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The map label for this gene is apxID [H]

Identifier: 126208906

GI number: 126208906

Start: 1649278

End: 1650714

Strand: Reverse

Name: apxID [H]

Synonym: APL_1442

Alternate gene names: 126208906

Gene position: 1650714-1649278 (Counterclockwise)

Preceding gene: 126208907

Following gene: 126208905

Centisome position: 72.58

GC content: 39.32

Gene sequence:

>1437_bases
ATGAAAACATGGCTAATGGGTTTATATGAGTTTTTCCAACGCTATAAAACGGTTTGGACGGAGATCTGGAAAATTCGTCA
TCAATTGGATACGCCGGATCGAGAAAAGGATGAAAATGAATTTTTACCTGCACACTTAGAGCTGATTGAAACACCGGTGT
CAAAAAAACCGAGATTGATCGCTTATTTAATTATGCTGTTCCTATTTTTGGCATTAGTTATTTCAATTGTCAGTCACGTA
GAAATTGTGGCGACCGCAACGGGCAAATTAGCGTTTAGCGGACGTAGCAAAGAAATTAAGCCGATTGAAAACGCCTTGGT
TAAAGAAATCTTTGTGCAAGACGGACAATTTGTTGAGAAAGATCAGTTGCTGTTACACTTGACCGCATTGGGAGCCGATG
CGGATCAACAAAAAACCAAAAGTTCGTTATCGCTGACTAAATTGGAACGTTATCGTTATGAAATTTTATTAGAGGCGGTT
GCGGCGGATAGGTTGCCGCTCATTGAACTGACAAAGGATGAATTTAAACATGCTACGGAAGAAGATAAAACCAGAATTCG
CTATTTGATCACCGAGCAATTTGAAGCTTGGCAAAAGCAAAAGTATCAAAAAGAATTAGCTTTGCAACGTAGAGAAGCAG
AAAAACAAACGGTTCTAGCTAATATTCGTAAATATGAGGGAATCAGTCGAGTTGAAAATGAAAGATTAAAAGATCTTAAA
AAATTATTTAATTCGAAATCGACTTCTAAACATGATGTCTTGACTCAAGAAAATCGTCATATCGAAGCGGTAAATGAGTT
GGCGGTGTATAAATCTCGGTTGAATGAAGTGGAAAGTGACTTACGTCAAGCCAAAGAGGAAATACATTTAATAACTCAGT
TGTTTAGAGCCGATATTCTGGAGAAGTTGAAACAAAATGTTGAAGCGGAGAAACAGCTTTCGCTCGAATTAGAAAAAAAT
GAGCAGCGTCAAATTGCTTCGGTGATTCGTGCGCCGGTTTCCGGTACGGTTCAGCAACTTAAAACCCATACGGTAGGCGG
CGTCGTGACGACTGCCGAAACCTTGATGGTAATTGCTCCGGAAGATGATGTTTTAGAGGTAACGGCGTTAATTCAAAATA
AGGATATTGGTTTTATCGAGGTCGGTCAGGATGCGGTGATTAAAGTAGAAACTTTTCCTTATACTCGTTACGGCTATTTA
ATGGGTAAAGTAAAAAATATCACGCTGGAAGCCATCGAACATCCGCAACTCGGCCTAGTTTTTAACTCGATTATTTCTAT
TGATAGAAAAACTTTATCCGGCAAAGACGGCAAAGAAATTGAACTTGGATCAGGTATGAGTGTGACGGCGGAAATTAAAA
CTGGAGAACGTAGCGTTATTAGTTATTTACTCAGTCCGTTGGAAGAATCCGTTTCGGAGAGTTTAAGAGAACGCTAA

Upstream 100 bases:

>100_bases
AAGGTCAGATTGTGGAACAAGGTAAGCATAAAGAGCTGCTTGCTGATCCAAACGGCTTATATCACTACTTACACCAATTA
CAATCGGAATAGGAGGACTT

Downstream 100 bases:

>100_bases
AGCAGATAAAACAAGCGGCCATATTTTCTTACTTTTTGGCATAGTAGACAAAAAGGTTGGTAAAAAGTGGGTTAAAGCCT
TATAGTACAAGGCTTTAACC

Product: RTX-I toxin secretion component

Products: NA

Alternate protein names: APX-ID; Cytolysin ID; CLY-ID; HLY-ID; Toxin RTX-I secretion protein D [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKTWLMGLYEFFQRYKTVWTEIWKIRHQLDTPDREKDENEFLPAHLELIETPVSKKPRLIAYLIMLFLFLALVISIVSHV
EIVATATGKLAFSGRSKEIKPIENALVKEIFVQDGQFVEKDQLLLHLTALGADADQQKTKSSLSLTKLERYRYEILLEAV
AADRLPLIELTKDEFKHATEEDKTRIRYLITEQFEAWQKQKYQKELALQRREAEKQTVLANIRKYEGISRVENERLKDLK
KLFNSKSTSKHDVLTQENRHIEAVNELAVYKSRLNEVESDLRQAKEEIHLITQLFRADILEKLKQNVEAEKQLSLELEKN
EQRQIASVIRAPVSGTVQQLKTHTVGGVVTTAETLMVIAPEDDVLEVTALIQNKDIGFIEVGQDAVIKVETFPYTRYGYL
MGKVKNITLEAIEHPQLGLVFNSIISIDRKTLSGKDGKEIELGSGMSVTAEIKTGERSVISYLLSPLEESVSESLRER

Sequences:

>Translated_478_residues
MKTWLMGLYEFFQRYKTVWTEIWKIRHQLDTPDREKDENEFLPAHLELIETPVSKKPRLIAYLIMLFLFLALVISIVSHV
EIVATATGKLAFSGRSKEIKPIENALVKEIFVQDGQFVEKDQLLLHLTALGADADQQKTKSSLSLTKLERYRYEILLEAV
AADRLPLIELTKDEFKHATEEDKTRIRYLITEQFEAWQKQKYQKELALQRREAEKQTVLANIRKYEGISRVENERLKDLK
KLFNSKSTSKHDVLTQENRHIEAVNELAVYKSRLNEVESDLRQAKEEIHLITQLFRADILEKLKQNVEAEKQLSLELEKN
EQRQIASVIRAPVSGTVQQLKTHTVGGVVTTAETLMVIAPEDDVLEVTALIQNKDIGFIEVGQDAVIKVETFPYTRYGYL
MGKVKNITLEAIEHPQLGLVFNSIISIDRKTLSGKDGKEIELGSGMSVTAEIKTGERSVISYLLSPLEESVSESLRER
>Mature_478_residues
MKTWLMGLYEFFQRYKTVWTEIWKIRHQLDTPDREKDENEFLPAHLELIETPVSKKPRLIAYLIMLFLFLALVISIVSHV
EIVATATGKLAFSGRSKEIKPIENALVKEIFVQDGQFVEKDQLLLHLTALGADADQQKTKSSLSLTKLERYRYEILLEAV
AADRLPLIELTKDEFKHATEEDKTRIRYLITEQFEAWQKQKYQKELALQRREAEKQTVLANIRKYEGISRVENERLKDLK
KLFNSKSTSKHDVLTQENRHIEAVNELAVYKSRLNEVESDLRQAKEEIHLITQLFRADILEKLKQNVEAEKQLSLELEKN
EQRQIASVIRAPVSGTVQQLKTHTVGGVVTTAETLMVIAPEDDVLEVTALIQNKDIGFIEVGQDAVIKVETFPYTRYGYL
MGKVKNITLEAIEHPQLGLVFNSIISIDRKTLSGKDGKEIELGSGMSVTAEIKTGERSVISYLLSPLEESVSESLRER

Specific function: Involved in the transport of the toxin RTX-I as well as that of RTX-II [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 54834; Mature: 54834

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00543 HLYD_FAMILY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTWLMGLYEFFQRYKTVWTEIWKIRHQLDTPDREKDENEFLPAHLELIETPVSKKPRLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHH
AYLIMLFLFLALVISIVSHVEIVATATGKLAFSGRSKEIKPIENALVKEIFVQDGQFVEK
HHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCH
DQLLLHLTALGADADQQKTKSSLSLTKLERYRYEILLEAVAADRLPLIELTKDEFKHATE
HHHHEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCCCH
EDKTRIRYLITEQFEAWQKQKYQKELALQRREAEKQTVLANIRKYEGISRVENERLKDLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
KLFNSKSTSKHDVLTQENRHIEAVNELAVYKSRLNEVESDLRQAKEEIHLITQLFRADIL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLKQNVEAEKQLSLELEKNEQRQIASVIRAPVSGTVQQLKTHTVGGVVTTAETLMVIAP
HHHHHCCCHHHHHHEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCEEEEECC
EDDVLEVTALIQNKDIGFIEVGQDAVIKVETFPYTRYGYLMGKVKNITLEAIEHPQLGLV
CCCHHHHHHHHHCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHEEHHHHCCCCHHHH
FNSIISIDRKTLSGKDGKEIELGSGMSVTAEIKTGERSVISYLLSPLEESVSESLRER
HHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTWLMGLYEFFQRYKTVWTEIWKIRHQLDTPDREKDENEFLPAHLELIETPVSKKPRLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHH
AYLIMLFLFLALVISIVSHVEIVATATGKLAFSGRSKEIKPIENALVKEIFVQDGQFVEK
HHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCH
DQLLLHLTALGADADQQKTKSSLSLTKLERYRYEILLEAVAADRLPLIELTKDEFKHATE
HHHHEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCCCH
EDKTRIRYLITEQFEAWQKQKYQKELALQRREAEKQTVLANIRKYEGISRVENERLKDLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
KLFNSKSTSKHDVLTQENRHIEAVNELAVYKSRLNEVESDLRQAKEEIHLITQLFRADIL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLKQNVEAEKQLSLELEKNEQRQIASVIRAPVSGTVQQLKTHTVGGVVTTAETLMVIAP
HHHHHCCCHHHHHHEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCEEEEECC
EDDVLEVTALIQNKDIGFIEVGQDAVIKVETFPYTRYGYLMGKVKNITLEAIEHPQLGLV
CCCHHHHHHHHHCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHEEHHHHCCCCHHHH
FNSIISIDRKTLSGKDGKEIELGSGMSVTAEIKTGERSVISYLLSPLEESVSESLRER
HHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1860823; 1937809; 8181764 [H]