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The map label for this gene is thrC [H]

Identifier: 126208963

GI number: 126208963

Start: 1714873

End: 1716153

Strand: Direct

Name: thrC [H]

Synonym: APL_1499

Alternate gene names: 126208963

Gene position: 1714873-1716153 (Clockwise)

Preceding gene: 126208960

Following gene: 126208964

Centisome position: 75.4

GC content: 44.11

Gene sequence:

>1281_bases
ATGAACTTATACAACATCAAACACCCAGAAGAACAAGTTAATTTCGCACAAGGCGTGCGCCAAGGTTTAGGTAAGGATCA
GGGGTTATTTTTCCCTGAAGTGTTACCGAAATTTGACGATATTGATGCGTTACTGGATTTACCTTTGGTTGAACGCAGCC
AAAAAATTTTGGCGGCACTTATCGGTAACGAACTTCCGCAAGAAACGGTAAATGCCATGGTAAAAAATGCGTTTACTTTC
CCTGCTCCATTAGCAAAAGTGAATGACTATATTTATGCACTTGAGCTGTTCCACGGCCCGACATTGGCATTTAAAGACTT
CGGCGGTCGTTTTATGGCGCAAGCACTGGCAAGCGTGCGTGGTGACGGCAAAATCACCATTTTAACCGCAACCTCAGGCG
ACACCGGTGCGGCGGTAGCGCACGCATTTTATGGCTTAGAAAATATCAATGTAGTGATCCTTTACCCGAAAGGCAAAATC
AGCCCGTTACAAGAAAAATTATTCTGTACCTTAGGCGGTAACATTCGTACCGTTGCGATTGAATCGGATTTTGACGCTTG
CCAAGTGTTAGTAAAACAAGCGTTTGACGATGCTGAATTACGTCAAGCGATCGGCTTAAACTCCGCAAACTCAATCAATA
TCAGCCGTTTATTAGCGCAAGTTTGTTATTACTTTGAAGCGGTAGCACAATTACCGAAAGCAAAACGTTCTGATGTAGTG
GTTTCAGTACCAAGCGGTAACTTCGGTAACTTAACCGCTGGTTTAATCGCAAAAACCTTAGGTTTACCAATTAAACGTTT
TATCGCATCAACCAATGCGAATGACACAGTGCCGCGTTATTTAAAATCAGGTAAATGGGAACCGAACGCAACGGTAGCAA
CGCTTTCAAACGCAATGGACGTAAGCCGCCCGAACAACTGGCCTCGTGTGGAAGAATTATTTAAACGCAACGGTTGGGCG
TTAAGCGATTTAGGTTCGGCGGCATTAAACGATGCGGAAACCGAAGCGGCATTAAAAGCACAATATGCGGAAGGTTATTT
ATGCGAACCGCACGGTGCAATCGCTTACCAAGCGTTAAAAGATCAGCTTCAAGCGGGCGAAACCGGTATTTTCCTCTGCA
CCGCTCACCCGGCAAAATTCAAAGAAAGCGTAGAACGTATTCTTAACATCGAATTACCACTACCGGAAGCATTGGATAAA
CATAACAAAATGGAATTATTATCCGACACTATGCCGGCGGATTTCGCCAAATTACGTGAGTATTTGTTAGCGGGTAACTA
A

Upstream 100 bases:

>100_bases
ATAATACCGCTTATTTACGCCTTTTGCATTGACTAACGAACGATAATAGCTAGAATCTGACAAATCACTCTTAATACTTA
ATAATAAAGGACTTTTCCTA

Downstream 100 bases:

>100_bases
TTAGCTATTAAAAGAAAAGCACTCGGAGTGATCTGCCCCCCAAAAGTTGGACTAAACCTCCAACGGATTAAGGTGCAGAT
TTTTTATGACTAAATATAAC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNLYNIKHPEEQVNFAQGVRQGLGKDQGLFFPEVLPKFDDIDALLDLPLVERSQKILAALIGNELPQETVNAMVKNAFTF
PAPLAKVNDYIYALELFHGPTLAFKDFGGRFMAQALASVRGDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKI
SPLQEKLFCTLGGNIRTVAIESDFDACQVLVKQAFDDAELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKAKRSDVV
VSVPSGNFGNLTAGLIAKTLGLPIKRFIASTNANDTVPRYLKSGKWEPNATVATLSNAMDVSRPNNWPRVEELFKRNGWA
LSDLGSAALNDAETEAALKAQYAEGYLCEPHGAIAYQALKDQLQAGETGIFLCTAHPAKFKESVERILNIELPLPEALDK
HNKMELLSDTMPADFAKLREYLLAGN

Sequences:

>Translated_426_residues
MNLYNIKHPEEQVNFAQGVRQGLGKDQGLFFPEVLPKFDDIDALLDLPLVERSQKILAALIGNELPQETVNAMVKNAFTF
PAPLAKVNDYIYALELFHGPTLAFKDFGGRFMAQALASVRGDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKI
SPLQEKLFCTLGGNIRTVAIESDFDACQVLVKQAFDDAELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKAKRSDVV
VSVPSGNFGNLTAGLIAKTLGLPIKRFIASTNANDTVPRYLKSGKWEPNATVATLSNAMDVSRPNNWPRVEELFKRNGWA
LSDLGSAALNDAETEAALKAQYAEGYLCEPHGAIAYQALKDQLQAGETGIFLCTAHPAKFKESVERILNIELPLPEALDK
HNKMELLSDTMPADFAKLREYLLAGN
>Mature_426_residues
MNLYNIKHPEEQVNFAQGVRQGLGKDQGLFFPEVLPKFDDIDALLDLPLVERSQKILAALIGNELPQETVNAMVKNAFTF
PAPLAKVNDYIYALELFHGPTLAFKDFGGRFMAQALASVRGDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKI
SPLQEKLFCTLGGNIRTVAIESDFDACQVLVKQAFDDAELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKAKRSDVV
VSVPSGNFGNLTAGLIAKTLGLPIKRFIASTNANDTVPRYLKSGKWEPNATVATLSNAMDVSRPNNWPRVEELFKRNGWA
LSDLGSAALNDAETEAALKAQYAEGYLCEPHGAIAYQALKDQLQAGETGIFLCTAHPAKFKESVERILNIELPLPEALDK
HNKMELLSDTMPADFAKLREYLLAGN

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=433, Percent_Identity=30.715935334873, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI149193323, Length=419, Percent_Identity=30.7875894988067, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI1786185, Length=425, Percent_Identity=67.5294117647059, Blast_Score=573, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319901, Length=447, Percent_Identity=33.3333333333333, Blast_Score=207, Evalue=3e-54,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46447; Mature: 46447

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLYNIKHPEEQVNFAQGVRQGLGKDQGLFFPEVLPKFDDIDALLDLPLVERSQKILAAL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHCCHHHHHHHHHHHHH
IGNELPQETVNAMVKNAFTFPAPLAKVNDYIYALELFHGPTLAFKDFGGRFMAQALASVR
HCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHEEEEHHCCCCEEHHHCCHHHHHHHHHHHC
GDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKISPLQEKLFCTLGGNIRTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHEEEEECCCEEEEEE
ESDFDACQVLVKQAFDDAELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKAKRSDVV
ECCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEE
VSVPSGNFGNLTAGLIAKTLGLPIKRFIASTNANDTVPRYLKSGKWEPNATVATLSNAMD
EECCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH
VSRPNNWPRVEELFKRNGWALSDLGSAALNDAETEAALKAQYAEGYLCEPHGAIAYQALK
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHCCCEEECCCCHHHHHHHH
DQLQAGETGIFLCTAHPAKFKESVERILNIELPLPEALDKHNKMELLSDTMPADFAKLRE
HHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHCCCHHHHHHHH
YLLAGN
HHHCCC
>Mature Secondary Structure
MNLYNIKHPEEQVNFAQGVRQGLGKDQGLFFPEVLPKFDDIDALLDLPLVERSQKILAAL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHCCHHHHHHHHHHHHH
IGNELPQETVNAMVKNAFTFPAPLAKVNDYIYALELFHGPTLAFKDFGGRFMAQALASVR
HCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHEEEEHHCCCCEEHHHCCHHHHHHHHHHHC
GDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKISPLQEKLFCTLGGNIRTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHEEEEECCCEEEEEE
ESDFDACQVLVKQAFDDAELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKAKRSDVV
ECCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEE
VSVPSGNFGNLTAGLIAKTLGLPIKRFIASTNANDTVPRYLKSGKWEPNATVATLSNAMD
EECCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH
VSRPNNWPRVEELFKRNGWALSDLGSAALNDAETEAALKAQYAEGYLCEPHGAIAYQALK
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHCCCEEECCCCHHHHHHHH
DQLQAGETGIFLCTAHPAKFKESVERILNIELPLPEALDKHNKMELLSDTMPADFAKLRE
HHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHCCCHHHHHHHH
YLLAGN
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]