Click here to switch to the map view.

The map label for this gene is lpxH [H]

Identifier: 126209272

GI number: 126209272

Start: 2030513

End: 2031244

Strand: Reverse

Name: lpxH [H]

Synonym: APL_1808

Alternate gene names: 126209272

Gene position: 2031244-2030513 (Counterclockwise)

Preceding gene: 126209273

Following gene: 126209271

Centisome position: 89.31

GC content: 43.85

Gene sequence:

>732_bases
TTGCAAATTGAACCGTTTTTTATTGCGAGCGAAATGATTTATTTTATTGCAGACCTACACCTCAACGAGGCACAGCCTCA
GATCACCGAACACTTTTTGCAATTTATGCGACAAAAAGCACCGCTTGCGGAAAGCGTGTATATCCTAGGTGATTTCTTTG
ATTTCTGGATTGGCGACGACGAACAATCCGCCCTTATCGACCAAGTGAAAAACGCCCTAAAAACCCTCACCACAAGCGGT
GTAAAATGCTATTTTATTTGCGGAAACCGCGACTTCTTATTAGGCAAACGCTTCGCACAAGAAACCGGTATTGAAATTCT
GCCCGATTATTACCTGCTCGATTTATACGGCAATAAGACGCTGATTTGCCATGGCGATACGCTTTGCATTGATGATGTAA
AATACCAACAATTCCGCCGTAAAGTACATCAGAAATGGCTGCAGTGGCTCTTTTTACGCTTACCGCTCTCTCTGCGAATT
CGTATCGCGCAAAAAATTCGAACCAAAAGCAAACAAGATAAACAAGCTAAATCGGCCGATATTATGGATGTGAATCCGGC
ATTTACCGCCGAAACGGTAAAACGCTTTGGCGCAACTTATCTGATTCATGGCCATACCCACCGCCAAGCGGTGCATTCTG
AGGTGGAATTTACCCGCATCGTCCTCGGTGACTGGAAAGCGGATTACGCTTCCGTTTTAAAATTTGATGAACAGGGATTT
GAGTTTATATGA

Upstream 100 bases:

>100_bases
ACGGCGTATTAGCACTGCTCTTCTTCCTGTCTATTCAATTTATTCGTGGCATCTTCCGTAGCGAATAAGCTATTCCAAGC
GGTTCAATTTTGCTAGAATT

Downstream 100 bases:

>100_bases
TAGATGTGATTATTCCTTGCTATAACGCCGAACAGACGTTAATGCGTGCGGTACAAAGTGCGTTAAACCAACCGGAATTA
GGTACGTTATGGCTAATTGA

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MQIEPFFIASEMIYFIADLHLNEAQPQITEHFLQFMRQKAPLAESVYILGDFFDFWIGDDEQSALIDQVKNALKTLTTSG
VKCYFICGNRDFLLGKRFAQETGIEILPDYYLLDLYGNKTLICHGDTLCIDDVKYQQFRRKVHQKWLQWLFLRLPLSLRI
RIAQKIRTKSKQDKQAKSADIMDVNPAFTAETVKRFGATYLIHGHTHRQAVHSEVEFTRIVLGDWKADYASVLKFDEQGF
EFI

Sequences:

>Translated_243_residues
MQIEPFFIASEMIYFIADLHLNEAQPQITEHFLQFMRQKAPLAESVYILGDFFDFWIGDDEQSALIDQVKNALKTLTTSG
VKCYFICGNRDFLLGKRFAQETGIEILPDYYLLDLYGNKTLICHGDTLCIDDVKYQQFRRKVHQKWLQWLFLRLPLSLRI
RIAQKIRTKSKQDKQAKSADIMDVNPAFTAETVKRFGATYLIHGHTHRQAVHSEVEFTRIVLGDWKADYASVLKFDEQGF
EFI
>Mature_243_residues
MQIEPFFIASEMIYFIADLHLNEAQPQITEHFLQFMRQKAPLAESVYILGDFFDFWIGDDEQSALIDQVKNALKTLTTSG
VKCYFICGNRDFLLGKRFAQETGIEILPDYYLLDLYGNKTLICHGDTLCIDDVKYQQFRRKVHQKWLQWLFLRLPLSLRI
RIAQKIRTKSKQDKQAKSADIMDVNPAFTAETVKRFGATYLIHGHTHRQAVHSEVEFTRIVLGDWKADYASVLKFDEQGF
EFI

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=233, Percent_Identity=49.7854077253219, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: 3.6.1.-

Molecular weight: Translated: 28371; Mature: 28371

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIEPFFIASEMIYFIADLHLNEAQPQITEHFLQFMRQKAPLAESVYILGDFFDFWIGDD
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
EQSALIDQVKNALKTLTTSGVKCYFICGNRDFLLGKRFAQETGIEILPDYYLLDLYGNKT
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHCCCEECCCEEEEEEECCEE
LICHGDTLCIDDVKYQQFRRKVHQKWLQWLFLRLPLSLRIRIAQKIRTKSKQDKQAKSAD
EEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCC
IMDVNPAFTAETVKRFGATYLIHGHTHRQAVHSEVEFTRIVLGDWKADYASVLKFDEQGF
CEECCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCCC
EFI
CCC
>Mature Secondary Structure
MQIEPFFIASEMIYFIADLHLNEAQPQITEHFLQFMRQKAPLAESVYILGDFFDFWIGDD
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
EQSALIDQVKNALKTLTTSGVKCYFICGNRDFLLGKRFAQETGIEILPDYYLLDLYGNKT
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHCCCEECCCEEEEEEECCEE
LICHGDTLCIDDVKYQQFRRKVHQKWLQWLFLRLPLSLRIRIAQKIRTKSKQDKQAKSAD
EEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCC
IMDVNPAFTAETVKRFGATYLIHGHTHRQAVHSEVEFTRIVLGDWKADYASVLKFDEQGF
CEECCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCCC
EFI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA