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The map label for this gene is tktA [H]

Identifier: 126208457

GI number: 126208457

Start: 1136203

End: 1138209

Strand: Direct

Name: tktA [H]

Synonym: APL_0983

Alternate gene names: 126208457

Gene position: 1136203-1138209 (Clockwise)

Preceding gene: 126208455

Following gene: 126208458

Centisome position: 49.95

GC content: 44.54

Gene sequence:

>2007_bases
ATGGCAGAACGTAAAGTATTAGCGAATGCAATTCGCTTTCTAAGTATGGATGCGGTACAAAAAGCTAATTCCGGTCACCC
GGGCGCCCCAATGGGGATGGCGGATATCGCAGAGGTATTATGGCGCGATTTTTTAAAACACAATCCGACCAATCCTAAGT
GGGCGGATCGCGACCGTTTCGTACTTTCAAACGGCCATGGTTCAATGTTAATTTATAGCTTATTACACTTAACGGGCTAT
GATCTTTCAATTGAAGATTTAAAACAATTCCGTCAATTACATTCTAAAACACCGGGTCACCCTGAATACGGTTATGCTCC
GGGTGTTGAAACTACGACCGGTCCGTTAGGTCAAGGTATCACTAATGCGGTCGGTATGGCGATTGCGGAAAAAACCTTAG
CCGCACAGTTTAACCGTGAAGGTCATAAAATCGTTGATCACTATACCTATGCGTTTTTAGGTGACGGTTGTTTAATGGAA
GGTATCTCACATGAAGCATGCTCATTAGCGGGTACTTTAGGCTTAGGCAAATTAATCGCTTTCTATGACGATAATAATAT
TTCAATCGACGGTCATGTGGACGGCTGGTTCTCTGATGATACCGCACAACGTTTTGAAGCATACGGTTGGCAAGTGATCC
GTAATGTGGACGGTCATGATGCGGAACAAATCAAATTTGCGATTGAAAATGCAAAAGCGGAGACCGAGCGTCCGACATTA
ATTATCTGTAAAACCATTATCGGTTACGGTTCTCCGAACAAATCGGCATCGCATGACTGCCACGGTGCGCCGTTAGGTAA
TGATGAAATCGCATTAACCCGTAAAGCACTCAACTGGGAATATGCGCCGTTTGAAATTCCGGCTGAAATCTATGCGGAAT
GGGATGCCAAAGCGCAAGGTGCGGTTGTAGAAAAAGAATGGAATGCTAAATTTGCGGCTTATGAAGCGGCGTATCCTGAA
TTAGCGGCGGAATTTAAACGTCGTATGGCGGGTGATTTACCGGCAAACTGGGAAGCGGAAAGTAAAGCGTTTATTGAAAA
ATTACAAGCAAATCCGGCGGCAATCGCAAGCCGTAAAGCATCACAAAATGCGATTGAAGCTTATGCGCATATCTTACCGG
AATTCTTAGGCGGTTCTGCCGACTTAGCAAGTTCTAACTTAACCTTATGGTCAGGTTCAAAACCAATCCGTGCGGATCAT
AACGTCGATGGTAACTACATCAACTACGGTGTACGTGAATTCGGTATGTCTGCAATTATGAACGGTATTGCATTACACGG
CGGTTTTATTCCTTACGGTGCAACATTCTTAATGTTCTATGAATATGCCCACAATGCGGTGCGTATGGCGGCATTAATGA
AACAACGCTCATTATTCGTTTATACACATGATTCTATCGGTTTAGGCGAAGACGGCCCGACTCACCAACCGGTAGAACAA
ACCGCATCATTACGTTTCATTCCGAACTTAGAAACATGGCGTCCGGCTGACCAAGTGGAATCTGCTGTTGCATGGAAAGC
AGCGGTTGAACGTAAAGACGGCCCGAGTGCATTAATCTTTACTCGCCAAAATCTTGCGCAACAAACACGTACGCCGGAAC
AATTGGCAAACGTTGCTCGCGGTGGTTATATCTTACGTGAATGCTGTCAAAAAGGCGGTTGTCCGGATTTAATTCTCATC
GCAACCGGCTCAGAAGTGGATTTAGCTATGAAAGCAGCTGAAGTATTAGATGCGGAAGGTACGAAAGTACGTGTTGTTTC
CATGCCAAGTACCAATGTATTCGACAAACAAGATGCCGCATATCGTGAAAGCGTATTACCAAGCTCAGTAACCAAACGTG
TAGCAATCGAAGCACAATTATCTGATTTCTGGTACAAATACGTTGGCTTTGAAGGGCGTATCGTCGGTATGAATAGCTTC
GGTGAGTCTGCGCCAGCGGATCAACTTTTCAAACTATTCGGTTTCACTGTTGATAACGTGGTAGCGAAAGCGAAAGAAAT
TTTATAA

Upstream 100 bases:

>100_bases
GATTTTTTGAGTATTACTTCAAAAATAGTGTAGAATCCGTCTATCGACTAATTTTATTTTAATTAGAGTATTTGTCATTT
TCTTGTCTAGGAGTAAACAC

Downstream 100 bases:

>100_bases
TTTCGTTTAGACATTAAAGACAAAGGCGAGAAGATTCTCGCCTTTTTAATTTTTGTAAAAAAGCACTAAAATTGATCTGC
ACCCCAAAAGTTGGACTAAA

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MAERKVLANAIRFLSMDAVQKANSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAAQFNREGHKIVDHYTYAFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAQRFEAYGWQVIRNVDGHDAEQIKFAIENAKAETERPTL
IICKTIIGYGSPNKSASHDCHGAPLGNDEIALTRKALNWEYAPFEIPAEIYAEWDAKAQGAVVEKEWNAKFAAYEAAYPE
LAAEFKRRMAGDLPANWEAESKAFIEKLQANPAAIASRKASQNAIEAYAHILPEFLGGSADLASSNLTLWSGSKPIRADH
NVDGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
TASLRFIPNLETWRPADQVESAVAWKAAVERKDGPSALIFTRQNLAQQTRTPEQLANVARGGYILRECCQKGGCPDLILI
ATGSEVDLAMKAAEVLDAEGTKVRVVSMPSTNVFDKQDAAYRESVLPSSVTKRVAIEAQLSDFWYKYVGFEGRIVGMNSF
GESAPADQLFKLFGFTVDNVVAKAKEIL

Sequences:

>Translated_668_residues
MAERKVLANAIRFLSMDAVQKANSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAAQFNREGHKIVDHYTYAFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAQRFEAYGWQVIRNVDGHDAEQIKFAIENAKAETERPTL
IICKTIIGYGSPNKSASHDCHGAPLGNDEIALTRKALNWEYAPFEIPAEIYAEWDAKAQGAVVEKEWNAKFAAYEAAYPE
LAAEFKRRMAGDLPANWEAESKAFIEKLQANPAAIASRKASQNAIEAYAHILPEFLGGSADLASSNLTLWSGSKPIRADH
NVDGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
TASLRFIPNLETWRPADQVESAVAWKAAVERKDGPSALIFTRQNLAQQTRTPEQLANVARGGYILRECCQKGGCPDLILI
ATGSEVDLAMKAAEVLDAEGTKVRVVSMPSTNVFDKQDAAYRESVLPSSVTKRVAIEAQLSDFWYKYVGFEGRIVGMNSF
GESAPADQLFKLFGFTVDNVVAKAKEIL
>Mature_667_residues
AERKVLANAIRFLSMDAVQKANSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGYD
LSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAAQFNREGHKIVDHYTYAFLGDGCLMEG
ISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAQRFEAYGWQVIRNVDGHDAEQIKFAIENAKAETERPTLI
ICKTIIGYGSPNKSASHDCHGAPLGNDEIALTRKALNWEYAPFEIPAEIYAEWDAKAQGAVVEKEWNAKFAAYEAAYPEL
AAEFKRRMAGDLPANWEAESKAFIEKLQANPAAIASRKASQNAIEAYAHILPEFLGGSADLASSNLTLWSGSKPIRADHN
VDGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQT
ASLRFIPNLETWRPADQVESAVAWKAAVERKDGPSALIFTRQNLAQQTRTPEQLANVARGGYILRECCQKGGCPDLILIA
TGSEVDLAMKAAEVLDAEGTKVRVVSMPSTNVFDKQDAAYRESVLPSSVTKRVAIEAQLSDFWYKYVGFEGRIVGMNSFG
ESAPADQLFKLFGFTVDNVVAKAKEIL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=687, Percent_Identity=25.9097525473071, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI4507521, Length=687, Percent_Identity=25.9097525473071, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI133778974, Length=259, Percent_Identity=33.5907335907336, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI225637459, Length=593, Percent_Identity=22.2596964586847, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI225637463, Length=516, Percent_Identity=22.2868217054264, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI225637461, Length=516, Percent_Identity=22.2868217054264, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI48994911, Length=668, Percent_Identity=76.7964071856288, Blast_Score=1083, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=665, Percent_Identity=68.5714285714286, Blast_Score=983, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=680, Percent_Identity=25, Blast_Score=154, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6325331, Length=673, Percent_Identity=49.0341753343239, Blast_Score=623, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6319593, Length=676, Percent_Identity=45.5621301775148, Blast_Score=579, Evalue=1e-166,
Organism=Drosophila melanogaster, GI45551847, Length=687, Percent_Identity=26.0553129548763, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45550715, Length=687, Percent_Identity=26.0553129548763, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24645119, Length=653, Percent_Identity=25.4211332312404, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24666278, Length=262, Percent_Identity=30.5343511450382, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73263; Mature: 73132

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERKVLANAIRFLSMDAVQKANSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGMAIAEKTLAAQFNREGHKIVDHYTYAFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFSDDTAQRFEAYGWQVIRNVDGHDAEQIKFAIENAKAETERPTL
EEECCCEEECCCCCCCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCCCCEE
IICKTIIGYGSPNKSASHDCHGAPLGNDEIALTRKALNWEYAPFEIPAEIYAEWDAKAQG
EEEEHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCCCCCHHHHHCCCCCCCC
AVVEKEWNAKFAAYEAAYPELAAEFKRRMAGDLPANWEAESKAFIEKLQANPAAIASRKA
CEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
SQNAIEAYAHILPEFLGGSADLASSNLTLWSGSKPIRADHNVDGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHH
NGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHH
TASLRFIPNLETWRPADQVESAVAWKAAVERKDGPSALIFTRQNLAQQTRTPEQLANVAR
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCHHHHHHHHH
GGYILRECCQKGGCPDLILIATGSEVDLAMKAAEVLDAEGTKVRVVSMPSTNVFDKQDAA
CCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHH
YRESVLPSSVTKRVAIEAQLSDFWYKYVGFEGRIVGMNSFGESAPADQLFKLFGFTVDNV
HHHHCCCHHHHHHHHEEHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHH
VAKAKEIL
HHHHHHCC
>Mature Secondary Structure 
AERKVLANAIRFLSMDAVQKANSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRF
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGMAIAEKTLAAQFNREGHKIVDHYTYAFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFSDDTAQRFEAYGWQVIRNVDGHDAEQIKFAIENAKAETERPTL
EEECCCEEECCCCCCCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCCCCEE
IICKTIIGYGSPNKSASHDCHGAPLGNDEIALTRKALNWEYAPFEIPAEIYAEWDAKAQG
EEEEHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCCCCCHHHHHCCCCCCCC
AVVEKEWNAKFAAYEAAYPELAAEFKRRMAGDLPANWEAESKAFIEKLQANPAAIASRKA
CEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
SQNAIEAYAHILPEFLGGSADLASSNLTLWSGSKPIRADHNVDGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHH
NGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHH
TASLRFIPNLETWRPADQVESAVAWKAAVERKDGPSALIFTRQNLAQQTRTPEQLANVAR
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCHHHHHHHHH
GGYILRECCQKGGCPDLILIATGSEVDLAMKAAEVLDAEGTKVRVVSMPSTNVFDKQDAA
CCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHH
YRESVLPSSVTKRVAIEAQLSDFWYKYVGFEGRIVGMNSFGESAPADQLFKLFGFTVDNV
HHHHCCCHHHHHHHHEEHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHH
VAKAKEIL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]