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The map label for this gene is phoR [H]

Identifier: 126208722

GI number: 126208722

Start: 1445572

End: 1446864

Strand: Reverse

Name: phoR [H]

Synonym: APL_1256

Alternate gene names: 126208722

Gene position: 1446864-1445572 (Counterclockwise)

Preceding gene: 126208723

Following gene: 126208721

Centisome position: 63.61

GC content: 39.91

Gene sequence:

>1293_bases
ATGAAAAAATTCAGCCTTTCTTTCAAGCATTTTTTTATCGAAGCGATGCTTGCCGTTGCGACGGCATTTTTATTCGGCTT
ATTTGCTTGGGACTTCCTGACTTGGTTAGGGCTAATTTTGGTGCTGTTACTGGTTTGGCATCATTATAACGATCAACGTT
TATTGCATCTGATTGATCCGAATCGCGACAGCAGCCGTAAAGTGCTGACGACATGGGAACATATCTCGCAAACCGTCGCG
TTTTATCAAAAACGTAATCGTCGCGAGAAAATCAAAACCTTACGCTTACTCTCGAAATTAAATCGAAATATTCAATATTT
GCCGGACGGTATCATTATTTGTAACCATGCCGGTACTATTCTATGGTGTAACAACGCTTCACAAGAAATCTTAAAGTTTT
ATTGGGACAAAAAGTTAGAAAAAAGCGTATTTAACGTGATTTTTTATGAAGAGTTTAAAAAATATTTTCATCAAAATAAG
AAAAACAGACCGCTTGTCTTAATGGACAGTGACGGGCGATATATCGAATTTCATTTAAACGATTATGACAGCGAAAGTTA
TTTAATTATTGCGCGTGACGTGACGCAAATGATTCGTTTATTGCATTCCAGACAAATGTTCCTAACCAATATGAATCACG
AATTGCGCACGCCGCTGACCGTATTGCGAGGTTATTTGGAATTATTGGAAGGGCAGGCGGAAACCGAATTGCAGCAAAAA
AGTATTCATGCGATGCAATCCCAAGCGAAACGGATGGGAAATTTATTGGATCAGCTTAATTTATTGGCAAAAATTGAGAC
GTCTTCCAGTAAAGAACATTATGTGGTTGAAATGTCGGCGATGATTTCCGCTTTACAAAAAAATGCGGATTTTTTAAATC
AGAGCAAGCAACAAATTATTTTTAATATCACGCCGAATATTACTGTATTAGGCGATGAAACCCAGTTGCAAAGTGCGGTT
TCCAACTTGATTTACAATGCGGTTAAACATGCCGGTGACGGTGCAACCATTGAGGTGGATTGGCATTGGTGCGAAGAAGG
TGCGGAATTTAGCGTTAAAGACAACGGTATCGGTATCGAAGACGAGCATTTACCGCATTTAACCGAGCGTTTCTATCGAG
TGGACGAGTCGCGCAGCAATCAAACCGGCGGCAGCGGCTTAGGTTTGGCGATTGTTAAATATGCGTTGGAACAACACGGC
TCGCAGTTACAAATTAAAAGTGAATTCGGCAAAGGCAGCCGGTTTAGCTTTATCATCAAAAAATCGCTGCTTGGTGAAAC
AAAAAATCATTAA

Upstream 100 bases:

>100_bases
GTCGGTTAAGAAAAAGTTTGGAACCCTGCGGTTTCGAGCGCTATGTGCAAACGGTACGCGGATCCGGTTATCGTTTTTCC
AACCACTTTCAGGATAATTA

Downstream 100 bases:

>100_bases
AACAGTATTTTTTACTCAACAAATGGGGAATTTGCCAGTAAAATGCCTGCTTTTCTGTCCACAAAGAGAGCTTAGTCATG
TCTGATAAACGCTACGGTGC

Product: phosphate regulon sensor protein PhoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKKFSLSFKHFFIEAMLAVATAFLFGLFAWDFLTWLGLILVLLLVWHHYNDQRLLHLIDPNRDSSRKVLTTWEHISQTVA
FYQKRNRREKIKTLRLLSKLNRNIQYLPDGIIICNHAGTILWCNNASQEILKFYWDKKLEKSVFNVIFYEEFKKYFHQNK
KNRPLVLMDSDGRYIEFHLNDYDSESYLIIARDVTQMIRLLHSRQMFLTNMNHELRTPLTVLRGYLELLEGQAETELQQK
SIHAMQSQAKRMGNLLDQLNLLAKIETSSSKEHYVVEMSAMISALQKNADFLNQSKQQIIFNITPNITVLGDETQLQSAV
SNLIYNAVKHAGDGATIEVDWHWCEEGAEFSVKDNGIGIEDEHLPHLTERFYRVDESRSNQTGGSGLGLAIVKYALEQHG
SQLQIKSEFGKGSRFSFIIKKSLLGETKNH

Sequences:

>Translated_430_residues
MKKFSLSFKHFFIEAMLAVATAFLFGLFAWDFLTWLGLILVLLLVWHHYNDQRLLHLIDPNRDSSRKVLTTWEHISQTVA
FYQKRNRREKIKTLRLLSKLNRNIQYLPDGIIICNHAGTILWCNNASQEILKFYWDKKLEKSVFNVIFYEEFKKYFHQNK
KNRPLVLMDSDGRYIEFHLNDYDSESYLIIARDVTQMIRLLHSRQMFLTNMNHELRTPLTVLRGYLELLEGQAETELQQK
SIHAMQSQAKRMGNLLDQLNLLAKIETSSSKEHYVVEMSAMISALQKNADFLNQSKQQIIFNITPNITVLGDETQLQSAV
SNLIYNAVKHAGDGATIEVDWHWCEEGAEFSVKDNGIGIEDEHLPHLTERFYRVDESRSNQTGGSGLGLAIVKYALEQHG
SQLQIKSEFGKGSRFSFIIKKSLLGETKNH
>Mature_430_residues
MKKFSLSFKHFFIEAMLAVATAFLFGLFAWDFLTWLGLILVLLLVWHHYNDQRLLHLIDPNRDSSRKVLTTWEHISQTVA
FYQKRNRREKIKTLRLLSKLNRNIQYLPDGIIICNHAGTILWCNNASQEILKFYWDKKLEKSVFNVIFYEEFKKYFHQNK
KNRPLVLMDSDGRYIEFHLNDYDSESYLIIARDVTQMIRLLHSRQMFLTNMNHELRTPLTVLRGYLELLEGQAETELQQK
SIHAMQSQAKRMGNLLDQLNLLAKIETSSSKEHYVVEMSAMISALQKNADFLNQSKQQIIFNITPNITVLGDETQLQSAV
SNLIYNAVKHAGDGATIEVDWHWCEEGAEFSVKDNGIGIEDEHLPHLTERFYRVDESRSNQTGGSGLGLAIVKYALEQHG
SQLQIKSEFGKGSRFSFIIKKSLLGETKNH

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=430, Percent_Identity=40.6976744186046, Blast_Score=321, Evalue=5e-89,
Organism=Escherichia coli, GI1790346, Length=208, Percent_Identity=30.2884615384615, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=28.5087719298246, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786783, Length=211, Percent_Identity=28.436018957346, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI48994928, Length=252, Percent_Identity=28.1746031746032, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI145693157, Length=225, Percent_Identity=28.8888888888889, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787894, Length=220, Percent_Identity=29.5454545454545, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=234, Percent_Identity=29.4871794871795, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789149, Length=233, Percent_Identity=28.3261802575107, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790861, Length=189, Percent_Identity=27.5132275132275, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789403, Length=241, Percent_Identity=30.2904564315353, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=25.9433962264151, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=28.5106382978723, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=380, Percent_Identity=20.5263157894737, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789808, Length=275, Percent_Identity=24.7272727272727, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=24.6808510638298, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788279, Length=201, Percent_Identity=26.3681592039801, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082128, Length=222, Percent_Identity=23.8738738738739, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49905; Mature: 49905

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFSLSFKHFFIEAMLAVATAFLFGLFAWDFLTWLGLILVLLLVWHHYNDQRLLHLIDP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
NRDSSRKVLTTWEHISQTVAFYQKRNRREKIKTLRLLSKLNRNIQYLPDGIIICNHAGTI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCEE
LWCNNASQEILKFYWDKKLEKSVFNVIFYEEFKKYFHQNKKNRPLVLMDSDGRYIEFHLN
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEC
DYDSESYLIIARDVTQMIRLLHSRQMFLTNMNHELRTPLTVLRGYLELLEGQAETELQQK
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCCCHHHHHHHH
SIHAMQSQAKRMGNLLDQLNLLAKIETSSSKEHYVVEMSAMISALQKNADFLNQSKQQII
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEE
FNITPNITVLGDETQLQSAVSNLIYNAVKHAGDGATIEVDWHWCEEGAEFSVKDNGIGIE
EEECCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEECCCCCCCC
DEHLPHLTERFYRVDESRSNQTGGSGLGLAIVKYALEQHGSQLQIKSEFGKGSRFSFIIK
CCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHH
KSLLGETKNH
HHHHCCCCCC
>Mature Secondary Structure
MKKFSLSFKHFFIEAMLAVATAFLFGLFAWDFLTWLGLILVLLLVWHHYNDQRLLHLIDP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
NRDSSRKVLTTWEHISQTVAFYQKRNRREKIKTLRLLSKLNRNIQYLPDGIIICNHAGTI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCEE
LWCNNASQEILKFYWDKKLEKSVFNVIFYEEFKKYFHQNKKNRPLVLMDSDGRYIEFHLN
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEC
DYDSESYLIIARDVTQMIRLLHSRQMFLTNMNHELRTPLTVLRGYLELLEGQAETELQQK
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCCCHHHHHHHH
SIHAMQSQAKRMGNLLDQLNLLAKIETSSSKEHYVVEMSAMISALQKNADFLNQSKQQII
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEE
FNITPNITVLGDETQLQSAVSNLIYNAVKHAGDGATIEVDWHWCEEGAEFSVKDNGIGIE
EEECCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEECCCCCCCC
DEHLPHLTERFYRVDESRSNQTGGSGLGLAIVKYALEQHGSQLQIKSEFGKGSRFSFIIK
CCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHH
KSLLGETKNH
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]