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The map label for this gene is manA [H]

Identifier: 126208859

GI number: 126208859

Start: 1595554

End: 1596759

Strand: Direct

Name: manA [H]

Synonym: APL_1395

Alternate gene names: 126208859

Gene position: 1595554-1596759 (Clockwise)

Preceding gene: 126208858

Following gene: 126208860

Centisome position: 70.15

GC content: 42.7

Gene sequence:

>1206_bases
ATGATTTTTAAACTAAAAGGGAAATTTCAGCATTATGTTTGGGGAGGTATGAACTTTATCCCGAATTTCCTTAAGTTATC
CGATCCCGATGACAAACCTTATGCCGAATATTGGCTGGGTGCGCATCCCGTTGCCCCTTCCGAAATCCTGTTTGAACAAA
ATTGGCTTCCTCTGGATAAAGTGATTGAAACGACACCCGAATTACTCGGGGAAAAAATTCGCACCCAATTCGGCGACACA
TTGCCTTATCTATTGAAAATTTTAGATATAAAACAACCGCTTTCCATTCAAGTTCACCCGACTAAAAACGAAGCCGAGTA
CGGATTCGAACAAGAAAATTTACGTAATATTCCGCTTAACGCACCGAATCGAATTTATAAAGACGCCAATCATAAACCTG
AAATGATGATCGCATTATCGGATGTCTGGGCGTTGCACGGCTTCAAACCGATTATCGATATTCAAGCCGCGCTTCAAGTA
CACGACTCGCTCAAACCGATTGCTCAAGCCTTGGAAGAAAAAGGGCTGCCGCTTGTGTATGCGGATATTATGCAAGCCGA
TAAACAGCAACTTGCCCAATGGATTTTACCGGTCGTCGAAGCCAAACGCGAAGAATATCAAGCGGATAAACTGAAGTTGG
ATAATCCCGATTATTGGGTGTGTTACATTGTAGAAAATATGCAATCGCCGCTTGAAGAAATCGACGGCGGTTTAATTTGT
TTCTATTTCTTCAATATCGTGCATATGAAAAAAGGCGAAGGTTTATATCAAGGAGCCGGTTTACCGCACGCTTATTTGCG
CGGGCAAAATATTGAATTAATGGCAAATTCGGATAACGTTATCCGCGGCGGCTTAACTCCGAAATATATTGATGTGCCAG
CGTTATTACATTCGATAGATTATCGCCCGATTACCCCGAAGATTATTCCGCCTTATCAAGAAAACGACGGTTTCATTCAT
CTTTATCCGACGCCTGAAGCGAAAGATTTTGCATTGCAACATATGCAATTCAACGCATTTGACGAAGAAAACTTTACGGC
CGACTGTGCAAGTATCTTATTGGTGATGAAAGGCAGTATCTATATCGACCTCGGTGAAGAGTCCATTTATCTCCAACAAG
GCGAAGCGATTTTCATTGCGGCGGAAAGCCAAGTCGAGATTATTGCCGAATCGGACGGTTATGCGGTCATTGCAACTGTG
CCGTAA

Upstream 100 bases:

>100_bases
TCTTAGTCATCGATTTAAAAAGCGGCAGACGTTTACTCGTGCGTATTCAAGAGAAAGAAGATATTGAAAAAGTCGTGAAC
TTCTTTGGAGGATATAAACA

Downstream 100 bases:

>100_bases
ATCTGACAATATATAGCGTAATATATCAAGTCGGCTTTTAGCTCTCATTACGAGGTGAATTATGAAACACATTAAATTAC
TTAGCACGGCGGTAGCATCA

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MIFKLKGKFQHYVWGGMNFIPNFLKLSDPDDKPYAEYWLGAHPVAPSEILFEQNWLPLDKVIETTPELLGEKIRTQFGDT
LPYLLKILDIKQPLSIQVHPTKNEAEYGFEQENLRNIPLNAPNRIYKDANHKPEMMIALSDVWALHGFKPIIDIQAALQV
HDSLKPIAQALEEKGLPLVYADIMQADKQQLAQWILPVVEAKREEYQADKLKLDNPDYWVCYIVENMQSPLEEIDGGLIC
FYFFNIVHMKKGEGLYQGAGLPHAYLRGQNIELMANSDNVIRGGLTPKYIDVPALLHSIDYRPITPKIIPPYQENDGFIH
LYPTPEAKDFALQHMQFNAFDEENFTADCASILLVMKGSIYIDLGEESIYLQQGEAIFIAAESQVEIIAESDGYAVIATV
P

Sequences:

>Translated_401_residues
MIFKLKGKFQHYVWGGMNFIPNFLKLSDPDDKPYAEYWLGAHPVAPSEILFEQNWLPLDKVIETTPELLGEKIRTQFGDT
LPYLLKILDIKQPLSIQVHPTKNEAEYGFEQENLRNIPLNAPNRIYKDANHKPEMMIALSDVWALHGFKPIIDIQAALQV
HDSLKPIAQALEEKGLPLVYADIMQADKQQLAQWILPVVEAKREEYQADKLKLDNPDYWVCYIVENMQSPLEEIDGGLIC
FYFFNIVHMKKGEGLYQGAGLPHAYLRGQNIELMANSDNVIRGGLTPKYIDVPALLHSIDYRPITPKIIPPYQENDGFIH
LYPTPEAKDFALQHMQFNAFDEENFTADCASILLVMKGSIYIDLGEESIYLQQGEAIFIAAESQVEIIAESDGYAVIATV
P
>Mature_401_residues
MIFKLKGKFQHYVWGGMNFIPNFLKLSDPDDKPYAEYWLGAHPVAPSEILFEQNWLPLDKVIETTPELLGEKIRTQFGDT
LPYLLKILDIKQPLSIQVHPTKNEAEYGFEQENLRNIPLNAPNRIYKDANHKPEMMIALSDVWALHGFKPIIDIQAALQV
HDSLKPIAQALEEKGLPLVYADIMQADKQQLAQWILPVVEAKREEYQADKLKLDNPDYWVCYIVENMQSPLEEIDGGLIC
FYFFNIVHMKKGEGLYQGAGLPHAYLRGQNIELMANSDNVIRGGLTPKYIDVPALLHSIDYRPITPKIIPPYQENDGFIH
LYPTPEAKDFALQHMQFNAFDEENFTADCASILLVMKGSIYIDLGEESIYLQQGEAIFIAAESQVEIIAESDGYAVIATV
P

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=420, Percent_Identity=32.1428571428571, Blast_Score=194, Evalue=2e-49,
Organism=Escherichia coli, GI1787899, Length=411, Percent_Identity=34.3065693430657, Blast_Score=201, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71997620, Length=411, Percent_Identity=31.6301703163017, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17557650, Length=398, Percent_Identity=26.6331658291457, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320839, Length=437, Percent_Identity=30.2059496567506, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21356061, Length=417, Percent_Identity=31.1750599520384, Blast_Score=152, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 45593; Mature: 45593

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00965 PMI_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFKLKGKFQHYVWGGMNFIPNFLKLSDPDDKPYAEYWLGAHPVAPSEILFEQNWLPLDK
CEEEEECCEEEEEECCHHHCCHHHCCCCCCCCCHHHHHCCCCCCCCHHHEEECCCCCHHH
VIETTPELLGEKIRTQFGDTLPYLLKILDIKQPLSIQVHPTKNEAEYGFEQENLRNIPLN
HHHHCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCHHCCCCHHCCCCCCCC
APNRIYKDANHKPEMMIALSDVWALHGFKPIIDIQAALQVHDSLKPIAQALEEKGLPLVY
CCHHHHCCCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ADIMQADKQQLAQWILPVVEAKREEYQADKLKLDNPDYWVCYIVENMQSPLEEIDGGLIC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEHHHHHHHHHHCCCEEE
FYFFNIVHMKKGEGLYQGAGLPHAYLRGQNIELMANSDNVIRGGLTPKYIDVPALLHSID
EEHHHHHEEECCCCCCCCCCCCHHHHCCCCEEEEECCCCEEECCCCCCEEEHHHHHHHCC
YRPITPKIIPPYQENDGFIHLYPTPEAKDFALQHMQFNAFDEENFTADCASILLVMKGSI
CCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCE
YIDLGEESIYLQQGEAIFIAAESQVEIIAESDGYAVIATVP
EEEECCCEEEEECCCEEEEEECCCEEEEEECCCEEEEEECC
>Mature Secondary Structure
MIFKLKGKFQHYVWGGMNFIPNFLKLSDPDDKPYAEYWLGAHPVAPSEILFEQNWLPLDK
CEEEEECCEEEEEECCHHHCCHHHCCCCCCCCCHHHHHCCCCCCCCHHHEEECCCCCHHH
VIETTPELLGEKIRTQFGDTLPYLLKILDIKQPLSIQVHPTKNEAEYGFEQENLRNIPLN
HHHHCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCHHCCCCHHCCCCCCCC
APNRIYKDANHKPEMMIALSDVWALHGFKPIIDIQAALQVHDSLKPIAQALEEKGLPLVY
CCHHHHCCCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ADIMQADKQQLAQWILPVVEAKREEYQADKLKLDNPDYWVCYIVENMQSPLEEIDGGLIC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEHHHHHHHHHHCCCEEE
FYFFNIVHMKKGEGLYQGAGLPHAYLRGQNIELMANSDNVIRGGLTPKYIDVPALLHSID
EEHHHHHEEECCCCCCCCCCCCHHHHCCCCEEEEECCCCEEECCCCCCEEEHHHHHHHCC
YRPITPKIIPPYQENDGFIHLYPTPEAKDFALQHMQFNAFDEENFTADCASILLVMKGSI
CCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCE
YIDLGEESIYLQQGEAIFIAAESQVEIIAESDGYAVIATVP
EEEECCCEEEEECCCEEEEEECCCEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]