Click here to switch to the map view.

The map label for this gene is yeiG [H]

Identifier: 126208672

GI number: 126208672

Start: 1386848

End: 1387705

Strand: Reverse

Name: yeiG [H]

Synonym: APL_1204

Alternate gene names: 126208672

Gene position: 1387705-1386848 (Counterclockwise)

Preceding gene: 126208673

Following gene: 126208670

Centisome position: 61.01

GC content: 46.74

Gene sequence:

>858_bases
ATGACCGCGCTTACTCAACTTGCCCGCTATAAAATGTTTGGCGGCTATCACGAACGTTATACGCATTATTCGAACAGCAC
CCACTGTGAAATGACTTTTGCCATCTACTTGCCGCCGCAAGTGGAACAAGGGCAAAAAGTGCCGGTACTTTATTGGCTTT
CAGGGCTGACTTGTACCGATGAGAACTTTGCCACCAAAGCCGGCGCACAACAATTTGCCGCCCAGTACGGTATTGCGATC
GTAATGCCGGATACTTCGCCACGTGGTGAAGCCGTTGCAAATGATGAAGGTTACGACTTAGGCCAAGGTGCCGGTTTCTA
CCTCAATGCCACCCAACAACCGTGGGATAAATATTTCAAAATGTATGACTACATCGTGCAAGAACTGCCGGCGCTTATTG
AGGCAAGCTTCCCGGTTAGCGATAAACGTTCAATTTCAGGTCACAGTATGGGCGGACACGGTGCAATCCAAATCGGTCTA
AAGAATCCTGATCGTTACTGTGCGATCTCGGCTTTCTCGCCGATCGTTACCCCAAGCCAAGTGCCGTGGGGACAAAAAGC
CTTTACCGCTTATTTAGGCGAAGATCAGACCGCTTGGGCTGAATATGACAGCTTTGCGTTATTAGATAACGTATCACCTG
CTCATCCTATTTTGATTGAGCAAGGGCTTGCCGATAGCTTCTATCCAACACAATTGCAGCCGGAAATATTTACCGAAAAA
GCACAAAAACTGGGCTTTGATGTCACGCTCAATTTGCACGAAGGCTATGATCACAGCTATTTCTTTATCGCGAGTTTTAT
TGAAAAGCATATTGCATTTCATGCAAAAGCGTTAATGGAATCACAGGAAGATCGCTAA

Upstream 100 bases:

>100_bases
ACCTGATGCGTTGGGCGGAACAGATTGCTAACCGTCCGGCTGTGATTCGTGCCTTAGCCAAAGAATATCGTCCGATTAAA
TCGTAAAAAAAGGGAGAAAA

Downstream 100 bases:

>100_bases
GAAGAATACTGATTACAAGTAAGCGGTTAAATTTTACAAAAAATTTGCAAATTTTGACCGCTTGTTTGTGATTTTAGTTA
TTAAATTCTGTTAAGTATTT

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTALTQLARYKMFGGYHERYTHYSNSTHCEMTFAIYLPPQVEQGQKVPVLYWLSGLTCTDENFATKAGAQQFAAQYGIAI
VMPDTSPRGEAVANDEGYDLGQGAGFYLNATQQPWDKYFKMYDYIVQELPALIEASFPVSDKRSISGHSMGGHGAIQIGL
KNPDRYCAISAFSPIVTPSQVPWGQKAFTAYLGEDQTAWAEYDSFALLDNVSPAHPILIEQGLADSFYPTQLQPEIFTEK
AQKLGFDVTLNLHEGYDHSYFFIASFIEKHIAFHAKALMESQEDR

Sequences:

>Translated_285_residues
MTALTQLARYKMFGGYHERYTHYSNSTHCEMTFAIYLPPQVEQGQKVPVLYWLSGLTCTDENFATKAGAQQFAAQYGIAI
VMPDTSPRGEAVANDEGYDLGQGAGFYLNATQQPWDKYFKMYDYIVQELPALIEASFPVSDKRSISGHSMGGHGAIQIGL
KNPDRYCAISAFSPIVTPSQVPWGQKAFTAYLGEDQTAWAEYDSFALLDNVSPAHPILIEQGLADSFYPTQLQPEIFTEK
AQKLGFDVTLNLHEGYDHSYFFIASFIEKHIAFHAKALMESQEDR
>Mature_284_residues
TALTQLARYKMFGGYHERYTHYSNSTHCEMTFAIYLPPQVEQGQKVPVLYWLSGLTCTDENFATKAGAQQFAAQYGIAIV
MPDTSPRGEAVANDEGYDLGQGAGFYLNATQQPWDKYFKMYDYIVQELPALIEASFPVSDKRSISGHSMGGHGAIQIGLK
NPDRYCAISAFSPIVTPSQVPWGQKAFTAYLGEDQTAWAEYDSFALLDNVSPAHPILIEQGLADSFYPTQLQPEIFTEKA
QKLGFDVTLNLHEGYDHSYFFIASFIEKHIAFHAKALMESQEDR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=49.6428571428571, Blast_Score=281, Evalue=4e-76,
Organism=Escherichia coli, GI1788477, Length=279, Percent_Identity=57.3476702508961, Blast_Score=337, Evalue=7e-94,
Organism=Escherichia coli, GI1786551, Length=272, Percent_Identity=53.6764705882353, Blast_Score=327, Evalue=7e-91,
Organism=Caenorhabditis elegans, GI17510185, Length=281, Percent_Identity=47.3309608540925, Blast_Score=253, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=43.5810810810811, Blast_Score=233, Evalue=3e-62,
Organism=Drosophila melanogaster, GI45551932, Length=285, Percent_Identity=47.719298245614, Blast_Score=265, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=47.7031802120141, Blast_Score=265, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31906; Mature: 31775

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALTQLARYKMFGGYHERYTHYSNSTHCEMTFAIYLPPQVEQGQKVPVLYWLSGLTCTD
CCHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCEEEEEECCCEECC
ENFATKAGAQQFAAQYGIAIVMPDTSPRGEAVANDEGYDLGQGAGFYLNATQQPWDKYFK
CCHHHHHHHHHHHHHCCEEEEECCCCCCCCEEECCCCCCCCCCCCEEEECCCCHHHHHHH
MYDYIVQELPALIEASFPVSDKRSISGHSMGGHGAIQIGLKNPDRYCAISAFSPIVTPSQ
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCC
VPWGQKAFTAYLGEDQTAWAEYDSFALLDNVSPAHPILIEQGLADSFYPTQLQPEIFTEK
CCCCHHHHHHCCCCCCCHHHCCCCEEEECCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
AQKLGFDVTLNLHEGYDHSYFFIASFIEKHIAFHAKALMESQEDR
HHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TALTQLARYKMFGGYHERYTHYSNSTHCEMTFAIYLPPQVEQGQKVPVLYWLSGLTCTD
CHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCEEEEEECCCEECC
ENFATKAGAQQFAAQYGIAIVMPDTSPRGEAVANDEGYDLGQGAGFYLNATQQPWDKYFK
CCHHHHHHHHHHHHHCCEEEEECCCCCCCCEEECCCCCCCCCCCCEEEECCCCHHHHHHH
MYDYIVQELPALIEASFPVSDKRSISGHSMGGHGAIQIGLKNPDRYCAISAFSPIVTPSQ
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCC
VPWGQKAFTAYLGEDQTAWAEYDSFALLDNVSPAHPILIEQGLADSFYPTQLQPEIFTEK
CCCCHHHHHHCCCCCCCHHHCCCCEEEECCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
AQKLGFDVTLNLHEGYDHSYFFIASFIEKHIAFHAKALMESQEDR
HHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA