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The map label for this gene is sdaA [H]

Identifier: 126208333

GI number: 126208333

Start: 996347

End: 997726

Strand: Direct

Name: sdaA [H]

Synonym: APL_0857

Alternate gene names: 126208333

Gene position: 996347-997726 (Clockwise)

Preceding gene: 126208332

Following gene: 126208336

Centisome position: 43.81

GC content: 43.55

Gene sequence:

>1380_bases
ATGATTAGTGTATTTGATATTTTTAAAGTAGGCATAGGCCCTTCCAGCTCACATACGGTCGGACCGATGAAAGCCGCCAA
ACAATTTATTGATGAATTACTGGTTCGCAAACTTTTGGCTAAAACAGACCGCTTGCAGGCCGATATTTACGGTTCGCTTG
CGCTAACCGGTCGAGGCCATAGCACCGATATTGCGGTGGTAATGGGCTTAATGGGATATTTACCCGATAACGTGGATATC
GAACGAATTGAAACGGTTATCGAACAAGTGAAGCAAGAAAGCAGATTAGTTGTTGCCGAAGCGATACCGGAAATGGCAAA
AACCATCATTTTCGATTTCTATAAAGATATGCCTTTTCATTACGATTTCTTAGCTCGTCATGAAAACGGAATGATTTTAA
AAGCGTTTGAAGGCGAAACACTGTTATTTGAAAAAACTTTCTATTCTATCGGAGGCGGTTTTATCGTTGATGATGAAAAT
TTTGACAAACAATCCGACGATACCCTATCCGTGCCGTTCCCTTATAAAAATGCGGAAGATTTACTTAAGCATTGTAAAGA
ACAAGGATTACCGCTTTCCAGTTTAGTATGGAAAAACGAAACGGCTCTGCGTCCGAAACAAGAAATCTCTGATTACCTTG
CTAAAATTTGGAAAACGATGGAAGACTGTATCCAACACGGTTTACACACGGAAGGATTATTGCCCGGTCCATTAAAAGTG
GTACGCCGCGCGCCGTCTTTACGCAGAACATTAGAAGCAACCGGCAAATTTAATACTGACCCGATGCAAATTATTGACTG
GGTAAATATGTTTGCGCTTGCAGTGAATGAAGAAAATGCGGCGGGCGGACGTGTTGTTACCGCACCGACTAACGGTGCTT
GCGGTATTGTGCCGGCAGTATTGGCTTACTATCAGCAATTTATCGCACCGCTTAATCAAGAAACGATCGAGCGTTATTTA
TTGGCGTGTAGCGTTGTCGGTACACTGTACAAAATGAATGCGTCTATTTCCGGTGCGGAAGTAGGTTGCCAAGGTGAAGT
CGGCGTAGCTTGTTCAATGGCGGCAGCCGGTTTAACCGAGATCATGGGAGGAACACCCGATCAAGTGTGTATCGCAGCTG
AAATCGCAATGGAACACAACCTCGGCTTAACCTGTGACCCGGTTGGCGGACAAGTACAAGTACCTTGTATCGAACGTAAT
GCGATTGCTTCGGTTAAGGCGATCAACGCAAGTCGCATGGCTTTACGCTTAACATCGCAACCTCGAGTGACTTTAGATAA
AGTGATCGAAACGATGTATGAAACAGGTAAAGATATGAATGCTAAATACCGTGAAACTTCAACCGGCGGTTTAGCAATTA
AAATTTTACCTTGCGATTAA

Upstream 100 bases:

>100_bases
TATAATCGCTGTATAATCGCTCCCTTTCCAATTTTCAGGCAATAAACCTAATATATCTTTGGTGTTTATTGCCTTTTTAA
CATAGAGTGTTTTAGATATT

Downstream 100 bases:

>100_bases
GCATTGTATTTGACAACGAGTGCTTAACGACTTATGATTTGAAGAACTGAGCGGATTAACCGCTCAGTTGAGTTATTTCT
TATTAGTAAGCTGGGGAGCT

Product: L-serine dehydratase

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MISVFDIFKVGIGPSSSHTVGPMKAAKQFIDELLVRKLLAKTDRLQADIYGSLALTGRGHSTDIAVVMGLMGYLPDNVDI
ERIETVIEQVKQESRLVVAEAIPEMAKTIIFDFYKDMPFHYDFLARHENGMILKAFEGETLLFEKTFYSIGGGFIVDDEN
FDKQSDDTLSVPFPYKNAEDLLKHCKEQGLPLSSLVWKNETALRPKQEISDYLAKIWKTMEDCIQHGLHTEGLLPGPLKV
VRRAPSLRRTLEATGKFNTDPMQIIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYQQFIAPLNQETIERYL
LACSVVGTLYKMNASISGAEVGCQGEVGVACSMAAAGLTEIMGGTPDQVCIAAEIAMEHNLGLTCDPVGGQVQVPCIERN
AIASVKAINASRMALRLTSQPRVTLDKVIETMYETGKDMNAKYRETSTGGLAIKILPCD

Sequences:

>Translated_459_residues
MISVFDIFKVGIGPSSSHTVGPMKAAKQFIDELLVRKLLAKTDRLQADIYGSLALTGRGHSTDIAVVMGLMGYLPDNVDI
ERIETVIEQVKQESRLVVAEAIPEMAKTIIFDFYKDMPFHYDFLARHENGMILKAFEGETLLFEKTFYSIGGGFIVDDEN
FDKQSDDTLSVPFPYKNAEDLLKHCKEQGLPLSSLVWKNETALRPKQEISDYLAKIWKTMEDCIQHGLHTEGLLPGPLKV
VRRAPSLRRTLEATGKFNTDPMQIIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYQQFIAPLNQETIERYL
LACSVVGTLYKMNASISGAEVGCQGEVGVACSMAAAGLTEIMGGTPDQVCIAAEIAMEHNLGLTCDPVGGQVQVPCIERN
AIASVKAINASRMALRLTSQPRVTLDKVIETMYETGKDMNAKYRETSTGGLAIKILPCD
>Mature_459_residues
MISVFDIFKVGIGPSSSHTVGPMKAAKQFIDELLVRKLLAKTDRLQADIYGSLALTGRGHSTDIAVVMGLMGYLPDNVDI
ERIETVIEQVKQESRLVVAEAIPEMAKTIIFDFYKDMPFHYDFLARHENGMILKAFEGETLLFEKTFYSIGGGFIVDDEN
FDKQSDDTLSVPFPYKNAEDLLKHCKEQGLPLSSLVWKNETALRPKQEISDYLAKIWKTMEDCIQHGLHTEGLLPGPLKV
VRRAPSLRRTLEATGKFNTDPMQIIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYQQFIAPLNQETIERYL
LACSVVGTLYKMNASISGAEVGCQGEVGVACSMAAAGLTEIMGGTPDQVCIAAEIAMEHNLGLTCDPVGGQVQVPCIERN
AIASVKAINASRMALRLTSQPRVTLDKVIETMYETGKDMNAKYRETSTGGLAIKILPCD

Specific function: Deaminates Also Threonine, Particularly When It Is Present In High Concentration. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1789161, Length=459, Percent_Identity=65.359477124183, Blast_Score=635, Evalue=0.0,
Organism=Escherichia coli, GI1788116, Length=461, Percent_Identity=64.6420824295011, Blast_Score=624, Evalue=1e-180,
Organism=Escherichia coli, GI48994925, Length=456, Percent_Identity=62.5, Blast_Score=594, Evalue=1e-171,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 50252; Mature: 50252

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVFDIFKVGIGPSSSHTVGPMKAAKQFIDELLVRKLLAKTDRLQADIYGSLALTGRGH
CCCCEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCC
STDIAVVMGLMGYLPDNVDIERIETVIEQVKQESRLVVAEAIPEMAKTIIFDFYKDMPFH
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHCCCCC
YDFLARHENGMILKAFEGETLLFEKTFYSIGGGFIVDDENFDKQSDDTLSVPFPYKNAED
CHHHEECCCCEEEEEECCCEEEEEHHHHHCCCCEEECCCCCCCCCCCEEECCCCCCCHHH
LLKHCKEQGLPLSSLVWKNETALRPKQEISDYLAKIWKTMEDCIQHGLHTEGLLPGPLKV
HHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
VRRAPSLRRTLEATGKFNTDPMQIIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAV
HHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCHHHHHH
LAYYQQFIAPLNQETIERYLLACSVVGTLYKMNASISGAEVGCQGEVGVACSMAAAGLTE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IMGGTPDQVCIAAEIAMEHNLGLTCDPVGGQVQVPCIERNAIASVKAINASRMALRLTSQ
HHCCCCCCEEEHHHHHHHCCCCEEECCCCCEEEEEEECCCHHHHHHHCCCCEEEEEECCC
PRVTLDKVIETMYETGKDMNAKYRETSTGGLAIKILPCD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MISVFDIFKVGIGPSSSHTVGPMKAAKQFIDELLVRKLLAKTDRLQADIYGSLALTGRGH
CCCCEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCC
STDIAVVMGLMGYLPDNVDIERIETVIEQVKQESRLVVAEAIPEMAKTIIFDFYKDMPFH
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHCCCCC
YDFLARHENGMILKAFEGETLLFEKTFYSIGGGFIVDDENFDKQSDDTLSVPFPYKNAED
CHHHEECCCCEEEEEECCCEEEEEHHHHHCCCCEEECCCCCCCCCCCEEECCCCCCCHHH
LLKHCKEQGLPLSSLVWKNETALRPKQEISDYLAKIWKTMEDCIQHGLHTEGLLPGPLKV
HHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
VRRAPSLRRTLEATGKFNTDPMQIIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAV
HHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCHHHHHH
LAYYQQFIAPLNQETIERYLLACSVVGTLYKMNASISGAEVGCQGEVGVACSMAAAGLTE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IMGGTPDQVCIAAEIAMEHNLGLTCDPVGGQVQVPCIERNAIASVKAINASRMALRLTSQ
HHCCCCCCEEEHHHHHHHCCCCEEECCCCCEEEEEEECCCHHHHHHHCCCCEEEEEECCC
PRVTLDKVIETMYETGKDMNAKYRETSTGGLAIKILPCD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]