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The map label for this gene is gpsA

Identifier: 126208974

GI number: 126208974

Start: 1725946

End: 1726956

Strand: Direct

Name: gpsA

Synonym: APL_1510

Alternate gene names: 126208974

Gene position: 1725946-1726956 (Clockwise)

Preceding gene: 126208973

Following gene: 126208975

Centisome position: 75.88

GC content: 45.7

Gene sequence:

>1011_bases
ATGAGTGAAATGTATTCGGCACCCGTTACGGTTTTAGGTGCCGGTTCTTACGGTACCGCTTTGGCAATCGCACTTGCACG
TAACGGACATAAAACCTACCTATGGGGACATCAACCGGAAAAAATGGCGGTGTTGGCAACCGAGCGAATGAATAACGCTT
TTTTACCGGATATTGCTTTTCCCGATGCCTTAGAGATTGAAAGTGACTTAGTTCAAGCCATTGCTAAAGCCAAAGACATT
TTAATCGTTGTACCAAGCCATGTATTTGCCGATGTGCTAAAACAAATAAAGCCTCTGTTAAGTGCCCATCATCGTATTAT
GTGGGCAACGAAAGGACTGGAACGTAATACCGGACGACTATTACAAACCGTAGCACAAGAAATTCTTGGTAATCAATACC
CGTTAGCGGTACTATCCGGGCCGACATTTGCCAAAGAACTCGCTCAAGGTTTACCGACAGCTATCGCACTATCCTCAACA
GACAGCCAATTTGCCGATGAAATGCAGCAACGTATTCACTGTGCTAAAGCGTTTCGAGTCTATTTGAACAACGATATGAT
AGGTGTGCAATTAGGCGGTGCGATTAAGAATGTCATTGCAATCGGGGCTGGTATTTCCGATGGAATGGGCTTTGGTGCTA
ATGCAAGAACGGCACTTATTACGCGCGGTTTAGCTGAGATCAGCCGTTTAGGCGCATCACTCGGTGCAAATGCCAATACT
TTTATGGGTATGGCGGGACTTGGCGATTTGGTACTAACTTGTACCGATAACCAATCGCGTAACCGTCGTTTCGGTTTAAT
GCTCGGACAAGGAAAATCCGCTGAGGAAGCTATGGCGGAAATCGGGCAAGTGGTGGAAGGTTTCTACAATACCAAAGAAG
CGTATTTATTGGCTCAGACCCAAGGTGTCGAAATGCCGATTGTCGAACAAATCTATCAAATGCTATTCTGCGGTAAGAAT
GCGCATGATGTTGCTACGAGCCTATTAGGGCGTGAACGCAAAGGCGAATAA

Upstream 100 bases:

>100_bases
ATAATTGACGGATTTATCTCAAATGATATATTGAGCGTTATTGTTTAACAGCCTATACGAATGCTAATTTCAACATATTT
CATCAGATAAGGACAATATA

Downstream 100 bases:

>100_bases
AGAGGTTTTAGATGAACGAAAGTGAACTTAATCAAATTTGGAAAAATATTAGAGAAGAAGCTCAAGAACTTGTCGATAAT
GAACCGATGCTTGCCAGCTT

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSEMYSAPVTVLGAGSYGTALAIALARNGHKTYLWGHQPEKMAVLATERMNNAFLPDIAFPDALEIESDLVQAIAKAKDI
LIVVPSHVFADVLKQIKPLLSAHHRIMWATKGLERNTGRLLQTVAQEILGNQYPLAVLSGPTFAKELAQGLPTAIALSST
DSQFADEMQQRIHCAKAFRVYLNNDMIGVQLGGAIKNVIAIGAGISDGMGFGANARTALITRGLAEISRLGASLGANANT
FMGMAGLGDLVLTCTDNQSRNRRFGLMLGQGKSAEEAMAEIGQVVEGFYNTKEAYLLAQTQGVEMPIVEQIYQMLFCGKN
AHDVATSLLGRERKGE

Sequences:

>Translated_336_residues
MSEMYSAPVTVLGAGSYGTALAIALARNGHKTYLWGHQPEKMAVLATERMNNAFLPDIAFPDALEIESDLVQAIAKAKDI
LIVVPSHVFADVLKQIKPLLSAHHRIMWATKGLERNTGRLLQTVAQEILGNQYPLAVLSGPTFAKELAQGLPTAIALSST
DSQFADEMQQRIHCAKAFRVYLNNDMIGVQLGGAIKNVIAIGAGISDGMGFGANARTALITRGLAEISRLGASLGANANT
FMGMAGLGDLVLTCTDNQSRNRRFGLMLGQGKSAEEAMAEIGQVVEGFYNTKEAYLLAQTQGVEMPIVEQIYQMLFCGKN
AHDVATSLLGRERKGE
>Mature_335_residues
SEMYSAPVTVLGAGSYGTALAIALARNGHKTYLWGHQPEKMAVLATERMNNAFLPDIAFPDALEIESDLVQAIAKAKDIL
IVVPSHVFADVLKQIKPLLSAHHRIMWATKGLERNTGRLLQTVAQEILGNQYPLAVLSGPTFAKELAQGLPTAIALSSTD
SQFADEMQQRIHCAKAFRVYLNNDMIGVQLGGAIKNVIAIGAGISDGMGFGANARTALITRGLAEISRLGASLGANANTF
MGMAGLGDLVLTCTDNQSRNRRFGLMLGQGKSAEEAMAEIGQVVEGFYNTKEAYLLAQTQGVEMPIVEQIYQMLFCGKNA
HDVATSLLGRERKGE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=341, Percent_Identity=28.7390029325513, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI24307999, Length=353, Percent_Identity=24.929178470255, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1790037, Length=331, Percent_Identity=70.392749244713, Blast_Score=489, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI32564399, Length=338, Percent_Identity=25.4437869822485, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI32564403, Length=347, Percent_Identity=24.7838616714697, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI193210136, Length=344, Percent_Identity=25, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17507425, Length=285, Percent_Identity=24.5614035087719, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193210134, Length=203, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320181, Length=340, Percent_Identity=30, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324513, Length=343, Percent_Identity=30.0291545189504, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17136202, Length=327, Percent_Identity=27.82874617737, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17136200, Length=327, Percent_Identity=27.82874617737, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17136204, Length=327, Percent_Identity=27.82874617737, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI22026922, Length=330, Percent_Identity=23.6363636363636, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI45551945, Length=239, Percent_Identity=26.7782426778243, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281362270, Length=239, Percent_Identity=26.7782426778243, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648969, Length=193, Percent_Identity=29.0155440414508, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_ACTP2 (A3N2F8)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054199.1
- ProteinModelPortal:   A3N2F8
- SMR:   A3N2F8
- STRING:   A3N2F8
- GeneID:   4850014
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1510
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- PhylomeDB:   A3N2F8
- ProtClustDB:   PRK00094
- BioCyc:   APLE416269:APL_1510-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 36052; Mature: 35921

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 196-196 BINDING 111-111 BINDING 111-111 BINDING 144-144 BINDING 260-260 BINDING 286-286

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEMYSAPVTVLGAGSYGTALAIALARNGHKTYLWGHQPEKMAVLATERMNNAFLPDIAF
CCCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHCCCCCCCCCCC
PDALEIESDLVQAIAKAKDILIVVPSHVFADVLKQIKPLLSAHHRIMWATKGLERNTGRL
CCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHH
LQTVAQEILGNQYPLAVLSGPTFAKELAQGLPTAIALSSTDSQFADEMQQRIHCAKAFRV
HHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
YLNNDMIGVQLGGAIKNVIAIGAGISDGMGFGANARTALITRGLAEISRLGASLGANANT
HCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
FMGMAGLGDLVLTCTDNQSRNRRFGLMLGQGKSAEEAMAEIGQVVEGFYNTKEAYLLAQT
HEECCCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEC
QGVEMPIVEQIYQMLFCGKNAHDVATSLLGRERKGE
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEMYSAPVTVLGAGSYGTALAIALARNGHKTYLWGHQPEKMAVLATERMNNAFLPDIAF
CCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHCCCCCCCCCCC
PDALEIESDLVQAIAKAKDILIVVPSHVFADVLKQIKPLLSAHHRIMWATKGLERNTGRL
CCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHH
LQTVAQEILGNQYPLAVLSGPTFAKELAQGLPTAIALSSTDSQFADEMQQRIHCAKAFRV
HHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
YLNNDMIGVQLGGAIKNVIAIGAGISDGMGFGANARTALITRGLAEISRLGASLGANANT
HCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
FMGMAGLGDLVLTCTDNQSRNRRFGLMLGQGKSAEEAMAEIGQVVEGFYNTKEAYLLAQT
HEECCCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEC
QGVEMPIVEQIYQMLFCGKNAHDVATSLLGRERKGE
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA