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The map label for this gene is tlpB [H]

Identifier: 126443034

GI number: 126443034

Start: 2574360

End: 2576000

Strand: Reverse

Name: tlpB [H]

Synonym: BURPS668_A2687

Alternate gene names: 126443034

Gene position: 2576000-2574360 (Counterclockwise)

Preceding gene: 126443741

Following gene: 126445005

Centisome position: 82.37

GC content: 68.62

Gene sequence:

>1641_bases
TTGCGCAAATCCGCCGCCGGCAGCCGGCTCACGCTCGGCAACCGGATCCTGTTCAGCTTCGGCGTGCTGTTCGTGCTGAT
GCTGTTCATGGCGGCGCTGTCCTACCAGCGCCTGCGCGCGATCAACGACGAGGCGATCAGCATCGAGCGCGATTCGCTGC
CGGGCGTCTATCTCGCGTCGTCGCTGCGCGCGTCGGCGAACGAGTCGTACATCGTGCTGCAGCGCGCGGTGTTCGTCGAT
GCCGAAGCCGAAGCGGTGCAGCGCGATCTCGCGAAGGTGCCGGGCCTGCTCGAGGAGTTCGACAAGCTGTCGTCCGCGTA
CCAGGCGTCGACGTTCCGCAGCGACGATCAGGAGCGCTTCAACGCGTTTCGCGCGGCGTACGAGCGCTACCTGCCGCTGC
TGAACGACGCCGTGCAGAAGGCGCGCGGCGCGAGGCCCGACGCGCTCGCTGCCTACGCGAGGGTGACGCCTGCGTGGGAA
GAGGTGATTCGCCATGCGAACGTGCTCGTGCAGGAGAACCGGCGCTTCGCCGATCAGTCGGCCACGCTGATCCGCGAATC
GGTGCACGGCACCGAGATCACGCTCGCGGTGGCGCTCGGCGTCGTGCTCGTGGTCGCGCTGATGCTCGGCTATCTGCTGC
ATCGCGCGGTGACCGTGCCGATGGCGCGGCTCATCGACGTGCACGACGTGATGCGCACCGGCAACCTGACGCAGCGCCTG
AACCTCGGCCGCAGCGACGAGTTCGGCACGCTCGAGAGCGGCTTCAACCGGATGGCCGACGAGCTGACCGCGCTCGTCGC
GCAGGCGCAGCAGTCGTCGCTGCAGGTGACGACGTCGGTGGCCGAGATCGCGGCGACCTCGCGCGAGCAGCAGGCGACCG
CGAACGAAACGGCGGCGACGACGACCGAGATCGGCGCGACCTCGCGCGAGATCTTCGCGACCTCGCGCGACCTGCTGCGC
ACGATGAACGAAGTGTCGGCGGTGGCCGAGCAGTCGGCGACGCTCGCGGGCGTCGGCCAGAGCGGCCTCACGCGGATGGG
CGAGACGATGCGCAGCGTGATGGACGCGGCGGGCTCGGTGAACGCGAAGCTCGCGATCCTCAACGAGAAGGCGATCAACA
TCAACCAGGTCGTCGCGACGATCACGAAGGTCGCCGACCAGACCAACCTGCTGTCGCTGAACGCGGCGATCGAGGCGGAG
AAGGCGGGCGAGTACGGCCGCGGCTTCGCGGTCGTCGCGACCGAGATCCGCCGCCTCGCCGATCAGACGGCCGTCGCGAC
GTACGACATCGAGCAGACGGTGAAGGAGATCCAGTCGGCGGTGTCGGCGGGCGTGATGGGCATGGACAAGTTCTCGGAGG
AAGTGCGCCGCGGGATGCGCGACGTGCAGCAGGTGGGCGGACAGTTGTCGCAGATCATCGCCGAGGTGCAGACGCTCGCG
CCGCGCTTCCAGATGGTCAACGAAGGGATGCAGACGCAGGCGAGCGGCGCCGAGCAGATCACGCAGGCGCTCGCGCAGTT
GTCCGAGGCCGCGCAGCAGACGGCGGAATCGCTGCGGCAGTCGTCGCAGGCGATCGACGATCTGACGCTCGTCGCGAACC
AGCTGCGCACCGGCGTGTCGCGCTTCAAGGTCGACGCGTGA

Upstream 100 bases:

>100_bases
GATCCGCCCGGTGCGCCGCGCGCCGCTTCATTCACCTGATTTTCCGCCAGCCGGATAGAACGACATGCCCACTGTGACGC
CTCGCGCCAGCAACGAGACC

Downstream 100 bases:

>100_bases
TGCGCGCCGCGTGACGGGAAAGGCGGAGCCGATCATGCTGTTCCTGCTGTTTCACCTCGACGGCGAGCGTTACGCGCTCG
ATGCGGCGGAGATCGCCGAA

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MRKSAAGSRLTLGNRILFSFGVLFVLMLFMAALSYQRLRAINDEAISIERDSLPGVYLASSLRASANESYIVLQRAVFVD
AEAEAVQRDLAKVPGLLEEFDKLSSAYQASTFRSDDQERFNAFRAAYERYLPLLNDAVQKARGARPDALAAYARVTPAWE
EVIRHANVLVQENRRFADQSATLIRESVHGTEITLAVALGVVLVVALMLGYLLHRAVTVPMARLIDVHDVMRTGNLTQRL
NLGRSDEFGTLESGFNRMADELTALVAQAQQSSLQVTTSVAEIAATSREQQATANETAATTTEIGATSREIFATSRDLLR
TMNEVSAVAEQSATLAGVGQSGLTRMGETMRSVMDAAGSVNAKLAILNEKAININQVVATITKVADQTNLLSLNAAIEAE
KAGEYGRGFAVVATEIRRLADQTAVATYDIEQTVKEIQSAVSAGVMGMDKFSEEVRRGMRDVQQVGGQLSQIIAEVQTLA
PRFQMVNEGMQTQASGAEQITQALAQLSEAAQQTAESLRQSSQAIDDLTLVANQLRTGVSRFKVDA

Sequences:

>Translated_546_residues
MRKSAAGSRLTLGNRILFSFGVLFVLMLFMAALSYQRLRAINDEAISIERDSLPGVYLASSLRASANESYIVLQRAVFVD
AEAEAVQRDLAKVPGLLEEFDKLSSAYQASTFRSDDQERFNAFRAAYERYLPLLNDAVQKARGARPDALAAYARVTPAWE
EVIRHANVLVQENRRFADQSATLIRESVHGTEITLAVALGVVLVVALMLGYLLHRAVTVPMARLIDVHDVMRTGNLTQRL
NLGRSDEFGTLESGFNRMADELTALVAQAQQSSLQVTTSVAEIAATSREQQATANETAATTTEIGATSREIFATSRDLLR
TMNEVSAVAEQSATLAGVGQSGLTRMGETMRSVMDAAGSVNAKLAILNEKAININQVVATITKVADQTNLLSLNAAIEAE
KAGEYGRGFAVVATEIRRLADQTAVATYDIEQTVKEIQSAVSAGVMGMDKFSEEVRRGMRDVQQVGGQLSQIIAEVQTLA
PRFQMVNEGMQTQASGAEQITQALAQLSEAAQQTAESLRQSSQAIDDLTLVANQLRTGVSRFKVDA
>Mature_546_residues
MRKSAAGSRLTLGNRILFSFGVLFVLMLFMAALSYQRLRAINDEAISIERDSLPGVYLASSLRASANESYIVLQRAVFVD
AEAEAVQRDLAKVPGLLEEFDKLSSAYQASTFRSDDQERFNAFRAAYERYLPLLNDAVQKARGARPDALAAYARVTPAWE
EVIRHANVLVQENRRFADQSATLIRESVHGTEITLAVALGVVLVVALMLGYLLHRAVTVPMARLIDVHDVMRTGNLTQRL
NLGRSDEFGTLESGFNRMADELTALVAQAQQSSLQVTTSVAEIAATSREQQATANETAATTTEIGATSREIFATSRDLLR
TMNEVSAVAEQSATLAGVGQSGLTRMGETMRSVMDAAGSVNAKLAILNEKAININQVVATITKVADQTNLLSLNAAIEAE
KAGEYGRGFAVVATEIRRLADQTAVATYDIEQTVKEIQSAVSAGVMGMDKFSEEVRRGMRDVQQVGGQLSQIIAEVQTLA
PRFQMVNEGMQTQASGAEQITQALAQLSEAAQQTAESLRQSSQAIDDLTLVANQLRTGVSRFKVDA

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=470, Percent_Identity=24.8936170212766, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788194, Length=357, Percent_Identity=25.2100840336134, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI2367378, Length=314, Percent_Identity=26.4331210191083, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788195, Length=312, Percent_Identity=28.8461538461538, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789453, Length=233, Percent_Identity=28.3261802575107, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 59148; Mature: 59148

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSAAGSRLTLGNRILFSFGVLFVLMLFMAALSYQRLRAINDEAISIERDSLPGVYLAS
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHH
SLRASANESYIVLQRAVFVDAEAEAVQRDLAKVPGLLEEFDKLSSAYQASTFRSDDQERF
HHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHH
NAFRAAYERYLPLLNDAVQKARGARPDALAAYARVTPAWEEVIRHANVLVQENRRFADQS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ATLIRESVHGTEITLAVALGVVLVVALMLGYLLHRAVTVPMARLIDVHDVMRTGNLTQRL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
NLGRSDEFGTLESGFNRMADELTALVAQAQQSSLQVTTSVAEIAATSREQQATANETAAT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
TTEIGATSREIFATSRDLLRTMNEVSAVAEQSATLAGVGQSGLTRMGETMRSVMDAAGSV
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
NAKLAILNEKAININQVVATITKVADQTNLLSLNAAIEAEKAGEYGRGFAVVATEIRRLA
CCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHH
DQTAVATYDIEQTVKEIQSAVSAGVMGMDKFSEEVRRGMRDVQQVGGQLSQIIAEVQTLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PRFQMVNEGMQTQASGAEQITQALAQLSEAAQQTAESLRQSSQAIDDLTLVANQLRTGVS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFKVDA
HHCCCC
>Mature Secondary Structure
MRKSAAGSRLTLGNRILFSFGVLFVLMLFMAALSYQRLRAINDEAISIERDSLPGVYLAS
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHH
SLRASANESYIVLQRAVFVDAEAEAVQRDLAKVPGLLEEFDKLSSAYQASTFRSDDQERF
HHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHH
NAFRAAYERYLPLLNDAVQKARGARPDALAAYARVTPAWEEVIRHANVLVQENRRFADQS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ATLIRESVHGTEITLAVALGVVLVVALMLGYLLHRAVTVPMARLIDVHDVMRTGNLTQRL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
NLGRSDEFGTLESGFNRMADELTALVAQAQQSSLQVTTSVAEIAATSREQQATANETAAT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
TTEIGATSREIFATSRDLLRTMNEVSAVAEQSATLAGVGQSGLTRMGETMRSVMDAAGSV
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
NAKLAILNEKAININQVVATITKVADQTNLLSLNAAIEAEKAGEYGRGFAVVATEIRRLA
CCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHH
DQTAVATYDIEQTVKEIQSAVSAGVMGMDKFSEEVRRGMRDVQQVGGQLSQIIAEVQTLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PRFQMVNEGMQTQASGAEQITQALAQLSEAAQQTAESLRQSSQAIDDLTLVANQLRTGVS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFKVDA
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]