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The map label for this gene is yjcE [H]

Identifier: 126443712

GI number: 126443712

Start: 2582178

End: 2583758

Strand: Reverse

Name: yjcE [H]

Synonym: BURPS668_A2698

Alternate gene names: 126443712

Gene position: 2583758-2582178 (Counterclockwise)

Preceding gene: 126445074

Following gene: 126442796

Centisome position: 82.62

GC content: 70.71

Gene sequence:

>1581_bases
ATGTCTCCGGTCTCGGCATTCAAGCTCGTTTTGCTGTCCTTTCTCGCGATCGTCGCGCTCGAGCTGCTCGCGAAGCGGCT
CCGGCTGCCGCCCGCCGCCGCGCTGCTCGTCGGCGGCGCGGGCATCGCGTTCCTGCCCGGGCTGCCGCCCGTCAATCTCG
ATCCGGACCTCGTGCTGATCGTGTTCCTGCCGCCGTTGTTGATGGACGGCGCGTACTTCTCGGTGTGGGAAGAGTTCAAG
CGCAACGTCGGCGGCATCATGATGCTCGCGATCGGCGCGGTCGCGTTCACGACGCTCGCCGTCGGCGTCGCCGTGCATCT
CGTCGCGCCCGGGCTGCCGTGGGCCGCGTGCTTCGCGCTCGGCGCGATCGTGTCGCCGCCCGACGCGGTCGCCGCGAAGG
CGGTGCTCGAGCGCGTCGCGCTGCCGCGCCGGCTGATGGTGCTGCTCGAAGGCGAGAGCCTCCTGAACGACGCGGCGGGG
CTCGTGCTGTTCCGCTTCGCGGTTGCCGCCGCGCTGACGGGCGCGTTCGGCACGGGCGACGCCGTCGTGCGCTTCGCGCA
GCTCGGCGTCGGCGGCGTCGCGGTCGGCTTCATCGTCGGCTGGCTGATCGTGCGGTTCCTGAAGCTCGTCGAGGACGACT
ATCTGGTGATCACGGTGGCCGTTCTCGCCGCGTGGGTCAGCTACATCGCGGGCGAACTGTTCGAAGTGTCCGGCGTGATC
GCGACCGTGACGACCGGGATGATGCTCGGCTGGCATCAGCACGAAGTGTTCTCGGCTTCGGTGCGCAACCGCGGCACCGC
GTTCTGGCAGGTGATCGTGTTCCTGCTCGAGGCGCTCGTGTTCGTGCTGATCGGGCTGTCGCTGCGCGGCGTGATCGAGC
GGCTCGGCGGGCTCGGCGAGGTGTTCGCGACGATGACGCCCGCGGTGGCGGCGGTGGTCGCGGCCGTCGTCGCGTCGCGC
TTCGTCTGGGTGTTCGCGGTCGAACTGCTGAAGGCGCCCGTCGCGCGCTTGCGCGGGCGCGGCCCGCGCGGCGACTGGAA
GGCGGCGACCGTGATGGGCTGGGCCGGGATGCGCGGCGTCGTCACGCTCGCGATCGCGCTGTCGCTGCCGGATGCGATGC
CCGGGCGCGACCTGATTCTCGTCGCCGCGTTCGCGGTGATTCTCGTCACCGTGCTGCTGCAGGGCACGACGATCGGGCCG
CTGATCCGGCTGCTGAAGCTGCGCGATCCGGGGCCCGCAGCACACCATCTGACGGAGCCGCAGACCTGGGCGCGCGTCGA
GGCCGCGCAGCTCTCGGCGATCCAGCCGCTCGTGCACGATGCCGAGGGCAACGTGATCCATCCGCGCCTGCTCGAGCAAT
ATACGTACCGCGCGAGCGTGACCGCGCGCCATCAGGACGAGCCCGCATTTCCGCAGCGCGAGCGCGACGCGCATTACGAC
GTCGTGCTCGCGGCGATCGCGGCCGGCCGCGCGGAGCTGCTGCGGCTGCATCGCGGCGGCCAGATCCACGACGAGATGCT
GTACCTGCTCGAGCGCGATCTCGATCTGCAGGAGATCGCGGCGCAGCACGCGAAGGGCTAG

Upstream 100 bases:

>100_bases
ACATGCGCGAACTCGACGCGACACGCGCGCTCATGCTGTAATCGCGCGAGCCGGCCGAACGTTGGTTCGGCCGCTCAACC
CTTGCGTAGAAGGCGCTTCC

Downstream 100 bases:

>100_bases
CGGCGCGCAGCGCCGTCGCGCGAGCCCGGCACGCCTGTCACTGTTTCGTCATTCGAGCGCGCCGAAGCGACTTTTTCGCC
GATCACCTACAATCGAAGAG

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSPVSAFKLVLLSFLAIVALELLAKRLRLPPAAALLVGGAGIAFLPGLPPVNLDPDLVLIVFLPPLLMDGAYFSVWEEFK
RNVGGIMMLAIGAVAFTTLAVGVAVHLVAPGLPWAACFALGAIVSPPDAVAAKAVLERVALPRRLMVLLEGESLLNDAAG
LVLFRFAVAAALTGAFGTGDAVVRFAQLGVGGVAVGFIVGWLIVRFLKLVEDDYLVITVAVLAAWVSYIAGELFEVSGVI
ATVTTGMMLGWHQHEVFSASVRNRGTAFWQVIVFLLEALVFVLIGLSLRGVIERLGGLGEVFATMTPAVAAVVAAVVASR
FVWVFAVELLKAPVARLRGRGPRGDWKAATVMGWAGMRGVVTLAIALSLPDAMPGRDLILVAAFAVILVTVLLQGTTIGP
LIRLLKLRDPGPAAHHLTEPQTWARVEAAQLSAIQPLVHDAEGNVIHPRLLEQYTYRASVTARHQDEPAFPQRERDAHYD
VVLAAIAAGRAELLRLHRGGQIHDEMLYLLERDLDLQEIAAQHAKG

Sequences:

>Translated_526_residues
MSPVSAFKLVLLSFLAIVALELLAKRLRLPPAAALLVGGAGIAFLPGLPPVNLDPDLVLIVFLPPLLMDGAYFSVWEEFK
RNVGGIMMLAIGAVAFTTLAVGVAVHLVAPGLPWAACFALGAIVSPPDAVAAKAVLERVALPRRLMVLLEGESLLNDAAG
LVLFRFAVAAALTGAFGTGDAVVRFAQLGVGGVAVGFIVGWLIVRFLKLVEDDYLVITVAVLAAWVSYIAGELFEVSGVI
ATVTTGMMLGWHQHEVFSASVRNRGTAFWQVIVFLLEALVFVLIGLSLRGVIERLGGLGEVFATMTPAVAAVVAAVVASR
FVWVFAVELLKAPVARLRGRGPRGDWKAATVMGWAGMRGVVTLAIALSLPDAMPGRDLILVAAFAVILVTVLLQGTTIGP
LIRLLKLRDPGPAAHHLTEPQTWARVEAAQLSAIQPLVHDAEGNVIHPRLLEQYTYRASVTARHQDEPAFPQRERDAHYD
VVLAAIAAGRAELLRLHRGGQIHDEMLYLLERDLDLQEIAAQHAKG
>Mature_525_residues
SPVSAFKLVLLSFLAIVALELLAKRLRLPPAAALLVGGAGIAFLPGLPPVNLDPDLVLIVFLPPLLMDGAYFSVWEEFKR
NVGGIMMLAIGAVAFTTLAVGVAVHLVAPGLPWAACFALGAIVSPPDAVAAKAVLERVALPRRLMVLLEGESLLNDAAGL
VLFRFAVAAALTGAFGTGDAVVRFAQLGVGGVAVGFIVGWLIVRFLKLVEDDYLVITVAVLAAWVSYIAGELFEVSGVIA
TVTTGMMLGWHQHEVFSASVRNRGTAFWQVIVFLLEALVFVLIGLSLRGVIERLGGLGEVFATMTPAVAAVVAAVVASRF
VWVFAVELLKAPVARLRGRGPRGDWKAATVMGWAGMRGVVTLAIALSLPDAMPGRDLILVAAFAVILVTVLLQGTTIGPL
IRLLKLRDPGPAAHHLTEPQTWARVEAAQLSAIQPLVHDAEGNVIHPRLLEQYTYRASVTARHQDEPAFPQRERDAHYDV
VLAAIAAGRAELLRLHRGGQIHDEMLYLLERDLDLQEIAAQHAKG

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=432, Percent_Identity=25.462962962963, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI148727259, Length=425, Percent_Identity=24.9411764705882, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI41872703, Length=538, Percent_Identity=23.6059479553903, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI110227626, Length=424, Percent_Identity=24.7641509433962, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI294997330, Length=424, Percent_Identity=24.7641509433962, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI5454070, Length=421, Percent_Identity=24.7030878859857, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI27734935, Length=410, Percent_Identity=22.4390243902439, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI14211919, Length=383, Percent_Identity=24.5430809399478, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI27777632, Length=475, Percent_Identity=22.3157894736842, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI194239733, Length=424, Percent_Identity=23.8207547169811, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4759144, Length=389, Percent_Identity=25.9640102827763, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790501, Length=503, Percent_Identity=30.8151093439364, Blast_Score=174, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI71980847, Length=385, Percent_Identity=23.6363636363636, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71999819, Length=467, Percent_Identity=22.6980728051392, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71999817, Length=467, Percent_Identity=22.6980728051392, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71999821, Length=467, Percent_Identity=22.6980728051392, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71990932, Length=381, Percent_Identity=23.6220472440945, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71990924, Length=381, Percent_Identity=23.6220472440945, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI71987537, Length=468, Percent_Identity=20.7264957264957, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71987535, Length=468, Percent_Identity=20.7264957264957, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25147678, Length=433, Percent_Identity=24.2494226327945, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71992101, Length=367, Percent_Identity=21.7983651226158, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71992107, Length=367, Percent_Identity=21.7983651226158, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25150332, Length=403, Percent_Identity=23.0769230769231, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71987559, Length=436, Percent_Identity=21.3302752293578, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71993590, Length=385, Percent_Identity=25.974025974026, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71987545, Length=436, Percent_Identity=21.1009174311927, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71993582, Length=385, Percent_Identity=25.974025974026, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320663, Length=341, Percent_Identity=23.7536656891496, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221510734, Length=379, Percent_Identity=25.3298153034301, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221510738, Length=379, Percent_Identity=25.3298153034301, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221510736, Length=379, Percent_Identity=25.3298153034301, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221510732, Length=379, Percent_Identity=25.3298153034301, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585580, Length=379, Percent_Identity=25.3298153034301, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585578, Length=379, Percent_Identity=25.3298153034301, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI221510740, Length=379, Percent_Identity=25.3298153034301, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281360447, Length=370, Percent_Identity=23.5135135135135, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI221473212, Length=468, Percent_Identity=21.7948717948718, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281364513, Length=375, Percent_Identity=23.4666666666667, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI221473215, Length=375, Percent_Identity=23.4666666666667, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI221473222, Length=375, Percent_Identity=23.4666666666667, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 56082; Mature: 55951

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SPVSAFKLVLLSFLAIVALELLAKRLRLPPAAALLVGGAGIAFLPGLPPVNLDPDLVLI
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHCCCCCCCCCCCCEEEH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HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]