYTRIVAPMDGEVVAIVTQEGQTVIAQQQAPVILKLAQLDTMTVKAQVSEADVIRIHP
EQAAYFTILGEPDKRYYGKLRAIEPAPQNFLDTQGGMGGAGGGSAKTNTAVFYNALFEVPNPGHRLRISMTAQVNILLGT
ARNALNIPVAALGAKGKDGAYAVRVVGADGKVATRQVRTGINNNVKVEVLSGLTEGERVIIGDAAEPAGAGAAASDARN

Sequences:

>Translated_399_residues
MKKSQRRWIAVAAGGVVLVSLALLYHRFVSKDKAPHYLTANVARADLENAVLATGTLHAFKQVDVGAQVSGQLKSLKVKL
GDKVTKDQWLAEIDPVISRNELRQAEANVENLVAQKRSSSAQFKQAELAFRRQQQMLPDDATSRQDYEAAAASLDVQRAS
LAALDAQIRAARIKIETARANLGYTRIVAPMDGEVVAIVTQEGQTVIAQQQAPVILKLAQLDTMTVKAQVSEADVIRIHP
EQAAYFTILGEPDKRYYGKLRAIEPAPQNFLDTQGGMGGAGGGSAKTNTAVFYNALFEVPNPGHRLRISMTAQVNILLGT
ARNALNIPVAALGAKGKDGAYAVRVVGADGKVATRQVRTGINNNVKVEVLSGLTEGERVIIGDAAEPAGAGAAASDARN
>Mature_399_residues
MKKSQRRWIAVAAGGVVLVSLALLYHRFVSKDKAPHYLTANVARADLENAVLATGTLHAFKQVDVGAQVSGQLKSLKVKL
GDKVTKDQWLAEIDPVISRNELRQAEANVENLVAQKRSSSAQFKQAELAFRRQQQMLPDDATSRQDYEAAAASLDVQRAS
LAALDAQIRAARIKIETARANLGYTRIVAPMDGEVVAIVTQEGQTVIAQQQAPVILKLAQLDTMTVKAQVSEADVIRIHP
EQAAYFTILGEPDKRYYGKLRAIEPAPQNFLDTQGGMGGAGGGSAKTNTAVFYNALFEVPNPGHRLRISMTAQVNILLGT
ARNALNIPVAALGAKGKDGAYAVRVVGADGKVATRQVRTGINNNVKVEVLSGLTEGERVIIGDAAEPAGAGAAASDARN

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=383, Percent_Identity=44.3864229765013, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI87082036, Length=349, Percent_Identity=27.7936962750716, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786668, Length=335, Percent_Identity=27.4626865671642, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789929, Length=335, Percent_Identity=25.3731343283582, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42576; Mature: 42576

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSQRRWIAVAAGGVVLVSLALLYHRFVSKDKAPHYLTANVARADLENAVLATGTLHAF
CCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHCCCEEEECHHHHH
KQVDVGAQVSGQLKSLKVKLGDKVTKDQWLAEIDPVISRNELRQAEANVENLVAQKRSSS
HHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCHHCHHHHHHHHCCHHHHHHHHCCCC
AQFKQAELAFRRQQQMLPDDATSRQDYEAAAASLDVQRASLAALDAQIRAARIKIETARA
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEECC
NLGYTRIVAPMDGEVVAIVTQEGQTVIAQQQAPVILKLAQLDTMTVKAQVSEADVIRIHP
CCCEEEEEECCCCCEEEEEECCCCEEEEECCCCEEEEEECCCEEEEEEECCCCCEEEECC
EQAAYFTILGEPDKRYYGKLRAIEPAPQNFLDTQGGMGGAGGGSAKTNTAVFYNALFEVP
CCCEEEEEECCCCHHHHCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCC
NPGHRLRISMTAQVNILLGTARNALNIPVAALGAKGKDGAYAVRVVGADGKVATRQVRTG
CCCCEEEEEEEEEEEEEEECCCCCCCCCEEEECCCCCCCEEEEEEECCCCCEEHHHHHCC
INNNVKVEVLSGLTEGERVIIGDAAEPAGAGAAASDARN
CCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKSQRRWIAVAAGGVVLVSLALLYHRFVSKDKAPHYLTANVARADLENAVLATGTLHAF
CCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHCCCEEEECHHHHH
KQVDVGAQVSGQLKSLKVKLGDKVTKDQWLAEIDPVISRNELRQAEANVENLVAQKRSSS
HHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCHHCHHHHHHHHCCHHHHHHHHCCCC
AQFKQAELAFRRQQQMLPDDATSRQDYEAAAASLDVQRASLAALDAQIRAARIKIETARA
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEECC
NLGYTRIVAPMDGEVVAIVTQEGQTVIAQQQAPVILKLAQLDTMTVKAQVSEADVIRIHP
CCCEEEEEECCCCCEEEEEECCCCEEEEECCCCEEEEEECCCEEEEEEECCCCCEEEECC
EQAAYFTILGEPDKRYYGKLRAIEPAPQNFLDTQGGMGGAGGGSAKTNTAVFYNALFEVP
CCCEEEEEECCCCHHHHCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCC
NPGHRLRISMTAQVNILLGTARNALNIPVAALGAKGKDGAYAVRVVGADGKVATRQVRTG
CCCCEEEEEEEEEEEEEEECCCCCCCCCEEEECCCCCCCEEEEEEECCCCCEEHHHHHCC
INNNVKVEVLSGLTEGERVIIGDAAEPAGAGAAASDARN
CCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]