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The map label for this gene is clpP [H]

Identifier: 126208746

GI number: 126208746

Start: 1471681

End: 1472271

Strand: Reverse

Name: clpP [H]

Synonym: APL_1280

Alternate gene names: 126208746

Gene position: 1472271-1471681 (Counterclockwise)

Preceding gene: 126208748

Following gene: 126208745

Centisome position: 64.73

GC content: 43.99

Gene sequence:

>591_bases
ATGGCATTAGTACCGATAGTGGTTGAGCAAACCTCAAAAGGCGAAAGATCGTATGATATTTATTCTCGCTTGCTTAAAGA
ACGTATTATTTTTTTAACGGGGCAAGTGGAAGATCATATGGCGAATTTAATCGTCGCTCAAATGCTTTTCTTAGAAGCGG
AAGATCCGGAAAAAGATATTTATTTATATATTAACTCACCGGGCGGCGTAGTTACCGCCGGCTTGGCGATTTACGACACC
ATGAACTTTATTAAACCGGATGTGGCGACACTTTGTACCGGACAGGCTTGCTCAATGGGGGCGTTCTTGTTATCTGGCGG
CGCGAAGGGTAAGCGTTTCGCTTTACCGAATGCTCGTGTGATGATCCACCAACCTCTAGGCGGTGCGAGAGGACAAGCGA
CCGATATTCAAATTCAGGCGCAAGAAATTTTAAAATTAAAAGAAATGCTGACTCGAAAAATGGCGGAGCATAGCGGACAG
CCGTTTGAGAAAGTGGCGGCGGATACTGAGCGAGATAATTTTATGTCGGCGGTTGAAGCGATGGAATACGGTCTAATTGA
TAAAGTTTTAACGCACAGAGATATGAAATAA

Upstream 100 bases:

>100_bases
ATTTTGCAAAAGATTTTAACAATCTGACCGCTTATTGTTAATGATTTTCTTAAAGTTTGATAGAATTACTCGTTTTTTGA
TTTTATATAGGAATACAAAA

Downstream 100 bases:

>100_bases
TGGCAAATTTCGAGAAAGAACCGCATTGTAGTTTTTGTGGTAAAAGACGTACCGAAGTTGATCAACTGGTAGAAGGTACG
GAAGGTTATATCTGTAATCA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MALVPIVVEQTSKGERSYDIYSRLLKERIIFLTGQVEDHMANLIVAQMLFLEAEDPEKDIYLYINSPGGVVTAGLAIYDT
MNFIKPDVATLCTGQACSMGAFLLSGGAKGKRFALPNARVMIHQPLGGARGQATDIQIQAQEILKLKEMLTRKMAEHSGQ
PFEKVAADTERDNFMSAVEAMEYGLIDKVLTHRDMK

Sequences:

>Translated_196_residues
MALVPIVVEQTSKGERSYDIYSRLLKERIIFLTGQVEDHMANLIVAQMLFLEAEDPEKDIYLYINSPGGVVTAGLAIYDT
MNFIKPDVATLCTGQACSMGAFLLSGGAKGKRFALPNARVMIHQPLGGARGQATDIQIQAQEILKLKEMLTRKMAEHSGQ
PFEKVAADTERDNFMSAVEAMEYGLIDKVLTHRDMK
>Mature_195_residues
ALVPIVVEQTSKGERSYDIYSRLLKERIIFLTGQVEDHMANLIVAQMLFLEAEDPEKDIYLYINSPGGVVTAGLAIYDTM
NFIKPDVATLCTGQACSMGAFLLSGGAKGKRFALPNARVMIHQPLGGARGQATDIQIQAQEILKLKEMLTRKMAEHSGQP
FEKVAADTERDNFMSAVEAMEYGLIDKVLTHRDMK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=58.3333333333333, Blast_Score=247, Evalue=4e-66,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=76.2886597938144, Blast_Score=322, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17538017, Length=189, Percent_Identity=51.3227513227513, Blast_Score=213, Evalue=4e-56,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=60, Blast_Score=250, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21684; Mature: 21552

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVPIVVEQTSKGERSYDIYSRLLKERIIFLTGQVEDHMANLIVAQMLFLEAEDPEKDI
CCEEEEEEECCCCCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHCCCCCCCEE
YLYINSPGGVVTAGLAIYDTMNFIKPDVATLCTGQACSMGAFLLSGGAKGKRFALPNARV
EEEEECCCCEEEHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHCCCCCCCEEECCCCEE
MIHQPLGGARGQATDIQIQAQEILKLKEMLTRKMAEHSGQPFEKVAADTERDNFMSAVEA
EEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHH
MEYGLIDKVLTHRDMK
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALVPIVVEQTSKGERSYDIYSRLLKERIIFLTGQVEDHMANLIVAQMLFLEAEDPEKDI
CEEEEEEECCCCCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHCCCCCCCEE
YLYINSPGGVVTAGLAIYDTMNFIKPDVATLCTGQACSMGAFLLSGGAKGKRFALPNARV
EEEEECCCCEEEHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHCCCCCCCEEECCCCEE
MIHQPLGGARGQATDIQIQAQEILKLKEMLTRKMAEHSGQPFEKVAADTERDNFMSAVEA
EEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHH
MEYGLIDKVLTHRDMK
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA