Click here to switch to the map view.

The map label for this gene is arsC [H]

Identifier: 126208561

GI number: 126208561

Start: 1260945

End: 1261349

Strand: Reverse

Name: arsC [H]

Synonym: APL_1089

Alternate gene names: 126208561

Gene position: 1261349-1260945 (Counterclockwise)

Preceding gene: 126208562

Following gene: 126208560

Centisome position: 55.46

GC content: 39.51

Gene sequence:

>405_bases
ATGGAAAAAGTTACGATTTATCATAATCCAAAATGTGGAACTTCACGTAATACACTAGCTCTTATTCGCCACTTAGGGAT
TGAACCAACGATCATACACTACCTCGAAACGCCTCCCGATGAGGTTACACTACGAAACCTAATTTCAGAAATAGGGATTC
GTGTGCGAGATCTGCTTCGGACGAATGTACCTCCCTACGAAACATTAAATTTAAGTCGCATGGAATTGAGTGATGACGAG
TTGATTGCTGCAATGCTTGCCGAACCGATTTTGATTAATCGTCCGATTGTTATCACAAGCAAAGGTGTTCGACTTTGTCG
CCCATCTGAAAAGTTTTTAGAAATTTCACCGGTTTCATTGGATAAACCTTTTATTAAAGAAGATGGTGGAGTGATTGAGT
TATAA

Upstream 100 bases:

>100_bases
GTAAAGAAAGCGATGATCCGAATTGCAAATTTTGTGGGTGAAATGCCCACAAAATTTTTTACCTTAACATTTCAATAAAT
ATTGAAATATTGGAGAAAAT

Downstream 100 bases:

>100_bases
GGAAGAAATATATGGGAATTTTTGAACGATTTTTAACAATTTGGGTTGCTTTAGCTATTACAGCTGGAGTTGCATTAGGT
ATAGCATTTCCGCAAGTGGT

Product: arsenate reductase

Products: NA

Alternate protein names: Arsenical pump modifier [H]

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MEKVTIYHNPKCGTSRNTLALIRHLGIEPTIIHYLETPPDEVTLRNLISEIGIRVRDLLRTNVPPYETLNLSRMELSDDE
LIAAMLAEPILINRPIVITSKGVRLCRPSEKFLEISPVSLDKPFIKEDGGVIEL

Sequences:

>Translated_134_residues
MEKVTIYHNPKCGTSRNTLALIRHLGIEPTIIHYLETPPDEVTLRNLISEIGIRVRDLLRTNVPPYETLNLSRMELSDDE
LIAAMLAEPILINRPIVITSKGVRLCRPSEKFLEISPVSLDKPFIKEDGGVIEL
>Mature_134_residues
MEKVTIYHNPKCGTSRNTLALIRHLGIEPTIIHYLETPPDEVTLRNLISEIGIRVRDLLRTNVPPYETLNLSRMELSDDE
LIAAMLAEPILINRPIVITSKGVRLCRPSEKFLEISPVSLDKPFIKEDGGVIEL

Specific function: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance [H]

COG id: COG1393

COG function: function code P; Arsenate reductase and related proteins, glutaredoxin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsC family [H]

Homologues:

Organism=Escherichia coli, GI1789918, Length=129, Percent_Identity=62.015503875969, Blast_Score=157, Evalue=3e-40,
Organism=Escherichia coli, GI1788841, Length=115, Percent_Identity=45.2173913043478, Blast_Score=105, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006659
- InterPro:   IPR006660
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF03960 ArsC [H]

EC number: =1.20.4.1 [H]

Molecular weight: Translated: 15140; Mature: 15140

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVTIYHNPKCGTSRNTLALIRHLGIEPTIIHYLETPPDEVTLRNLISEIGIRVRDLLR
CCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCHHHHHHHH
TNVPPYETLNLSRMELSDDELIAAMLAEPILINRPIVITSKGVRLCRPSEKFLEISPVSL
CCCCCCCCCCCEEEECCCHHHHHHHHHCCEECCCCEEEECCCCEEECCCCHHEEECCCCC
DKPFIKEDGGVIEL
CCCCCCCCCCEEEC
>Mature Secondary Structure
MEKVTIYHNPKCGTSRNTLALIRHLGIEPTIIHYLETPPDEVTLRNLISEIGIRVRDLLR
CCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCHHHHHHHH
TNVPPYETLNLSRMELSDDELIAAMLAEPILINRPIVITSKGVRLCRPSEKFLEISPVSL
CCCCCCCCCCCEEEECCCHHHHHHHHHCCEECCCCEEEECCCCEEECCCCHHEEECCCCC
DKPFIKEDGGVIEL
CCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9006011 [H]