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The map label for this gene is adh2 [H]

Identifier: 126208485

GI number: 126208485

Start: 1175244

End: 1177859

Strand: Direct

Name: adh2 [H]

Synonym: APL_1011

Alternate gene names: 126208485

Gene position: 1175244-1177859 (Clockwise)

Preceding gene: 126208480

Following gene: 126208491

Centisome position: 51.67

GC content: 43.73

Gene sequence:

>2616_bases
ATGGCTAACAATGCAAAAAATGCACAACCATATGATGCTCAAACCGAAGTAAATCAGCTAGTTGAAAACGGTTTAAAAGC
TCTCGAAGAATTTCGTCAGCTTAACCAAGAACAAGTGGATTACATCGTTGCAAAAGCCTCCGTGGCGGCATTGGATAAAC
ATGGCGTTCTAGCAATGCACGCTTATGAAGAAACGGGGCGGGGCGTATTTGAAGACAAAGCGACTAAAAATCTATTTGCT
TGTGAATATGTCGTAAATAATATGCGACATTTAAAAACGGCGGGGATAATTAGTGAAGATAACGTAACCGGTATTACCGA
AATCGCCGACCCTGTCGGTGTCGTATGCGGCATAACTCCGACAACCAACCCAACCTCAACCACTATCTTCAAAGCGTTAA
TCGCCCTCAAAACTCGTAACCCAATCGTTTTTGCTTTCCACCCTTCCGCACAACAATCTTCCGCTCATGCCGCTCAAGTT
GTATATGATGCCGCCGTTGCTGCCGGCGCACCGAAAAATTGTGTGCAATGGATTAAAACCCCGTCAATGGAAGGTACTTC
CGCATTAATGAAACATCCGGGTATTGCAACCATTCTTGCTACCGGCGGTAATGCCATGGTTGAAGCGGCATATTCTTGCG
GTAAGCCGGCATTAGGCGTAGGGGCGGGTAACGTACCGGCTTATGTGGAAAAAACTGCTAAACTAGAACAAGCTGTTTAC
GACATTGTGATGTCAAAATCTTTTGACAACGGTATGATTTGTGCATCCGAACAAGCGGCGATTGTCGATAAAGAAATCTA
TGCCGATTTCGTGAAAGAAATGCAATCTTACGGCGTATATCTGGTAAATAAAAAAGAAAAAGTACTGTTAGAAAAATTCA
TTTTCGGTGTGGATAAAGCCAAAGATGAAAACTGTGCCGGAGCAAAATTAAATGCGGCGGTCGTAGGTAAACCGGCGGCA
TGGATTGCCGAACAAGCGGGTTTTAGCGTGCCACCAAAAACAAACATCCTACTTGCAGAATGTGCGTTTGTCGGTGAAGG
CGAACCGCTTACTCGTGAGAAATTATCACCGGTACTTGCATTATTAAAATCGAATTCAACCGAACACGGTTTAGAACTTT
CCGAAGCGATGGTAAATTTCTACGGTTTAGGTCACTCGGCGGCAATCCATACGCAAAATGTCGAATTAGCAAAAACATTC
GGCGAGCGCGTTAAAGCGATTCGTGTAATTTGGAACTCGCCATCAACATTCGGTGGTATCGGTGACGTGTATAACTCATT
CCTTCCGTCCCTCACATTAGGTTGTGGTTCTTACGGTAAAAACTCCGTAAGTAACAACGTAAGTGCGGTGAACTTAATTA
ATATTAAACGTGTGGGCAGACGGAGAAACAATATGCAATGGTTTAAAGTTCCATCAAAAATCTACTTTGAGCGTGATTCA
ATTCAATATCTCAAATCAATGAAAGATGCGGAAAAAGTGATGATCGTGACCGACCGCTCAATGGTAGATCTCGGTTTTGT
CGATAGAATTACCGACCAATTACGCCAACGTCGTAATAAAGTGATGATTCAGTTATTTACCGATGTTGAACCGAATCCAA
GTTTACAAACCGTACAACGCGGGACGGAACTTATGCGTAGCTTCCAACCGGATACCATTATTGCCTTAGGTGGCGGCTCG
CCGATGGATGCGGCAAAAGTAATGTGGTTATTCTATGAACAACCGGAAGTGGATTTCCGTGATTTAGTTCAGAAATTTAT
GGATATTCGTAAACGTGCGTTCAAATTCCCGCAATTAGGTCGTAAAGCGAAATTTGTCGGTATCCCGACCACATCCGGTA
CCGGTTCCGAAGTTACGCCGTTTGCGGTCATTACTGACGGCGATATTAAATATCCGTTGGCCGACTACTCTCTCACGCCG
ACAATTGCGATTGTAGATCCTGCATTAGTGATGTCAGTGCCGGCTCATGTTGCGGCGGATACCGGTTTAGACGTATTAAC
TCACGCAACTGAGGCTTATACTTCAATTCTTGCCAACGACTACACCGACGGTTTAGCGTTACAGGCAATTAAACTGGTAT
TCGAAAATTTAGAAAAATCCGTGAAAGAATTTGATGAAGTCGCTCGCGAGAAAATGCACAATGCTTCAACTATGGCAGGT
ATGGCGTTTGCAAACGCATTCTTAGGTATTTGTCACTCAATGGCGCATAAAATCGGCGGTAAATTCCATACGATTCACGG
TCGTACCAATGCGATTTTATTACCGCACGTAATTCGTTATAACGGTACTCGCCCGACTAAAGTGGCAACTTGGCCGAAAT
ACACAAACTATGTTGCGGATAAACGCTTCCAAGACATCGCACGTATTTTAGGTTTACCGGCGACAACGCCTGAAGAAGCG
GTGGAATCTTACGCTAAAGCGGTACATGATTTAGCAGTACGTTGTGGTATTAAAATGTCTTTACGTGAACAAGGTATTGA
CGAACAAGAGTTCTTAGACGCACGTCGTGAACTTGCATTAAATGCCTTTGAAGACCAATGTACTCCGGCAAATCCACGTC
TTGCAATGGTAGAAGATATGGAAGAGATAATGACAAAAGCTTACTATGGCAAATAA

Upstream 100 bases:

>100_bases
TCTCTAAAGAGTTATGAATTTAATGCAATCTACAAATATTTAGGTAATAATTTTATCAATTAAAAAAATTTGAAATTTGA
AACTTTAGAGGAACCAAACT

Downstream 100 bases:

>100_bases
TTGACAAATAATCTTTTTCTCCCTTAATATGATTGAATGATGAAATGTACCAAGGGCTAACAAAAGTTAGCCCTTTTTTT
CATATTTTGCCTAATATGTG

Product: bifunctional acetaldehyde-CoA/alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH; Pyruvate-formate-lyase deactivase; PFL deactivase [H]

Number of amino acids: Translated: 871; Mature: 870

Protein sequence:

>871_residues
MANNAKNAQPYDAQTEVNQLVENGLKALEEFRQLNQEQVDYIVAKASVAALDKHGVLAMHAYEETGRGVFEDKATKNLFA
CEYVVNNMRHLKTAGIISEDNVTGITEIADPVGVVCGITPTTNPTSTTIFKALIALKTRNPIVFAFHPSAQQSSAHAAQV
VYDAAVAAGAPKNCVQWIKTPSMEGTSALMKHPGIATILATGGNAMVEAAYSCGKPALGVGAGNVPAYVEKTAKLEQAVY
DIVMSKSFDNGMICASEQAAIVDKEIYADFVKEMQSYGVYLVNKKEKVLLEKFIFGVDKAKDENCAGAKLNAAVVGKPAA
WIAEQAGFSVPPKTNILLAECAFVGEGEPLTREKLSPVLALLKSNSTEHGLELSEAMVNFYGLGHSAAIHTQNVELAKTF
GERVKAIRVIWNSPSTFGGIGDVYNSFLPSLTLGCGSYGKNSVSNNVSAVNLINIKRVGRRRNNMQWFKVPSKIYFERDS
IQYLKSMKDAEKVMIVTDRSMVDLGFVDRITDQLRQRRNKVMIQLFTDVEPNPSLQTVQRGTELMRSFQPDTIIALGGGS
PMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPQLGRKAKFVGIPTTSGTGSEVTPFAVITDGDIKYPLADYSLTP
TIAIVDPALVMSVPAHVAADTGLDVLTHATEAYTSILANDYTDGLALQAIKLVFENLEKSVKEFDEVAREKMHNASTMAG
MAFANAFLGICHSMAHKIGGKFHTIHGRTNAILLPHVIRYNGTRPTKVATWPKYTNYVADKRFQDIARILGLPATTPEEA
VESYAKAVHDLAVRCGIKMSLREQGIDEQEFLDARRELALNAFEDQCTPANPRLAMVEDMEEIMTKAYYGK

Sequences:

>Translated_871_residues
MANNAKNAQPYDAQTEVNQLVENGLKALEEFRQLNQEQVDYIVAKASVAALDKHGVLAMHAYEETGRGVFEDKATKNLFA
CEYVVNNMRHLKTAGIISEDNVTGITEIADPVGVVCGITPTTNPTSTTIFKALIALKTRNPIVFAFHPSAQQSSAHAAQV
VYDAAVAAGAPKNCVQWIKTPSMEGTSALMKHPGIATILATGGNAMVEAAYSCGKPALGVGAGNVPAYVEKTAKLEQAVY
DIVMSKSFDNGMICASEQAAIVDKEIYADFVKEMQSYGVYLVNKKEKVLLEKFIFGVDKAKDENCAGAKLNAAVVGKPAA
WIAEQAGFSVPPKTNILLAECAFVGEGEPLTREKLSPVLALLKSNSTEHGLELSEAMVNFYGLGHSAAIHTQNVELAKTF
GERVKAIRVIWNSPSTFGGIGDVYNSFLPSLTLGCGSYGKNSVSNNVSAVNLINIKRVGRRRNNMQWFKVPSKIYFERDS
IQYLKSMKDAEKVMIVTDRSMVDLGFVDRITDQLRQRRNKVMIQLFTDVEPNPSLQTVQRGTELMRSFQPDTIIALGGGS
PMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPQLGRKAKFVGIPTTSGTGSEVTPFAVITDGDIKYPLADYSLTP
TIAIVDPALVMSVPAHVAADTGLDVLTHATEAYTSILANDYTDGLALQAIKLVFENLEKSVKEFDEVAREKMHNASTMAG
MAFANAFLGICHSMAHKIGGKFHTIHGRTNAILLPHVIRYNGTRPTKVATWPKYTNYVADKRFQDIARILGLPATTPEEA
VESYAKAVHDLAVRCGIKMSLREQGIDEQEFLDARRELALNAFEDQCTPANPRLAMVEDMEEIMTKAYYGK
>Mature_870_residues
ANNAKNAQPYDAQTEVNQLVENGLKALEEFRQLNQEQVDYIVAKASVAALDKHGVLAMHAYEETGRGVFEDKATKNLFAC
EYVVNNMRHLKTAGIISEDNVTGITEIADPVGVVCGITPTTNPTSTTIFKALIALKTRNPIVFAFHPSAQQSSAHAAQVV
YDAAVAAGAPKNCVQWIKTPSMEGTSALMKHPGIATILATGGNAMVEAAYSCGKPALGVGAGNVPAYVEKTAKLEQAVYD
IVMSKSFDNGMICASEQAAIVDKEIYADFVKEMQSYGVYLVNKKEKVLLEKFIFGVDKAKDENCAGAKLNAAVVGKPAAW
IAEQAGFSVPPKTNILLAECAFVGEGEPLTREKLSPVLALLKSNSTEHGLELSEAMVNFYGLGHSAAIHTQNVELAKTFG
ERVKAIRVIWNSPSTFGGIGDVYNSFLPSLTLGCGSYGKNSVSNNVSAVNLINIKRVGRRRNNMQWFKVPSKIYFERDSI
QYLKSMKDAEKVMIVTDRSMVDLGFVDRITDQLRQRRNKVMIQLFTDVEPNPSLQTVQRGTELMRSFQPDTIIALGGGSP
MDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPQLGRKAKFVGIPTTSGTGSEVTPFAVITDGDIKYPLADYSLTPT
IAIVDPALVMSVPAHVAADTGLDVLTHATEAYTSILANDYTDGLALQAIKLVFENLEKSVKEFDEVAREKMHNASTMAGM
AFANAFLGICHSMAHKIGGKFHTIHGRTNAILLPHVIRYNGTRPTKVATWPKYTNYVADKRFQDIARILGLPATTPEEAV
ESYAKAVHDLAVRCGIKMSLREQGIDEQEFLDARRELALNAFEDQCTPANPRLAMVEDMEEIMTKAYYGK

Specific function: This enzyme has three activities:ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=333, Percent_Identity=28.5285285285285, Blast_Score=108, Evalue=2e-23,
Organism=Escherichia coli, GI1787493, Length=870, Percent_Identity=49.1954022988506, Blast_Score=801, Evalue=0.0,
Organism=Escherichia coli, GI48994951, Length=404, Percent_Identity=34.9009900990099, Blast_Score=206, Evalue=7e-54,
Organism=Escherichia coli, GI1789163, Length=401, Percent_Identity=33.4164588528678, Blast_Score=200, Evalue=3e-52,
Organism=Escherichia coli, GI87082107, Length=418, Percent_Identity=32.5358851674641, Blast_Score=185, Evalue=1e-47,
Organism=Escherichia coli, GI1788797, Length=368, Percent_Identity=31.7934782608696, Blast_Score=154, Evalue=3e-38,
Organism=Escherichia coli, GI1789386, Length=389, Percent_Identity=24.1645244215938, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17537053, Length=275, Percent_Identity=29.8181818181818, Blast_Score=119, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321181, Length=418, Percent_Identity=33.2535885167464, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24657991, Length=406, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR012079 [H]

Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]

EC number: =1.1.1.1; =1.2.1.10 [H]

Molecular weight: Translated: 95338; Mature: 95207

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANNAKNAQPYDAQTEVNQLVENGLKALEEFRQLNQEQVDYIVAKASVAALDKHGVLAMH
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEE
AYEETGRGVFEDKATKNLFACEYVVNNMRHLKTAGIISEDNVTGITEIADPVGVVCGITP
EHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEECCC
TTNPTSTTIFKALIALKTRNPIVFAFHPSAQQSSAHAAQVVYDAAVAAGAPKNCVQWIKT
CCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCC
PSMEGTSALMKHPGIATILATGGNAMVEAAYSCGKPALGVGAGNVPAYVEKTAKLEQAVY
CCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DIVMSKSFDNGMICASEQAAIVDKEIYADFVKEMQSYGVYLVNKKEKVLLEKFIFGVDKA
HHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHCCCCC
KDENCAGAKLNAAVVGKPAAWIAEQAGFSVPPKTNILLAECAFVGEGEPLTREKLSPVLA
CCCCCCCCEECEEEECCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHH
LLKSNSTEHGLELSEAMVNFYGLGHSAAIHTQNVELAKTFGERVKAIRVIWNSPSTFGGI
HHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHEEEEEECCCCCCCCH
GDVYNSFLPSLTLGCGSYGKNSVSNNVSAVNLINIKRVGRRRNNMQWFKVPSKIYFERDS
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEECCHHHEEECHH
IQYLKSMKDAEKVMIVTDRSMVDLGFVDRITDQLRQRRNKVMIQLFTDVEPNPSLQTVQR
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHH
GTELMRSFQPDTIIALGGGSPMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPQLG
HHHHHHHCCCCEEEEECCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
RKAKFVGIPTTSGTGSEVTPFAVITDGDIKYPLADYSLTPTIAIVDPALVMSVPAHVAAD
CCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECHHHHHHCCHHHHHC
TGLDVLTHATEAYTSILANDYTDGLALQAIKLVFENLEKSVKEFDEVAREKMHNASTMAG
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAFANAFLGICHSMAHKIGGKFHTIHGRTNAILLPHVIRYNGTRPTKVATWPKYTNYVAD
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEECCHHEEECCCCCCEEECCCHHHHHHHH
KRFQDIARILGLPATTPEEAVESYAKAVHDLAVRCGIKMSLREQGIDEQEFLDARRELAL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEHHHHCCCCHHHHHHHHHHHHH
NAFEDQCTPANPRLAMVEDMEEIMTKAYYGK
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ANNAKNAQPYDAQTEVNQLVENGLKALEEFRQLNQEQVDYIVAKASVAALDKHGVLAMH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEE
AYEETGRGVFEDKATKNLFACEYVVNNMRHLKTAGIISEDNVTGITEIADPVGVVCGITP
EHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEECCC
TTNPTSTTIFKALIALKTRNPIVFAFHPSAQQSSAHAAQVVYDAAVAAGAPKNCVQWIKT
CCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCC
PSMEGTSALMKHPGIATILATGGNAMVEAAYSCGKPALGVGAGNVPAYVEKTAKLEQAVY
CCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DIVMSKSFDNGMICASEQAAIVDKEIYADFVKEMQSYGVYLVNKKEKVLLEKFIFGVDKA
HHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHCCCCC
KDENCAGAKLNAAVVGKPAAWIAEQAGFSVPPKTNILLAECAFVGEGEPLTREKLSPVLA
CCCCCCCCEECEEEECCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHH
LLKSNSTEHGLELSEAMVNFYGLGHSAAIHTQNVELAKTFGERVKAIRVIWNSPSTFGGI
HHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHEEEEEECCCCCCCCH
GDVYNSFLPSLTLGCGSYGKNSVSNNVSAVNLINIKRVGRRRNNMQWFKVPSKIYFERDS
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEECCHHHEEECHH
IQYLKSMKDAEKVMIVTDRSMVDLGFVDRITDQLRQRRNKVMIQLFTDVEPNPSLQTVQR
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHH
GTELMRSFQPDTIIALGGGSPMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPQLG
HHHHHHHCCCCEEEEECCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
RKAKFVGIPTTSGTGSEVTPFAVITDGDIKYPLADYSLTPTIAIVDPALVMSVPAHVAAD
CCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECHHHHHHCCHHHHHC
TGLDVLTHATEAYTSILANDYTDGLALQAIKLVFENLEKSVKEFDEVAREKMHNASTMAG
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAFANAFLGICHSMAHKIGGKFHTIHGRTNAILLPHVIRYNGTRPTKVATWPKYTNYVAD
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEECCHHEEECCCCCCEEECCCHHHHHHHH
KRFQDIARILGLPATTPEEAVESYAKAVHDLAVRCGIKMSLREQGIDEQEFLDARRELAL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEHHHHCCCCHHHHHHHHHHHHH
NAFEDQCTPANPRLAMVEDMEEIMTKAYYGK
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]