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The map label for this gene is adhC [H]

Identifier: 126208676

GI number: 126208676

Start: 1389494

End: 1390612

Strand: Reverse

Name: adhC [H]

Synonym: APL_1208

Alternate gene names: 126208676

Gene position: 1390612-1389494 (Counterclockwise)

Preceding gene: 126208677

Following gene: 126208675

Centisome position: 61.14

GC content: 46.92

Gene sequence:

>1119_bases
ATGGAATTTATCAAAACTCGTGCGGCGGTCGCTTGGGCGCCGAATGAACCGCTAAAAATTGAAGAATTGGATTTAATGCC
GCCGCAAAAAGGCGAAGTGTTAGTCCGTTTAGTGGCAACCGGTGTGTGTCATACCGATGCTTATACCCTTTCCGGTCAAG
ATAGCGAAGGCGTGTTCCCGTGCGTACTTGGTCACGAAGGTGCAGGGATTGTAGAAGCAGTCGGCGAAGGTGTCACCGAT
TTTAAAGTGGGTGATCACGTTATTCCGCTTTACACTGCAGAATGTCGTAAATGTAAATTCTGTTTATCGGGCAAAACCAA
CCTTTGTTCGGCAGTACGTGAAACCCAAGGTAAAGGCTTAATGCCGGATGGAACGGTACGTTTCTTTAAAGACGATCAGC
CGATTTTCCATTATATGGGGACTTCAACCTTCTCCGAATATACGGTGGTTTCCGAATACTCATTGGCAAAAATTCAGGAA
AACGCACCGCTTGACGAGGTGTGCTTACTTGGTTGCGGCGTTACCACCGGTATCGGTGCAGTAACTCGTACGGCAAAAGT
GAAAAAAGGCGATACAGTCGCAATTTTCGGCTTAGGCGGTATCGGTCTTGCGGCAATTATCGGGGCAAGAATGGCGGGTG
CAGGTCGTATTATTGCGATCGACATTAATCCGGCTAAGTTTGAGAAAGCTAAAGAGCTTGGTGCAACGGATTGTATTAAC
CCGAAAGATTACGAGCAGCCAATCCAAAATGTGATTATCGAGATGACTGACGGTGGTGTGGATTTCTCATTTGAATGTGT
GGGTAACGTGGATTTAATGCGTTCGGCATTAGAATGTTGCCACAAAGGTTGGGGTGAAAGCATCATTATCGGTGTCGCAC
CGGCAGGTGCGGAAATCCGTACTCGTCCGTTCCAATTAGTTACCGGCCGTGTGTGGCGTGGTTCGGCATTCGGCGGCGTG
AAAGGTCGTACCGAATTACCGGGTATTATCGACCAATTTATGAAAGGCGAATTTAAATTGCGTGATTTCATCACTCACAC
AATGCCGTTGGAAGACATCAATAAAGCCTTCGATTTAATGCACGAAGGTAAATCAATCCGCACGGTGATTCACTTTTAA

Upstream 100 bases:

>100_bases
TTTACAGTTATAATCCTTATAAGAAAAGATGATTATATTTTATATCTCAGTATAGGATAAAATAGCAAAATAGACTTTTT
ATGATAATAGGAAAGCAATC

Downstream 100 bases:

>100_bases
TTTCATTAAATAAGGGGCGTAAGCCCCTTTTGTTTTTCCTACCGAATTTCTTCTCTCAAAATTTCCCTACCATTTTTCAA
TAGGCTTGCGAATGTTCATA

Product: putative alcohol dehydrogenase class 3

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MEFIKTRAAVAWAPNEPLKIEELDLMPPQKGEVLVRLVATGVCHTDAYTLSGQDSEGVFPCVLGHEGAGIVEAVGEGVTD
FKVGDHVIPLYTAECRKCKFCLSGKTNLCSAVRETQGKGLMPDGTVRFFKDDQPIFHYMGTSTFSEYTVVSEYSLAKIQE
NAPLDEVCLLGCGVTTGIGAVTRTAKVKKGDTVAIFGLGGIGLAAIIGARMAGAGRIIAIDINPAKFEKAKELGATDCIN
PKDYEQPIQNVIIEMTDGGVDFSFECVGNVDLMRSALECCHKGWGESIIIGVAPAGAEIRTRPFQLVTGRVWRGSAFGGV
KGRTELPGIIDQFMKGEFKLRDFITHTMPLEDINKAFDLMHEGKSIRTVIHF

Sequences:

>Translated_372_residues
MEFIKTRAAVAWAPNEPLKIEELDLMPPQKGEVLVRLVATGVCHTDAYTLSGQDSEGVFPCVLGHEGAGIVEAVGEGVTD
FKVGDHVIPLYTAECRKCKFCLSGKTNLCSAVRETQGKGLMPDGTVRFFKDDQPIFHYMGTSTFSEYTVVSEYSLAKIQE
NAPLDEVCLLGCGVTTGIGAVTRTAKVKKGDTVAIFGLGGIGLAAIIGARMAGAGRIIAIDINPAKFEKAKELGATDCIN
PKDYEQPIQNVIIEMTDGGVDFSFECVGNVDLMRSALECCHKGWGESIIIGVAPAGAEIRTRPFQLVTGRVWRGSAFGGV
KGRTELPGIIDQFMKGEFKLRDFITHTMPLEDINKAFDLMHEGKSIRTVIHF
>Mature_372_residues
MEFIKTRAAVAWAPNEPLKIEELDLMPPQKGEVLVRLVATGVCHTDAYTLSGQDSEGVFPCVLGHEGAGIVEAVGEGVTD
FKVGDHVIPLYTAECRKCKFCLSGKTNLCSAVRETQGKGLMPDGTVRFFKDDQPIFHYMGTSTFSEYTVVSEYSLAKIQE
NAPLDEVCLLGCGVTTGIGAVTRTAKVKKGDTVAIFGLGGIGLAAIIGARMAGAGRIIAIDINPAKFEKAKELGATDCIN
PKDYEQPIQNVIIEMTDGGVDFSFECVGNVDLMRSALECCHKGWGESIIIGVAPAGAEIRTRPFQLVTGRVWRGSAFGGV
KGRTELPGIIDQFMKGEFKLRDFITHTMPLEDINKAFDLMHEGKSIRTVIHF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=62.6016260162602, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=51.4824797843666, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=50.6738544474393, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=50.1347708894879, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=49.6, Blast_Score=390, Evalue=1e-109,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=46.6124661246612, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=46.3611859838275, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=44.9864498644986, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=45.1790633608815, Blast_Score=357, Evalue=7e-99,
Organism=Homo sapiens, GI156627571, Length=359, Percent_Identity=25.3481894150418, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=69.1056910569106, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI87082125, Length=384, Percent_Identity=26.5625, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790045, Length=368, Percent_Identity=26.6304347826087, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1787863, Length=354, Percent_Identity=26.8361581920904, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788073, Length=362, Percent_Identity=27.9005524861878, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081918, Length=352, Percent_Identity=30.1136363636364, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786518, Length=335, Percent_Identity=25.6716417910448, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786825, Length=367, Percent_Identity=24.2506811989101, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788075, Length=366, Percent_Identity=23.7704918032787, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI226510992, Length=201, Percent_Identity=27.363184079602, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790718, Length=328, Percent_Identity=22.8658536585366, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=55.4666666666667, Blast_Score=446, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=55.1724137931034, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=55.6851311953353, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562876, Length=360, Percent_Identity=25.8333333333333, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562584, Length=364, Percent_Identity=26.3736263736264, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=372, Percent_Identity=27.6881720430108, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=267, Percent_Identity=28.4644194756554, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=375, Percent_Identity=26.4, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=61.1859838274933, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6323729, Length=368, Percent_Identity=29.0760869565217, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319621, Length=370, Percent_Identity=29.7297297297297, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=339, Percent_Identity=26.5486725663717, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=349, Percent_Identity=28.080229226361, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=365, Percent_Identity=27.9452054794521, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=365, Percent_Identity=27.9452054794521, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=328, Percent_Identity=26.8292682926829, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=26.7924528301887, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=276, Percent_Identity=25.7246376811594, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=59.5174262734584, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI17137530, Length=363, Percent_Identity=27.5482093663912, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 40184; Mature: 40184

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFIKTRAAVAWAPNEPLKIEELDLMPPQKGEVLVRLVATGVCHTDAYTLSGQDSEGVFP
CCCHHCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCEE
CVLGHEGAGIVEAVGEGVTDFKVGDHVIPLYTAECRKCKFCLSGKTNLCSAVRETQGKGL
EEECCCCCCHHHHHCCCCCEEECCCEEEEEEECCHHHEEEEECCCHHHHHHHHHHCCCCC
MPDGTVRFFKDDQPIFHYMGTSTFSEYTVVSEYSLAKIQENAPLDEVCLLGCGVTTGIGA
CCCCCEEEEECCCCEEEEECCCCCCCEEEEECCHHHHHHCCCCHHHHHHHHCCHHHCCHH
VTRTAKVKKGDTVAIFGLGGIGLAAIIGARMAGAGRIIAIDINPAKFEKAKELGATDCIN
HHHCCEECCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCC
PKDYEQPIQNVIIEMTDGGVDFSFECVGNVDLMRSALECCHKGWGESIIIGVAPAGAEIR
CCHHHHHHHHHEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
TRPFQLVTGRVWRGSAFGGVKGRTELPGIIDQFMKGEFKLRDFITHTMPLEDINKAFDLM
CCCEEEEECEEEECCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHH
HEGKSIRTVIHF
HCCCCEEEEECC
>Mature Secondary Structure
MEFIKTRAAVAWAPNEPLKIEELDLMPPQKGEVLVRLVATGVCHTDAYTLSGQDSEGVFP
CCCHHCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCEE
CVLGHEGAGIVEAVGEGVTDFKVGDHVIPLYTAECRKCKFCLSGKTNLCSAVRETQGKGL
EEECCCCCCHHHHHCCCCCEEECCCEEEEEEECCHHHEEEEECCCHHHHHHHHHHCCCCC
MPDGTVRFFKDDQPIFHYMGTSTFSEYTVVSEYSLAKIQENAPLDEVCLLGCGVTTGIGA
CCCCCEEEEECCCCEEEEECCCCCCCEEEEECCHHHHHHCCCCHHHHHHHHCCHHHCCHH
VTRTAKVKKGDTVAIFGLGGIGLAAIIGARMAGAGRIIAIDINPAKFEKAKELGATDCIN
HHHCCEECCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCC
PKDYEQPIQNVIIEMTDGGVDFSFECVGNVDLMRSALECCHKGWGESIIIGVAPAGAEIR
CCHHHHHHHHHEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
TRPFQLVTGRVWRGSAFGGVKGRTELPGIIDQFMKGEFKLRDFITHTMPLEDINKAFDLM
CCCEEEEECEEEECCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHH
HEGKSIRTVIHF
HCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]