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The map label for this gene is lolC [H]

Identifier: 126209492

GI number: 126209492

Start: 2265296

End: 2266468

Strand: Reverse

Name: lolC [H]

Synonym: APL_2038

Alternate gene names: 126209492

Gene position: 2266468-2265296 (Counterclockwise)

Preceding gene: 126209493

Following gene: 126209491

Centisome position: 99.65

GC content: 42.97

Gene sequence:

>1173_bases
ATGAATTTAACAACTCTTTTTATTGCCTTTCGTTATTGGCGTTCCAAAAGTGCCGACAGGTTCGGGCGTTTGGTGACCAA
CTTAGCAAGTTTCGGGATCGTACTTGGCGTAATGGCATTAGTGATCGTGCTGTCGGTAATGAACGGTTTGGAGAATATGC
AAAAGCGCAATTTACTTTCAACGCTGCCGCACGCCATTGTGTTACCACAAGAAGGACATTTCGATAAAAATCAATCGCTT
AGCTTACCGGCATTTGCCAGTAAAAGTGTGGCGATTAATAAAGCGAATGTGATTATCCAAAGCCAGCAAGGGATCAACGC
CGGTCAGTTACTCGGTGTTGAGAATGAAAGCGACGATCCAATGTTGATTGGCGAAGACGTCAAAACCCTCTTACCACAAG
GCGAATTTAACGTATTGATCGGTTCACGCCTTGCAAATAAGTTGAATATTGGCACAGGCGAAAAGATCCGTTTGATGATT
ACCGAAAACAGCCAATATACGCCGATGGGACGTGTGCCGGTTCAGCGTTTATTTAATGTGGTTGGGATTTATCACAGTAA
CAATGAAGCGAGCGAATATACCCTTTTCGCTAATCTTGCCGATGTTGGGCGTTTACTGCGGATAACTGAGGACCAAGTGC
AAGGTATGCGGTTATATTTGCAAGATCCGTTCCAAGTTACCGAGCTTAACCAACATTTCGATGCAAATAACTACAAAATT
AGTGACTGGCGTGAACAAAAAGGCGAATTTTTCCAAGCGGTTCGTATGGAAAAAAATATGATGGGTTTATTGATCAGTCT
GATCATTATCGTTGCCATTTCCAATATCGTGACTTCACTCAGTCTGATGGTGGTGGATAAACAAGCTGAAATCGCCATCT
TACAAACCCAAGGTTTAACTAAACGACAAGTAACACAAATTTTTATTTTCCAAGGTGCGATTGTCGGAGTAATCGGTTCG
ATTTTAGGCGGTATTATCGGTACGGTTATCACGCTCAATTTGGATGAGATTGTGGCTTTACTCAATCCGAATATTCATCT
GCCGACACTCATTTCGCCAATGCAGGTGGCAACCATTATCGTGATTTCGATTGTGTTGTCATTGGTTTGTACCCTTTATC
CGGCATACCGAGCGGCAAAAATTGAGCCGGCTCAGGCATTGAGATACGAATAG

Upstream 100 bases:

>100_bases
CCAAAGACACAAGCGGTTTAAAATTAGCGAAAATTTGCAAAAAATTCGGTAAATTTGACCGCTTGCTTTTGTATTGGAGT
GATGTAACTCAAGATAAACT

Downstream 100 bases:

>100_bases
TTTTAACCACGGAATACTCGGATAACACGGAAAATATCTCTGTGTTCCGTGGTTCTAAATATAATCTGTGGTTTCCCACT
TAAATGAAGATAAAAACAAT

Product: lipoprotein-releasing system transmembrane protein lolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNLTTLFIAFRYWRSKSADRFGRLVTNLASFGIVLGVMALVIVLSVMNGLENMQKRNLLSTLPHAIVLPQEGHFDKNQSL
SLPAFASKSVAINKANVIIQSQQGINAGQLLGVENESDDPMLIGEDVKTLLPQGEFNVLIGSRLANKLNIGTGEKIRLMI
TENSQYTPMGRVPVQRLFNVVGIYHSNNEASEYTLFANLADVGRLLRITEDQVQGMRLYLQDPFQVTELNQHFDANNYKI
SDWREQKGEFFQAVRMEKNMMGLLISLIIIVAISNIVTSLSLMVVDKQAEIAILQTQGLTKRQVTQIFIFQGAIVGVIGS
ILGGIIGTVITLNLDEIVALLNPNIHLPTLISPMQVATIIVISIVLSLVCTLYPAYRAAKIEPAQALRYE

Sequences:

>Translated_390_residues
MNLTTLFIAFRYWRSKSADRFGRLVTNLASFGIVLGVMALVIVLSVMNGLENMQKRNLLSTLPHAIVLPQEGHFDKNQSL
SLPAFASKSVAINKANVIIQSQQGINAGQLLGVENESDDPMLIGEDVKTLLPQGEFNVLIGSRLANKLNIGTGEKIRLMI
TENSQYTPMGRVPVQRLFNVVGIYHSNNEASEYTLFANLADVGRLLRITEDQVQGMRLYLQDPFQVTELNQHFDANNYKI
SDWREQKGEFFQAVRMEKNMMGLLISLIIIVAISNIVTSLSLMVVDKQAEIAILQTQGLTKRQVTQIFIFQGAIVGVIGS
ILGGIIGTVITLNLDEIVALLNPNIHLPTLISPMQVATIIVISIVLSLVCTLYPAYRAAKIEPAQALRYE
>Mature_390_residues
MNLTTLFIAFRYWRSKSADRFGRLVTNLASFGIVLGVMALVIVLSVMNGLENMQKRNLLSTLPHAIVLPQEGHFDKNQSL
SLPAFASKSVAINKANVIIQSQQGINAGQLLGVENESDDPMLIGEDVKTLLPQGEFNVLIGSRLANKLNIGTGEKIRLMI
TENSQYTPMGRVPVQRLFNVVGIYHSNNEASEYTLFANLADVGRLLRITEDQVQGMRLYLQDPFQVTELNQHFDANNYKI
SDWREQKGEFFQAVRMEKNMMGLLISLIIIVAISNIVTSLSLMVVDKQAEIAILQTQGLTKRQVTQIFIFQGAIVGVIGS
ILGGIIGTVITLNLDEIVALLNPNIHLPTLISPMQVATIIVISIVLSLVCTLYPAYRAAKIEPAQALRYE

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=398, Percent_Identity=45.4773869346734, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1787362, Length=412, Percent_Identity=27.9126213592233, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 43135; Mature: 43135

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTTLFIAFRYWRSKSADRFGRLVTNLASFGIVLGVMALVIVLSVMNGLENMQKRNLLS
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLPHAIVLPQEGHFDKNQSLSLPAFASKSVAINKANVIIQSQQGINAGQLLGVENESDDP
HCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCEEECCCCCCCC
MLIGEDVKTLLPQGEFNVLIGSRLANKLNIGTGEKIRLMITENSQYTPMGRVPVQRLFNV
EEECCCHHHHCCCCCEEEEEHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
VGIYHSNNEASEYTLFANLADVGRLLRITEDQVQGMRLYLQDPFQVTELNQHFDANNYKI
HEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCCC
SDWREQKGEFFQAVRMEKNMMGLLISLIIIVAISNIVTSLSLMVVDKQAEIAILQTQGLT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCC
KRQVTQIFIFQGAIVGVIGSILGGIIGTVITLNLDEIVALLNPNIHLPTLISPMQVATII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHCCCCCCCCCCCHHHHHHHH
VISIVLSLVCTLYPAYRAAKIEPAQALRYE
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure
MNLTTLFIAFRYWRSKSADRFGRLVTNLASFGIVLGVMALVIVLSVMNGLENMQKRNLLS
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLPHAIVLPQEGHFDKNQSLSLPAFASKSVAINKANVIIQSQQGINAGQLLGVENESDDP
HCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCEEECCCCCCCC
MLIGEDVKTLLPQGEFNVLIGSRLANKLNIGTGEKIRLMITENSQYTPMGRVPVQRLFNV
EEECCCHHHHCCCCCEEEEEHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
VGIYHSNNEASEYTLFANLADVGRLLRITEDQVQGMRLYLQDPFQVTELNQHFDANNYKI
HEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCCC
SDWREQKGEFFQAVRMEKNMMGLLISLIIIVAISNIVTSLSLMVVDKQAEIAILQTQGLT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCC
KRQVTQIFIFQGAIVGVIGSILGGIIGTVITLNLDEIVALLNPNIHLPTLISPMQVATII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHCCCCCCCCCCCHHHHHHHH
VISIVLSLVCTLYPAYRAAKIEPAQALRYE
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]