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The map label for this gene is gntR [H]

Identifier: 126209131

GI number: 126209131

Start: 1892822

End: 1893820

Strand: Reverse

Name: gntR [H]

Synonym: APL_1667

Alternate gene names: 126209131

Gene position: 1893820-1892822 (Counterclockwise)

Preceding gene: 126209143

Following gene: 126209129

Centisome position: 83.26

GC content: 43.14

Gene sequence:

>999_bases
ATGAGCAAACATAAACGCCCTACTTTACAAGATATTGCCGAACATTTAGGCATTACCAAAATGACGATCAGTCGCTATTT
ACGTAATCCCTCCTCGGTTGCCGAAGAGACCGGTAAACGAATCGCCGTTGCGATTGGACAATTCGGTTATATTCCGAATC
GTGCGCCGGATATTCTGTCCAATGCCAAAAGTAAAGCGATTGGCGTATTGTTACCGTCTTTAACCAACCAAGTTTTTGCC
GATGTGTTAAAAGGGATTGAGAGCGTGACTGATGCTGCAGGTTATCAAACCATGCTCGCCCACTATGGTTATAGCGAACA
AAAAGAAGAACAACGTATTGAATCGCTCCTTTCTTATCATGTGGACGGATTGATCTTATCGGAAAATCACCACAGTGAGC
GTACGCTCAAAATGTTAAGCGTCGCGAAAATTCCGGTAATTGAAATAATGGATACCAGTGAAAAAGGACTGCAACAAGCG
GTCGGTTTTGACAATATTTTTGCTGCTCAAGCGATGGTTGAAACCATGATCAAACGTGGTTGCCGCCAAGTGGTTTATTT
TTCGGCAAGAATGGATAAACGAACCCGTTTAAAGATGCAAGGCTACGAACTTGCTATGCAAAAGCATAAACTAACGCCTT
ACACTATTGCCACGGAAGAATCCTCTTCTTTTACCTTGGGAGCTAGACAACTGCATATTGCACTGGAAAAATATCCGAAT
ATCGACGGCATTTTCTGTACCAATGACGATTTGGCAATCGGCGCATTGTTCGAATGCCAACGGTTAGGTATTAAAGTGCC
GCAACAAATTGCGATTGCCGGCTTTCACGGGCACGATGTTGGTCAATCGATTACTCCTCAACTGGCGAGCGTGATTACCC
CTCGGTTTGAAATCGGCAAAGTTGCCGCCCAGCAATTACTAAATAGAATTAATCACCAAACGCCACAAGATGAAATGATT
AATCTTGGCTATAAAATTCATACCGGTGAAACAATTTAG

Upstream 100 bases:

>100_bases
ACAAAATTTTGCTAAAATCTTACCGCTTGTTATTTTGCAAATAAAACATAAAATCATACTTTCCGTTAAAATAGCGACAT
ACTTCACAAAATTTAATCCT

Downstream 100 bases:

>100_bases
GCGATAAAAAAGCGGTCAAATTTCGCAAAAAATTTGCAGAAAATAACCGCTTGTTCTACTCAACATTCTTTTTATAGATA
GGCTTTAATCGCCTGTACGC

Product: HTH-type transcriptional regulator

Products: NA

Alternate protein names: Gluconate utilization system GNT-I transcriptional repressor [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSKHKRPTLQDIAEHLGITKMTISRYLRNPSSVAEETGKRIAVAIGQFGYIPNRAPDILSNAKSKAIGVLLPSLTNQVFA
DVLKGIESVTDAAGYQTMLAHYGYSEQKEEQRIESLLSYHVDGLILSENHHSERTLKMLSVAKIPVIEIMDTSEKGLQQA
VGFDNIFAAQAMVETMIKRGCRQVVYFSARMDKRTRLKMQGYELAMQKHKLTPYTIATEESSSFTLGARQLHIALEKYPN
IDGIFCTNDDLAIGALFECQRLGIKVPQQIAIAGFHGHDVGQSITPQLASVITPRFEIGKVAAQQLLNRINHQTPQDEMI
NLGYKIHTGETI

Sequences:

>Translated_332_residues
MSKHKRPTLQDIAEHLGITKMTISRYLRNPSSVAEETGKRIAVAIGQFGYIPNRAPDILSNAKSKAIGVLLPSLTNQVFA
DVLKGIESVTDAAGYQTMLAHYGYSEQKEEQRIESLLSYHVDGLILSENHHSERTLKMLSVAKIPVIEIMDTSEKGLQQA
VGFDNIFAAQAMVETMIKRGCRQVVYFSARMDKRTRLKMQGYELAMQKHKLTPYTIATEESSSFTLGARQLHIALEKYPN
IDGIFCTNDDLAIGALFECQRLGIKVPQQIAIAGFHGHDVGQSITPQLASVITPRFEIGKVAAQQLLNRINHQTPQDEMI
NLGYKIHTGETI
>Mature_331_residues
SKHKRPTLQDIAEHLGITKMTISRYLRNPSSVAEETGKRIAVAIGQFGYIPNRAPDILSNAKSKAIGVLLPSLTNQVFAD
VLKGIESVTDAAGYQTMLAHYGYSEQKEEQRIESLLSYHVDGLILSENHHSERTLKMLSVAKIPVIEIMDTSEKGLQQAV
GFDNIFAAQAMVETMIKRGCRQVVYFSARMDKRTRLKMQGYELAMQKHKLTPYTIATEESSSFTLGARQLHIALEKYPNI
DGIFCTNDDLAIGALFECQRLGIKVPQQIAIAGFHGHDVGQSITPQLASVITPRFEIGKVAAQQLLNRINHQTPQDEMIN
LGYKIHTGETI

Specific function: Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI48994940, Length=330, Percent_Identity=57.2727272727273, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1790715, Length=331, Percent_Identity=48.3383685800604, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1790369, Length=318, Percent_Identity=25.7861635220126, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1790194, Length=319, Percent_Identity=24.1379310344828, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787906, Length=332, Percent_Identity=26.5060240963855, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787948, Length=321, Percent_Identity=25.2336448598131, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1789068, Length=312, Percent_Identity=25, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1788474, Length=303, Percent_Identity=22.4422442244224, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789202, Length=302, Percent_Identity=23.1788079470199, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787580, Length=325, Percent_Identity=23.6923076923077, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786540, Length=308, Percent_Identity=22.4025974025974, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790689, Length=319, Percent_Identity=21.9435736677116, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36922; Mature: 36791

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKHKRPTLQDIAEHLGITKMTISRYLRNPSSVAEETGKRIAVAIGQFGYIPNRAPDILS
CCCCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHCCCEEEEEEHHHCCCCCCCHHHHH
NAKSKAIGVLLPSLTNQVFADVLKGIESVTDAAGYQTMLAHYGYSEQKEEQRIESLLSYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VDGLILSENHHSERTLKMLSVAKIPVIEIMDTSEKGLQQAVGFDNIFAAQAMVETMIKRG
HCCEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
CRQVVYFSARMDKRTRLKMQGYELAMQKHKLTPYTIATEESSSFTLGARQLHIALEKYPN
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECHHHHHHHHHHCCC
IDGIFCTNDDLAIGALFECQRLGIKVPQQIAIAGFHGHDVGQSITPQLASVITPRFEIGK
CCEEEECCCCCCHHHHHHHHHCCCCCCCHHEEEECCCCCCCCCHHHHHHHHHCCCHHHHH
VAAQQLLNRINHQTPQDEMINLGYKIHTGETI
HHHHHHHHHHCCCCCHHHHHHCCEEEECCCCC
>Mature Secondary Structure 
SKHKRPTLQDIAEHLGITKMTISRYLRNPSSVAEETGKRIAVAIGQFGYIPNRAPDILS
CCCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHCCCEEEEEEHHHCCCCCCCHHHHH
NAKSKAIGVLLPSLTNQVFADVLKGIESVTDAAGYQTMLAHYGYSEQKEEQRIESLLSYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VDGLILSENHHSERTLKMLSVAKIPVIEIMDTSEKGLQQAVGFDNIFAAQAMVETMIKRG
HCCEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
CRQVVYFSARMDKRTRLKMQGYELAMQKHKLTPYTIATEESSSFTLGARQLHIALEKYPN
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECHHHHHHHHHHCCC
IDGIFCTNDDLAIGALFECQRLGIKVPQQIAIAGFHGHDVGQSITPQLASVITPRFEIGK
CCEEEECCCCCCHHHHHHHHHCCCCCCCHHEEEECCCCCCCCCHHHHHHHHHCCCHHHHH
VAAQQLLNRINHQTPQDEMINLGYKIHTGETI
HHHHHHHHHHCCCCCHHHHHHCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]