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The map label for this gene is atpB

Identifier: 126209116

GI number: 126209116

Start: 1879085

End: 1879873

Strand: Reverse

Name: atpB

Synonym: APL_1652

Alternate gene names: 126209116

Gene position: 1879873-1879085 (Counterclockwise)

Preceding gene: 126209117

Following gene: 126209115

Centisome position: 82.65

GC content: 39.04

Gene sequence:

>789_bases
ATGGCTGGAACTACCGCAGAATATATTAGCCATCACTTGAGTTTTTTAGCTTCAGGTGACGGTTTTTGGGCTGTTCATTT
AGATACGCTCTTTTTCTCTCTGCTTGCTGGTGTTATTTTCCTTTTCGTATTTTCTCGAGTTGCGAAAAATGCGACGTCGG
GAGTACCGGGAAAATTGCAATGCTTCGTGGAAATTGTCATTGGTTGGGTGGACGGTTTAGTTAAAGATAACTTCCACGGA
CCGCGTAATGTCATTGCTCCGCTTGCACTTACTATTTTCTGCTGGGTATTCATTATGAATGCTATTGACTTAGTTCCGGT
GGATTTCTTACCTCAATTGGCAAATATGTTCGGTATCCATTATCTTCGTGCCGTTCCTACAGCGGATATTAGTGCACCCT
TAGGTATGTCTATCTGCGTATTCTTCTTAATTTTATTCTATACCGTAAAATCAAAAGGTTTCGGAGGTTTAGTCAAAGAA
TATACTTTACATCCGTTTAACCATTGGGTGTTTATTCCGGTAAACTTTATTCTCGAAACCGTTACGCTACTTGCAAAACC
GATTTCTTTAGCATTCCGTTTATTCGGTAATATGTATGCAGGCGAGCTAATCTTCATCCTTATTGCAGTAATGTATATGG
CCGATAACTTCGCGCTACAAGCGTTAGGTATCCCATTACACTTGGTTTGGGCTATTTTCCATATTTTAGTTATTACGCTT
CAAGCCTTTATCTTTATGATGCTAACGATTGTTTATTTGAGTATCGCTTATAATAAAGCGGATCATTAA

Upstream 100 bases:

>100_bases
GTTTTTTGTGGGATATTTAATGGCATTATTTTTAAATAATGTCATTCCGTTTATTTTAAGTAAACGAACTCATTAATTTC
TTATTCTAAAAGGATTCATT

Downstream 100 bases:

>100_bases
ACGAACCTAAAGAGCGGTCGAATTTGCGCAATATTTTGCAAAAATTTGATTGCTTGAATTATTTTATTAACAACAACCCT
GCCTTTTGGCGAATTCCTCA

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MAGTTAEYISHHLSFLASGDGFWAVHLDTLFFSLLAGVIFLFVFSRVAKNATSGVPGKLQCFVEIVIGWVDGLVKDNFHG
PRNVIAPLALTIFCWVFIMNAIDLVPVDFLPQLANMFGIHYLRAVPTADISAPLGMSICVFFLILFYTVKSKGFGGLVKE
YTLHPFNHWVFIPVNFILETVTLLAKPISLAFRLFGNMYAGELIFILIAVMYMADNFALQALGIPLHLVWAIFHILVITL
QAFIFMMLTIVYLSIAYNKADH

Sequences:

>Translated_262_residues
MAGTTAEYISHHLSFLASGDGFWAVHLDTLFFSLLAGVIFLFVFSRVAKNATSGVPGKLQCFVEIVIGWVDGLVKDNFHG
PRNVIAPLALTIFCWVFIMNAIDLVPVDFLPQLANMFGIHYLRAVPTADISAPLGMSICVFFLILFYTVKSKGFGGLVKE
YTLHPFNHWVFIPVNFILETVTLLAKPISLAFRLFGNMYAGELIFILIAVMYMADNFALQALGIPLHLVWAIFHILVITL
QAFIFMMLTIVYLSIAYNKADH
>Mature_261_residues
AGTTAEYISHHLSFLASGDGFWAVHLDTLFFSLLAGVIFLFVFSRVAKNATSGVPGKLQCFVEIVIGWVDGLVKDNFHGP
RNVIAPLALTIFCWVFIMNAIDLVPVDFLPQLANMFGIHYLRAVPTADISAPLGMSICVFFLILFYTVKSKGFGGLVKEY
TLHPFNHWVFIPVNFILETVTLLAKPISLAFRLFGNMYAGELIFILIAVMYMADNFALQALGIPLHLVWAIFHILVITLQ
AFIFMMLTIVYLSIAYNKADH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=270, Percent_Identity=55.1851851851852, Blast_Score=270, Evalue=7e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_ACTP2 (A3N2V0)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054341.1
- ProteinModelPortal:   A3N2V0
- SMR:   A3N2V0
- STRING:   A3N2V0
- GeneID:   4849825
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1652
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   AGELVFM
- PhylomeDB:   A3N2V0
- ProtClustDB:   PRK05815
- BioCyc:   APLE416269:APL_1652-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 29230; Mature: 29099

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00449 ATPASE_A; PS00223 ANNEXIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1da6a760)-; HASH(0x1eea7524)-; HASH(0x1ee99094)-; HASH(0x1d668918)-; HASH(0x1df41e40)-; HASH(0x1ed02e44)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
AGTTAEYISHHLSFLASGDGFWAVHLDTLFFSLLAGVIFLFVFSRVAKNATSGVPGKLQ
CCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
CFVEIVIGWVDGLVKDNFHGPRNVIAPLALTIFCWVFIMNAIDLVPVDFLPQLANMFGIH
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
YLRAVPTADISAPLGMSICVFFLILFYTVKSKGFGGLVKEYTLHPFNHWVFIPVNFILET
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEHHHHHHHH
VTLLAKPISLAFRLFGNMYAGELIFILIAVMYMADNFALQALGIPLHLVWAIFHILVITL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QAFIFMMLTIVYLSIAYNKADH
HHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA