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The map label for this gene is cpxA [H]

Identifier: 126444521

GI number: 126444521

Start: 2576207

End: 2577304

Strand: Reverse

Name: cpxA [H]

Synonym: BURPS668_A2689

Alternate gene names: 126444521

Gene position: 2577304-2576207 (Counterclockwise)

Preceding gene: 126444526

Following gene: 126443741

Centisome position: 82.41

GC content: 68.85

Gene sequence:

>1098_bases
ATGATGAACAAAACGAACAGGGATAATGCTTCGGATTCGCTTGAATCGGGGATCTCGGTGCTGCTGGTCGACGACCAGGC
GTTCGTCGGCGAGGTGATTCGCCGCTCGCTCGTCCCGGAGAGCGACATCGTGCTGCACACGTGCACCGACGCGCAGCGCG
CGCTCGCGATGGCGAAGGAAGTGAAGCCGACCGTGATCCTGCAGGATCTCGTGATGCCCGACATCGACGGCCTCGAGCTC
GTGCGCGCGTGGCGCGCCGACGCGCAGACGGCCCGCGTGCCGATCATCGTGCTGTCGGCGAAAGAGGAGCCCGCCGTCAA
GCGCGCGGCGTTCGTCGCGGGCGCGAACGACTATCTCGTCAAGCTGCCCGACACGATCGAGCTGATCGCGCGCATCCGCT
ATCACTCGAATTCGTATCTGATGCTGCGCCAGCGCGACGAGGTGCTCGACTTCCTGTCGCACGACATGCGCACGCCGCAG
ACGTCGATCCTCGCGCTCCTCGACGTCTATCGCAACGAGCACGGCGCGATGCCGCCGATCCTCGAGCGCATCGAGACGCA
TGCGCGCCGCGCGCTCGCGCTCGCCGACGGCTTCATTCATCTGACGCGCGCGCAATCGGAGAAGCGGCCGAGCGAGACGG
TGAGCTTGAACGAGGTCGTGCTCGACGCCGTCGACCAGATGTGGGAGAAGGCGGGCAGCGTCGGCAGCCGCGTGCGCGCG
GACGTGCCGCCGACCGAGTGCCTGTGCATCGGCGACCGGATGATGCTCACGCGCGCCGTGGCGAACCTCGTCGACAACGC
GCTGAAGTACGGCCCCGGGGGCTCCGAGGTGCGCTGCACGCTCGTCGAGGACGGCGACGGCTGGCTGATCGGCGTCGAGG
ATGAAGGCGCGGGCATCGCGCCCGATCAGCGCGCGGCCGCGACCGAATCGTTCGTGCGGCTCGTGCCGGCGGGCGGCGCG
CAGCGCGGCGGCTTCGGGCTCGGTCTCGCGTTCGTGCGCGCGACGGCCGCGAAGCATCGCGGGCAGATCCTGATGCGCTA
CACGCCGCGCGGCTTTCTCGCCGGGCTGCGGATTCCGAAGGACGTGAGCGCCGCGTGA

Upstream 100 bases:

>100_bases
GGGCTCGCGCTTACGCGATCGCATGCCTTTCCAGCCGGGCAAGCGAGTGGCGAACGGAGCTGGAACAGGCAACAAGGCAA
CGATTGTGTAGCGCTACGAC

Downstream 100 bases:

>100_bases
CGCGCGGCGGCAGCGCGCCCGGCGCGCGCCGGCCCCTCTTCGTTCACGATGGTTCAAGTTACACTCGCGATGCCCGGGGC
GCGCATCGCGCCGGGATCGA

Product: response regulator/sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MMNKTNRDNASDSLESGISVLLVDDQAFVGEVIRRSLVPESDIVLHTCTDAQRALAMAKEVKPTVILQDLVMPDIDGLEL
VRAWRADAQTARVPIIVLSAKEEPAVKRAAFVAGANDYLVKLPDTIELIARIRYHSNSYLMLRQRDEVLDFLSHDMRTPQ
TSILALLDVYRNEHGAMPPILERIETHARRALALADGFIHLTRAQSEKRPSETVSLNEVVLDAVDQMWEKAGSVGSRVRA
DVPPTECLCIGDRMMLTRAVANLVDNALKYGPGGSEVRCTLVEDGDGWLIGVEDEGAGIAPDQRAAATESFVRLVPAGGA
QRGGFGLGLAFVRATAAKHRGQILMRYTPRGFLAGLRIPKDVSAA

Sequences:

>Translated_365_residues
MMNKTNRDNASDSLESGISVLLVDDQAFVGEVIRRSLVPESDIVLHTCTDAQRALAMAKEVKPTVILQDLVMPDIDGLEL
VRAWRADAQTARVPIIVLSAKEEPAVKRAAFVAGANDYLVKLPDTIELIARIRYHSNSYLMLRQRDEVLDFLSHDMRTPQ
TSILALLDVYRNEHGAMPPILERIETHARRALALADGFIHLTRAQSEKRPSETVSLNEVVLDAVDQMWEKAGSVGSRVRA
DVPPTECLCIGDRMMLTRAVANLVDNALKYGPGGSEVRCTLVEDGDGWLIGVEDEGAGIAPDQRAAATESFVRLVPAGGA
QRGGFGLGLAFVRATAAKHRGQILMRYTPRGFLAGLRIPKDVSAA
>Mature_365_residues
MMNKTNRDNASDSLESGISVLLVDDQAFVGEVIRRSLVPESDIVLHTCTDAQRALAMAKEVKPTVILQDLVMPDIDGLEL
VRAWRADAQTARVPIIVLSAKEEPAVKRAAFVAGANDYLVKLPDTIELIARIRYHSNSYLMLRQRDEVLDFLSHDMRTPQ
TSILALLDVYRNEHGAMPPILERIETHARRALALADGFIHLTRAQSEKRPSETVSLNEVVLDAVDQMWEKAGSVGSRVRA
DVPPTECLCIGDRMMLTRAVANLVDNALKYGPGGSEVRCTLVEDGDGWLIGVEDEGAGIAPDQRAAATESFVRLVPAGGA
QRGGFGLGLAFVRATAAKHRGQILMRYTPRGFLAGLRIPKDVSAA

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG3706

COG function: function code T; Response regulator containing a CheY-like receiver domain and a GGDEF domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=219, Percent_Identity=30.5936073059361, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1790551, Length=223, Percent_Identity=28.2511210762332, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1786783, Length=211, Percent_Identity=29.3838862559242, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789808, Length=207, Percent_Identity=31.4009661835749, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786911, Length=115, Percent_Identity=41.7391304347826, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786912, Length=215, Percent_Identity=28.3720930232558, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787894, Length=206, Percent_Identity=27.6699029126214, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790861, Length=264, Percent_Identity=25.7575757575758, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87081816, Length=126, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39811; Mature: 39811

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNKTNRDNASDSLESGISVLLVDDQAFVGEVIRRSLVPESDIVLHTCTDAQRALAMAKE
CCCCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
VKPTVILQDLVMPDIDGLELVRAWRADAQTARVPIIVLSAKEEPAVKRAAFVAGANDYLV
CCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHEECCCCEEE
KLPDTIELIARIRYHSNSYLMLRQRDEVLDFLSHDMRTPQTSILALLDVYRNEHGAMPPI
ECCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHH
LERIETHARRALALADGFIHLTRAQSEKRPSETVSLNEVVLDAVDQMWEKAGSVGSRVRA
HHHHHHHHHHHHHHHHCHHEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEC
DVPPTECLCIGDRMMLTRAVANLVDNALKYGPGGSEVRCTLVEDGDGWLIGVEDEGAGIA
CCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCCCCCC
PDQRAAATESFVRLVPAGGAQRGGFGLGLAFVRATAAKHRGQILMRYTPRGFLAGLRIPK
CCHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCC
DVSAA
CCCCC
>Mature Secondary Structure
MMNKTNRDNASDSLESGISVLLVDDQAFVGEVIRRSLVPESDIVLHTCTDAQRALAMAKE
CCCCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
VKPTVILQDLVMPDIDGLELVRAWRADAQTARVPIIVLSAKEEPAVKRAAFVAGANDYLV
CCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHEECCCCEEE
KLPDTIELIARIRYHSNSYLMLRQRDEVLDFLSHDMRTPQTSILALLDVYRNEHGAMPPI
ECCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHH
LERIETHARRALALADGFIHLTRAQSEKRPSETVSLNEVVLDAVDQMWEKAGSVGSRVRA
HHHHHHHHHHHHHHHHCHHEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEC
DVPPTECLCIGDRMMLTRAVANLVDNALKYGPGGSEVRCTLVEDGDGWLIGVEDEGAGIA
CCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCCCCCC
PDQRAAATESFVRLVPAGGAQRGGFGLGLAFVRATAAKHRGQILMRYTPRGFLAGLRIPK
CCHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCC
DVSAA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]