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The map label for this gene is caiC [C]

Identifier: 126208877

GI number: 126208877

Start: 1614873

End: 1616648

Strand: Reverse

Name: caiC [C]

Synonym: APL_1413

Alternate gene names: 126208877

Gene position: 1616648-1614873 (Counterclockwise)

Preceding gene: 126208878

Following gene: 126208875

Centisome position: 71.08

GC content: 42.17

Gene sequence:

>1776_bases
ATGACTAACCAACCGAATTATCATCTTATCGACCAAGTACGCCGACGTGCCGAACAGTTCGCTTCCAAAACCGCTTTACG
TTATAAATCCCAACAAATCTGGCAAGATATTTCATGGCAATCTTTCCAACAGTCCGTTGATCTATTCTCCCTTGCACTTT
TAGCTCACGGTATCGAAGTACAGCAAAAAATTGCGATTTTTGCGCACAATATGCCGCAATGGACGATTACGGATTTCGGG
GCGCTGCAAATTCGTGCGGTAACCGTGCCGATTTATGCCACAAATACGGCTAAACAGGCGGAATTTATCCTTAATCATGC
GGATATTCGTATTCTGTTTGTCGGTGATCACGAGCAGCTCGAAGCGGCTTTAGAAGTAGCGGATAACTGCCCGTTACTGG
AAAAAATTGTTTGTATGAAATCGCAAGAAATCAGCCTAATTCGACCGCTTGCCCATACTAAAGTGGAAAATTGGAATGAT
TTTATTGCTTATGCTTCCCAAGATAAGCAAACAGAATTAAACCAACGTCTTGCCGATAAAAATCTTTCGGATCTATTCAC
TCTGATTTATACCTCCGGCACGACAGGCGAACCGAAAGGGGTCATGTTGGACTATGCCAATATTGCACATCAGTTGCACG
CTCACGATTTAGCCTTGCCGAAAATTGATGAAAATGACGTTTCGCTTTCTTTCCTGCCGTTTTCACATATTTTTGAACGA
GCGTGGGTGGCTTATGTGCTTTATCGCGGTGCGACCGTTTGTTATTTGGAAGATACCAATGAAGTGCGCAATGCGTTAAA
TGAAGTGAAACCGACTTTAATGTGCGCCGTGCCTCGTTTATATGAAAAAATGTATAGTGCGATTTGGGATAAAGTGAATA
AAGCTCCGATTCACCGCAGAGCGTTATTTAAGTGGGCGATTTCAGTCGGCAAGAAAAATCGGAAAAATACCTTATCTTAT
AAATTAGCGGATAAATTGGTATTAAATAAATTACGTGCTTTATTGGGCGGGCGTATTCGTATGATGCCGTGCGGCGGTGC
AAAATTGGAACCGACCATCGGGCAATTTTTCCAAGCTATCGGCGTTAATATCAAATTGGGCTACGGTATGACCGAAACTA
CCGCCACGGTTTCTTGTTGGGCGGACGATCAATTTGAACCAAATTCAATCGGGCGTTTAATGCCGAATGCCGAAGTGAAA
ATCGGCGAAAATAACGAGATTTTAGTACGTGGCGGTATGGTCATGCGAGGCTATTACAAACGTCCGGAGGAAACCGCGCT
TGCCTTTACCGAAGACGGTTTCTTAAAAACCGGTGATGCCGGCGAATTTGATGCGCAAAGCAATTTATATATTACCGACC
GCATCAAAGAGCTAATGAAAACCTCGAACGGTAAATATATCGCGCCGCAATATATCGAGGGTAAAATCGGTAAAGATAAA
TTTATCGAGCAGATTGCGATTATTGCCGATGCGAAGAAATATGTGTCAGCTTTAATCGTACCCTGCTTTGAAAGCCTCGA
AGAGTACGCGAAACAACTGAATATCAAATATCAAGACCGTATGGAATTAGTTAAACATTCGGAAATTGTGCAGTTATTTG
AAAAGCGTATCAACGAGTTGCAAAAAGAGCTGGCACACTTTGAGCAAATCAAGAAATTTACCCTGTTACCGCAAGCGTTT
AGCGTAAAAATGGAAGAAATCACACCAACCTTAAAATTACGTCGTAAAGTGATTTTAGAACGCTATCGTAAGCAGATTGA
ATCGATGTATAAATAA

Upstream 100 bases:

>100_bases
CGTTTCAGCGCACAGTTGTACACAAATTACTAGCATTTTAAGACGTTACATTTTATATTAGCGAACAGTTGTAAGCTGAA
ATAATAACGAATAACTTAAT

Downstream 100 bases:

>100_bases
TTTCAAGCGGCCGGATTTTGCTAAAAATTTACAAAATTCGACCGCTTGCTTATCTCAGTTATCTACGGAATATCGAAGCC
TTGGGCGGCGACATAGACTT

Product: putative long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MTNQPNYHLIDQVRRRAEQFASKTALRYKSQQIWQDISWQSFQQSVDLFSLALLAHGIEVQQKIAIFAHNMPQWTITDFG
ALQIRAVTVPIYATNTAKQAEFILNHADIRILFVGDHEQLEAALEVADNCPLLEKIVCMKSQEISLIRPLAHTKVENWND
FIAYASQDKQTELNQRLADKNLSDLFTLIYTSGTTGEPKGVMLDYANIAHQLHAHDLALPKIDENDVSLSFLPFSHIFER
AWVAYVLYRGATVCYLEDTNEVRNALNEVKPTLMCAVPRLYEKMYSAIWDKVNKAPIHRRALFKWAISVGKKNRKNTLSY
KLADKLVLNKLRALLGGRIRMMPCGGAKLEPTIGQFFQAIGVNIKLGYGMTETTATVSCWADDQFEPNSIGRLMPNAEVK
IGENNEILVRGGMVMRGYYKRPEETALAFTEDGFLKTGDAGEFDAQSNLYITDRIKELMKTSNGKYIAPQYIEGKIGKDK
FIEQIAIIADAKKYVSALIVPCFESLEEYAKQLNIKYQDRMELVKHSEIVQLFEKRINELQKELAHFEQIKKFTLLPQAF
SVKMEEITPTLKLRRKVILERYRKQIESMYK

Sequences:

>Translated_591_residues
MTNQPNYHLIDQVRRRAEQFASKTALRYKSQQIWQDISWQSFQQSVDLFSLALLAHGIEVQQKIAIFAHNMPQWTITDFG
ALQIRAVTVPIYATNTAKQAEFILNHADIRILFVGDHEQLEAALEVADNCPLLEKIVCMKSQEISLIRPLAHTKVENWND
FIAYASQDKQTELNQRLADKNLSDLFTLIYTSGTTGEPKGVMLDYANIAHQLHAHDLALPKIDENDVSLSFLPFSHIFER
AWVAYVLYRGATVCYLEDTNEVRNALNEVKPTLMCAVPRLYEKMYSAIWDKVNKAPIHRRALFKWAISVGKKNRKNTLSY
KLADKLVLNKLRALLGGRIRMMPCGGAKLEPTIGQFFQAIGVNIKLGYGMTETTATVSCWADDQFEPNSIGRLMPNAEVK
IGENNEILVRGGMVMRGYYKRPEETALAFTEDGFLKTGDAGEFDAQSNLYITDRIKELMKTSNGKYIAPQYIEGKIGKDK
FIEQIAIIADAKKYVSALIVPCFESLEEYAKQLNIKYQDRMELVKHSEIVQLFEKRINELQKELAHFEQIKKFTLLPQAF
SVKMEEITPTLKLRRKVILERYRKQIESMYK
>Mature_590_residues
TNQPNYHLIDQVRRRAEQFASKTALRYKSQQIWQDISWQSFQQSVDLFSLALLAHGIEVQQKIAIFAHNMPQWTITDFGA
LQIRAVTVPIYATNTAKQAEFILNHADIRILFVGDHEQLEAALEVADNCPLLEKIVCMKSQEISLIRPLAHTKVENWNDF
IAYASQDKQTELNQRLADKNLSDLFTLIYTSGTTGEPKGVMLDYANIAHQLHAHDLALPKIDENDVSLSFLPFSHIFERA
WVAYVLYRGATVCYLEDTNEVRNALNEVKPTLMCAVPRLYEKMYSAIWDKVNKAPIHRRALFKWAISVGKKNRKNTLSYK
LADKLVLNKLRALLGGRIRMMPCGGAKLEPTIGQFFQAIGVNIKLGYGMTETTATVSCWADDQFEPNSIGRLMPNAEVKI
GENNEILVRGGMVMRGYYKRPEETALAFTEDGFLKTGDAGEFDAQSNLYITDRIKELMKTSNGKYIAPQYIEGKIGKDKF
IEQIAIIADAKKYVSALIVPCFESLEEYAKQLNIKYQDRMELVKHSEIVQLFEKRINELQKELAHFEQIKKFTLLPQAFS
VKMEEITPTLKLRRKVILERYRKQIESMYK

Specific function: Could Catalyze The Transfer Of CoA To Crotonobetaine Or Carnitine. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=631, Percent_Identity=29.1600633914422, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI57165412, Length=596, Percent_Identity=29.8657718120805, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI57165410, Length=600, Percent_Identity=29.6666666666667, Blast_Score=237, Evalue=3e-62,
Organism=Homo sapiens, GI83745141, Length=614, Percent_Identity=26.2214983713355, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI27477105, Length=615, Percent_Identity=28.2926829268293, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI42794756, Length=591, Percent_Identity=28.9340101522843, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI42794760, Length=591, Percent_Identity=28.9340101522843, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI42794758, Length=591, Percent_Identity=28.9340101522843, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI42794754, Length=600, Percent_Identity=26.6666666666667, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI42794752, Length=600, Percent_Identity=26.6666666666667, Blast_Score=189, Evalue=7e-48,
Organism=Homo sapiens, GI12669909, Length=605, Percent_Identity=26.7768595041322, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI4758332, Length=605, Percent_Identity=26.7768595041322, Blast_Score=182, Evalue=8e-46,
Organism=Escherichia coli, GI1788107, Length=134, Percent_Identity=31.3432835820896, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510401, Length=597, Percent_Identity=30.1507537688442, Blast_Score=234, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17556552, Length=559, Percent_Identity=29.5169946332737, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17541856, Length=587, Percent_Identity=29.3015332197615, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17553312, Length=592, Percent_Identity=26.3513513513513, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI193204819, Length=627, Percent_Identity=27.4322169059011, Blast_Score=189, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI25147511, Length=602, Percent_Identity=25.2491694352159, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17564090, Length=535, Percent_Identity=26.3551401869159, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17559526, Length=480, Percent_Identity=27.5, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17558820, Length=325, Percent_Identity=26.7692307692308, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32563687, Length=334, Percent_Identity=26.9461077844311, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17531443, Length=316, Percent_Identity=26.8987341772152, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI133901848, Length=212, Percent_Identity=27.8301886792453, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71985884, Length=343, Percent_Identity=24.198250728863, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324893, Length=436, Percent_Identity=30.5045871559633, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320852, Length=571, Percent_Identity=24.8686514886165, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6322182, Length=448, Percent_Identity=28.5714285714286, Blast_Score=170, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6323903, Length=433, Percent_Identity=28.175519630485, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI281366413, Length=575, Percent_Identity=31.1304347826087, Blast_Score=252, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24666501, Length=575, Percent_Identity=31.1304347826087, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI24666497, Length=575, Percent_Identity=31.1304347826087, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI17933690, Length=620, Percent_Identity=24.6774193548387, Blast_Score=225, Evalue=7e-59,
Organism=Drosophila melanogaster, GI19921316, Length=632, Percent_Identity=26.8987341772152, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI62471689, Length=595, Percent_Identity=29.2436974789916, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI62471679, Length=595, Percent_Identity=29.2436974789916, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI62471683, Length=595, Percent_Identity=29.2436974789916, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI62471685, Length=595, Percent_Identity=29.2436974789916, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24586636, Length=595, Percent_Identity=29.2436974789916, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI62471681, Length=595, Percent_Identity=29.2436974789916, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI62471687, Length=595, Percent_Identity=29.2436974789916, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24586634, Length=595, Percent_Identity=29.2436974789916, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI22026970, Length=595, Percent_Identity=29.2436974789916, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI21355181, Length=449, Percent_Identity=23.8307349665924, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20130357, Length=213, Percent_Identity=30.5164319248826, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648260, Length=120, Percent_Identity=35, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24653035, Length=190, Percent_Identity=32.1052631578947, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24648257, Length=173, Percent_Identity=30.635838150289, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161076582, Length=189, Percent_Identity=32.2751322751323, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 67725; Mature: 67594

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQPNYHLIDQVRRRAEQFASKTALRYKSQQIWQDISWQSFQQSVDLFSLALLAHGIEV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHH
QQKIAIFAHNMPQWTITDFGALQIRAVTVPIYATNTAKQAEFILNHADIRILFVGDHEQL
HHHHHHHCCCCCCEEEECCCCEEEEEEEEEEEECCCHHHHHHHEECCCEEEEEECCHHHH
EAALEVADNCPLLEKIVCMKSQEISLIRPLAHTKVENWNDFIAYASQDKQTELNQRLADK
HHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHEECCCCHHHHHHHHHHCC
NLSDLFTLIYTSGTTGEPKGVMLDYANIAHQLHAHDLALPKIDENDVSLSFLPFSHIFER
CHHHHHHHHEECCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHH
AWVAYVLYRGATVCYLEDTNEVRNALNEVKPTLMCAVPRLYEKMYSAIWDKVNKAPIHRR
HHHHHHHHCCCEEEEEECCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ALFKWAISVGKKNRKNTLSYKLADKLVLNKLRALLGGRIRMMPCGGAKLEPTIGQFFQAI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHH
GVNIKLGYGMTETTATVSCWADDQFEPNSIGRLMPNAEVKIGENNEILVRGGMVMRGYYK
CCEEEECCCCCCCCEEEEECCCCCCCCCCHHCCCCCCEEEECCCCEEEEECCEEEECCCC
RPEETALAFTEDGFLKTGDAGEFDAQSNLYITDRIKELMKTSNGKYIAPQYIEGKIGKDK
CCCCCEEEEECCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCEECCHHHCCCCCHHH
FIEQIAIIADAKKYVSALIVPCFESLEEYAKQLNIKYQDRMELVKHSEIVQLFEKRINEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QKELAHFEQIKKFTLLPQAFSVKMEEITPTLKLRRKVILERYRKQIESMYK
HHHHHHHHHHHHHHCCCHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNQPNYHLIDQVRRRAEQFASKTALRYKSQQIWQDISWQSFQQSVDLFSLALLAHGIEV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHH
QQKIAIFAHNMPQWTITDFGALQIRAVTVPIYATNTAKQAEFILNHADIRILFVGDHEQL
HHHHHHHCCCCCCEEEECCCCEEEEEEEEEEEECCCHHHHHHHEECCCEEEEEECCHHHH
EAALEVADNCPLLEKIVCMKSQEISLIRPLAHTKVENWNDFIAYASQDKQTELNQRLADK
HHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHEECCCCHHHHHHHHHHCC
NLSDLFTLIYTSGTTGEPKGVMLDYANIAHQLHAHDLALPKIDENDVSLSFLPFSHIFER
CHHHHHHHHEECCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHH
AWVAYVLYRGATVCYLEDTNEVRNALNEVKPTLMCAVPRLYEKMYSAIWDKVNKAPIHRR
HHHHHHHHCCCEEEEEECCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ALFKWAISVGKKNRKNTLSYKLADKLVLNKLRALLGGRIRMMPCGGAKLEPTIGQFFQAI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHH
GVNIKLGYGMTETTATVSCWADDQFEPNSIGRLMPNAEVKIGENNEILVRGGMVMRGYYK
CCEEEECCCCCCCCEEEEECCCCCCCCCCHHCCCCCCEEEECCCCEEEEECCEEEECCCC
RPEETALAFTEDGFLKTGDAGEFDAQSNLYITDRIKELMKTSNGKYIAPQYIEGKIGKDK
CCCCCEEEEECCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCEECCHHHCCCCCHHH
FIEQIAIIADAKKYVSALIVPCFESLEEYAKQLNIKYQDRMELVKHSEIVQLFEKRINEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QKELAHFEQIKKFTLLPQAFSVKMEEITPTLKLRRKVILERYRKQIESMYK
HHHHHHHHHHHHHHCCCHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]