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The map label for this gene is recQ [H]

Identifier: 126208588

GI number: 126208588

Start: 1292903

End: 1294711

Strand: Reverse

Name: recQ [H]

Synonym: APL_1116

Alternate gene names: 126208588

Gene position: 1294711-1292903 (Counterclockwise)

Preceding gene: 126208589

Following gene: 126208579

Centisome position: 56.92

GC content: 43.62

Gene sequence:

>1809_bases
ATGCAATTATCTCAAACCGCCGCCAAAGACGTATTGAATAATGTCTTCGGTTATCAATCTTTTCGTCACGGACAACAAGA
AGTGATCGATTCGGTTCTGGCGGGTAGAGATTGTTTAGTCATTATGACCACCGGCGGCGGTAAGTCGCTTTGTTACCAAG
TACCGGCGCTTTGCTTAGACGGCATTACGCTAGTGATTTCTCCGCTGATTTCTTTGATGAAAGATCAGGTTGATCAGTTG
CTTACCAATGGTATCGAAGCCGGCTTTTTAAATTCCACGCAAACTTTTGAAGAACAACAGCTTGTCGAACAGAAAGCACT
TTCCGGTCAGTTGAAATTACTTTATCTCTCGCCGGAAAAAGTAATGACTCAAGGCTTTTTCCATTTTATTTCGTTATGCA
AAATTAGCCTGATTGCAGTCGATGAAGCGCATTGCGTTTCGCAATGGGGGCATGATTTCCGTCCGGAATACACTTTATTA
GGCAATTTGCGTGATACCTTTCCGAATGTGCCGCTGATGGCATTAACGGCAACGGCAGATCCTACGACTCGCCACGATAT
TCTGCAGCACCTGCGCTTAACCGATCCGCATACCTATTTAGGCAGTTTTGATCGCCCGAATATTCGCTATACGGTACAAG
AAAAATTTAAGCCGGTGGAACAGTTGGCAAAATTCATCAGTAAACAGCAGGGCAAGAGCGGTATCGTTTATTGCAATAGC
CGTAAAAAAGTGGAAGAAATTACCGAAAAATTGGCGTCACGTAAAATTTCAGTAATGGGTTACCACGCCGGTATGTCGGT
TCAGCAACGTGAAACGGTTCAAAATGCGTTTCAGCGAGATAATATTCAAGTTGTGGTGGCTACTATTGCTTTCGGGATGG
GGATTAATAAATCAAACGTGCGTTTTGTGGTGCATTTCGATTTGCCACGCAGTATCGAATCCTACTATCAAGAAACCGGG
CGTGCCGGACGTGATGATTTACCATCTGAAGCGGTGTTATTTTATGATCCCGCCGATTATGCGTGGTTACAGAAAGTATT
ATTGGAAGAGCCGGAAAGCGAACAGCGCGATATAAAGCAACATAAATTACAAGCCATCGGTGCTTTTGCCGAATCGCAAA
CCTGCCGCCGTTTAGTGCTATTGAATTATTTCGGCGAATCACGCCAAGAACCCTGTAAAAACTGTGATATTTGCTTAGAT
CCGCCTCGGAAATATGACGGTACGTTAGATGCGCAAAAAGTGATGTCGGTTATTTACCGTACCGGTCAAACTTTTGGCGC
ACACCATGTGATTGGCGTATTACGAGGGTTAAATAACCAAAAAATTCGCCAGTTTAATCATGATCAGCTTTCGGTGTACG
GTATCGGTAAAGAGCAGAGCCAAGATTATTGGTTAAGTATTATTCGTCAATTAATTCATTTGGGTTTAATTCGTCAAAAT
ATCGTGAACCATTCGGCATTACAGCTGACGGAAGAAGCTCGTCCGGTGCTGCGTTCGGAGAAAAAACTTGAATTGGCAAT
GCCTCGCTTAACCTTCTCGGCAACGGCTTATGTACAGAAACAGAGTTCGGTTCGTTACGATAAAGACTTATTTGCTCGCC
TGCGTTTTCTACGTAAACAAATTGCCGATAAAGAAAATATCCCGCCTTATGTGGTATTCAACGATGCGACTTTGCAGGAA
ATGGCGGAATTTTTACCGCTTAGCGAAGTGGAAATGTTGGATATTAATGGGGTCGGAGAACGTAAACTGGAACGTTTCGG
CGGTGCGTTTTTAAGCCTGATTCGAGAGCATTGTAATAATCGCCAATAA

Upstream 100 bases:

>100_bases
ACAAATCAGTTTTTAATCAATAAGCGGTCGCTTTTGCAAAATATTTTGCAAAAGCGACCGCTTGTCTAGTCTTTTTTTAG
CTTATCTTATCGGAACTATA

Downstream 100 bases:

>100_bases
ACGGACAAGCGGTTAAATTTTGTTAAAAATTAGCGAAATTTAACCACTTGTTTGGTGATTAGCCTAGCCATTTTTCCACT
AATTCGGTATTGGTTTCTTT

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MQLSQTAAKDVLNNVFGYQSFRHGQQEVIDSVLAGRDCLVIMTTGGGKSLCYQVPALCLDGITLVISPLISLMKDQVDQL
LTNGIEAGFLNSTQTFEEQQLVEQKALSGQLKLLYLSPEKVMTQGFFHFISLCKISLIAVDEAHCVSQWGHDFRPEYTLL
GNLRDTFPNVPLMALTATADPTTRHDILQHLRLTDPHTYLGSFDRPNIRYTVQEKFKPVEQLAKFISKQQGKSGIVYCNS
RKKVEEITEKLASRKISVMGYHAGMSVQQRETVQNAFQRDNIQVVVATIAFGMGINKSNVRFVVHFDLPRSIESYYQETG
RAGRDDLPSEAVLFYDPADYAWLQKVLLEEPESEQRDIKQHKLQAIGAFAESQTCRRLVLLNYFGESRQEPCKNCDICLD
PPRKYDGTLDAQKVMSVIYRTGQTFGAHHVIGVLRGLNNQKIRQFNHDQLSVYGIGKEQSQDYWLSIIRQLIHLGLIRQN
IVNHSALQLTEEARPVLRSEKKLELAMPRLTFSATAYVQKQSSVRYDKDLFARLRFLRKQIADKENIPPYVVFNDATLQE
MAEFLPLSEVEMLDINGVGERKLERFGGAFLSLIREHCNNRQ

Sequences:

>Translated_602_residues
MQLSQTAAKDVLNNVFGYQSFRHGQQEVIDSVLAGRDCLVIMTTGGGKSLCYQVPALCLDGITLVISPLISLMKDQVDQL
LTNGIEAGFLNSTQTFEEQQLVEQKALSGQLKLLYLSPEKVMTQGFFHFISLCKISLIAVDEAHCVSQWGHDFRPEYTLL
GNLRDTFPNVPLMALTATADPTTRHDILQHLRLTDPHTYLGSFDRPNIRYTVQEKFKPVEQLAKFISKQQGKSGIVYCNS
RKKVEEITEKLASRKISVMGYHAGMSVQQRETVQNAFQRDNIQVVVATIAFGMGINKSNVRFVVHFDLPRSIESYYQETG
RAGRDDLPSEAVLFYDPADYAWLQKVLLEEPESEQRDIKQHKLQAIGAFAESQTCRRLVLLNYFGESRQEPCKNCDICLD
PPRKYDGTLDAQKVMSVIYRTGQTFGAHHVIGVLRGLNNQKIRQFNHDQLSVYGIGKEQSQDYWLSIIRQLIHLGLIRQN
IVNHSALQLTEEARPVLRSEKKLELAMPRLTFSATAYVQKQSSVRYDKDLFARLRFLRKQIADKENIPPYVVFNDATLQE
MAEFLPLSEVEMLDINGVGERKLERFGGAFLSLIREHCNNRQ
>Mature_602_residues
MQLSQTAAKDVLNNVFGYQSFRHGQQEVIDSVLAGRDCLVIMTTGGGKSLCYQVPALCLDGITLVISPLISLMKDQVDQL
LTNGIEAGFLNSTQTFEEQQLVEQKALSGQLKLLYLSPEKVMTQGFFHFISLCKISLIAVDEAHCVSQWGHDFRPEYTLL
GNLRDTFPNVPLMALTATADPTTRHDILQHLRLTDPHTYLGSFDRPNIRYTVQEKFKPVEQLAKFISKQQGKSGIVYCNS
RKKVEEITEKLASRKISVMGYHAGMSVQQRETVQNAFQRDNIQVVVATIAFGMGINKSNVRFVVHFDLPRSIESYYQETG
RAGRDDLPSEAVLFYDPADYAWLQKVLLEEPESEQRDIKQHKLQAIGAFAESQTCRRLVLLNYFGESRQEPCKNCDICLD
PPRKYDGTLDAQKVMSVIYRTGQTFGAHHVIGVLRGLNNQKIRQFNHDQLSVYGIGKEQSQDYWLSIIRQLIHLGLIRQN
IVNHSALQLTEEARPVLRSEKKLELAMPRLTFSATAYVQKQSSVRYDKDLFARLRFLRKQIADKENIPPYVVFNDATLQE
MAEFLPLSEVEMLDINGVGERKLERFGGAFLSLIREHCNNRQ

Specific function: DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=642, Percent_Identity=34.1121495327103, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI110735439, Length=495, Percent_Identity=39.5959595959596, Blast_Score=319, Evalue=4e-87,
Organism=Homo sapiens, GI169218196, Length=495, Percent_Identity=39.5959595959596, Blast_Score=319, Evalue=5e-87,
Organism=Homo sapiens, GI14591902, Length=405, Percent_Identity=41.4814814814815, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI14591904, Length=405, Percent_Identity=41.4814814814815, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI148612816, Length=421, Percent_Identity=39.1923990498812, Blast_Score=284, Evalue=2e-76,
Organism=Homo sapiens, GI51242947, Length=351, Percent_Identity=41.8803418803419, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI51242943, Length=351, Percent_Identity=41.8803418803419, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI284005309, Length=368, Percent_Identity=37.5, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI4758138, Length=330, Percent_Identity=24.5454545454545, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI222352149, Length=341, Percent_Identity=25.2199413489736, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI7661920, Length=362, Percent_Identity=21.8232044198895, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI148613856, Length=332, Percent_Identity=22.8915662650602, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38201710, Length=332, Percent_Identity=22.8915662650602, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI262118318, Length=377, Percent_Identity=23.6074270557029, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI216548263, Length=380, Percent_Identity=23.9473684210526, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI262231852, Length=380, Percent_Identity=23.9473684210526, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI13518015, Length=380, Percent_Identity=23.9473684210526, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI48994977, Length=596, Percent_Identity=62.4161073825503, Blast_Score=811, Evalue=0.0,
Organism=Escherichia coli, GI87082221, Length=352, Percent_Identity=22.4431818181818, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25145561, Length=645, Percent_Identity=33.3333333333333, Blast_Score=330, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI32564293, Length=666, Percent_Identity=31.8318318318318, Blast_Score=310, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71987993, Length=406, Percent_Identity=40.64039408867, Blast_Score=299, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI71987997, Length=406, Percent_Identity=40.64039408867, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17552866, Length=445, Percent_Identity=36.4044943820225, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17537549, Length=396, Percent_Identity=22.7272727272727, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17552114, Length=337, Percent_Identity=25.8160237388724, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71987143, Length=127, Percent_Identity=29.1338582677165, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71995724, Length=364, Percent_Identity=23.0769230769231, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17507121, Length=364, Percent_Identity=22.8021978021978, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32565321, Length=380, Percent_Identity=23.1578947368421, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508543, Length=153, Percent_Identity=27.4509803921569, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=530, Percent_Identity=37.3584905660377, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6320224, Length=355, Percent_Identity=23.0985915492958, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320041, Length=331, Percent_Identity=23.5649546827795, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324217, Length=325, Percent_Identity=22.1538461538462, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322912, Length=82, Percent_Identity=31.7073170731707, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322323, Length=82, Percent_Identity=31.7073170731707, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24646066, Length=634, Percent_Identity=35.0157728706625, Blast_Score=360, Evalue=2e-99,
Organism=Drosophila melanogaster, GI24664226, Length=455, Percent_Identity=34.7252747252747, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI62472181, Length=455, Percent_Identity=34.7252747252747, Blast_Score=269, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24664230, Length=455, Percent_Identity=34.7252747252747, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI21358123, Length=357, Percent_Identity=38.9355742296919, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI28574962, Length=326, Percent_Identity=22.6993865030675, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583281, Length=335, Percent_Identity=22.6865671641791, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583279, Length=335, Percent_Identity=22.6865671641791, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24645031, Length=353, Percent_Identity=22.0963172804533, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 68460; Mature: 68460

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSQTAAKDVLNNVFGYQSFRHGQQEVIDSVLAGRDCLVIMTTGGGKSLCYQVPALCLD
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHC
GITLVISPLISLMKDQVDQLLTNGIEAGFLNSTQTFEEQQLVEQKALSGQLKLLYLSPEK
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECHHH
VMTQGFFHFISLCKISLIAVDEAHCVSQWGHDFRPEYTLLGNLRDTFPNVPLMALTATAD
HHHHHHHHHHHHHHHHHEEECHHHHHHHCCCCCCCCEEEECCHHHHCCCCCEEEEEECCC
PTTRHDILQHLRLTDPHTYLGSFDRPNIRYTVQEKFKPVEQLAKFISKQQGKSGIVYCNS
CCHHHHHHHHHCCCCCHHHCCCCCCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCEEEECC
RKKVEEITEKLASRKISVMGYHAGMSVQQRETVQNAFQRDNIQVVVATIAFGMGINKSNV
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCC
RFVVHFDLPRSIESYYQETGRAGRDDLPSEAVLFYDPADYAWLQKVLLEEPESEQRDIKQ
EEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHH
HKLQAIGAFAESQTCRRLVLLNYFGESRQEPCKNCDICLDPPRKYDGTLDAQKVMSVIYR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEECCCCCCCCCCCCHHHHHHHHHH
TGQTFGAHHVIGVLRGLNNQKIRQFNHDQLSVYGIGKEQSQDYWLSIIRQLIHLGLIRQN
CCCCCCHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
IVNHSALQLTEEARPVLRSEKKLELAMPRLTFSATAYVQKQSSVRYDKDLFARLRFLRKQ
HHCHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IADKENIPPYVVFNDATLQEMAEFLPLSEVEMLDINGVGERKLERFGGAFLSLIREHCNN
HCCCCCCCCEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
RQ
CC
>Mature Secondary Structure
MQLSQTAAKDVLNNVFGYQSFRHGQQEVIDSVLAGRDCLVIMTTGGGKSLCYQVPALCLD
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHC
GITLVISPLISLMKDQVDQLLTNGIEAGFLNSTQTFEEQQLVEQKALSGQLKLLYLSPEK
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECHHH
VMTQGFFHFISLCKISLIAVDEAHCVSQWGHDFRPEYTLLGNLRDTFPNVPLMALTATAD
HHHHHHHHHHHHHHHHHEEECHHHHHHHCCCCCCCCEEEECCHHHHCCCCCEEEEEECCC
PTTRHDILQHLRLTDPHTYLGSFDRPNIRYTVQEKFKPVEQLAKFISKQQGKSGIVYCNS
CCHHHHHHHHHCCCCCHHHCCCCCCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCEEEECC
RKKVEEITEKLASRKISVMGYHAGMSVQQRETVQNAFQRDNIQVVVATIAFGMGINKSNV
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCC
RFVVHFDLPRSIESYYQETGRAGRDDLPSEAVLFYDPADYAWLQKVLLEEPESEQRDIKQ
EEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHH
HKLQAIGAFAESQTCRRLVLLNYFGESRQEPCKNCDICLDPPRKYDGTLDAQKVMSVIYR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEECCCCCCCCCCCCHHHHHHHHHH
TGQTFGAHHVIGVLRGLNNQKIRQFNHDQLSVYGIGKEQSQDYWLSIIRQLIHLGLIRQN
CCCCCCHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
IVNHSALQLTEEARPVLRSEKKLELAMPRLTFSATAYVQKQSSVRYDKDLFARLRFLRKQ
HHCHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IADKENIPPYVVFNDATLQEMAEFLPLSEVEMLDINGVGERKLERFGGAFLSLIREHCNN
HCCCCCCCCEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
RQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]