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The map label for this gene is folP [H]

Identifier: 126209338

GI number: 126209338

Start: 2104747

End: 2105592

Strand: Reverse

Name: folP [H]

Synonym: APL_1876

Alternate gene names: 126209338

Gene position: 2105592-2104747 (Counterclockwise)

Preceding gene: 126209339

Following gene: 126209336

Centisome position: 92.57

GC content: 42.55

Gene sequence:

>846_bases
ATGCAAATTCATTTCAAAAATTATCAAAAAAAAGACCGCTTGTTAGATTTAACTCAGCCGCAAATTATGGGGATTTTAAA
CTTTACCCCTGATTCTTTTTCCGATTCCGGTAAGTTTTTTAGCTTGGATAAAGCGTTATTCCAAGTGGAAAAAATGTTAA
ATGAGGGAGCGGATATTATTGATATCGGCGGTGAATCGACCCGTCCTAATGCGGAACTTGTGACACTGGAACAAGAGTTG
GAACGTGTCGTACCATTAGTCGAAGCAGTACGTAAACGCTTTGATTGTTTGATTTCAATCGACAGTTCAAAAGCGGAAGT
ATTTAAACAATCCGCTATTGCAGGAGCGGATATTCTGAATGATATTCGAGCCTTAACCGAGCCGAATGCGCTAGACACAG
CTGTAGAATTAGGTCTGCCGATCTGTTTAATGCATATGCAAGGTAATCCGCAGAATATGCAGCAAAAACCTGAGTATGAT
GATGTATTGGAAGAAGTCGCGGATTTTCTCAATCAACGCATTTTTGAATGTATCACCGCAGGGATTCCTAAAGAACATAT
TATCCTCGATCCCGGCTTTGGTTTTGGTAAAAGTGTACAGCATAACTTTACACTACTTAAAAATTTGAAAGCCTTTTCGG
ATGCCGGTTTTCCGGTACTTGCCGGTTTATCTCGTAAGTCGATGCTCGGTGCGGTCACCGGTAAACCGGTTGAACAACGT
GTAACGGCATCGGTTGTCGGGGCGTTAATTGCAGTGCAAAACGGGGCGAAAATTATTCGCGTGCATGATGTGGCGGAAAC
CGCCGATATGCTGAAAGTATGGCAAGCGGTAGCGGAATGCGAATAA

Upstream 100 bases:

>100_bases
AAAGGTGTGTTAGCAAAGTTGAGAACATCTCAAGCCTAGGGATTAATTTATATACATCATCTAGTACGGTACAGCCGTGC
TAAGCGAAAGGAATACGGTA

Downstream 100 bases:

>100_bases
ATAAAAAAAGAGATGTGAGTTAATATTCACATCTCTTTTTTGTTACGTATTTAGTAAGAATATACTTCGTTTTTTACCGG
ATCCCAATTGACTTTAATGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MQIHFKNYQKKDRLLDLTQPQIMGILNFTPDSFSDSGKFFSLDKALFQVEKMLNEGADIIDIGGESTRPNAELVTLEQEL
ERVVPLVEAVRKRFDCLISIDSSKAEVFKQSAIAGADILNDIRALTEPNALDTAVELGLPICLMHMQGNPQNMQQKPEYD
DVLEEVADFLNQRIFECITAGIPKEHIILDPGFGFGKSVQHNFTLLKNLKAFSDAGFPVLAGLSRKSMLGAVTGKPVEQR
VTASVVGALIAVQNGAKIIRVHDVAETADMLKVWQAVAECE

Sequences:

>Translated_281_residues
MQIHFKNYQKKDRLLDLTQPQIMGILNFTPDSFSDSGKFFSLDKALFQVEKMLNEGADIIDIGGESTRPNAELVTLEQEL
ERVVPLVEAVRKRFDCLISIDSSKAEVFKQSAIAGADILNDIRALTEPNALDTAVELGLPICLMHMQGNPQNMQQKPEYD
DVLEEVADFLNQRIFECITAGIPKEHIILDPGFGFGKSVQHNFTLLKNLKAFSDAGFPVLAGLSRKSMLGAVTGKPVEQR
VTASVVGALIAVQNGAKIIRVHDVAETADMLKVWQAVAECE
>Mature_281_residues
MQIHFKNYQKKDRLLDLTQPQIMGILNFTPDSFSDSGKFFSLDKALFQVEKMLNEGADIIDIGGESTRPNAELVTLEQEL
ERVVPLVEAVRKRFDCLISIDSSKAEVFKQSAIAGADILNDIRALTEPNALDTAVELGLPICLMHMQGNPQNMQQKPEYD
DVLEEVADFLNQRIFECITAGIPKEHIILDPGFGFGKSVQHNFTLLKNLKAFSDAGFPVLAGLSRKSMLGAVTGKPVEQR
VTASVVGALIAVQNGAKIIRVHDVAETADMLKVWQAVAECE

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=262, Percent_Identity=53.4351145038168, Blast_Score=300, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=27.8481012658228, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30970; Mature: 30970

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIHFKNYQKKDRLLDLTQPQIMGILNFTPDSFSDSGKFFSLDKALFQVEKMLNEGADII
CEECCCCCCCHHHHHCCCCHHHEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEE
DIGGESTRPNAELVTLEQELERVVPLVEAVRKRFDCLISIDSSKAEVFKQSAIAGADILN
ECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHH
DIRALTEPNALDTAVELGLPICLMHMQGNPQNMQQKPEYDDVLEEVADFLNQRIFECITA
HHHHHCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GIPKEHIILDPGFGFGKSVQHNFTLLKNLKAFSDAGFPVLAGLSRKSMLGAVTGKPVEQR
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCHHHH
VTASVVGALIAVQNGAKIIRVHDVAETADMLKVWQAVAECE
HHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQIHFKNYQKKDRLLDLTQPQIMGILNFTPDSFSDSGKFFSLDKALFQVEKMLNEGADII
CEECCCCCCCHHHHHCCCCHHHEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEE
DIGGESTRPNAELVTLEQELERVVPLVEAVRKRFDCLISIDSSKAEVFKQSAIAGADILN
ECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHH
DIRALTEPNALDTAVELGLPICLMHMQGNPQNMQQKPEYDDVLEEVADFLNQRIFECITA
HHHHHCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GIPKEHIILDPGFGFGKSVQHNFTLLKNLKAFSDAGFPVLAGLSRKSMLGAVTGKPVEQR
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCHHHH
VTASVVGALIAVQNGAKIIRVHDVAETADMLKVWQAVAECE
HHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]