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The map label for this gene is frdB [H]

Identifier: 126208992

GI number: 126208992

Start: 1741547

End: 1742281

Strand: Reverse

Name: frdB [H]

Synonym: APL_1528

Alternate gene names: 126208992

Gene position: 1742281-1741547 (Counterclockwise)

Preceding gene: 126208993

Following gene: 126208991

Centisome position: 76.6

GC content: 44.76

Gene sequence:

>735_bases
ATGGCAAATTTAAGCAAAATGACCATCGAAGTGCTTCGCTACAACCCGGAAACAGATAGCGAACCACATTTAGATAAATA
TGAAGTGCCGTTCGACAGCCAAACTTCATTATTAGACGCACTCGGTTATATTAAAGACGAACTTGAGCCGGAACTCTCTT
ATCGTTGGTCTTGCCGTATGGCGATCTGCGGCTCGTGCGGTATGATGGTAAACGGTAAACCGAAATTAGCGTGTAAAACG
TTCTTACGTGATTACAGCGGCTTTATGCGAATCGAACCGCTTGCCAACTTCCCGATTGAGCGTGACTTAGTGGTGGATTT
AAGCCACTTTATCGATAGCATCGAAGCAATCAAACCTTATGTTATCGATAATAAAGCACCGGAAGGTCAGCGCACTAAAC
AAACACCGGCACAATTAGAGAAATATCGTCAATTCTCAATGTGTATTAACTGTGGCTTATGCTATGCGGCTTGTCCGCAA
TTTGGTTTAAACCCTGAGTTTATCGGCCCGGCGGCGATTACCCTTGCCCACCGTTATAACTTGGATAACCGTGACAACGG
TCGTGAGCAACGTATGAAACTCTTAAGCTCGAAAAACGGGGTGTGGAGTTGTACTTTCGTCGGTTATTGCTCGGAAGTGT
GTCCGAAACACGTCGGTCCGGCTTCCGCAATTAACCAAGGTAAATTGGAAAGTGCGAAAGATTACGTAATTTCAATGCTT
AAACCAAAAGGCTAG

Upstream 100 bases:

>100_bases
TAAATCACAACCGGCGAAACGTGTATATGGTGCGGAAGCCGAAGCGCAAGAAAAAGCGAAAAAAGCCGCAGAACAGGCAC
AAAAATAGGAGAGCGATAAT

Downstream 100 bases:

>100_bases
GGGGCAATATGACAACAGCAACTAAACGTAAAGCGTATGTACGCGAAATGAAAGCGAATTGGTGGACAAAATCAAGCTTC
TATAAAATGTACATGGTTCG

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MANLSKMTIEVLRYNPETDSEPHLDKYEVPFDSQTSLLDALGYIKDELEPELSYRWSCRMAICGSCGMMVNGKPKLACKT
FLRDYSGFMRIEPLANFPIERDLVVDLSHFIDSIEAIKPYVIDNKAPEGQRTKQTPAQLEKYRQFSMCINCGLCYAACPQ
FGLNPEFIGPAAITLAHRYNLDNRDNGREQRMKLLSSKNGVWSCTFVGYCSEVCPKHVGPASAINQGKLESAKDYVISML
KPKG

Sequences:

>Translated_244_residues
MANLSKMTIEVLRYNPETDSEPHLDKYEVPFDSQTSLLDALGYIKDELEPELSYRWSCRMAICGSCGMMVNGKPKLACKT
FLRDYSGFMRIEPLANFPIERDLVVDLSHFIDSIEAIKPYVIDNKAPEGQRTKQTPAQLEKYRQFSMCINCGLCYAACPQ
FGLNPEFIGPAAITLAHRYNLDNRDNGREQRMKLLSSKNGVWSCTFVGYCSEVCPKHVGPASAINQGKLESAKDYVISML
KPKG
>Mature_243_residues
ANLSKMTIEVLRYNPETDSEPHLDKYEVPFDSQTSLLDALGYIKDELEPELSYRWSCRMAICGSCGMMVNGKPKLACKTF
LRDYSGFMRIEPLANFPIERDLVVDLSHFIDSIEAIKPYVIDNKAPEGQRTKQTPAQLEKYRQFSMCINCGLCYAACPQF
GLNPEFIGPAAITLAHRYNLDNRDNGREQRMKLLSSKNGVWSCTFVGYCSEVCPKHVGPASAINQGKLESAKDYVISMLK
PKG

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=226, Percent_Identity=34.5132743362832, Blast_Score=131, Evalue=6e-31,
Organism=Escherichia coli, GI1790596, Length=244, Percent_Identity=73.3606557377049, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1786943, Length=230, Percent_Identity=39.1304347826087, Blast_Score=154, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17533915, Length=228, Percent_Identity=34.2105263157895, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322987, Length=226, Percent_Identity=35.3982300884956, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24643156, Length=228, Percent_Identity=35.5263157894737, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI17137106, Length=228, Percent_Identity=33.7719298245614, Blast_Score=131, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27471; Mature: 27340

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLSKMTIEVLRYNPETDSEPHLDKYEVPFDSQTSLLDALGYIKDELEPELSYRWSCRM
CCCHHHHEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
AICGSCGMMVNGKPKLACKTFLRDYSGFMRIEPLANFPIERDLVVDLSHFIDSIEAIKPY
EEECCCCEEECCCCHHHHHHHHHHHCCCEEECHHHCCCCCCHHHHHHHHHHHHHHHHCCE
VIDNKAPEGQRTKQTPAQLEKYRQFSMCINCGLCYAACPQFGLNPEFIGPAAITLAHRYN
EECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHCC
LDNRDNGREQRMKLLSSKNGVWSCTFVGYCSEVCPKHVGPASAINQGKLESAKDYVISML
CCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHH
KPKG
CCCC
>Mature Secondary Structure 
ANLSKMTIEVLRYNPETDSEPHLDKYEVPFDSQTSLLDALGYIKDELEPELSYRWSCRM
CCHHHHEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
AICGSCGMMVNGKPKLACKTFLRDYSGFMRIEPLANFPIERDLVVDLSHFIDSIEAIKPY
EEECCCCEEECCCCHHHHHHHHHHHCCCEEECHHHCCCCCCHHHHHHHHHHHHHHHHCCE
VIDNKAPEGQRTKQTPAQLEKYRQFSMCINCGLCYAACPQFGLNPEFIGPAAITLAHRYN
EECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHCC
LDNRDNGREQRMKLLSSKNGVWSCTFVGYCSEVCPKHVGPASAINQGKLESAKDYVISML
CCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHH
KPKG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]