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The map label for this gene is proA

Identifier: 126209409

GI number: 126209409

Start: 2181067

End: 2182305

Strand: Reverse

Name: proA

Synonym: APL_1951

Alternate gene names: 126209409

Gene position: 2182305-2181067 (Counterclockwise)

Preceding gene: 126209410

Following gene: 126209408

Centisome position: 95.95

GC content: 45.6

Gene sequence:

>1239_bases
ATGCAAATGCTTACCCTCGCTCAACAAGCTAAAATCGCCAGCATCGAACTGGCTCAATTCGGAAATGTTCAAAAAAATCA
CGCACTTCTTACCATTGCCGAACAATTGGAACAACGCTCGGCGGAAATTCTTGCCGCTAATGCCAAAGATATTGAATTTG
CAAAAAATCAGGGAATTTCGACCGCTATCATCGACCGTTTATTATTAAACGAAAGCCGTTTGCAAGGCATTGCCAACGAT
GTACGTAACGTGGCGAAGCTTGCAGATCCGGTCGGGCAGGTGATTGACGGCGGCGTATTAAATTCAGGGCTGAAAATTGA
ACGTCAGCGTGTGCCGCTCGGTGTAATTCTCACTATTTATGAAGCACGTCCTAATGTAACGATTGATGTTGCTTCGCTAT
GCTTGAAAACCGGCAATGCGGTGATTTTGCGCGGTGGCAAAGAAACCAAATTTACTAATGCGGTGTTAGTGGAAGTCGTA
CAACAAGCGTTAGAAACCGCCGGTTTACCGAAACTGGCGGTTCAGGCAGTCACCGATCCCGATCGTGCTTTATTACTCGA
ATTATTAAAACTCGATCGTTACATTGATATGGTAATCCCTCGTGGAGGTGCCGGTTTGCATCAGTTCTGTAAAGAGAACT
CGACCATTCCGGTAATTGTCGGTGGAATCGGTGTTTGTCATATGTTTGTCGAAAAAAGTGCCGACCAAGAAAAAGCGTTA
GAGCTGATTGCGAATGCTAAAACGCAACGTCCAAGTACTTGTAATACGCTTGAAACCCTATTAGTTGAAAAAGCAATAGC
GGGCGAATTTTTACCGAAACTTGCAAATCGAATGAAAGCATTAGACGTGACATTACATACCGATGATTTGCAAAAAACTG
AGGGAATTGAACCGCTTGATGACGCGAGAATGCGCCAAGAATGGCTTTCGTTAGATTTAAATGTGGTGGTGATCGATAAC
TTAACCAAAGCGGTGGAACATATTCGTGAATACGGCTCGCAACATTCGGAAGCCATTCTGACTTCCGATTACCAACTTGC
TCGCCAGTTTGTTGCCCAAGTCGATGCAGCGGCAGTCTATATCAATGCCAGCACCCGTTTTACTGACGGCGGTGAATTCG
GTTTAGGGGCGGAAGTGGCAGTCAGCACCCAGAAACTCCACGCACGAGGTCCAATGGGCTTAGAGGCGCTCACCACCTAT
AAATGGGTCTGTGAAGGGGATTATTTGGTGAGAAAATAA

Upstream 100 bases:

>100_bases
AGAATTATTTTCTTTTTTATTTGTAAAAAATTTCCGCTTTAACCCATATAAACAGCTATGATAGACTGTACTTAATTTAA
TGATTAAGAGATATATCGCT

Downstream 100 bases:

>100_bases
GTCAATGAAGGAAAATAATGTCTTTGTCACAACCGCTTTTTATTAAACTGCTTCTGAAACACTGGAAAATTCACAATATT
CCGGTTTCTGCAGGTTATTT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MQMLTLAQQAKIASIELAQFGNVQKNHALLTIAEQLEQRSAEILAANAKDIEFAKNQGISTAIIDRLLLNESRLQGIAND
VRNVAKLADPVGQVIDGGVLNSGLKIERQRVPLGVILTIYEARPNVTIDVASLCLKTGNAVILRGGKETKFTNAVLVEVV
QQALETAGLPKLAVQAVTDPDRALLLELLKLDRYIDMVIPRGGAGLHQFCKENSTIPVIVGGIGVCHMFVEKSADQEKAL
ELIANAKTQRPSTCNTLETLLVEKAIAGEFLPKLANRMKALDVTLHTDDLQKTEGIEPLDDARMRQEWLSLDLNVVVIDN
LTKAVEHIREYGSQHSEAILTSDYQLARQFVAQVDAAAVYINASTRFTDGGEFGLGAEVAVSTQKLHARGPMGLEALTTY
KWVCEGDYLVRK

Sequences:

>Translated_412_residues
MQMLTLAQQAKIASIELAQFGNVQKNHALLTIAEQLEQRSAEILAANAKDIEFAKNQGISTAIIDRLLLNESRLQGIAND
VRNVAKLADPVGQVIDGGVLNSGLKIERQRVPLGVILTIYEARPNVTIDVASLCLKTGNAVILRGGKETKFTNAVLVEVV
QQALETAGLPKLAVQAVTDPDRALLLELLKLDRYIDMVIPRGGAGLHQFCKENSTIPVIVGGIGVCHMFVEKSADQEKAL
ELIANAKTQRPSTCNTLETLLVEKAIAGEFLPKLANRMKALDVTLHTDDLQKTEGIEPLDDARMRQEWLSLDLNVVVIDN
LTKAVEHIREYGSQHSEAILTSDYQLARQFVAQVDAAAVYINASTRFTDGGEFGLGAEVAVSTQKLHARGPMGLEALTTY
KWVCEGDYLVRK
>Mature_412_residues
MQMLTLAQQAKIASIELAQFGNVQKNHALLTIAEQLEQRSAEILAANAKDIEFAKNQGISTAIIDRLLLNESRLQGIAND
VRNVAKLADPVGQVIDGGVLNSGLKIERQRVPLGVILTIYEARPNVTIDVASLCLKTGNAVILRGGKETKFTNAVLVEVV
QQALETAGLPKLAVQAVTDPDRALLLELLKLDRYIDMVIPRGGAGLHQFCKENSTIPVIVGGIGVCHMFVEKSADQEKAL
ELIANAKTQRPSTCNTLETLLVEKAIAGEFLPKLANRMKALDVTLHTDDLQKTEGIEPLDDARMRQEWLSLDLNVVVIDN
LTKAVEHIREYGSQHSEAILTSDYQLARQFVAQVDAAAVYINASTRFTDGGEFGLGAEVAVSTQKLHARGPMGLEALTTY
KWVCEGDYLVRK

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=414, Percent_Identity=36.7149758454106, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI21361368, Length=414, Percent_Identity=36.7149758454106, Blast_Score=256, Evalue=3e-68,
Organism=Escherichia coli, GI1786438, Length=413, Percent_Identity=62.4697336561743, Blast_Score=515, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17569967, Length=407, Percent_Identity=36.6093366093366, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17569969, Length=407, Percent_Identity=36.6093366093366, Blast_Score=256, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6324899, Length=425, Percent_Identity=34.1176470588235, Blast_Score=239, Evalue=6e-64,
Organism=Drosophila melanogaster, GI21357643, Length=405, Percent_Identity=36.5432098765432, Blast_Score=266, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_ACTP2 (A3N3P3)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054634.1
- ProteinModelPortal:   A3N3P3
- SMR:   A3N3P3
- STRING:   A3N3P3
- GeneID:   4848580
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1951
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- PhylomeDB:   A3N3P3
- ProtClustDB:   PRK00197
- BioCyc:   APLE416269:APL_1951-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44907; Mature: 44907

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMLTLAQQAKIASIELAQFGNVQKNHALLTIAEQLEQRSAEILAANAKDIEFAKNQGIS
CCHHHHHHHHHHHEEEHHHCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCHHHHHCCCCH
TAIIDRLLLNESRLQGIANDVRNVAKLADPVGQVIDGGVLNSGLKIERQRVPLGVILTIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHCCCEEEEEEEE
EARPNVTIDVASLCLKTGNAVILRGGKETKFTNAVLVEVVQQALETAGLPKLAVQAVTDP
ECCCCCEEHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHEECCCC
DRALLLELLKLDRYIDMVIPRGGAGLHQFCKENSTIPVIVGGIGVCHMFVEKSADQEKAL
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCHHHHH
ELIANAKTQRPSTCNTLETLLVEKAIAGEFLPKLANRMKALDVTLHTDDLQKTEGIEPLD
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCCH
DARMRQEWLSLDLNVVVIDNLTKAVEHIREYGSQHSEAILTSDYQLARQFVAQVDAAAVY
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCEEEE
INASTRFTDGGEFGLGAEVAVSTQKLHARGPMGLEALTTYKWVCEGDYLVRK
EECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHEEEEECCCEEECC
>Mature Secondary Structure
MQMLTLAQQAKIASIELAQFGNVQKNHALLTIAEQLEQRSAEILAANAKDIEFAKNQGIS
CCHHHHHHHHHHHEEEHHHCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCHHHHHCCCCH
TAIIDRLLLNESRLQGIANDVRNVAKLADPVGQVIDGGVLNSGLKIERQRVPLGVILTIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHCCCEEEEEEEE
EARPNVTIDVASLCLKTGNAVILRGGKETKFTNAVLVEVVQQALETAGLPKLAVQAVTDP
ECCCCCEEHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHEECCCC
DRALLLELLKLDRYIDMVIPRGGAGLHQFCKENSTIPVIVGGIGVCHMFVEKSADQEKAL
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCHHHHH
ELIANAKTQRPSTCNTLETLLVEKAIAGEFLPKLANRMKALDVTLHTDDLQKTEGIEPLD
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCCH
DARMRQEWLSLDLNVVVIDNLTKAVEHIREYGSQHSEAILTSDYQLARQFVAQVDAAAVY
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCEEEE
INASTRFTDGGEFGLGAEVAVSTQKLHARGPMGLEALTTYKWVCEGDYLVRK
EECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA