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The map label for this gene is ilvY [H]

Identifier: 126208452

GI number: 126208452

Start: 1131769

End: 1132653

Strand: Reverse

Name: ilvY [H]

Synonym: APL_0978

Alternate gene names: 126208452

Gene position: 1132653-1131769 (Counterclockwise)

Preceding gene: 126208453

Following gene: 126208447

Centisome position: 49.8

GC content: 41.69

Gene sequence:

>885_bases
ATGGAATTCCAATCCCTTAAACTGTTTTTAGATATTACTCAAACGCACAGCTTTATTCGTTCGGCTGAAAATAATTATAT
GAGTGCTTCGACACTTACACGCCATATTCAGCGAATTGAACAAGAGCTGGGGCAGCCGTTGTTTATCCGAGATAACCGAC
AAGTTCGCTTAACGGAAGCTGGCGAAAAATTTTTACTTTTTGCAAAACAAAGTTGGTCTGATTGGCAACAATTACAACAG
CAGTTGTCGCCGGTGCAAGGTCAGCTGGAAGGCGAATTGAAAGTCTTCTGTTCGGTAACGGCTGCGTATAGTCATTTACC
GCAAATTCTGGAACAGTTTCGTCAGGCTCACCCGAAAGTGGAGATAAAACTAAGCACCGGCGATCCGGCGCAAGCAGTGC
ATACGGTACATTCTTTCGAAGCGGATATTTCTTTAACCGGCAAACCGGAACATCTGCCGAATAGCATTGTGTTTCATTAT
ATTGATGATATTCATCTTTCGATTATTGCACCTCGAGTAGCTTGTGTTGCAACACAATATTTACAGCAACAACCGATTGA
TTGGCAGAATATTCCTTTTATTTTGCCGGTGGACGGTCCGGTACGAAAGCGAATTGATCGCTGGTTTAAAGAGCTGAAAA
TTAGAGAACCTAAAATTTATGCTACGGTTGCCGGACACGAAGCGATTGTACCGATGGTTGCTTTAGGATTCGGAGTAGCA
TTGTTACCTGATGTCGTGATTAAGCATAGTCCGATGAATAATCAAGTTTCTTATTTGAAATTAGCGGATCCTATATCGCC
GTTTGAATTGGGGATTTGTGTACAAGAAAAGAGGTTACAAGAACCGATTATTAAGGCATTTTGGGAATTGTTGCCGAAAG
ATTAA

Upstream 100 bases:

>100_bases
CTGGCATCCGAATAATAAGGCGGAAACCCATATTCTACGCTTTAAGCAGAGTGTGAATGATCTTGATTTTAATCGGATAC
AACCGGAATGGTTAAACTAA

Downstream 100 bases:

>100_bases
AGACAAGCGGTCAAATTTAAAGAATTTTTTGTAAATTTTTTGCTAAATTTGACCGCTTGTTTGCTATTTGAATACCGCCC
AAACCGGAGAATGATCCGAC

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MEFQSLKLFLDITQTHSFIRSAENNYMSASTLTRHIQRIEQELGQPLFIRDNRQVRLTEAGEKFLLFAKQSWSDWQQLQQ
QLSPVQGQLEGELKVFCSVTAAYSHLPQILEQFRQAHPKVEIKLSTGDPAQAVHTVHSFEADISLTGKPEHLPNSIVFHY
IDDIHLSIIAPRVACVATQYLQQQPIDWQNIPFILPVDGPVRKRIDRWFKELKIREPKIYATVAGHEAIVPMVALGFGVA
LLPDVVIKHSPMNNQVSYLKLADPISPFELGICVQEKRLQEPIIKAFWELLPKD

Sequences:

>Translated_294_residues
MEFQSLKLFLDITQTHSFIRSAENNYMSASTLTRHIQRIEQELGQPLFIRDNRQVRLTEAGEKFLLFAKQSWSDWQQLQQ
QLSPVQGQLEGELKVFCSVTAAYSHLPQILEQFRQAHPKVEIKLSTGDPAQAVHTVHSFEADISLTGKPEHLPNSIVFHY
IDDIHLSIIAPRVACVATQYLQQQPIDWQNIPFILPVDGPVRKRIDRWFKELKIREPKIYATVAGHEAIVPMVALGFGVA
LLPDVVIKHSPMNNQVSYLKLADPISPFELGICVQEKRLQEPIIKAFWELLPKD
>Mature_294_residues
MEFQSLKLFLDITQTHSFIRSAENNYMSASTLTRHIQRIEQELGQPLFIRDNRQVRLTEAGEKFLLFAKQSWSDWQQLQQ
QLSPVQGQLEGELKVFCSVTAAYSHLPQILEQFRQAHPKVEIKLSTGDPAQAVHTVHSFEADISLTGKPEHLPNSIVFHY
IDDIHLSIIAPRVACVATQYLQQQPIDWQNIPFILPVDGPVRKRIDRWFKELKIREPKIYATVAGHEAIVPMVALGFGVA
LLPDVVIKHSPMNNQVSYLKLADPISPFELGICVQEKRLQEPIIKAFWELLPKD

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=295, Percent_Identity=51.1864406779661, Blast_Score=306, Evalue=8e-85,
Organism=Escherichia coli, GI1787806, Length=269, Percent_Identity=24.907063197026, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788887, Length=244, Percent_Identity=25, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI145693105, Length=300, Percent_Identity=22.6666666666667, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787589, Length=248, Percent_Identity=27.8225806451613, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788296, Length=249, Percent_Identity=26.5060240963855, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787601, Length=150, Percent_Identity=26, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788297, Length=249, Percent_Identity=26.5060240963855, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI48994962, Length=149, Percent_Identity=28.8590604026846, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787530, Length=255, Percent_Identity=21.9607843137255, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI145693193, Length=150, Percent_Identity=28, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789440, Length=182, Percent_Identity=24.1758241758242, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33630; Mature: 33630

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFQSLKLFLDITQTHSFIRSAENNYMSASTLTRHIQRIEQELGQPLFIRDNRQVRLTEA
CCCCCEEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEC
GEKFLLFAKQSWSDWQQLQQQLSPVQGQLEGELKVFCSVTAAYSHLPQILEQFRQAHPKV
CCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCE
EIKLSTGDPAQAVHTVHSFEADISLTGKPEHLPNSIVFHYIDDIHLSIIAPRVACVATQY
EEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHH
LQQQPIDWQNIPFILPVDGPVRKRIDRWFKELKIREPKIYATVAGHEAIVPMVALGFGVA
HHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHH
LLPDVVIKHSPMNNQVSYLKLADPISPFELGICVQEKRLQEPIIKAFWELLPKD
HHHHHHHCCCCCCCCEEEEEECCCCCCHHHEEEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEFQSLKLFLDITQTHSFIRSAENNYMSASTLTRHIQRIEQELGQPLFIRDNRQVRLTEA
CCCCCEEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEC
GEKFLLFAKQSWSDWQQLQQQLSPVQGQLEGELKVFCSVTAAYSHLPQILEQFRQAHPKV
CCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCE
EIKLSTGDPAQAVHTVHSFEADISLTGKPEHLPNSIVFHYIDDIHLSIIAPRVACVATQY
EEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHH
LQQQPIDWQNIPFILPVDGPVRKRIDRWFKELKIREPKIYATVAGHEAIVPMVALGFGVA
HHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHH
LLPDVVIKHSPMNNQVSYLKLADPISPFELGICVQEKRLQEPIIKAFWELLPKD
HHHHHHHCCCCCCCCEEEEEECCCCCCHHHEEEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]