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The map label for this gene is fabA

Identifier: 126209349

GI number: 126209349

Start: 2121238

End: 2121768

Strand: Reverse

Name: fabA

Synonym: APL_1889

Alternate gene names: 126209349

Gene position: 2121768-2121238 (Counterclockwise)

Preceding gene: 126209350

Following gene: 126209348

Centisome position: 93.29

GC content: 44.63

Gene sequence:

>531_bases
ATGAACACGTGTACACCTAATATTAAATCCAGCTATACCTATGAAGATTTATTAGCTTCAGGTCGCGGCGAGCTTTTCGG
TAAAGAAGGCCCTCAATTACCGGCACCGACCATGCTGATGATGGATCGTATCAACCTAATGACCGAAAACGGCGGTTTGT
TTGATAAAGGTTACATTGAGGCGGAATTGGATATTCATCCGGACTTACCGTTTTTCAGTTGCCACTTTATCGGTGATCCG
GTAATGCCGGGTTGTTTAGGTTTGGATGCGATGTGGCAATTAGTCGGTTTCTTCCTCGGTTGGATCGGCGGTAAAGGTAA
AGGACGTGCGTTAGGTGTTGGCGAAGTGAAATTTACCGGACAAATTTTGCCGAATGCGAAAAAAGTGACTTACCGTATTC
ATATGAAACGTGTGATTAATCGTAAACTGGTTATGGGTATGGCGGACGGCGAAGTGGAAGTGGACGGTCGAGTGATTTAT
ACCGCAACGGATTTAAAAGTCGGTTTATTCCAAGACACTTCCGCATTCTAA

Upstream 100 bases:

>100_bases
TCAGCGAACAGTTGTTCGCTAATTTAAAAGCCTGTACTATCGCTTCAAATTGGAAGCCCTGATAGTACGGGCTTTTTTGT
TTGTCTATAGGAATAAAAAA

Downstream 100 bases:

>100_bases
TTTTGCGATCAAGATCGAATAACGAGCGGTAGTCGATTTTATTTATACCGCTTATCCAATAGTATTCTTCTTCGGGAGAA
TACTATTATGTTTTTTAAAG

Product: 3-hydroxydecanoyl-(acyl carrier protein) dehydratase

Products: NA

Alternate protein names: Beta-hydroxydecanoyl thioester dehydrase

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MNTCTPNIKSSYTYEDLLASGRGELFGKEGPQLPAPTMLMMDRINLMTENGGLFDKGYIEAELDIHPDLPFFSCHFIGDP
VMPGCLGLDAMWQLVGFFLGWIGGKGKGRALGVGEVKFTGQILPNAKKVTYRIHMKRVINRKLVMGMADGEVEVDGRVIY
TATDLKVGLFQDTSAF

Sequences:

>Translated_176_residues
MNTCTPNIKSSYTYEDLLASGRGELFGKEGPQLPAPTMLMMDRINLMTENGGLFDKGYIEAELDIHPDLPFFSCHFIGDP
VMPGCLGLDAMWQLVGFFLGWIGGKGKGRALGVGEVKFTGQILPNAKKVTYRIHMKRVINRKLVMGMADGEVEVDGRVIY
TATDLKVGLFQDTSAF
>Mature_176_residues
MNTCTPNIKSSYTYEDLLASGRGELFGKEGPQLPAPTMLMMDRINLMTENGGLFDKGYIEAELDIHPDLPFFSCHFIGDP
VMPGCLGLDAMWQLVGFFLGWIGGKGKGRALGVGEVKFTGQILPNAKKVTYRIHMKRVINRKLVMGMADGEVEVDGRVIY
TATDLKVGLFQDTSAF

Specific function: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabA subfamily

Homologues:

Organism=Escherichia coli, GI1787187, Length=168, Percent_Identity=82.7380952380952, Blast_Score=295, Evalue=9e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABA_ACTP2 (A3N3I3)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054574.1
- ProteinModelPortal:   A3N3I3
- SMR:   A3N3I3
- STRING:   A3N3I3
- GeneID:   4849568
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1889
- eggNOG:   COG0764
- HOGENOM:   HBG433282
- OMA:   CHFKGDP
- ProtClustDB:   PRK05174
- BioCyc:   APLE416269:APL_1889-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00405
- InterPro:   IPR010083
- InterPro:   IPR013114
- TIGRFAMs:   TIGR01749

Pfam domain/function: PF07977 FabA

EC number: =4.2.1.60

Molecular weight: Translated: 19371; Mature: 19371

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: ACT_SITE 75-75

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTCTPNIKSSYTYEDLLASGRGELFGKEGPQLPAPTMLMMDRINLMTENGGLFDKGYIE
CCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCEEECCEEE
AELDIHPDLPFFSCHFIGDPVMPGCLGLDAMWQLVGFFLGWIGGKGKGRALGVGEVKFTG
EEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCEEEEEC
QILPNAKKVTYRIHMKRVINRKLVMGMADGEVEVDGRVIYTATDLKVGLFQDTSAF
EECCCCEEEEEEEHHHHHHHHHEEEEECCCCEEECCEEEEEECCEEEEEECCCCCC
>Mature Secondary Structure
MNTCTPNIKSSYTYEDLLASGRGELFGKEGPQLPAPTMLMMDRINLMTENGGLFDKGYIE
CCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCEEECCEEE
AELDIHPDLPFFSCHFIGDPVMPGCLGLDAMWQLVGFFLGWIGGKGKGRALGVGEVKFTG
EEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCEEEEEC
QILPNAKKVTYRIHMKRVINRKLVMGMADGEVEVDGRVIYTATDLKVGLFQDTSAF
EECCCCEEEEEEEHHHHHHHHHEEEEECCCCEEECCEEEEEECCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA