Click here to switch to the map view.

The map label for this gene is lldD [H]

Identifier: 126444156

GI number: 126444156

Start: 2487161

End: 2488399

Strand: Reverse

Name: lldD [H]

Synonym: BURPS668_A2580

Alternate gene names: 126444156

Gene position: 2488399-2487161 (Counterclockwise)

Preceding gene: 126442883

Following gene: 126443700

Centisome position: 79.57

GC content: 65.78

Gene sequence:

>1239_bases
ATGGCCAATGTCGGCAAGGCTTGGAACATCGATGATTTGAGAAAAATGGCGCGAAAGCGCGTGCCCAAATATTTCTTCGA
TTATCTGGACGGCGGCGCGAACAGCGAAACCACGATGCGCGCGAACGAAAACGATTTCGCGCGCTGGCGGCTGCGTCAGA
AAGTATTGACCGGCGCGCAGAGCCGGGTTGCGGGTTTGGGGGCGACATACCTCGGCGCCGAGCATCGGCTTCCGATTCTG
CTCGGGCCGGTGGGATTTGCCGGCATGTATTGGTCGCGCGGCGAGATCGCGGCGGGACGCGCGGCCGACGACGCGGGCAT
CGGTCAGTGTTTGTCGACGTTCTCGATCTGTTCGCTCGAGGATGTCGCCGCGGCGCGCTCCGGTCCGCTGTATTTTCAGC
TCTACATGTTCCGCGATCGCGATCTGACCGAGGACATTCTCGCGCGCTGCCGGCTGGCGAACGTCGACGCCGTCTTTCTG
ACGGTGGACACCTGCTATATCCCGATTCGCGAACGCGATGCGCGCAACGGGTTTCGCGCCGATACGCGCTTGTCGGCGCG
CGGGGTATGGTCGATGCTCAAGCGCCCGGGCTGGTGCGCCGGTGCGTTGTCCCATGGCATGCCGAGGATCGGCAACGTGC
TGCGCTATCCGGAGCTTGGCGCATCGTTGCTCGAGCAATCCGCGGCGGTCGGCCGGATGATCGAGACGCGCTTGTCCTGG
GCCGACGTCAAGTGGCTGCGCGCGCGCTGGCCCGGCAGGATCGTCATCAAGGGGATTCTCGATCCCGACGACGCGCGGCG
CGCGGTCGACGAGGGCGTCGACGGCATCCTGATCTCGAATCATGGCGGCCGGCAACTCGATCCGGCGCCGTCGGTGATGG
ACGTGTTGCCGGAGATCGCCGAGGCGGTCGGCAAGCGCACCGAGATCCTGATGGACGGCGGTGTGCGGCGCGGTGCGGAC
GTGATCAAGGCGCTGGCGCTCGGGGCCAGCGCGGTCTCGATCGGGCGCGCCTACGTCTATGGGCTCGGTGCGGCGGGTGA
GAAGGGCGTCTCGCGATGTCTCGAATTGCTGAAGGGCGAGATGCTGCCGGCGCTTAACATGATGGGCTTTGAATCGATCG
CGGAACTCAGGGCCGCGGGCAAGTCCGCGTTGCGAATGGCGGTGCCGGTTCATGACGCGACGGCGGCTGTCGAAGGGGCG
GAGGGCGGGGCGCGCAGACTGACGGAGAGCGTGCTGTAG

Upstream 100 bases:

>100_bases
ATCGCGGTGCGCCAGCGTGAGCGCAATGAGCGTGCGCATCCGGCGCACGCCCGAAGACGAACGCCCGCGGTGCGCCGGCG
GAGAACGGAGAAGAATTCAG

Downstream 100 bases:

>100_bases
CATCAACGTGCCGATGGCGTGCCGTGGCGCCGCAACCGGCGGCGCACGGCGCTCATCGCGCAGGCTACTTGCAGACGTCG
ACCCATTCGGCTTCGACCAG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MANVGKAWNIDDLRKMARKRVPKYFFDYLDGGANSETTMRANENDFARWRLRQKVLTGAQSRVAGLGATYLGAEHRLPIL
LGPVGFAGMYWSRGEIAAGRAADDAGIGQCLSTFSICSLEDVAAARSGPLYFQLYMFRDRDLTEDILARCRLANVDAVFL
TVDTCYIPIRERDARNGFRADTRLSARGVWSMLKRPGWCAGALSHGMPRIGNVLRYPELGASLLEQSAAVGRMIETRLSW
ADVKWLRARWPGRIVIKGILDPDDARRAVDEGVDGILISNHGGRQLDPAPSVMDVLPEIAEAVGKRTEILMDGGVRRGAD
VIKALALGASAVSIGRAYVYGLGAAGEKGVSRCLELLKGEMLPALNMMGFESIAELRAAGKSALRMAVPVHDATAAVEGA
EGGARRLTESVL

Sequences:

>Translated_412_residues
MANVGKAWNIDDLRKMARKRVPKYFFDYLDGGANSETTMRANENDFARWRLRQKVLTGAQSRVAGLGATYLGAEHRLPIL
LGPVGFAGMYWSRGEIAAGRAADDAGIGQCLSTFSICSLEDVAAARSGPLYFQLYMFRDRDLTEDILARCRLANVDAVFL
TVDTCYIPIRERDARNGFRADTRLSARGVWSMLKRPGWCAGALSHGMPRIGNVLRYPELGASLLEQSAAVGRMIETRLSW
ADVKWLRARWPGRIVIKGILDPDDARRAVDEGVDGILISNHGGRQLDPAPSVMDVLPEIAEAVGKRTEILMDGGVRRGAD
VIKALALGASAVSIGRAYVYGLGAAGEKGVSRCLELLKGEMLPALNMMGFESIAELRAAGKSALRMAVPVHDATAAVEGA
EGGARRLTESVL
>Mature_411_residues
ANVGKAWNIDDLRKMARKRVPKYFFDYLDGGANSETTMRANENDFARWRLRQKVLTGAQSRVAGLGATYLGAEHRLPILL
GPVGFAGMYWSRGEIAAGRAADDAGIGQCLSTFSICSLEDVAAARSGPLYFQLYMFRDRDLTEDILARCRLANVDAVFLT
VDTCYIPIRERDARNGFRADTRLSARGVWSMLKRPGWCAGALSHGMPRIGNVLRYPELGASLLEQSAAVGRMIETRLSWA
DVKWLRARWPGRIVIKGILDPDDARRAVDEGVDGILISNHGGRQLDPAPSVMDVLPEIAEAVGKRTEILMDGGVRRGADV
IKALALGASAVSIGRAYVYGLGAAGEKGVSRCLELLKGEMLPALNMMGFESIAELRAAGKSALRMAVPVHDATAAVEGAE
GGARRLTESVL

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=368, Percent_Identity=38.8586956521739, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI54234014, Length=368, Percent_Identity=35.054347826087, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI7705393, Length=368, Percent_Identity=35.054347826087, Blast_Score=209, Evalue=4e-54,
Organism=Escherichia coli, GI1790033, Length=366, Percent_Identity=40.4371584699454, Blast_Score=262, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI193208036, Length=372, Percent_Identity=34.4086021505376, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI32566217, Length=282, Percent_Identity=30.8510638297872, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323587, Length=380, Percent_Identity=29.7368421052632, Blast_Score=169, Evalue=8e-43,
Organism=Drosophila melanogaster, GI281363140, Length=371, Percent_Identity=33.4231805929919, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI78707190, Length=371, Percent_Identity=33.4231805929919, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI78707188, Length=371, Percent_Identity=33.4231805929919, Blast_Score=187, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 44637; Mature: 44506

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANVGKAWNIDDLRKMARKRVPKYFFDYLDGGANSETTMRANENDFARWRLRQKVLTGAQ
CCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHCHH
SRVAGLGATYLGAEHRLPILLGPVGFAGMYWSRGEIAAGRAADDAGIGQCLSTFSICSLE
HHHHHCCHHHCCCCCCCCEEECCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHH
DVAAARSGPLYFQLYMFRDRDLTEDILARCRLANVDAVFLTVDTCYIPIRERDARNGFRA
HHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCC
DTRLSARGVWSMLKRPGWCAGALSHGMPRIGNVLRYPELGASLLEQSAAVGRMIETRLSW
CCCHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ADVKWLRARWPGRIVIKGILDPDDARRAVDEGVDGILISNHGGRQLDPAPSVMDVLPEIA
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
EAVGKRTEILMDGGVRRGADVIKALALGASAVSIGRAYVYGLGAAGEKGVSRCLELLKGE
HHHCCHHEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHH
MLPALNMMGFESIAELRAAGKSALRMAVPVHDATAAVEGAEGGARRLTESVL
HCHHHHHHHHHHHHHHHHCCHHHEEEEECCCHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure 
ANVGKAWNIDDLRKMARKRVPKYFFDYLDGGANSETTMRANENDFARWRLRQKVLTGAQ
CCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHCHH
SRVAGLGATYLGAEHRLPILLGPVGFAGMYWSRGEIAAGRAADDAGIGQCLSTFSICSLE
HHHHHCCHHHCCCCCCCCEEECCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHH
DVAAARSGPLYFQLYMFRDRDLTEDILARCRLANVDAVFLTVDTCYIPIRERDARNGFRA
HHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCC
DTRLSARGVWSMLKRPGWCAGALSHGMPRIGNVLRYPELGASLLEQSAAVGRMIETRLSW
CCCHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ADVKWLRARWPGRIVIKGILDPDDARRAVDEGVDGILISNHGGRQLDPAPSVMDVLPEIA
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
EAVGKRTEILMDGGVRRGADVIKALALGASAVSIGRAYVYGLGAAGEKGVSRCLELLKGE
HHHCCHHEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHH
MLPALNMMGFESIAELRAAGKSALRMAVPVHDATAAVEGAEGGARRLTESVL
HCHHHHHHHHHHHHHHHHCCHHHEEEEECCCHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA