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The map label for this gene is hbpA [H]

Identifier: 126208331

GI number: 126208331

Start: 993070

End: 994665

Strand: Reverse

Name: hbpA [H]

Synonym: APL_0855

Alternate gene names: 126208331

Gene position: 994665-993070 (Counterclockwise)

Preceding gene: 126208334

Following gene: 126208329

Centisome position: 43.73

GC content: 41.92

Gene sequence:

>1596_bases
ATGCGCTTTTCTAAGATTTTTTTCGCCCTACCTTTTATTAGTTTCTCGCCTTTTTTAGCAGCAGCGCCGGCACATACTTT
AGTAAATTGTGTCGCTACCGCTCCTCAAAAATTAAGCCCGGCAATTACCAACGATGCGAATGACTTTAACGCCAGTTCGC
AGCAAATTTATGACCGCCTATTGGCGTTTAAAGCCGGCAAAATTGATATCGAGCCGAGTTTGGCGGAAAAGTGGGAAGTG
AGTGAAGACGGTTTAACCTATACTTTCCATCTACGTAAAGATGTACAGTTTCACAGTAACAAGTTATTTACCCCAAGTCG
TAATTTAAATGCCGATGACGTGGTATTTTCTTTTCAACGTCAGGCGGATAAAAGTCACCCTTACTACAATGTTTCCGGCG
GCACTTATTTCTATTATCAATGGATGAATCTACCGAAAATTTTAAAATCGGTTGAGAAAGTTGATGATTATACGGTGAAA
ATGACGCTGAATCAGCCGAATAGTCCGTTTTTGACAACAGTTGCAATGGATTTCTTATCGATTTATTCCAAAGAATATGC
GGATAAATTATTAGCGGAAGGCAAGCCGGAATTATTAGATCAACAACCGATTGGCACGGGGCCGTTTGAATTTCAAGTTT
ATCAAACCGATCAGGCGGTACGTTATAAAGAGAACCCGAATTATTGGCAAGGTAAAGCAAAATTTGAGCGATTAATTTTT
GCGATTACTCCTGATGCCGGTACACGCTATGCCAAACTGAAAGCCGGTGAGTGTGATGTGATTGATTTCCCGAATATCGC
CGATATTGCACAAATGAAACAAGATCCTAAAGTGACGTTATTTGAGCGTGAAGGGTTAAATTTAGCTTATCTCGGACTCA
ATACCCAAAAAGCAGCATTAGATAATGTGAAGGTGCGCCAAGCACTACAACACGCTACCGATAAAAAAGCGATTGTTGCT
GCAGTATTCCAAGGCGGCGGTACGGTGGCGACTAATCCGTTCCCAAATTCGGTGCTTGGTTACAATGAAAATTTAGCTCA
GTATGAATTTGATTTGGAAAAAGCGAAAAATCTATTGGCGGAAGCAGGTTATCCGAACGGTTTTGAAACTGAAATCTGGG
TACAACCGGTGGTGCGCCCGTCAAATCCGAATCCAAGACGTACTGCAGAAATTATTCAAGCGGATTGGGCGAAAATTGGG
GTAAAAGCGAAATTAGTCTGCCACGAATGGGCGGATTTTAATAAGCGAACTCGTGAAGGCGAATTTTCAGCCGGTACTTA
CGGTTGGACGAGTCGTAACGGTGATCCGGACAATTTCCTGTTCCCGTTATTAAGCAAAGAAAATATTCCGGGCACCAATT
ATTCCCGTTGGACGGATAACGAATTTGAGGGCTTATTACAAAAAGCGGTACAAACACGAAATACCGCTGAACGTACACAG
TTATATCAACAAGCGGTCGAAATTTTCCAAAAAAATACACCGATAATTCCGATTGCTCATGCGATTAACTATGTACCGGT
CAGCAAACGTGTGCAAGGCTTTGTACAAAGCCCGTTCGGTTATACGTCTTTCTATAATGTGAGTCTAACGGAATAA

Upstream 100 bases:

>100_bases
GCATACGATTTATTAGTTATAAGAATGTTGATTTTGTTATTTCAAATTTATCTAAAAATGCCGTATGTTCGGAAAAATCA
ATCTATTTGAGGATTATTTT

Downstream 100 bases:

>100_bases
TTTTACGAGCCGGATCGCAAAATTCTGTTTTTTCTCAGCTTTTTTGTTAAGACCTCGATAAACTGTATGTTTATGGAGGT
CTTATGGTGTCAATTAGCAT

Product: heme-binding protein A precursor

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MRFSKIFFALPFISFSPFLAAAPAHTLVNCVATAPQKLSPAITNDANDFNASSQQIYDRLLAFKAGKIDIEPSLAEKWEV
SEDGLTYTFHLRKDVQFHSNKLFTPSRNLNADDVVFSFQRQADKSHPYYNVSGGTYFYYQWMNLPKILKSVEKVDDYTVK
MTLNQPNSPFLTTVAMDFLSIYSKEYADKLLAEGKPELLDQQPIGTGPFEFQVYQTDQAVRYKENPNYWQGKAKFERLIF
AITPDAGTRYAKLKAGECDVIDFPNIADIAQMKQDPKVTLFEREGLNLAYLGLNTQKAALDNVKVRQALQHATDKKAIVA
AVFQGGGTVATNPFPNSVLGYNENLAQYEFDLEKAKNLLAEAGYPNGFETEIWVQPVVRPSNPNPRRTAEIIQADWAKIG
VKAKLVCHEWADFNKRTREGEFSAGTYGWTSRNGDPDNFLFPLLSKENIPGTNYSRWTDNEFEGLLQKAVQTRNTAERTQ
LYQQAVEIFQKNTPIIPIAHAINYVPVSKRVQGFVQSPFGYTSFYNVSLTE

Sequences:

>Translated_531_residues
MRFSKIFFALPFISFSPFLAAAPAHTLVNCVATAPQKLSPAITNDANDFNASSQQIYDRLLAFKAGKIDIEPSLAEKWEV
SEDGLTYTFHLRKDVQFHSNKLFTPSRNLNADDVVFSFQRQADKSHPYYNVSGGTYFYYQWMNLPKILKSVEKVDDYTVK
MTLNQPNSPFLTTVAMDFLSIYSKEYADKLLAEGKPELLDQQPIGTGPFEFQVYQTDQAVRYKENPNYWQGKAKFERLIF
AITPDAGTRYAKLKAGECDVIDFPNIADIAQMKQDPKVTLFEREGLNLAYLGLNTQKAALDNVKVRQALQHATDKKAIVA
AVFQGGGTVATNPFPNSVLGYNENLAQYEFDLEKAKNLLAEAGYPNGFETEIWVQPVVRPSNPNPRRTAEIIQADWAKIG
VKAKLVCHEWADFNKRTREGEFSAGTYGWTSRNGDPDNFLFPLLSKENIPGTNYSRWTDNEFEGLLQKAVQTRNTAERTQ
LYQQAVEIFQKNTPIIPIAHAINYVPVSKRVQGFVQSPFGYTSFYNVSLTE
>Mature_531_residues
MRFSKIFFALPFISFSPFLAAAPAHTLVNCVATAPQKLSPAITNDANDFNASSQQIYDRLLAFKAGKIDIEPSLAEKWEV
SEDGLTYTFHLRKDVQFHSNKLFTPSRNLNADDVVFSFQRQADKSHPYYNVSGGTYFYYQWMNLPKILKSVEKVDDYTVK
MTLNQPNSPFLTTVAMDFLSIYSKEYADKLLAEGKPELLDQQPIGTGPFEFQVYQTDQAVRYKENPNYWQGKAKFERLIF
AITPDAGTRYAKLKAGECDVIDFPNIADIAQMKQDPKVTLFEREGLNLAYLGLNTQKAALDNVKVRQALQHATDKKAIVA
AVFQGGGTVATNPFPNSVLGYNENLAQYEFDLEKAKNLLAEAGYPNGFETEIWVQPVVRPSNPNPRRTAEIIQADWAKIG
VKAKLVCHEWADFNKRTREGEFSAGTYGWTSRNGDPDNFLFPLLSKENIPGTNYSRWTDNEFEGLLQKAVQTRNTAERTQ
LYQQAVEIFQKNTPIIPIAHAINYVPVSKRVQGFVQSPFGYTSFYNVSLTE

Specific function: Important role in heme acquisition or metabolism [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=513, Percent_Identity=50.682261208577, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1787551, Length=501, Percent_Identity=35.1297405189621, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1787762, Length=526, Percent_Identity=29.467680608365, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1787052, Length=499, Percent_Identity=29.0581162324649, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1789887, Length=482, Percent_Identity=25.5186721991701, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789397, Length=552, Percent_Identity=25.5434782608696, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787495, Length=514, Percent_Identity=24.9027237354086, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87081878, Length=472, Percent_Identity=23.728813559322, Blast_Score=89, Evalue=9e-19,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 60043; Mature: 60043

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSKIFFALPFISFSPFLAAAPAHTLVNCVATAPQKLSPAITNDANDFNASSQQIYDRL
CCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHH
LAFKAGKIDIEPSLAEKWEVSEDGLTYTFHLRKDVQFHSNKLFTPSRNLNADDVVFSFQR
HHHCCCCEECCCCHHHHCCCCCCCEEEEEEEEECCEECCCEEECCCCCCCHHHHHHHHHH
QADKSHPYYNVSGGTYFYYQWMNLPKILKSVEKVDDYTVKMTLNQPNSPFLTTVAMDFLS
HCCCCCCEEECCCCEEEEEEECCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHH
IYSKEYADKLLAEGKPELLDQQPIGTGPFEFQVYQTDQAVRYKENPNYWQGKAKFERLIF
HHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCHHCEEEEEE
AITPDAGTRYAKLKAGECDVIDFPNIADIAQMKQDPKVTLFEREGLNLAYLGLNTQKAAL
EECCCCCCCEEEEECCCCCEECCCCHHHHHHHCCCCCEEEEECCCCEEEEEECCCHHHHH
DNVKVRQALQHATDKKAIVAAVFQGGGTVATNPFPNSVLGYNENLAQYEFDLEKAKNLLA
HHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCCHHHHEECHHHHHHHHH
EAGYPNGFETEIWVQPVVRPSNPNPRRTAEIIQADWAKIGVKAKLVCHEWADFNKRTREG
HCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEHHHHCCCCCCCCC
EFSAGTYGWTSRNGDPDNFLFPLLSKENIPGTNYSRWTDNEFEGLLQKAVQTRNTAERTQ
CCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
LYQQAVEIFQKNTPIIPIAHAINYVPVSKRVQGFVQSPFGYTSFYNVSLTE
HHHHHHHHHHCCCCEEEHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEECC
>Mature Secondary Structure
MRFSKIFFALPFISFSPFLAAAPAHTLVNCVATAPQKLSPAITNDANDFNASSQQIYDRL
CCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHH
LAFKAGKIDIEPSLAEKWEVSEDGLTYTFHLRKDVQFHSNKLFTPSRNLNADDVVFSFQR
HHHCCCCEECCCCHHHHCCCCCCCEEEEEEEEECCEECCCEEECCCCCCCHHHHHHHHHH
QADKSHPYYNVSGGTYFYYQWMNLPKILKSVEKVDDYTVKMTLNQPNSPFLTTVAMDFLS
HCCCCCCEEECCCCEEEEEEECCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHH
IYSKEYADKLLAEGKPELLDQQPIGTGPFEFQVYQTDQAVRYKENPNYWQGKAKFERLIF
HHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCHHCEEEEEE
AITPDAGTRYAKLKAGECDVIDFPNIADIAQMKQDPKVTLFEREGLNLAYLGLNTQKAAL
EECCCCCCCEEEEECCCCCEECCCCHHHHHHHCCCCCEEEEECCCCEEEEEECCCHHHHH
DNVKVRQALQHATDKKAIVAAVFQGGGTVATNPFPNSVLGYNENLAQYEFDLEKAKNLLA
HHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCCHHHHEECHHHHHHHHH
EAGYPNGFETEIWVQPVVRPSNPNPRRTAEIIQADWAKIGVKAKLVCHEWADFNKRTREG
HCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEHHHHCCCCCCCCC
EFSAGTYGWTSRNGDPDNFLFPLLSKENIPGTNYSRWTDNEFEGLLQKAVQTRNTAERTQ
CCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
LYQQAVEIFQKNTPIIPIAHAINYVPVSKRVQGFVQSPFGYTSFYNVSLTE
HHHHHHHHHHCCCCEEEHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]