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The map label for this gene is pntB [H]

Identifier: 126208317

GI number: 126208317

Start: 976069

End: 977517

Strand: Reverse

Name: pntB [H]

Synonym: APL_0841

Alternate gene names: 126208317

Gene position: 977517-976069 (Counterclockwise)

Preceding gene: 126208318

Following gene: 126208312

Centisome position: 42.98

GC content: 44.79

Gene sequence:

>1449_bases
ATGTCTTTTGGATTTGTAACGGCCGCATATATTATTGCTGCGATTCTCTTTATTATGAGTTTAGCAGGACTTTCTAAACA
CGAAACGGCAAAAGCGGGTTGTTGGTACGGTATCGTCGGGATGGCGATTGCGTTAGTCGCAACTATCTTCGGTCCGCAAT
CGCAAGGTACGCTTTGGATCTTAATCGCAATGGCAATCGGCGGATTTATCGGTGTGAGAAAAGCCGTAAAAGTTGAAATG
ACGGAAATGCCGGAACTAGTGGCGATTCTACATAGCTTTGTCGGTTTAGCTGCGGTATTAGTCGGTTTTAACAGCTACGG
TTTACACGTAGATGCGATTCCACCGGCAAACTTAGATGAAGTGGCACTAGCGGCATTCCAAGCCGAACAAGCGACACTCG
CTAACATTCATAATGTTGAAGTGTTCCTCGGTATCTTTATCGGTGCGGTAACATTCTCCGGTTCATTAGTGGCATTCGGT
AAATTAAGCGGTAAATTATTCGGTCGTAAAGTGTCTTCGGCTGCATTAAATATTCCGCATAAACACAAATGGAACTTAGC
GGCATTAATCGTTTCCGCATTATTAATGATCGTCTTCTTAAATCACCCTGAGAATATTTTCCCGGTGTTGATTATGACGG
TAATCGCATTAGTATTCGGTTGGCACTTAGTATCGTCTATCGGCGGTGCGGATATGCCGGTAGTGGTTTCAATGCTGAAT
TCATATTCGGGTTGGGCGGCGGCGGCGGCCGGTTTTATGTTAAGTAATGACTTGCTCATTGTAACCGGTGCGTTAGTAGG
TTCGTCCGGTGCGATTTTGTCTTACATTATGTGTAAAGCAATGAACCGCTCGTTTATCAGCGTGATTGCAGGCGGCTTCG
GTACGGAAGTTAAAGCAAGCTCAGGTGATGAAGAACAAGGTGAGCATCGTGAAACTACTGCGGAAGAAGTGGCGGAAATG
CTGAAAAATGCAAGTTCTGTGATTATCACTCCGGGATACGGTATGGCGGTGGCACAAGCACAATATCCGGTTGCGGAAAT
TACGGCGAAATTACGTGAGAAAGGTGTGAATGTGCGTTTCGGTATTCACCCTGTCGCAGGTCGTTTACCGGGTCATATGA
ACGTATTACTTGCGGAAGCGAAAGTGCCTTACGATGTGGTACTTGAAATGGATGAAATCAATGATGATTTCGAAGAAACC
GATGTCGTATTGGTTATCGGTGCAAATGACACGGTAAACCCAGCGGCATTAGATGATCCGTCAAGCCCAATCGCAGGTAT
GCCGGTATTAGAAGTGTGGAAAGCACAAAACGTTATCGTATTCAAACGTTCAATGGCGGTTGGTTACGCAGGCGTTCAAA
ATCCTCTATTCTTCAAAGAAAATACTCAAATGTTATTCGGTGATGCGAAAGAGCGTGTGGATGACATTTTAAGAGCATTA
AATAGCTAA

Upstream 100 bases:

>100_bases
GCGTTTATTGCGATTTTAGTCGCAAGCATTAATATCTTCGGCGGTTTCAAAGTCACGCAACGTATGCTTGCGATGTTTAG
AAAAGGTTAAGGAGAAACTC

Downstream 100 bases:

>100_bases
TCCAGCGACATAAAAAAAGGGATCTTCGGATCTCTTTTTTGTTTTGTATTTATTGCTCCGTTCGAAATGTATAGATTCTA
CCAACCGCCCCCAATCGATT

Product: pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSFGFVTAAYIIAAILFIMSLAGLSKHETAKAGCWYGIVGMAIALVATIFGPQSQGTLWILIAMAIGGFIGVRKAVKVEM
TEMPELVAILHSFVGLAAVLVGFNSYGLHVDAIPPANLDEVALAAFQAEQATLANIHNVEVFLGIFIGAVTFSGSLVAFG
KLSGKLFGRKVSSAALNIPHKHKWNLAALIVSALLMIVFLNHPENIFPVLIMTVIALVFGWHLVSSIGGADMPVVVSMLN
SYSGWAAAAAGFMLSNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTEVKASSGDEEQGEHRETTAEEVAEM
LKNASSVIITPGYGMAVAQAQYPVAEITAKLREKGVNVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFEET
DVVLVIGANDTVNPAALDDPSSPIAGMPVLEVWKAQNVIVFKRSMAVGYAGVQNPLFFKENTQMLFGDAKERVDDILRAL
NS

Sequences:

>Translated_482_residues
MSFGFVTAAYIIAAILFIMSLAGLSKHETAKAGCWYGIVGMAIALVATIFGPQSQGTLWILIAMAIGGFIGVRKAVKVEM
TEMPELVAILHSFVGLAAVLVGFNSYGLHVDAIPPANLDEVALAAFQAEQATLANIHNVEVFLGIFIGAVTFSGSLVAFG
KLSGKLFGRKVSSAALNIPHKHKWNLAALIVSALLMIVFLNHPENIFPVLIMTVIALVFGWHLVSSIGGADMPVVVSMLN
SYSGWAAAAAGFMLSNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTEVKASSGDEEQGEHRETTAEEVAEM
LKNASSVIITPGYGMAVAQAQYPVAEITAKLREKGVNVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFEET
DVVLVIGANDTVNPAALDDPSSPIAGMPVLEVWKAQNVIVFKRSMAVGYAGVQNPLFFKENTQMLFGDAKERVDDILRAL
NS
>Mature_481_residues
SFGFVTAAYIIAAILFIMSLAGLSKHETAKAGCWYGIVGMAIALVATIFGPQSQGTLWILIAMAIGGFIGVRKAVKVEMT
EMPELVAILHSFVGLAAVLVGFNSYGLHVDAIPPANLDEVALAAFQAEQATLANIHNVEVFLGIFIGAVTFSGSLVAFGK
LSGKLFGRKVSSAALNIPHKHKWNLAALIVSALLMIVFLNHPENIFPVLIMTVIALVFGWHLVSSIGGADMPVVVSMLNS
YSGWAAAAAGFMLSNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTEVKASSGDEEQGEHRETTAEEVAEML
KNASSVIITPGYGMAVAQAQYPVAEITAKLREKGVNVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFEETD
VVLVIGANDTVNPAALDDPSSPIAGMPVLEVWKAQNVIVFKRSMAVGYAGVQNPLFFKENTQMLFGDAKERVDDILRALN
S

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=471, Percent_Identity=49.6815286624204, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI122939153, Length=471, Percent_Identity=49.6815286624204, Blast_Score=433, Evalue=1e-121,
Organism=Escherichia coli, GI1787886, Length=483, Percent_Identity=76.3975155279503, Blast_Score=713, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17550456, Length=481, Percent_Identity=47.8170478170478, Blast_Score=398, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 51140; Mature: 51009

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFGFVTAAYIIAAILFIMSLAGLSKHETAKAGCWYGIVGMAIALVATIFGPQSQGTLWI
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
LIAMAIGGFIGVRKAVKVEMTEMPELVAILHSFVGLAAVLVGFNSYGLHVDAIPPANLDE
HHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
VALAAFQAEQATLANIHNVEVFLGIFIGAVTFSGSLVAFGKLSGKLFGRKVSSAALNIPH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCC
KHKWNLAALIVSALLMIVFLNHPENIFPVLIMTVIALVFGWHLVSSIGGADMPVVVSMLN
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SYSGWAAAAAGFMLSNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTEVKAS
CCCCHHHHHHHHHHCCCEEEEEEEHHCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCC
SGDEEQGEHRETTAEEVAEMLKNASSVIITPGYGMAVAQAQYPVAEITAKLREKGVNVRF
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHCCCCHHHHHHHHHHCCCCEEE
GIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFEETDVVLVIGANDTVNPAALDDP
ECCHHCCCCCCCCEEEEECCCCCHHHEEEEHHCCCCCCCCCEEEEECCCCCCCCCCCCCC
SSPIAGMPVLEVWKAQNVIVFKRSMAVGYAGVQNPLFFKENTQMLFGDAKERVDDILRAL
CCCCCCCCHHHHHCCCCEEEEEEHHHHCCCCCCCCEEEECCCCEEECCHHHHHHHHHHHH
NS
CC
>Mature Secondary Structure 
SFGFVTAAYIIAAILFIMSLAGLSKHETAKAGCWYGIVGMAIALVATIFGPQSQGTLWI
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
LIAMAIGGFIGVRKAVKVEMTEMPELVAILHSFVGLAAVLVGFNSYGLHVDAIPPANLDE
HHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
VALAAFQAEQATLANIHNVEVFLGIFIGAVTFSGSLVAFGKLSGKLFGRKVSSAALNIPH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCC
KHKWNLAALIVSALLMIVFLNHPENIFPVLIMTVIALVFGWHLVSSIGGADMPVVVSMLN
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SYSGWAAAAAGFMLSNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTEVKAS
CCCCHHHHHHHHHHCCCEEEEEEEHHCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCC
SGDEEQGEHRETTAEEVAEMLKNASSVIITPGYGMAVAQAQYPVAEITAKLREKGVNVRF
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHCCCCHHHHHHHHHHCCCCEEE
GIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFEETDVVLVIGANDTVNPAALDDP
ECCHHCCCCCCCCEEEEECCCCCHHHEEEEHHCCCCCCCCCEEEEECCCCCCCCCCCCCC
SSPIAGMPVLEVWKAQNVIVFKRSMAVGYAGVQNPLFFKENTQMLFGDAKERVDDILRAL
CCCCCCCCHHHHHCCCCEEEEEEHHHHCCCCCCCCEEEECCCCEEECCHHHHHHHHHHHH
NS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 8635745 [H]