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The map label for this gene is bioA [C]

Identifier: 126443798

GI number: 126443798

Start: 497808

End: 499229

Strand: Reverse

Name: bioA [C]

Synonym: BURPS668_A0532

Alternate gene names: 126443798

Gene position: 499229-497808 (Counterclockwise)

Preceding gene: 126443062

Following gene: 284159989

Centisome position: 15.96

GC content: 69.69

Gene sequence:

>1422_bases
ATGGCATACCGAAACGATTCCCTTCTCACGAGCGCGCAGCAGGACACGCGGCATCTGCTGCACCCGTGGGCCGATCTGTC
CGCGCTCGGCCGCGAGACGCCGACCGTCATCGTCGACGCGCAGGGCACGCGCGTGACCGACGCCGACGGGCGCACCTATC
TCGACGCGATCGGCGGCATGTGGTGCGTGACGCTCGGCTACGGCCGGCGCGAGATCGCCGACGCGATCCGCGATCAGGCG
CTGCGCATGCCGTTCTACACGCCGTTCGGCGCGATGACGAACGAGCCCGCCGCCGCGCTCGGCGCGCGGCTCGCCGCGCT
CGCGCCCGGCGATCTGAAGCGCGTGCACCTGACCACCTGCGGCTCGACAGCGGTCGAATCGGCGCTGCGTTTCGCGCACT
ACTACTTCGGCGCGACGGGCCGCCCGCACAAGCGCCACATCGTCACGCGCGGCGACGCGTACCACGGCAGCACGTATCTC
GCCGCATCGATATCCGGCAAGGCGTGGGACCGCACGTGCTTTCACTACGACAGCACGATCGTCCATCACCTGTCGTCGCC
GAACCCGTACCGGCGGCCGGCCGGCATGAGCGTCGACGCGTTCTGCGCGTCGCTCGTCGACGAATTCGACGCGCTGATCG
CGAAGCTCGGCGCGGAGCAGATCGCATGCTTCATCGCCGAGCCGATCCTCGCGTCGGGCGGCGTGATCGTGCCGCCGCCC
GGCTATCTCGCCGCGATGCGCGAGCGCTGCCGCCGGCACGACATCCTGTACATCAGCGACGAAGTCGTCACGGGCTTCGG
CCGCGTCGGCCACTTCTTCGCGTCGCACGCGCACTTCGGCATCGAGCCCGACATGATCGTCGTCGCGAAGGGGCTCACCT
CCGGCTACCAGCCGCTCGGCGCGGTGCTGATCTCGGAGCGGCTCGTCGATGCGGTATCCGGCGAGCACGCGTACGGCAAC
GGCGTGTTCACGAACGGTTTCACCTACTCGGGCCATCCGGTCGCCTGCGCGGCCGCGCTCGCCAACATCGAGCTGATGGA
GCGCGAGCGGATCTGCGAGCACGTGCGCGACGTCGGCCCGTACTTCATTCGCCGGCTCGATGCGCTGCGGCGCCTGCCGA
TCGTCGGCGACGTGCGCGGCGATCATCTGATGGCGTGCATCGAATGCACGAGCGGCGCGGGCGCGACGGGCGCGTTGCCG
ACGCCCGCGGACATCGCGATCGCGCAGCGCGTCGATCGCCACTGCGAAGAGATGGGCCTGCTCGTGCGGCCCTACGAGAG
CATGTGCATCCTGTCGCCGCCCCTCACCGTGACGCGCGCCGACATCGACGAAATCTGCGCGATTCTCGCGGCCGCGCTCG
AGCGCGCGCAGCGCGAGCTCGCGCAACATGCCCCCGTTCGCGAGGAAAACGAAACATGCTGA

Upstream 100 bases:

>100_bases
GCGACGTGCTCGTGCTCGACAACGTCTACGTGCAGCACGGCCGCTTCGCGTTCTCCGGGCCGCGCCTGCATCTCGTCAGC
CTGACCGACTGAGGCAACAC

Downstream 100 bases:

>100_bases
TCAACGGCCTTTGCATCGAAGGGGGCGGCGAGCCGCTGTCGATCGTCGATCCGGCGACGGGCGAGCCGCTCGCGGCGCCC
GCCGCCGCGAGCGCGGCCGA

Product: hypothetical protein

Products: S-Adenosyl-4-methylthio-2-oxobutanoate; 7,8-Diaminononanoate [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MAYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVDAQGTRVTDADGRTYLDAIGGMWCVTLGYGRREIADAIRDQA
LRMPFYTPFGAMTNEPAAALGARLAALAPGDLKRVHLTTCGSTAVESALRFAHYYFGATGRPHKRHIVTRGDAYHGSTYL
AASISGKAWDRTCFHYDSTIVHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLGAVLISERLVDAVSGEHAYGN
GVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGPYFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALP
TPADIAIAQRVDRHCEEMGLLVRPYESMCILSPPLTVTRADIDEICAILAAALERAQRELAQHAPVREENETC

Sequences:

>Translated_473_residues
MAYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVDAQGTRVTDADGRTYLDAIGGMWCVTLGYGRREIADAIRDQA
LRMPFYTPFGAMTNEPAAALGARLAALAPGDLKRVHLTTCGSTAVESALRFAHYYFGATGRPHKRHIVTRGDAYHGSTYL
AASISGKAWDRTCFHYDSTIVHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLGAVLISERLVDAVSGEHAYGN
GVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGPYFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALP
TPADIAIAQRVDRHCEEMGLLVRPYESMCILSPPLTVTRADIDEICAILAAALERAQRELAQHAPVREENETC
>Mature_472_residues
AYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVDAQGTRVTDADGRTYLDAIGGMWCVTLGYGRREIADAIRDQAL
RMPFYTPFGAMTNEPAAALGARLAALAPGDLKRVHLTTCGSTAVESALRFAHYYFGATGRPHKRHIVTRGDAYHGSTYLA
ASISGKAWDRTCFHYDSTIVHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPPG
YLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLGAVLISERLVDAVSGEHAYGNG
VFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGPYFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALPT
PADIAIAQRVDRHCEEMGLLVRPYESMCILSPPLTVTRADIDEICAILAAALERAQRELAQHAPVREENETC

Specific function: Biotin biosynthesis. [C]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=456, Percent_Identity=26.5350877192982, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI226442705, Length=436, Percent_Identity=27.5229357798165, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI37574042, Length=435, Percent_Identity=27.816091954023, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI24119277, Length=436, Percent_Identity=27.0642201834862, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI4557809, Length=424, Percent_Identity=26.6509433962264, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI226442709, Length=366, Percent_Identity=28.6885245901639, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI284507298, Length=293, Percent_Identity=29.6928327645051, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1786991, Length=446, Percent_Identity=30.2690582959641, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788044, Length=428, Percent_Identity=28.9719626168224, Blast_Score=152, Evalue=7e-38,
Organism=Escherichia coli, GI145693181, Length=349, Percent_Identity=30.0859598853868, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789016, Length=436, Percent_Identity=29.5871559633028, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI1787560, Length=425, Percent_Identity=30.1176470588235, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789759, Length=412, Percent_Identity=28.1553398058252, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786349, Length=316, Percent_Identity=28.1645569620253, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32564660, Length=447, Percent_Identity=28.4116331096197, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI25144271, Length=423, Percent_Identity=24.822695035461, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=267, Percent_Identity=28.8389513108614, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=444, Percent_Identity=25.2252252252252, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17541228, Length=398, Percent_Identity=24.6231155778894, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=488, Percent_Identity=25.4098360655738, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6323470, Length=418, Percent_Identity=26.7942583732057, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6324432, Length=421, Percent_Identity=26.3657957244656, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=359, Percent_Identity=23.9554317548747, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574759, Length=449, Percent_Identity=28.0623608017817, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI161085790, Length=450, Percent_Identity=27.5555555555556, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21356575, Length=426, Percent_Identity=28.169014084507, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21357415, Length=430, Percent_Identity=24.8837209302326, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62 [C]

Molecular weight: Translated: 51327; Mature: 51196

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVDAQGTRVTDADGRTYLDAIGGM
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHCCE
WCVTLGYGRREIADAIRDQALRMPFYTPFGAMTNEPAAALGARLAALAPGDLKRVHLTTC
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
GSTAVESALRFAHYYFGATGRPHKRHIVTRGDAYHGSTYLAASISGKAWDRTCFHYDSTI
CHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCHHHHHCHHH
VHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEECCC
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLG
HHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHH
AVLISERLVDAVSGEHAYGNGVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGP
HHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
YFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALPTPADIAIAQRVDRHCEEMGL
HHHHHHHHHHHCCCEECCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
LVRPYESMCILSPPLTVTRADIDEICAILAAALERAQRELAQHAPVREENETC
EECCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVDAQGTRVTDADGRTYLDAIGGM
CCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHCCE
WCVTLGYGRREIADAIRDQALRMPFYTPFGAMTNEPAAALGARLAALAPGDLKRVHLTTC
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
GSTAVESALRFAHYYFGATGRPHKRHIVTRGDAYHGSTYLAASISGKAWDRTCFHYDSTI
CHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCHHHHHCHHH
VHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEECCC
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLG
HHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHH
AVLISERLVDAVSGEHAYGNGVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGP
HHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
YFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALPTPADIAIAQRVDRHCEEMGL
HHHHHHHHHHHCCCEECCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
LVRPYESMCILSPPLTVTRADIDEICAILAAALERAQRELAQHAPVREENETC
EECCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Amino-7-oxononanoate; S-Adenosyl-L-methionine [C]

Specific reaction: 8-Amino-7-oxononanoate + S-Adenosyl-L-methionine <==> S-Adenosyl-4-methylthio-2-oxobutanoate + 7,8-Diaminononanoate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]