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The map label for this gene is msrAB [H]

Identifier: 126208498

GI number: 126208498

Start: 1188983

End: 1189489

Strand: Direct

Name: msrAB [H]

Synonym: APL_1024

Alternate gene names: 126208498

Gene position: 1188983-1189489 (Clockwise)

Preceding gene: 126208497

Following gene: 126208505

Centisome position: 52.27

GC content: 39.25

Gene sequence:

>507_bases
ATGGCGAACATTCGAGAAATTTATTTGGCGGGCGGGTGCTTTTGGGGTACGGAAGCTTTTATGCAACGTATTAACGGAGT
GCTTGATGCACAATCGGGATATGCGAACGGCAATACTGAAAACCCGAGTTATCAAGAAGTGTGTGCCGGCAGCGGTCATG
CGGAAGTGGTGAAAGTGACTTACGATGCGGATAAAATCAGCCTAGCAAAATTATTAGATTACTATTTTAAAGTGATTGAT
CCGGTAAGTGTAAATCAACAAGGCGAAGATAAAGGTATTCAATATCGCACCGGTATTTATTATGTTGATCCGCAAGATAT
TCCTGTTATTAATCAGGCACTTGCCGATTTACAAACACAATATGAGCAACCACTTGTGGTTGAAAATACAATGTTAGAAC
ATTACTTCCCTGCGGAAGAATATCATCAAGACTATTTAGATAAGAATCCGAATGGCTATTGCCATATTGATTTGCAATTA
ATGAACGAGATTCTACGTAATCAATAA

Upstream 100 bases:

>100_bases
GAGAAATTAGTACCTTGTACTCCGTAATAAATCGCTATATGCTATGACCACTTACAACAAGCGGTCTAATTCCGTGAAAA
TTTTACAAACAGGAGAAAAT

Downstream 100 bases:

>100_bases
AAAATTAAGGCGTATCATTGGATACGCCTTTTTATTATTTACGCATTAAACCGTAAATCGCTTTAAGGGCGGCAAGCGGT
AAAATTCTCGGCAAACCTCG

Product: peptide methionine sulfoxide reductase MsrA

Products: NA

Alternate protein names: Thioredoxin; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MANIREIYLAGGCFWGTEAFMQRINGVLDAQSGYANGNTENPSYQEVCAGSGHAEVVKVTYDADKISLAKLLDYYFKVID
PVSVNQQGEDKGIQYRTGIYYVDPQDIPVINQALADLQTQYEQPLVVENTMLEHYFPAEEYHQDYLDKNPNGYCHIDLQL
MNEILRNQ

Sequences:

>Translated_168_residues
MANIREIYLAGGCFWGTEAFMQRINGVLDAQSGYANGNTENPSYQEVCAGSGHAEVVKVTYDADKISLAKLLDYYFKVID
PVSVNQQGEDKGIQYRTGIYYVDPQDIPVINQALADLQTQYEQPLVVENTMLEHYFPAEEYHQDYLDKNPNGYCHIDLQL
MNEILRNQ
>Mature_167_residues
ANIREIYLAGGCFWGTEAFMQRINGVLDAQSGYANGNTENPSYQEVCAGSGHAEVVKVTYDADKISLAKLLDYYFKVIDP
VSVNQQGEDKGIQYRTGIYYVDPQDIPVINQALADLQTQYEQPLVVENTMLEHYFPAEEYHQDYLDKNPNGYCHIDLQLM
NEILRNQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=150, Percent_Identity=38, Blast_Score=113, Evalue=9e-26,
Organism=Homo sapiens, GI208609995, Length=150, Percent_Identity=38, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI208609993, Length=146, Percent_Identity=32.1917808219178, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790665, Length=148, Percent_Identity=37.1621621621622, Blast_Score=104, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17533973, Length=152, Percent_Identity=29.6052631578947, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=37.888198757764, Blast_Score=116, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24664627, Length=140, Percent_Identity=30, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=30, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01625 PMSR; PF08534 Redoxin; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 19113; Mature: 18981

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIREIYLAGGCFWGTEAFMQRINGVLDAQSGYANGNTENPSYQEVCAGSGHAEVVKVT
CCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEE
YDADKISLAKLLDYYFKVIDPVSVNQQGEDKGIQYRTGIYYVDPQDIPVINQALADLQTQ
ECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHHH
YEQPLVVENTMLEHYFPAEEYHQDYLDKNPNGYCHIDLQLMNEILRNQ
HCCCEEEHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCC
>Mature Secondary Structure 
ANIREIYLAGGCFWGTEAFMQRINGVLDAQSGYANGNTENPSYQEVCAGSGHAEVVKVT
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEE
YDADKISLAKLLDYYFKVIDPVSVNQQGEDKGIQYRTGIYYVDPQDIPVINQALADLQTQ
ECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHHH
YEQPLVVENTMLEHYFPAEEYHQDYLDKNPNGYCHIDLQLMNEILRNQ
HCCCEEEHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2854063; 8755589 [H]