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The map label for this gene is Hgd [H]

Identifier: 126208665

GI number: 126208665

Start: 1379926

End: 1380792

Strand: Reverse

Name: Hgd [H]

Synonym: APL_1197

Alternate gene names: 126208665

Gene position: 1380792-1379926 (Counterclockwise)

Preceding gene: 126208668

Following gene: 126208664

Centisome position: 60.71

GC content: 43.71

Gene sequence:

>867_bases
ATGACAACAGCATTTACACAAATTGGTTGGATCGGCTTAGGTCAAATGGGCGTACCTATGGTTAATCGTTTACTGGCGAA
TAATATCGATGTCAGTGTTTATAACCGAAATACGGCGAAAAGTGCTGAATTTGCAGCAAAAGGTGCAAAAGTTGCGAGTT
CGGTAGAACAATTAGTATCTGAAAACCAAGCGGTTATTTTGATGGTTTCGGACTATGCGGCTGCAGCGGATATTTTAAAT
CCGGACGTTTGTGCAAAACTGCAAGGTAAAGTTATCGTTAATATGAGTACGGTTTCCCCGACTGAAAACTTAAAATTAAA
AGTGTTGGTGGAAGAACACGGCGGTTTATTTGCCGAAGCACCAGTATCCGGCTCGGTTGTACCGGCGACTAACGGTACTT
TACTGATTTTATTCGGCGGACAAGAAGCGGTATTAAAACCGTTACAACCGGTATTTGACGTACTCGGTCAGCGTACTTTC
CATTTTGGCGATGTGGGTAAAGGCTCCGGTGCGAAATTGGTACTGAATTCTTTACTTGGTGTGTTCGGCGAAGCTTATGC
GGAAGCAATGTTAATGGGCGAACAATTCGGCATTAATTTAAATGATCTCGCCGAAGCAATTGGCGGATCGGCAATGAACT
CGCCAATGTTCCAAACCAAAAAGCCATTATTACTCGCGAAAGAATTTCCGGCAGCATTTATGCTCAAACACGCAAGTAAA
GATCTTAATCTCGCTTGTGGCGAGCTAGAAAAAGCAAATCTAGATCTACCTGCAGTAAAAACTGTCGCCGAACAATACCG
CAACGCCGTTGCCGCAGATCTTGGTGAACAGGATGTTTCAGGCATTTATTTGCAGCTGGCGAAATAG

Upstream 100 bases:

>100_bases
TAATTGAAATTTATGTTAGAAAGTCGCTTTTTAAGCGTTTACAACCTTAAAAAATAAGCTACAATCAATTAAATTTGTCC
CACATCAGAAGGAAAATACT

Downstream 100 bases:

>100_bases
CCCTCCTTATTTGAAAAGAAACGCTGTCAGATAAACTGACGGCGTTTTTTATATTCTGAAGAAAGCAGAAATTAGTGTAA
TATATACTTATCTCAATAAA

Product: 3-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTTAFTQIGWIGLGQMGVPMVNRLLANNIDVSVYNRNTAKSAEFAAKGAKVASSVEQLVSENQAVILMVSDYAAAADILN
PDVCAKLQGKVIVNMSTVSPTENLKLKVLVEEHGGLFAEAPVSGSVVPATNGTLLILFGGQEAVLKPLQPVFDVLGQRTF
HFGDVGKGSGAKLVLNSLLGVFGEAYAEAMLMGEQFGINLNDLAEAIGGSAMNSPMFQTKKPLLLAKEFPAAFMLKHASK
DLNLACGELEKANLDLPAVKTVAEQYRNAVAADLGEQDVSGIYLQLAK

Sequences:

>Translated_288_residues
MTTAFTQIGWIGLGQMGVPMVNRLLANNIDVSVYNRNTAKSAEFAAKGAKVASSVEQLVSENQAVILMVSDYAAAADILN
PDVCAKLQGKVIVNMSTVSPTENLKLKVLVEEHGGLFAEAPVSGSVVPATNGTLLILFGGQEAVLKPLQPVFDVLGQRTF
HFGDVGKGSGAKLVLNSLLGVFGEAYAEAMLMGEQFGINLNDLAEAIGGSAMNSPMFQTKKPLLLAKEFPAAFMLKHASK
DLNLACGELEKANLDLPAVKTVAEQYRNAVAADLGEQDVSGIYLQLAK
>Mature_287_residues
TTAFTQIGWIGLGQMGVPMVNRLLANNIDVSVYNRNTAKSAEFAAKGAKVASSVEQLVSENQAVILMVSDYAAAADILNP
DVCAKLQGKVIVNMSTVSPTENLKLKVLVEEHGGLFAEAPVSGSVVPATNGTLLILFGGQEAVLKPLQPVFDVLGQRTFH
FGDVGKGSGAKLVLNSLLGVFGEAYAEAMLMGEQFGINLNDLAEAIGGSAMNSPMFQTKKPLLLAKEFPAAFMLKHASKD
LNLACGELEKANLDLPAVKTVAEQYRNAVAADLGEQDVSGIYLQLAK

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=286, Percent_Identity=30.4195804195804, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=27.0547945205479, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786719, Length=274, Percent_Identity=31.021897810219, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI145693186, Length=288, Percent_Identity=26.7361111111111, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790315, Length=283, Percent_Identity=28.2685512367491, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17557316, Length=248, Percent_Identity=27.8225806451613, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28574115, Length=283, Percent_Identity=28.9752650176678, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=28.0821917808219, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=28.0821917808219, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30383; Mature: 30251

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAFTQIGWIGLGQMGVPMVNRLLANNIDVSVYNRNTAKSAEFAAKGAKVASSVEQLVS
CCCCCCCCCEEECCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
ENQAVILMVSDYAAAADILNPDVCAKLQGKVIVNMSTVSPTENLKLKVLVEEHGGLFAEA
CCCEEEEEEECCHHHHHHCCCHHHHHCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEC
PVSGSVVPATNGTLLILFGGQEAVLKPLQPVFDVLGQRTFHFGDVGKGSGAKLVLNSLLG
CCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHH
VFGEAYAEAMLMGEQFGINLNDLAEAIGGSAMNSPMFQTKKPLLLAKEFPAAFMLKHASK
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHCCCCEEEEHHCCHHHHHHHCCC
DLNLACGELEKANLDLPAVKTVAEQYRNAVAADLGEQDVSGIYLQLAK
CCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
>Mature Secondary Structure 
TTAFTQIGWIGLGQMGVPMVNRLLANNIDVSVYNRNTAKSAEFAAKGAKVASSVEQLVS
CCCCCCCCEEECCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
ENQAVILMVSDYAAAADILNPDVCAKLQGKVIVNMSTVSPTENLKLKVLVEEHGGLFAEA
CCCEEEEEEECCHHHHHHCCCHHHHHCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEC
PVSGSVVPATNGTLLILFGGQEAVLKPLQPVFDVLGQRTFHFGDVGKGSGAKLVLNSLLG
CCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHH
VFGEAYAEAMLMGEQFGINLNDLAEAIGGSAMNSPMFQTKKPLLLAKEFPAAFMLKHASK
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHCCCCEEEEHHCCHHHHHHHCCC
DLNLACGELEKANLDLPAVKTVAEQYRNAVAADLGEQDVSGIYLQLAK
CCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA