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The map label for this gene is hbpA [H]

Identifier: 126209464

GI number: 126209464

Start: 2234459

End: 2236096

Strand: Reverse

Name: hbpA [H]

Synonym: APL_2010

Alternate gene names: 126209464

Gene position: 2236096-2234459 (Counterclockwise)

Preceding gene: 126209465

Following gene: 126209459

Centisome position: 98.31

GC content: 43.71

Gene sequence:

>1638_bases
ATGAAATTAGCCAATTTAACTAAAGTAAGCGCAGCCGTATTAGCGGTACTGGCTTTAGCCGCTTGCGATGATAAAAATGC
GGACGGTAAAACTACAGCGAAACCGGCTGCCGAAAAAACTTTCGTAAACTGCGTTAGCCGTTCGCCGCAATATTTCAGTC
CGGCACTGGCAATGGACGGTATTTCGTACAATGCAAGTTCTCAACAAGTTTATAACCGTTTAGTCGAATTTAAACGCGGT
TCAACCGAGATTGAACCGGCGTTAGCCGAATCGTGGGATATTTCCGAAGACGGCTTAACTTACACTTTCCACTTACGCAA
AGGGGTAAAATTCCACTCAAACAAAGAATTTACCCCAAGCCGTGATTTTAATGCCGATGACGTAGTCTTTTCATTTAACC
GCCAATTAGATCCGAATCATCCTTACCATACGGTATCAAAAGCGACTTATCCGTACTTTAAAGCGATGAAATTCCCGACT
TTATTAAAATCGGTAGAGAAAGTGGATGATCATACGGTGAAATTTACTTTAACCAAACGTGATGCGACCTTCGTTTCAAG
TTTAGGGATGGATTTCACTTCAATCTATTCTGCGGAATATGCGGATGCGATGTTAAAAGCGGGTAAACCGGAAACCATCG
ATACCACACCGATTGGTACCGGTCCGTTCGCCTTTACCGGTTACGTATTAGATCAGGCAAGCCGTTATGTGGCGTATAAA
GATTATTGGAAAGGTAAAGCCGATTTCGACCGCTTAATTTTTGAAATCGTACCGGATGCAACCGCTCGTTATGCAAAATT
ACAAGCGGGTCAATGTGATTTAATCGACTTCCCGAATGCGACCGATATTGAAAAAATGAAAACCGATCCGAAAGTGCAAT
TGCTTTCACAACCGGGTTTAAATATCGCTTATGTAGCATTTAACACCGAAAAAGCACCGTTTGATAATGTCAAAGTACGC
CAAGCGTTAAATCTTGCGGTCGATAAAAAAGCGATTATTGATGTGGTTTACCAAGGTGCCGGTATTGCGGCGAAAAATCC
GTTACCGCCAACTATTTGGGGCTACAACGACAGCTTAGCGGAATCGGAATTTAATATTGAGAAAGCGAAACAACTTTTAG
CAGAAGCAGGCTATCCGAACGGTTTCGAAACCGAACTTTGGGTACAGCCGGTGGTGCGCGCATCAAATCCGAACCCACGC
CGTATGTCTGAAATCATTCAAGCGGACTGGGCAAAAATCGGTGTGAAAGCGAAATTAGTGACCTATGAGTGGGGCGATTA
TATTAAACGTACCAAAGCAGGCGAATTAACTGCCGGTACTTACGGTTGGTCAGGCGATAACGGTGATCCGGATAACTTCT
TATCGCCGTTATTCGGTTCGGCAAACGTTGGCAACAGTAACTATGCTCGCTTTAACAGCCCTGAGTTAGACGCACTATTA
GATAAAGCGCTTGGCTTATCGGATAAAGCGGAACGTACTAAACTCTACGAACAAGCACAAGCATTGTTAAGAGAACAAGC
ACCGTGGATTAACGTGGCACACTCAATTAACTTTGCACCGACCAGCAAACGTGTACAAGACTACAAACAAAGTCCGTTCG
GTTACACTTATCTGTACGGTACAAAATTAGCCGACTAA

Upstream 100 bases:

>100_bases
CTTATAACGAAATGCCTTTTGTTCTTTACTCTCACCATCAGACAAGGTAATCTCTGGTGAATTATGCTTTTTATAATTCT
AATCCTACTTGGAGAAACCT

Downstream 100 bases:

>100_bases
AAGTCTTTAGACTAATTCAGGCAAATCAACAAAAATGGTGGGAAATCCCACCATTTTTTATCTCTGCCGTCTTACGGCGA
TAATCTTTCTTTATGCCATG

Product: Heme-binding protein A

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MKLANLTKVSAAVLAVLALAACDDKNADGKTTAKPAAEKTFVNCVSRSPQYFSPALAMDGISYNASSQQVYNRLVEFKRG
STEIEPALAESWDISEDGLTYTFHLRKGVKFHSNKEFTPSRDFNADDVVFSFNRQLDPNHPYHTVSKATYPYFKAMKFPT
LLKSVEKVDDHTVKFTLTKRDATFVSSLGMDFTSIYSAEYADAMLKAGKPETIDTTPIGTGPFAFTGYVLDQASRYVAYK
DYWKGKADFDRLIFEIVPDATARYAKLQAGQCDLIDFPNATDIEKMKTDPKVQLLSQPGLNIAYVAFNTEKAPFDNVKVR
QALNLAVDKKAIIDVVYQGAGIAAKNPLPPTIWGYNDSLAESEFNIEKAKQLLAEAGYPNGFETELWVQPVVRASNPNPR
RMSEIIQADWAKIGVKAKLVTYEWGDYIKRTKAGELTAGTYGWSGDNGDPDNFLSPLFGSANVGNSNYARFNSPELDALL
DKALGLSDKAERTKLYEQAQALLREQAPWINVAHSINFAPTSKRVQDYKQSPFGYTYLYGTKLAD

Sequences:

>Translated_545_residues
MKLANLTKVSAAVLAVLALAACDDKNADGKTTAKPAAEKTFVNCVSRSPQYFSPALAMDGISYNASSQQVYNRLVEFKRG
STEIEPALAESWDISEDGLTYTFHLRKGVKFHSNKEFTPSRDFNADDVVFSFNRQLDPNHPYHTVSKATYPYFKAMKFPT
LLKSVEKVDDHTVKFTLTKRDATFVSSLGMDFTSIYSAEYADAMLKAGKPETIDTTPIGTGPFAFTGYVLDQASRYVAYK
DYWKGKADFDRLIFEIVPDATARYAKLQAGQCDLIDFPNATDIEKMKTDPKVQLLSQPGLNIAYVAFNTEKAPFDNVKVR
QALNLAVDKKAIIDVVYQGAGIAAKNPLPPTIWGYNDSLAESEFNIEKAKQLLAEAGYPNGFETELWVQPVVRASNPNPR
RMSEIIQADWAKIGVKAKLVTYEWGDYIKRTKAGELTAGTYGWSGDNGDPDNFLSPLFGSANVGNSNYARFNSPELDALL
DKALGLSDKAERTKLYEQAQALLREQAPWINVAHSINFAPTSKRVQDYKQSPFGYTYLYGTKLAD
>Mature_545_residues
MKLANLTKVSAAVLAVLALAACDDKNADGKTTAKPAAEKTFVNCVSRSPQYFSPALAMDGISYNASSQQVYNRLVEFKRG
STEIEPALAESWDISEDGLTYTFHLRKGVKFHSNKEFTPSRDFNADDVVFSFNRQLDPNHPYHTVSKATYPYFKAMKFPT
LLKSVEKVDDHTVKFTLTKRDATFVSSLGMDFTSIYSAEYADAMLKAGKPETIDTTPIGTGPFAFTGYVLDQASRYVAYK
DYWKGKADFDRLIFEIVPDATARYAKLQAGQCDLIDFPNATDIEKMKTDPKVQLLSQPGLNIAYVAFNTEKAPFDNVKVR
QALNLAVDKKAIIDVVYQGAGIAAKNPLPPTIWGYNDSLAESEFNIEKAKQLLAEAGYPNGFETELWVQPVVRASNPNPR
RMSEIIQADWAKIGVKAKLVTYEWGDYIKRTKAGELTAGTYGWSGDNGDPDNFLSPLFGSANVGNSNYARFNSPELDALL
DKALGLSDKAERTKLYEQAQALLREQAPWINVAHSINFAPTSKRVQDYKQSPFGYTYLYGTKLAD

Specific function: Important role in heme acquisition or metabolism [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=505, Percent_Identity=53.0693069306931, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1787551, Length=502, Percent_Identity=35.6573705179283, Blast_Score=341, Evalue=7e-95,
Organism=Escherichia coli, GI1787052, Length=501, Percent_Identity=30.938123752495, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1787762, Length=471, Percent_Identity=27.6008492569002, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1787495, Length=534, Percent_Identity=26.4044943820225, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1789887, Length=539, Percent_Identity=27.2727272727273, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789397, Length=478, Percent_Identity=27.4058577405858, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI87081878, Length=522, Percent_Identity=26.6283524904215, Blast_Score=125, Evalue=5e-30,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 60510; Mature: 60510

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLANLTKVSAAVLAVLALAACDDKNADGKTTAKPAAEKTFVNCVSRSPQYFSPALAMDG
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCC
ISYNASSQQVYNRLVEFKRGSTEIEPALAESWDISEDGLTYTFHLRKGVKFHSNKEFTPS
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCEECCCCCCCCC
RDFNADDVVFSFNRQLDPNHPYHTVSKATYPYFKAMKFPTLLKSVEKVDDHTVKFTLTKR
CCCCCCCEEEEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
DATFVSSLGMDFTSIYSAEYADAMLKAGKPETIDTTPIGTGPFAFTGYVLDQASRYVAYK
CHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEH
DYWKGKADFDRLIFEIVPDATARYAKLQAGQCDLIDFPNATDIEKMKTDPKVQLLSQPGL
HHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCCCCCHHHHCCCCCEEEECCCCC
NIAYVAFNTEKAPFDNVKVRQALNLAVDKKAIIDVVYQGAGIAAKNPLPPTIWGYNDSLA
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHH
ESEFNIEKAKQLLAEAGYPNGFETELWVQPVVRASNPNPRRMSEIIQADWAKIGVKAKLV
CCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCEEEEEE
TYEWGDYIKRTKAGELTAGTYGWSGDNGDPDNFLSPLFGSANVGNSNYARFNSPELDALL
EEEHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
DKALGLSDKAERTKLYEQAQALLREQAPWINVAHSINFAPTSKRVQDYKQSPFGYTYLYG
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEC
TKLAD
CCCCC
>Mature Secondary Structure
MKLANLTKVSAAVLAVLALAACDDKNADGKTTAKPAAEKTFVNCVSRSPQYFSPALAMDG
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCC
ISYNASSQQVYNRLVEFKRGSTEIEPALAESWDISEDGLTYTFHLRKGVKFHSNKEFTPS
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCEECCCCCCCCC
RDFNADDVVFSFNRQLDPNHPYHTVSKATYPYFKAMKFPTLLKSVEKVDDHTVKFTLTKR
CCCCCCCEEEEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
DATFVSSLGMDFTSIYSAEYADAMLKAGKPETIDTTPIGTGPFAFTGYVLDQASRYVAYK
CHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEH
DYWKGKADFDRLIFEIVPDATARYAKLQAGQCDLIDFPNATDIEKMKTDPKVQLLSQPGL
HHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCCCCCHHHHCCCCCEEEECCCCC
NIAYVAFNTEKAPFDNVKVRQALNLAVDKKAIIDVVYQGAGIAAKNPLPPTIWGYNDSLA
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHH
ESEFNIEKAKQLLAEAGYPNGFETELWVQPVVRASNPNPRRMSEIIQADWAKIGVKAKLV
CCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCEEEEEE
TYEWGDYIKRTKAGELTAGTYGWSGDNGDPDNFLSPLFGSANVGNSNYARFNSPELDALL
EEEHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
DKALGLSDKAERTKLYEQAQALLREQAPWINVAHSINFAPTSKRVQDYKQSPFGYTYLYG
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEC
TKLAD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]