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The map label for this gene is nhaP [H]

Identifier: 126208478

GI number: 126208478

Start: 1167952

End: 1169265

Strand: Direct

Name: nhaP [H]

Synonym: APL_1004

Alternate gene names: 126208478

Gene position: 1167952-1169265 (Clockwise)

Preceding gene: 126208471

Following gene: 126208479

Centisome position: 51.35

GC content: 40.72

Gene sequence:

>1314_bases
ATGGGAATTTATGCCTATATTTGTTTCCTCTCCGCTCTGTCTATTTTACTCGGCTTCATTACAAGTAAAATTAGTGCCAA
AGTACAATCCACTATTGCAATTAGTGCCGCTGCAATGGTCTGTTCTCTACTCGTTTGGATTTTAGGTTCTTTAGGTTTAT
TTAACATCGATACGATGGCTAAAGAAGTAATGGAACAAATTGATTTCAAAAGTTTCTTACTTAACGGCATTTTAGGGTTC
TTACTGTTTGCCGGTTCTTTAGGTGTCAAACTGCCGATTCTTAAAGATCAAAAATGGGAAATCACCGTTTTTGCGCTCTT
CTCAACGCTTGCCTCTACTTTCTTTATCGCCGGTTTAATTTATGCCGTCAGCCATCTTATCGGTTTACCGATTGACTTTA
TTTACTGCATAGTATTCGGTGCGTTAATCTCTCCGACCGACCCTATCGCCGTATTAGCGATTATCAAAAACTTACGTGCG
CCAAAACGCTTATCGATGCAGGTGGAAGGCGAGTCTTTATTTAATGACGGCGTCGGTTTGGTTATTTTTATTACGGTATT
TACCATTGCGTTCGGTGGTAAAGAAACCGGTTTCTCCGACATTATGGGGCTTTTTCTACATGAAGCAATCGGCGGTATCC
TATTCGGTTTCGTACTGGGTTTCATCGCACATATCTTAATTTCCTCCACCGATGACGGTTCGATGGAAATGTTGATTACG
CTAACCATTCCGACCGCCGGTTTTATGTTCGCAAGTAACGTATTGCATGTATCCGGCGCATTAGCGATGGTAGTAGCGGG
CATTATGATGGGAAACTGGACGCGCCATTCGGGGTTCTCCGAACAGAGCCAACGTTATCTGGACCATTTCTGGGAAATGA
TCGATCATTTCTTAAATTCTTTATTGTTTTTCCTTATCGGCTTTGCATTATTACTGGTAGATTTCAATATTTATGGGGTC
ATTTTAATGATTGCCGCTATCCCGATTTGCCTGATCTCTCGCTATTTTAGCTTATGGATTCCGTTTAAATTGATGCAACA
ATTCCGCACCTATAATCCTTACACGTTAAAAATTATGAGTTGGGGCGGATTACGCGGCGGATTGGCTTTAGCTATGGCTC
TTTCTATTCCGAGTAAAGTCGTATTTGTTGAAGATATTGATGTTAAAGATCTTATTTTAGTTATGACCTATGCTGTCGTG
ATGTTTTCCATCTTAGTACAAGGCTCCACAATTGAACCGATGATTCGTAAAGCGAAAACCGTCGATCCGAATAGAGAGGA
ATATTTAAAACCGAGCGGTCATTCTTTGCATTAA

Upstream 100 bases:

>100_bases
CTATTCTTTACATTAATTCGGAAACTTGTTTTAATCTATGCTTTAGACCTATATGCAAGCGGTCTGTTTTCACTTTTTAT
TTACTTCGACAGGATTACCC

Downstream 100 bases:

>100_bases
TTTTGCAAATTTTAGTTGAAATTTAACCGCTTTATCTTTAGAATTCGCAGTTCCTGTCCTAGCTGAGTTAGAGATCGGCT
ACGGATGTATTATCAACCCT

Product: Na(+)/H(+) exchanger beta-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MGIYAYICFLSALSILLGFITSKISAKVQSTIAISAAAMVCSLLVWILGSLGLFNIDTMAKEVMEQIDFKSFLLNGILGF
LLFAGSLGVKLPILKDQKWEITVFALFSTLASTFFIAGLIYAVSHLIGLPIDFIYCIVFGALISPTDPIAVLAIIKNLRA
PKRLSMQVEGESLFNDGVGLVIFITVFTIAFGGKETGFSDIMGLFLHEAIGGILFGFVLGFIAHILISSTDDGSMEMLIT
LTIPTAGFMFASNVLHVSGALAMVVAGIMMGNWTRHSGFSEQSQRYLDHFWEMIDHFLNSLLFFLIGFALLLVDFNIYGV
ILMIAAIPICLISRYFSLWIPFKLMQQFRTYNPYTLKIMSWGGLRGGLALAMALSIPSKVVFVEDIDVKDLILVMTYAVV
MFSILVQGSTIEPMIRKAKTVDPNREEYLKPSGHSLH

Sequences:

>Translated_437_residues
MGIYAYICFLSALSILLGFITSKISAKVQSTIAISAAAMVCSLLVWILGSLGLFNIDTMAKEVMEQIDFKSFLLNGILGF
LLFAGSLGVKLPILKDQKWEITVFALFSTLASTFFIAGLIYAVSHLIGLPIDFIYCIVFGALISPTDPIAVLAIIKNLRA
PKRLSMQVEGESLFNDGVGLVIFITVFTIAFGGKETGFSDIMGLFLHEAIGGILFGFVLGFIAHILISSTDDGSMEMLIT
LTIPTAGFMFASNVLHVSGALAMVVAGIMMGNWTRHSGFSEQSQRYLDHFWEMIDHFLNSLLFFLIGFALLLVDFNIYGV
ILMIAAIPICLISRYFSLWIPFKLMQQFRTYNPYTLKIMSWGGLRGGLALAMALSIPSKVVFVEDIDVKDLILVMTYAVV
MFSILVQGSTIEPMIRKAKTVDPNREEYLKPSGHSLH
>Mature_436_residues
GIYAYICFLSALSILLGFITSKISAKVQSTIAISAAAMVCSLLVWILGSLGLFNIDTMAKEVMEQIDFKSFLLNGILGFL
LFAGSLGVKLPILKDQKWEITVFALFSTLASTFFIAGLIYAVSHLIGLPIDFIYCIVFGALISPTDPIAVLAIIKNLRAP
KRLSMQVEGESLFNDGVGLVIFITVFTIAFGGKETGFSDIMGLFLHEAIGGILFGFVLGFIAHILISSTDDGSMEMLITL
TIPTAGFMFASNVLHVSGALAMVVAGIMMGNWTRHSGFSEQSQRYLDHFWEMIDHFLNSLLFFLIGFALLLVDFNIYGVI
LMIAAIPICLISRYFSLWIPFKLMQQFRTYNPYTLKIMSWGGLRGGLALAMALSIPSKVVFVEDIDVKDLILVMTYAVVM
FSILVQGSTIEPMIRKAKTVDPNREEYLKPSGHSLH

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=313, Percent_Identity=26.1980830670927, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI15529998, Length=315, Percent_Identity=26.031746031746, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI27777632, Length=331, Percent_Identity=26.5861027190332, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI41872703, Length=349, Percent_Identity=26.647564469914, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI194239733, Length=341, Percent_Identity=27.5659824046921, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI14211919, Length=350, Percent_Identity=24.8571428571429, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI27734935, Length=331, Percent_Identity=24.1691842900302, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI110227626, Length=333, Percent_Identity=23.1231231231231, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI5454070, Length=333, Percent_Identity=23.1231231231231, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI294997330, Length=333, Percent_Identity=23.1231231231231, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4759144, Length=316, Percent_Identity=25.3164556962025, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790501, Length=292, Percent_Identity=28.7671232876712, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71999819, Length=348, Percent_Identity=26.7241379310345, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71999817, Length=348, Percent_Identity=26.7241379310345, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71999821, Length=348, Percent_Identity=26.7241379310345, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25150332, Length=325, Percent_Identity=26.7692307692308, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71987535, Length=353, Percent_Identity=26.9121813031161, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71987537, Length=353, Percent_Identity=26.9121813031161, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71990924, Length=331, Percent_Identity=24.1691842900302, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71980847, Length=331, Percent_Identity=24.4712990936556, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71993590, Length=340, Percent_Identity=25.8823529411765, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71993582, Length=340, Percent_Identity=25.8823529411765, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71990932, Length=331, Percent_Identity=24.1691842900302, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25147678, Length=306, Percent_Identity=26.797385620915, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71992101, Length=333, Percent_Identity=23.7237237237237, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71992107, Length=333, Percent_Identity=23.7237237237237, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71987559, Length=342, Percent_Identity=23.6842105263158, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=312, Percent_Identity=27.2435897435897, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221510740, Length=344, Percent_Identity=27.0348837209302, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI221510734, Length=344, Percent_Identity=26.7441860465116, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221510738, Length=344, Percent_Identity=26.7441860465116, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI221510736, Length=344, Percent_Identity=26.7441860465116, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221510732, Length=344, Percent_Identity=26.7441860465116, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24585580, Length=344, Percent_Identity=26.7441860465116, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585578, Length=344, Percent_Identity=26.7441860465116, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281360447, Length=351, Percent_Identity=26.4957264957265, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281364513, Length=369, Percent_Identity=24.1192411924119, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221473222, Length=369, Percent_Identity=24.1192411924119, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221473212, Length=369, Percent_Identity=24.1192411924119, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221473215, Length=369, Percent_Identity=24.1192411924119, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 48082; Mature: 47951

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIYAYICFLSALSILLGFITSKISAKVQSTIAISAAAMVCSLLVWILGSLGLFNIDTMA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KEVMEQIDFKSFLLNGILGFLLFAGSLGVKLPILKDQKWEITVFALFSTLASTFFIAGLI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
YAVSHLIGLPIDFIYCIVFGALISPTDPIAVLAIIKNLRAPKRLSMQVEGESLFNDGVGL
HHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHCCCCHH
VIFITVFTIAFGGKETGFSDIMGLFLHEAIGGILFGFVLGFIAHILISSTDDGSMEMLIT
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
LTIPTAGFMFASNVLHVSGALAMVVAGIMMGNWTRHSGFSEQSQRYLDHFWEMIDHFLNS
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLFFLIGFALLLVDFNIYGVILMIAAIPICLISRYFSLWIPFKLMQQFRTYNPYTLKIMS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEE
WGGLRGGLALAMALSIPSKVVFVEDIDVKDLILVMTYAVVMFSILVQGSTIEPMIRKAKT
CCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
VDPNREEYLKPSGHSLH
CCCCHHHHCCCCCCCCC
>Mature Secondary Structure 
GIYAYICFLSALSILLGFITSKISAKVQSTIAISAAAMVCSLLVWILGSLGLFNIDTMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KEVMEQIDFKSFLLNGILGFLLFAGSLGVKLPILKDQKWEITVFALFSTLASTFFIAGLI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
YAVSHLIGLPIDFIYCIVFGALISPTDPIAVLAIIKNLRAPKRLSMQVEGESLFNDGVGL
HHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHCCCCHH
VIFITVFTIAFGGKETGFSDIMGLFLHEAIGGILFGFVLGFIAHILISSTDDGSMEMLIT
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
LTIPTAGFMFASNVLHVSGALAMVVAGIMMGNWTRHSGFSEQSQRYLDHFWEMIDHFLNS
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLFFLIGFALLLVDFNIYGVILMIAAIPICLISRYFSLWIPFKLMQQFRTYNPYTLKIMS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEE
WGGLRGGLALAMALSIPSKVVFVEDIDVKDLILVMTYAVVMFSILVQGSTIEPMIRKAKT
CCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
VDPNREEYLKPSGHSLH
CCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA