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The map label for this gene is nagA [H]

Identifier: 126209220

GI number: 126209220

Start: 1992866

End: 1994011

Strand: Direct

Name: nagA [H]

Synonym: APL_1756

Alternate gene names: 126209220

Gene position: 1992866-1994011 (Clockwise)

Preceding gene: 126209219

Following gene: 126209223

Centisome position: 87.62

GC content: 44.85

Gene sequence:

>1146_bases
ATGAAATATGCTTTTACTAATAGCGTGATTTATACCGCCAAAGAGGTGCTTTACGGACACGCTGTGGTTATTGAAAATGA
CAGAATTCAAGCGATTGTTCGTGAAGAACAATTAGCGGACGATATCCAACGTATCGATTTACAAGGGCATAATCTTACCG
CCGGTTTTATTGATTTACAGCTAAACGGCTGTGGCGGCGTAATGGTAAATAGTGAACCGACCGTCCGCACTTTTGAGATT
ATGCAGCAAACCAATTTACGTTCCGGTACGACAAGTTATTTACCGACCTTTATTACTGCACCTGATGAGGGAATGAAACA
AGTAGTCGCAGCGATGCGTGATTATTTGCAGAAATATCAAAACCAAGCGCTCGGTTTACACTTAGAAGGCCCTTATCTTA
GCCTTGAGAAAAAAGGTGTACACCGTGCCGAATATGTGCGTGAAATCAGCCCTGAAATGCAGCGGTTTTTATGTAATAAC
GCCGATGTGATTACCAAAATTACCTTAGCGGCGGAAAATCCGACCGCAAAAGCGATTCCCGAGTTTGTGAAAAGCGGCAT
TATTTTATCGGTCGGACATTCGAACGCCACTTATGAAGTGGCAAAACAGGCGTTTGCCAACGGTGCAACCTTTGCCACTC
ATTTACACAATGCGATGTCGCCGATTAGTTCCGGACGTGCAATGGGCGTTGTCGGTGCGGTGTTAGACAGCGATGAGGTT
TATACCGGTATTATTGTGGACGGTTTACACGTCGAATTCGGTAATGTCAAAATCGCCAAACGAGCTAAAGGTGACAAACT
TTGTATCGTCACCGATGCCACCGCAGCGGCAGGTTCGGATATCGAACAATTTGATTTTGTCGGTACTACGGTATATGTGC
GTGACGGTAAATGCTATGACGCTAACGGCACTTTAGGCGGTGCATCCATTACGATGATTGAATCGGTTAAAAATGCGGTG
CAAGAAGTCGGTATTCCGTTAGATGAAACGCTAAGAATGTGTAACTACTATCCGGCGAAAGCGATTGGTGTTGATGATCG
TTTGGGTTCGATTGAAGCGGGTAAAATTGCGAACCTGACCGTCTTTACCAACCGTTTTGAAGTTATCGGTTGTGCGGTAA
ACGGCGAATGGAACGCTTTTAGCTAA

Upstream 100 bases:

>100_bases
GAAATATTTCACCCAATTGGAAACGCAAGCGATTCAAAGCGTGTTGTAAGTTTTAAGGTCTGTTACACTATAAATAGACC
TTTTCATTTGGAGAACAAGA

Downstream 100 bases:

>100_bases
GATTCAATAAGTATTGAATGAAACAAGCGGTTAAATTTTGAGAAAGTTTTGCAAAAAAACACTGAAATTTAACCGCTTGT
TCTACAACTTTGACATAGTA

Product: N-acetylglucosamine-6-phosphate deacetylase

Products: NA

Alternate protein names: GlcNAc 6-P deacetylase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKYAFTNSVIYTAKEVLYGHAVVIENDRIQAIVREEQLADDIQRIDLQGHNLTAGFIDLQLNGCGGVMVNSEPTVRTFEI
MQQTNLRSGTTSYLPTFITAPDEGMKQVVAAMRDYLQKYQNQALGLHLEGPYLSLEKKGVHRAEYVREISPEMQRFLCNN
ADVITKITLAAENPTAKAIPEFVKSGIILSVGHSNATYEVAKQAFANGATFATHLHNAMSPISSGRAMGVVGAVLDSDEV
YTGIIVDGLHVEFGNVKIAKRAKGDKLCIVTDATAAAGSDIEQFDFVGTTVYVRDGKCYDANGTLGGASITMIESVKNAV
QEVGIPLDETLRMCNYYPAKAIGVDDRLGSIEAGKIANLTVFTNRFEVIGCAVNGEWNAFS

Sequences:

>Translated_381_residues
MKYAFTNSVIYTAKEVLYGHAVVIENDRIQAIVREEQLADDIQRIDLQGHNLTAGFIDLQLNGCGGVMVNSEPTVRTFEI
MQQTNLRSGTTSYLPTFITAPDEGMKQVVAAMRDYLQKYQNQALGLHLEGPYLSLEKKGVHRAEYVREISPEMQRFLCNN
ADVITKITLAAENPTAKAIPEFVKSGIILSVGHSNATYEVAKQAFANGATFATHLHNAMSPISSGRAMGVVGAVLDSDEV
YTGIIVDGLHVEFGNVKIAKRAKGDKLCIVTDATAAAGSDIEQFDFVGTTVYVRDGKCYDANGTLGGASITMIESVKNAV
QEVGIPLDETLRMCNYYPAKAIGVDDRLGSIEAGKIANLTVFTNRFEVIGCAVNGEWNAFS
>Mature_381_residues
MKYAFTNSVIYTAKEVLYGHAVVIENDRIQAIVREEQLADDIQRIDLQGHNLTAGFIDLQLNGCGGVMVNSEPTVRTFEI
MQQTNLRSGTTSYLPTFITAPDEGMKQVVAAMRDYLQKYQNQALGLHLEGPYLSLEKKGVHRAEYVREISPEMQRFLCNN
ADVITKITLAAENPTAKAIPEFVKSGIILSVGHSNATYEVAKQAFANGATFATHLHNAMSPISSGRAMGVVGAVLDSDEV
YTGIIVDGLHVEFGNVKIAKRAKGDKLCIVTDATAAAGSDIEQFDFVGTTVYVRDGKCYDANGTLGGASITMIESVKNAV
QEVGIPLDETLRMCNYYPAKAIGVDDRLGSIEAGKIANLTVFTNRFEVIGCAVNGEWNAFS

Specific function: N-acetylglucosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI21361513, Length=425, Percent_Identity=29.4117647058824, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI224922791, Length=420, Percent_Identity=29.0476190476191, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786892, Length=376, Percent_Identity=54.7872340425532, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17553768, Length=375, Percent_Identity=29.8666666666667, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI19920392, Length=344, Percent_Identity=29.9418604651163, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281361140, Length=358, Percent_Identity=29.0502793296089, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR003764
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.1.25 [H]

Molecular weight: Translated: 41320; Mature: 41320

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYAFTNSVIYTAKEVLYGHAVVIENDRIQAIVREEQLADDIQRIDLQGHNLTAGFIDLQ
CCEEEECCHHHHHHHHHCCCEEEEECCCEEEHHHHHHHHHHHHHEECCCCEEEEEEEEEE
LNGCGGVMVNSEPTVRTFEIMQQTNLRSGTTSYLPTFITAPDEGMKQVVAAMRDYLQKYQ
ECCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHC
NQALGLHLEGPYLSLEKKGVHRAEYVREISPEMQRFLCNNADVITKITLAAENPTAKAIP
CCEEEEEECCCEEEEECCCCHHHHHHHHHCHHHHHHHCCCCCEEEEEEEEECCCCHHHHH
EFVKSGIILSVGHSNATYEVAKQAFANGATFATHLHNAMSPISSGRAMGVVGAVLDSDEV
HHHHCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCHHHCCCCEEEEEEEECCCCE
YTGIIVDGLHVEFGNVKIAKRAKGDKLCIVTDATAAAGSDIEQFDFVGTTVYVRDGKCYD
EEEEEEEEEEEEECCEEEEECCCCCEEEEEECCCCCCCCCCHHHEEECEEEEEECCEEEE
ANGTLGGASITMIESVKNAVQEVGIPLDETLRMCNYYPAKAIGVDDRLGSIEAGKIANLT
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEECCCCCCCCCCCCCEEEEE
VFTNRFEVIGCAVNGEWNAFS
EEECCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MKYAFTNSVIYTAKEVLYGHAVVIENDRIQAIVREEQLADDIQRIDLQGHNLTAGFIDLQ
CCEEEECCHHHHHHHHHCCCEEEEECCCEEEHHHHHHHHHHHHHEECCCCEEEEEEEEEE
LNGCGGVMVNSEPTVRTFEIMQQTNLRSGTTSYLPTFITAPDEGMKQVVAAMRDYLQKYQ
ECCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHC
NQALGLHLEGPYLSLEKKGVHRAEYVREISPEMQRFLCNNADVITKITLAAENPTAKAIP
CCEEEEEECCCEEEEECCCCHHHHHHHHHCHHHHHHHCCCCCEEEEEEEEECCCCHHHHH
EFVKSGIILSVGHSNATYEVAKQAFANGATFATHLHNAMSPISSGRAMGVVGAVLDSDEV
HHHHCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCHHHCCCCEEEEEEEECCCCE
YTGIIVDGLHVEFGNVKIAKRAKGDKLCIVTDATAAAGSDIEQFDFVGTTVYVRDGKCYD
EEEEEEEEEEEEECCEEEEECCCCCEEEEEECCCCCCCCCCHHHEEECEEEEEECCEEEE
ANGTLGGASITMIESVKNAVQEVGIPLDETLRMCNYYPAKAIGVDDRLGSIEAGKIANLT
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEECCCCCCCCCCCCCEEEEE
VFTNRFEVIGCAVNGEWNAFS
EEECCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]