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The map label for this gene is atpA

Identifier: 126209112

GI number: 126209112

Start: 1876081

End: 1877622

Strand: Reverse

Name: atpA

Synonym: APL_1648

Alternate gene names: 126209112

Gene position: 1877622-1876081 (Counterclockwise)

Preceding gene: 126209113

Following gene: 126209111

Centisome position: 82.55

GC content: 43.32

Gene sequence:

>1542_bases
ATGCAACTAAATTCAACTGAAATTAGTGAATTGATAAAAAAACGTATTGCCCAGTTTGATGTGGTGAGCGAAGCTCAAAG
CACAGGGACAATCGTTTCGGTAAGCGACGGTATCATTCGTATCCACGGTCTTGCCGATGTAATGCAAGGCGAGATGATCG
AATTGCCGGGTAATCGCTATGCGATTGCACTTAACTTAGAACGTGATTCTGTCGGTGCTGTAGTAATGGGGCCTTATGCG
GATTTAGCTGAAGGTATGTCGGTTAAATGTACCGGTCGTATCTTAGAAGTTCCGGTAGGTCGAGGTTTATTAGGCCGTGT
TGTAAATACGTTAGGTCAGCCTATTGACGGTAAAGGTGAAATCGATAACGACGGTTTCTCTCCGGTAGAAGTTATTGCGC
CGGGTGTTATCGACCGTCAATCGGTAGATCAACCGGTTCAAACCGGTTATAAAGCGGTTGACTCAATGGTGCCAATCGGT
CGTGGTCAGCGTGAGTTAATCATCGGTGACCGTCAAACCGGTAAAACGGCATTAGCAATCGATGCAATTATTGCACAGAA
AGATTCGGGTATTAAATGTATCTATGTAGCAATCGGTCAAAAAGCATCTACGATTGCGAACGTAGTACGTAAATTAGAAG
AACACGGCGCATTAGCAAATACAATCGTTGTGGTTGCTTCGGCTTCCGAATCCGCGGCATTACAATACCTTGCTCCGTAT
TCTGGTTGTGCAATGGGCGAATATTTCCGTGATCGTGGTGAAGACGCTTTAATCGTTTATGATGATTTATCTAAACAAGC
GGTTGCTTATCGTCAAATTTCATTATTATTACGCCGTCCGCCGGGTCGTGAAGCATTCCCGGGTGACGTATTCTACCTAC
ACTCTCGTTTACTAGAGCGTGCGGCACGTGTAAGTGCGGATTATGTAGAGCGTTTCACTAACGGTGCGGTAAAAGGTCAA
ACAGGTTCATTAACTGCATTACCGATTATCGAGACACAAGCGGGTGACGTATCGGCTTTCGTTCCGACAAACGTAATTTC
TATTACTGACGGTCAGATTTTCTTAGAGTCAAGTTTATTTAACTCAGGTATTCGTCCTGCGGTAAACCCGGGTATTTCCG
TATCTCGTGTAGGTTCTGCGGCGCAAACTAAAGCTATCAAGAAATTATCTGGCGGTATCCGTACCGCATTAGCTCAGTAT
CGTGAATTAGCGGCGTTTGCTCAATTTGCTTCCGATTTAGATGATGCGACTCGTAAACAGCTTTCTCACGGTCAAAAAGT
GACGGAATTACTTAAACAAAAACAATTTGCTCCAATGCCGGTAAGCGAACAAGCATTAGTTCTTTTTGCTGCTGAATTCG
GTTATTTAGATGATGTAGAGCTTGAACGTATCGGTTCATTCGAATCTGCTTTATTGGCTTACGCAAATAGTAATCACACC
GACTTTATGAAAAATTTGGCAAAATCTGGCGATTATAACGATTCAATCAAGGATCAATTAAAAGCTATCGTAGAAGATTT
CAAAAAGAACGGTGCGTGGTAA

Upstream 100 bases:

>100_bases
AGGCGTAATTATTAAATACGATGATGTTGTTATTGATGGTAGTAGCCGCGGTCAGTTAAATCGCTTAGCGTCAGCGTTGA
GCTTGTAAGAGGAATAAAAA

Downstream 100 bases:

>100_bases
TCACGACTAGCGGAGAAAAATTATGGCAGGTGCGAAAGAGATAAGAACCAAAATTGCAAGTGTGAAAAATACTCAAAAAA
TCACCAAAGCAATGGAAATG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MQLNSTEISELIKKRIAQFDVVSEAQSTGTIVSVSDGIIRIHGLADVMQGEMIELPGNRYAIALNLERDSVGAVVMGPYA
DLAEGMSVKCTGRILEVPVGRGLLGRVVNTLGQPIDGKGEIDNDGFSPVEVIAPGVIDRQSVDQPVQTGYKAVDSMVPIG
RGQRELIIGDRQTGKTALAIDAIIAQKDSGIKCIYVAIGQKASTIANVVRKLEEHGALANTIVVVASASESAALQYLAPY
SGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVSADYVERFTNGAVKGQ
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESSLFNSGIRPAVNPGISVSRVGSAAQTKAIKKLSGGIRTALAQY
RELAAFAQFASDLDDATRKQLSHGQKVTELLKQKQFAPMPVSEQALVLFAAEFGYLDDVELERIGSFESALLAYANSNHT
DFMKNLAKSGDYNDSIKDQLKAIVEDFKKNGAW

Sequences:

>Translated_513_residues
MQLNSTEISELIKKRIAQFDVVSEAQSTGTIVSVSDGIIRIHGLADVMQGEMIELPGNRYAIALNLERDSVGAVVMGPYA
DLAEGMSVKCTGRILEVPVGRGLLGRVVNTLGQPIDGKGEIDNDGFSPVEVIAPGVIDRQSVDQPVQTGYKAVDSMVPIG
RGQRELIIGDRQTGKTALAIDAIIAQKDSGIKCIYVAIGQKASTIANVVRKLEEHGALANTIVVVASASESAALQYLAPY
SGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVSADYVERFTNGAVKGQ
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESSLFNSGIRPAVNPGISVSRVGSAAQTKAIKKLSGGIRTALAQY
RELAAFAQFASDLDDATRKQLSHGQKVTELLKQKQFAPMPVSEQALVLFAAEFGYLDDVELERIGSFESALLAYANSNHT
DFMKNLAKSGDYNDSIKDQLKAIVEDFKKNGAW
>Mature_513_residues
MQLNSTEISELIKKRIAQFDVVSEAQSTGTIVSVSDGIIRIHGLADVMQGEMIELPGNRYAIALNLERDSVGAVVMGPYA
DLAEGMSVKCTGRILEVPVGRGLLGRVVNTLGQPIDGKGEIDNDGFSPVEVIAPGVIDRQSVDQPVQTGYKAVDSMVPIG
RGQRELIIGDRQTGKTALAIDAIIAQKDSGIKCIYVAIGQKASTIANVVRKLEEHGALANTIVVVASASESAALQYLAPY
SGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVSADYVERFTNGAVKGQ
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESSLFNSGIRPAVNPGISVSRVGSAAQTKAIKKLSGGIRTALAQY
RELAAFAQFASDLDDATRKQLSHGQKVTELLKQKQFAPMPVSEQALVLFAAEFGYLDDVELERIGSFESALLAYANSNHT
DFMKNLAKSGDYNDSIKDQLKAIVEDFKKNGAW

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=511, Percent_Identity=57.3385518590998, Blast_Score=564, Evalue=1e-161,
Organism=Homo sapiens, GI4757810, Length=511, Percent_Identity=57.3385518590998, Blast_Score=564, Evalue=1e-161,
Organism=Homo sapiens, GI19913428, Length=315, Percent_Identity=27.6190476190476, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI19913426, Length=333, Percent_Identity=26.4264264264264, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI32189394, Length=469, Percent_Identity=24.9466950959488, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI19913424, Length=263, Percent_Identity=26.9961977186312, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790172, Length=513, Percent_Identity=85.7699805068226, Blast_Score=907, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=426, Percent_Identity=24.8826291079812, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788251, Length=356, Percent_Identity=24.438202247191, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=512, Percent_Identity=57.03125, Blast_Score=563, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71988080, Length=512, Percent_Identity=57.03125, Blast_Score=561, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71988074, Length=512, Percent_Identity=53.3203125, Blast_Score=516, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17510931, Length=373, Percent_Identity=25.7372654155496, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17570191, Length=315, Percent_Identity=26.3492063492064, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI25144756, Length=440, Percent_Identity=23.6363636363636, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17509265, Length=47, Percent_Identity=65.9574468085106, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17565854, Length=262, Percent_Identity=26.3358778625954, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=510, Percent_Identity=55.0980392156863, Blast_Score=565, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319603, Length=369, Percent_Identity=26.0162601626016, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6322581, Length=378, Percent_Identity=25.9259259259259, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24658560, Length=511, Percent_Identity=56.3600782778865, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI281361666, Length=313, Percent_Identity=27.4760383386581, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24646341, Length=313, Percent_Identity=27.4760383386581, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17136796, Length=313, Percent_Identity=27.4760383386581, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24638766, Length=425, Percent_Identity=25.6470588235294, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574560, Length=322, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24583988, Length=263, Percent_Identity=27.3764258555133, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583986, Length=263, Percent_Identity=27.3764258555133, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583984, Length=263, Percent_Identity=27.3764258555133, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583992, Length=263, Percent_Identity=27.3764258555133, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI20129479, Length=258, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_ACTP2 (A3N2U6)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054337.1
- ProteinModelPortal:   A3N2U6
- SMR:   A3N2U6
- STRING:   A3N2U6
- GeneID:   4850203
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1648
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- PhylomeDB:   A3N2U6
- ProtClustDB:   PRK09281
- BioCyc:   APLE416269:APL_1648-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55161; Mature: 55161

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNSTEISELIKKRIAQFDVVSEAQSTGTIVSVSDGIIRIHGLADVMQGEMIELPGNRY
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECHHHHHCCCEEECCCCEE
AIALNLERDSVGAVVMGPYADLAEGMSVKCTGRILEVPVGRGLLGRVVNTLGQPIDGKGE
EEEEEECCCCCCEEEECCHHHHHCCCEEEECCEEEECCCCCCHHHHHHHHHCCCCCCCCC
IDNDGFSPVEVIAPGVIDRQSVDQPVQTGYKAVDSMVPIGRGQRELIIGDRQTGKTALAI
CCCCCCCHHHHHCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHH
DAIIAQKDSGIKCIYVAIGQKASTIANVVRKLEEHGALANTIVVVASASESAALQYLAPY
HHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHCCC
SGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLER
CCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AARVSADYVERFTNGAVKGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESSLF
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCEEEEHHHH
NSGIRPAVNPGISVSRVGSAAQTKAIKKLSGGIRTALAQYRELAAFAQFASDLDDATRKQ
CCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSHGQKVTELLKQKQFAPMPVSEQALVLFAAEFGYLDDVELERIGSFESALLAYANSNHT
HHCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHCCHHHHHHHHCCCCCH
DFMKNLAKSGDYNDSIKDQLKAIVEDFKKNGAW
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQLNSTEISELIKKRIAQFDVVSEAQSTGTIVSVSDGIIRIHGLADVMQGEMIELPGNRY
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECHHHHHCCCEEECCCCEE
AIALNLERDSVGAVVMGPYADLAEGMSVKCTGRILEVPVGRGLLGRVVNTLGQPIDGKGE
EEEEEECCCCCCEEEECCHHHHHCCCEEEECCEEEECCCCCCHHHHHHHHHCCCCCCCCC
IDNDGFSPVEVIAPGVIDRQSVDQPVQTGYKAVDSMVPIGRGQRELIIGDRQTGKTALAI
CCCCCCCHHHHHCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHH
DAIIAQKDSGIKCIYVAIGQKASTIANVVRKLEEHGALANTIVVVASASESAALQYLAPY
HHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHCCC
SGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLER
CCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AARVSADYVERFTNGAVKGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESSLF
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCEEEEHHHH
NSGIRPAVNPGISVSRVGSAAQTKAIKKLSGGIRTALAQYRELAAFAQFASDLDDATRKQ
CCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSHGQKVTELLKQKQFAPMPVSEQALVLFAAEFGYLDDVELERIGSFESALLAYANSNHT
HHCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHCCHHHHHHHHCCCCCH
DFMKNLAKSGDYNDSIKDQLKAIVEDFKKNGAW
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA