Click here to switch to the map view.

The map label for this gene is pepA

Identifier: 126208573

GI number: 126208573

Start: 1272039

End: 1273538

Strand: Reverse

Name: pepA

Synonym: APL_1101

Alternate gene names: 126208573

Gene position: 1273538-1272039 (Counterclockwise)

Preceding gene: 126208578

Following gene: 126208572

Centisome position: 55.99

GC content: 46.0

Gene sequence:

>1500_bases
ATGGAATTTAGCGTAAAAAACGGTAGTGTCGAAAAACAACGTACTGCCTGTTTAGTGGTCGGCGTGTACGAGCCTCGCCG
TTTATCTGCGGCGGCAGAACAATTAGACAAGTTAAGTGAAGGCTATATCAGCACGTTATTACGTCGTGGCGATTTGGAAG
GCAAGGCGGGGCAAACGCTTTTACTGCATAATGTACCTAACGTACCTGCTGATCGCGTGTTATTGGTCGGTTGCGGAAAA
GAAAGAGAATTAACCGAACGCCAATATAAACAAATTATTCAAAAAATGGTACAAGCCGTCAGTGAAACGGGTTCGATGGA
AGTAGTTTGTTTTCTGACCGAATTACACGTAAAAGGTCGTACAAGTTATTGGAATGTTCGTTTTGCGATTGAAGCGATTC
AAGAAAGTTTATACAGCTATAACGATTTCAAAAGCATTAAGCCGGAAGTGCGCCGAGAATTCCGTCGTGTGATTTTTAAC
GTCGCGAACCGTAAGGATTTAGCCGATGCGGAACGTGCGTTAGAACACGGTAAAGCGATCTCAACCGGTGTTGCCTTTGC
GAAAAACGTCGCAAACTGCCCGCCGAACGTTTGTAATCCGGCGTATCTTGCCGAATTGGCAAAAGGCTTAGCCGCAGAAT
ATGACAATATTCGTACCACGGTAATTGATGAAGCGGAAATGGCGGCATTAGGGATGAATGCTTATTTGGCGGTTTCGCGC
GGTTCGCAGAATCCGGCGTATTTATCGGTAATCGAATATAAAAATCATCCGAATCCCGATGCCAAACCAATCGTCTTAGT
GGGTAAAGGACTGACTTTCGACTCGGGCGGTATTTCGATTAAACCGTCCGATTCAATGGATGAAATGAAATATGATATGG
GCGGTGCCGCTTCGGTTTACGGTACGATGAAAGCGTTAGCGGAAATGAAATTACCGCTGAACGTTATCGGCGTGCTGGCA
GGCTGTGAGAATATGCCGGACGGCAATGCCTATCGCCCGGGAGATATTCTGACTACGATGAACGGTTTAACCGTAGAAGT
GTTGAATACCGATGCGGAAGGTCGTTTAGTGCTGTGTGATACGCTGACTTATGTAGAACGCTTCGAGCCGGAACTGGTCA
TTGATATGGCAACGCTGACCGGTGCTTGTATGATTGCGTTAGGTGCGCATAACAGCGGTTTGATGTCCACCAGTAACGTA
TTGGCAAACGAATTATTAAATGCGGCGGAACAAGCGGACGATAAAGCGTGGCGTTTACCGTTAGGCGAAGAATATCAAGA
ACAGCTTAAATCTAACTTTGCCGATTTAGCCAATATCGGCGGACGTTTAGGCGGAGCGATTACTGCAGGGCAGTTCTTAT
CGAACTTTACCAAAAAATATAGTTGGGCGCATTTGGATATCGCCGGTACGGCTTGGAAGTCCGGTGCGGCAAAAGGTGCA
ACCGGAAGACCGGTTTCACTGTTAAGCCAATTCTTGATTAATAAAGCAAATAATCAATAA

Upstream 100 bases:

>100_bases
TTTTCTGCTTGTAATTTTTTAGATAAATCGGTAGCTTATTCGTAATATGAGTAGCGAGAAAGTTACTTTAGCCTTGGTTT
TTACAATAAAGGAGTTACGA

Downstream 100 bases:

>100_bases
GCGGTCAAATTTTTATCAAAAATTGAAAAGCCCTCAGGTAGTGATATTTGAGGGCTTTTTGTTCAATAGATAGTAGGATG
TGTGTTTTTATGTAAAAAGT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MEFSVKNGSVEKQRTACLVVGVYEPRRLSAAAEQLDKLSEGYISTLLRRGDLEGKAGQTLLLHNVPNVPADRVLLVGCGK
ERELTERQYKQIIQKMVQAVSETGSMEVVCFLTELHVKGRTSYWNVRFAIEAIQESLYSYNDFKSIKPEVRREFRRVIFN
VANRKDLADAERALEHGKAISTGVAFAKNVANCPPNVCNPAYLAELAKGLAAEYDNIRTTVIDEAEMAALGMNAYLAVSR
GSQNPAYLSVIEYKNHPNPDAKPIVLVGKGLTFDSGGISIKPSDSMDEMKYDMGGAASVYGTMKALAEMKLPLNVIGVLA
GCENMPDGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCDTLTYVERFEPELVIDMATLTGACMIALGAHNSGLMSTSNV
LANELLNAAEQADDKAWRLPLGEEYQEQLKSNFADLANIGGRLGGAITAGQFLSNFTKKYSWAHLDIAGTAWKSGAAKGA
TGRPVSLLSQFLINKANNQ

Sequences:

>Translated_499_residues
MEFSVKNGSVEKQRTACLVVGVYEPRRLSAAAEQLDKLSEGYISTLLRRGDLEGKAGQTLLLHNVPNVPADRVLLVGCGK
ERELTERQYKQIIQKMVQAVSETGSMEVVCFLTELHVKGRTSYWNVRFAIEAIQESLYSYNDFKSIKPEVRREFRRVIFN
VANRKDLADAERALEHGKAISTGVAFAKNVANCPPNVCNPAYLAELAKGLAAEYDNIRTTVIDEAEMAALGMNAYLAVSR
GSQNPAYLSVIEYKNHPNPDAKPIVLVGKGLTFDSGGISIKPSDSMDEMKYDMGGAASVYGTMKALAEMKLPLNVIGVLA
GCENMPDGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCDTLTYVERFEPELVIDMATLTGACMIALGAHNSGLMSTSNV
LANELLNAAEQADDKAWRLPLGEEYQEQLKSNFADLANIGGRLGGAITAGQFLSNFTKKYSWAHLDIAGTAWKSGAAKGA
TGRPVSLLSQFLINKANNQ
>Mature_499_residues
MEFSVKNGSVEKQRTACLVVGVYEPRRLSAAAEQLDKLSEGYISTLLRRGDLEGKAGQTLLLHNVPNVPADRVLLVGCGK
ERELTERQYKQIIQKMVQAVSETGSMEVVCFLTELHVKGRTSYWNVRFAIEAIQESLYSYNDFKSIKPEVRREFRRVIFN
VANRKDLADAERALEHGKAISTGVAFAKNVANCPPNVCNPAYLAELAKGLAAEYDNIRTTVIDEAEMAALGMNAYLAVSR
GSQNPAYLSVIEYKNHPNPDAKPIVLVGKGLTFDSGGISIKPSDSMDEMKYDMGGAASVYGTMKALAEMKLPLNVIGVLA
GCENMPDGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCDTLTYVERFEPELVIDMATLTGACMIALGAHNSGLMSTSNV
LANELLNAAEQADDKAWRLPLGEEYQEQLKSNFADLANIGGRLGGAITAGQFLSNFTKKYSWAHLDIAGTAWKSGAAKGA
TGRPVSLLSQFLINKANNQ

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=494, Percent_Identity=34.8178137651822, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI47155554, Length=315, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1790710, Length=497, Percent_Identity=70.0201207243461, Blast_Score=729, Evalue=0.0,
Organism=Escherichia coli, GI87082123, Length=351, Percent_Identity=39.3162393162393, Blast_Score=195, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17556903, Length=263, Percent_Identity=33.8403041825095, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17565172, Length=242, Percent_Identity=28.9256198347107, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129969, Length=515, Percent_Identity=28.7378640776699, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24662227, Length=521, Percent_Identity=28.4069097888676, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI161077148, Length=510, Percent_Identity=28.4313725490196, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI20130057, Length=510, Percent_Identity=28.4313725490196, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI21355645, Length=507, Percent_Identity=27.2189349112426, Blast_Score=178, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24662223, Length=507, Percent_Identity=27.2189349112426, Blast_Score=178, Evalue=9e-45,
Organism=Drosophila melanogaster, GI21355725, Length=509, Percent_Identity=29.4695481335953, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24661038, Length=363, Percent_Identity=32.5068870523416, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI20129963, Length=502, Percent_Identity=27.4900398406374, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI19922386, Length=512, Percent_Identity=27.34375, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI21357381, Length=279, Percent_Identity=35.1254480286738, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI221379063, Length=279, Percent_Identity=35.1254480286738, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI221379062, Length=279, Percent_Identity=35.1254480286738, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646701, Length=356, Percent_Identity=25.8426966292135, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646703, Length=356, Percent_Identity=25.8426966292135, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358201, Length=356, Percent_Identity=25.8426966292135, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_ACTP2 (A3N1A7)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053798.1
- ProteinModelPortal:   A3N1A7
- SMR:   A3N1A7
- STRING:   A3N1A7
- MEROPS:   M17.003
- GeneID:   4848868
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1101
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   LGHHNSG
- PhylomeDB:   A3N1A7
- ProtClustDB:   PRK00913
- BioCyc:   APLE416269:APL_1101-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 54220; Mature: 54220

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 281-281 ACT_SITE 355-355

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSVKNGSVEKQRTACLVVGVYEPRRLSAAAEQLDKLSEGYISTLLRRGDLEGKAGQTL
CCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LLHNVPNVPADRVLLVGCGKERELTERQYKQIIQKMVQAVSETGSMEVVCFLTELHVKGR
EEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHCCCC
TSYWNVRFAIEAIQESLYSYNDFKSIKPEVRREFRRVIFNVANRKDLADAERALEHGKAI
CCEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
STGVAFAKNVANCPPNVCNPAYLAELAKGLAAEYDNIRTTVIDEAEMAALGMNAYLAVSR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCEEEEEEC
GSQNPAYLSVIEYKNHPNPDAKPIVLVGKGLTFDSGGISIKPSDSMDEMKYDMGGAASVY
CCCCCCEEEEEEECCCCCCCCCEEEEEECCCEECCCCEEECCCCCHHHHHHCCCCHHHHH
GTMKALAEMKLPLNVIGVLAGCENMPDGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCD
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCEEEEH
TLTYVERFEPELVIDMATLTGACMIALGAHNSGLMSTSNVLANELLNAAEQADDKAWRLP
HHHHHHHCCCCCEEEHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECC
LGEEYQEQLKSNFADLANIGGRLGGAITAGQFLSNFTKKYSWAHLDIAGTAWKSGAAKGA
CCHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCC
TGRPVSLLSQFLINKANNQ
CCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEFSVKNGSVEKQRTACLVVGVYEPRRLSAAAEQLDKLSEGYISTLLRRGDLEGKAGQTL
CCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LLHNVPNVPADRVLLVGCGKERELTERQYKQIIQKMVQAVSETGSMEVVCFLTELHVKGR
EEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHCCCC
TSYWNVRFAIEAIQESLYSYNDFKSIKPEVRREFRRVIFNVANRKDLADAERALEHGKAI
CCEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
STGVAFAKNVANCPPNVCNPAYLAELAKGLAAEYDNIRTTVIDEAEMAALGMNAYLAVSR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCEEEEEEC
GSQNPAYLSVIEYKNHPNPDAKPIVLVGKGLTFDSGGISIKPSDSMDEMKYDMGGAASVY
CCCCCCEEEEEEECCCCCCCCCEEEEEECCCEECCCCEEECCCCCHHHHHHCCCCHHHHH
GTMKALAEMKLPLNVIGVLAGCENMPDGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCD
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCEEEEH
TLTYVERFEPELVIDMATLTGACMIALGAHNSGLMSTSNVLANELLNAAEQADDKAWRLP
HHHHHHHCCCCCEEEHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECC
LGEEYQEQLKSNFADLANIGGRLGGAITAGQFLSNFTKKYSWAHLDIAGTAWKSGAAKGA
CCHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCC
TGRPVSLLSQFLINKANNQ
CCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA