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The map label for this gene is chuW [H]

Identifier: 126208987

GI number: 126208987

Start: 1736466

End: 1738283

Strand: Reverse

Name: chuW [H]

Synonym: APL_1523

Alternate gene names: 126208987

Gene position: 1738283-1736466 (Counterclockwise)

Preceding gene: 126208988

Following gene: 126208986

Centisome position: 76.43

GC content: 43.78

Gene sequence:

>1818_bases
ATGATTACAACAACAAATTGGCAGGCAAGCCAAGCCGCTCCGAAAGCATTTCCCGAACGTCAGGCGTTAATGCCGATCTG
GGGCGGTGAAGTCGTACCGCAACAAGAATGGCAGAGCGTATGGGGACAAGCCGCTATTCACGCCCTCAAACAAGACGGTT
TAGCATATGTCCATATCCCTTTTTGTGCCGGTCACTGTATTTTCTGTGGTTTTTACCGTAATGCGTGGAAACAAGAATAC
AGTAAAATCTATACCGATAAATTAATTAAAGAATTGGCGTACGAAGCAAGTATCCGCCAAGGTAGCGGTAAAATCAAAGC
GGTTTATTTTGGCGGCGGAACGCCAACCGCCTTGGATACCGAAGATTTAGTCCGCTTAATCAAAGCCTGCTATCAATATT
TACCGTTAGCGGACGATTGCGAATTTACGATTGAAGGGCGTATCAGTCATTTTGATATTGAAAAGGCGCGTGCTTGCGTA
GCCGCCGGTGCGAATCGTATTTCAATCGGTATTCAAACCTTTAACTCAAACATTCGTAAGCGTTTAGGGCGTAAACATAG
CGGCGAAGAAGCTTACGCATATCTCAAAGCCTTGTGCGAATTGGATGCGGTTGTCGTTGCCGATTTAATTTTCGGCTTAC
CGAATCAAACGGATGAAGTTTGGGCGAACGATATTCAAGTGGCAAGCACTCTACCGTTATCCGGTTTAGATATTTATGCG
TTTAATAATTATCCGTTTTTACCGATTAATAAAATGATTGAACACGGTTCTCTGCCTGCCGCTGCAAGTTTTGAAGTTCA
AGCGCAGCATTATGCTTATGCGATAGAACATTTACAAAACACCGGTTGGCAACAAGTGAGTAATAACCACTTTGCTTTCC
CGAATCGCAGGGAACGTAACCGTTATAACACGTTAGTCAAATCCAATATGCCGTGTCTTGCCTTCGGCTCCGGCGCAGGT
GGTAATTTCGGCGGTTATAGTTTCCAAGTACATTCCACACTACAAACTTATTTAGACACACCGGCAGATAAAAAAGCGCT
GTCGTTTTTAAGTAAACACGGTGCGAATAAGCCGTTACTTGGTGTCGTGCAACACGATTTAGAACTGGGTTATCTGGATA
TTAAATTATTTAAACATAACCCGAAAGCAATGAAATTGCTGATGCAATGGCAGCAATTATCTTTATTAAACATTGATCAA
GACGGTATCGCTCGCTTGAATATCAGCGGTCGATACTGGTCACCGACTTTGATCCGTAAATTAATGCTCACGCTGCCCAC
AGAAGATAAAAAGGAGAACAGTATGGTTAAATTAAGTGAAGAACAATTAAGCGAATTACGTCAATCGCTTGCCGAAAATC
CGGGGCAAATTTTAGAAATGGTTGCCGGTATGAAACAATGCAGCTTAGAAGAAGTGATTAGCTGCTTACCGGCGGAAATG
GTCACCAAAACGGACGGCGCACGTTTTGTGGAAATTATGCAAGCGTTAGCAACGCTAGAAGATGCGGTGACCTTTATTGC
ACACACGCCGGATGCGGTGGTTGAGGTCACCGGCAAGCTACCAAGCGGTCAAATCGGCAGAGGTTTTTACAATTTCGATC
ACGCTCAGGAAGGCGGCGTACACGGTCACCTACGTTATGAAAACTGTGCGGCGATTTATTTACTTGAGCGTCCGTTTATG
GGCAAACATACCGTATCGCTTAACTTTATTAACCATCAAGGCGGTGCAATGTTTAAAATCTTTGTCGGACGTGATGAAGA
TCGCAATTTACGCCAAAATCAAATCGACTTTATGCGTCAATTAATTAAGGGTGAGTAA

Upstream 100 bases:

>100_bases
ATGCTTATTAACTTGACAAATATTGATAAGAATCAATATCATTTACAATTAGATTTTGTATAAATCCTTTCTTCGTTTTG
AAAGAATTGAGAAAGTGATG

Downstream 100 bases:

>100_bases
TGATTTTATTATTTGGAGCCAACGGCTTAGCCGGACGTGCATTACTGGAAGCGGCCGAACAACCGATCGTCTCTGTATTG
CGCCGACCTTCGGACGATCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MITTTNWQASQAAPKAFPERQALMPIWGGEVVPQQEWQSVWGQAAIHALKQDGLAYVHIPFCAGHCIFCGFYRNAWKQEY
SKIYTDKLIKELAYEASIRQGSGKIKAVYFGGGTPTALDTEDLVRLIKACYQYLPLADDCEFTIEGRISHFDIEKARACV
AAGANRISIGIQTFNSNIRKRLGRKHSGEEAYAYLKALCELDAVVVADLIFGLPNQTDEVWANDIQVASTLPLSGLDIYA
FNNYPFLPINKMIEHGSLPAAASFEVQAQHYAYAIEHLQNTGWQQVSNNHFAFPNRRERNRYNTLVKSNMPCLAFGSGAG
GNFGGYSFQVHSTLQTYLDTPADKKALSFLSKHGANKPLLGVVQHDLELGYLDIKLFKHNPKAMKLLMQWQQLSLLNIDQ
DGIARLNISGRYWSPTLIRKLMLTLPTEDKKENSMVKLSEEQLSELRQSLAENPGQILEMVAGMKQCSLEEVISCLPAEM
VTKTDGARFVEIMQALATLEDAVTFIAHTPDAVVEVTGKLPSGQIGRGFYNFDHAQEGGVHGHLRYENCAAIYLLERPFM
GKHTVSLNFINHQGGAMFKIFVGRDEDRNLRQNQIDFMRQLIKGE

Sequences:

>Translated_605_residues
MITTTNWQASQAAPKAFPERQALMPIWGGEVVPQQEWQSVWGQAAIHALKQDGLAYVHIPFCAGHCIFCGFYRNAWKQEY
SKIYTDKLIKELAYEASIRQGSGKIKAVYFGGGTPTALDTEDLVRLIKACYQYLPLADDCEFTIEGRISHFDIEKARACV
AAGANRISIGIQTFNSNIRKRLGRKHSGEEAYAYLKALCELDAVVVADLIFGLPNQTDEVWANDIQVASTLPLSGLDIYA
FNNYPFLPINKMIEHGSLPAAASFEVQAQHYAYAIEHLQNTGWQQVSNNHFAFPNRRERNRYNTLVKSNMPCLAFGSGAG
GNFGGYSFQVHSTLQTYLDTPADKKALSFLSKHGANKPLLGVVQHDLELGYLDIKLFKHNPKAMKLLMQWQQLSLLNIDQ
DGIARLNISGRYWSPTLIRKLMLTLPTEDKKENSMVKLSEEQLSELRQSLAENPGQILEMVAGMKQCSLEEVISCLPAEM
VTKTDGARFVEIMQALATLEDAVTFIAHTPDAVVEVTGKLPSGQIGRGFYNFDHAQEGGVHGHLRYENCAAIYLLERPFM
GKHTVSLNFINHQGGAMFKIFVGRDEDRNLRQNQIDFMRQLIKGE
>Mature_605_residues
MITTTNWQASQAAPKAFPERQALMPIWGGEVVPQQEWQSVWGQAAIHALKQDGLAYVHIPFCAGHCIFCGFYRNAWKQEY
SKIYTDKLIKELAYEASIRQGSGKIKAVYFGGGTPTALDTEDLVRLIKACYQYLPLADDCEFTIEGRISHFDIEKARACV
AAGANRISIGIQTFNSNIRKRLGRKHSGEEAYAYLKALCELDAVVVADLIFGLPNQTDEVWANDIQVASTLPLSGLDIYA
FNNYPFLPINKMIEHGSLPAAASFEVQAQHYAYAIEHLQNTGWQQVSNNHFAFPNRRERNRYNTLVKSNMPCLAFGSGAG
GNFGGYSFQVHSTLQTYLDTPADKKALSFLSKHGANKPLLGVVQHDLELGYLDIKLFKHNPKAMKLLMQWQQLSLLNIDQ
DGIARLNISGRYWSPTLIRKLMLTLPTEDKKENSMVKLSEEQLSELRQSLAENPGQILEMVAGMKQCSLEEVISCLPAEM
VTKTDGARFVEIMQALATLEDAVTFIAHTPDAVVEVTGKLPSGQIGRGFYNFDHAQEGGVHGHLRYENCAAIYLLERPFM
GKHTVSLNFINHQGGAMFKIFVGRDEDRNLRQNQIDFMRQLIKGE

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=241, Percent_Identity=27.3858921161826, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI87082341, Length=409, Percent_Identity=24.2053789731051, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789325, Length=192, Percent_Identity=33.8541666666667, Blast_Score=99, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 67736; Mature: 67736

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTTNWQASQAAPKAFPERQALMPIWGGEVVPQQEWQSVWGQAAIHALKQDGLAYVHIP
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEE
FCAGHCIFCGFYRNAWKQEYSKIYTDKLIKELAYEASIRQGSGKIKAVYFGGGTPTALDT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCH
EDLVRLIKACYQYLPLADDCEFTIEGRISHFDIEKARACVAAGANRISIGIQTFNSNIRK
HHHHHHHHHHHHHCCCCCCCCEEEECCEEEECHHHHHHHHHCCCCEEEEEEEHHHHHHHH
RLGRKHSGEEAYAYLKALCELDAVVVADLIFGLPNQTDEVWANDIQVASTLPLSGLDIYA
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEECCCCCEEEEE
FNNYPFLPINKMIEHGSLPAAASFEVQAQHYAYAIEHLQNTGWQQVSNNHFAFPNRRERN
ECCCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHH
RYNTLVKSNMPCLAFGSGAGGNFGGYSFQVHSTLQTYLDTPADKKALSFLSKHGANKPLL
HHHHHHHCCCCEEEECCCCCCCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHCCCCCCCH
GVVQHDLELGYLDIKLFKHNPKAMKLLMQWQQLSLLNIDQDGIARLNISGRYWSPTLIRK
HHHHHCCEEEEEEEEEEECCHHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCCHHHHHH
LMLTLPTEDKKENSMVKLSEEQLSELRQSLAENPGQILEMVAGMKQCSLEEVISCLPAEM
HHHHCCCCCCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHCCHHH
VTKTDGARFVEIMQALATLEDAVTFIAHTPDAVVEVTGKLPSGQIGRGFYNFDHAQEGGV
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
HGHLRYENCAAIYLLERPFMGKHTVSLNFINHQGGAMFKIFVGRDEDRNLRQNQIDFMRQ
EEEEEECCCEEEEEECCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHH
LIKGE
HHCCC
>Mature Secondary Structure
MITTTNWQASQAAPKAFPERQALMPIWGGEVVPQQEWQSVWGQAAIHALKQDGLAYVHIP
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEE
FCAGHCIFCGFYRNAWKQEYSKIYTDKLIKELAYEASIRQGSGKIKAVYFGGGTPTALDT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCH
EDLVRLIKACYQYLPLADDCEFTIEGRISHFDIEKARACVAAGANRISIGIQTFNSNIRK
HHHHHHHHHHHHHCCCCCCCCEEEECCEEEECHHHHHHHHHCCCCEEEEEEEHHHHHHHH
RLGRKHSGEEAYAYLKALCELDAVVVADLIFGLPNQTDEVWANDIQVASTLPLSGLDIYA
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEECCCCCEEEEE
FNNYPFLPINKMIEHGSLPAAASFEVQAQHYAYAIEHLQNTGWQQVSNNHFAFPNRRERN
ECCCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHH
RYNTLVKSNMPCLAFGSGAGGNFGGYSFQVHSTLQTYLDTPADKKALSFLSKHGANKPLL
HHHHHHHCCCCEEEECCCCCCCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHCCCCCCCH
GVVQHDLELGYLDIKLFKHNPKAMKLLMQWQQLSLLNIDQDGIARLNISGRYWSPTLIRK
HHHHHCCEEEEEEEEEEECCHHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCCHHHHHH
LMLTLPTEDKKENSMVKLSEEQLSELRQSLAENPGQILEMVAGMKQCSLEEVISCLPAEM
HHHHCCCCCCCCCCEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHCCHHH
VTKTDGARFVEIMQALATLEDAVTFIAHTPDAVVEVTGKLPSGQIGRGFYNFDHAQEGGV
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
HGHLRYENCAAIYLLERPFMGKHTVSLNFINHQGGAMFKIFVGRDEDRNLRQNQIDFMRQ
EEEEEECCCEEEEEECCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHH
LIKGE
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]