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The map label for this gene is gmhA

Identifier: 126208274

GI number: 126208274

Start: 920224

End: 920808

Strand: Direct

Name: gmhA

Synonym: APL_0798

Alternate gene names: 126208274

Gene position: 920224-920808 (Clockwise)

Preceding gene: 126208267

Following gene: 126208275

Centisome position: 40.46

GC content: 41.03

Gene sequence:

>585_bases
ATGTATTTAGCACAAATAAAAGCAGAACTCCAAGAAGCGGCCGACGTTTTAGACAAGTTTATGTCTGACGAAAAAAATAT
CCAATTAATCCAAGATGCCGCATTATTAATTTCTAATAGTTTTAAACAAGGCGGAAAAGTACTGTCATGCGGTAACGGCG
GTTCACACTGTGATGCGATGCACTTTGCCGAAGAATTAACAGGACGTTATCGTGAAAATCGCCCGGGTTATCCGGCGATC
GCTATTTCGGACGTTAGCCATTTAAGTTGCGTAAGTAATGATTTCGGTTACGAATACGTATTCTCTCGTTATCTTGAAGC
GGTAGGTCAAAAAGGCGATGTACTTTTCGGCTTATCAACTTCCGGTAACTCTAAAAACGTACTTAATGCAATTAAAGTCG
CTAAAGAAAAAGGTATGAAAGTGATTGCGATGACGGGTAAAGACGGCGGACAAATGGCAGGGTTAGCAGACGTCGAGATT
CGTGTTCCGCACTTCCGTTATGCTGACCGTACCCAAGAAATTCACATCAAAGTGATTCATATCCTCATGATGTTGATTGA
ATTTGAAATGGCAAAACAAGCATAG

Upstream 100 bases:

>100_bases
CTCTTGTTTACTTTAAGATAACAATCTCATACACTTTCGAACGCATCGAACCATATCGATGGTAAATTAACCATTCTATG
ATTAAGTTAAGGATTTTCTT

Downstream 100 bases:

>100_bases
TATTTAATACGAAAAATATTTTTAAGAAATCTATTGCTAAAGGACTGAAGTCAGAAATCGGCTCAGTCCTTTTTATTTTC
TTTGTTATTGTAAAACTGGG

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MYLAQIKAELQEAADVLDKFMSDEKNIQLIQDAALLISNSFKQGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAI
AISDVSHLSCVSNDFGYEYVFSRYLEAVGQKGDVLFGLSTSGNSKNVLNAIKVAKEKGMKVIAMTGKDGGQMAGLADVEI
RVPHFRYADRTQEIHIKVIHILMMLIEFEMAKQA

Sequences:

>Translated_194_residues
MYLAQIKAELQEAADVLDKFMSDEKNIQLIQDAALLISNSFKQGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAI
AISDVSHLSCVSNDFGYEYVFSRYLEAVGQKGDVLFGLSTSGNSKNVLNAIKVAKEKGMKVIAMTGKDGGQMAGLADVEI
RVPHFRYADRTQEIHIKVIHILMMLIEFEMAKQA
>Mature_194_residues
MYLAQIKAELQEAADVLDKFMSDEKNIQLIQDAALLISNSFKQGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAI
AISDVSHLSCVSNDFGYEYVFSRYLEAVGQKGDVLFGLSTSGNSKNVLNAIKVAKEKGMKVIAMTGKDGGQMAGLADVEI
RVPHFRYADRTQEIHIKVIHILMMLIEFEMAKQA

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1786416, Length=192, Percent_Identity=73.9583333333333, Blast_Score=303, Evalue=5e-84,
Organism=Escherichia coli, GI1789539, Length=162, Percent_Identity=40.7407407407407, Blast_Score=133, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_ACTP2 (A3N0F8)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053499.1
- ProteinModelPortal:   A3N0F8
- SMR:   A3N0F8
- STRING:   A3N0F8
- GeneID:   4849187
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0798
- eggNOG:   COG0279
- HOGENOM:   HBG671955
- OMA:   ANDLGYD
- PhylomeDB:   A3N0F8
- ProtClustDB:   PRK00414
- BioCyc:   APLE416269:APL_0798-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR004515
- InterPro:   IPR020620
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00441

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 21381; Mature: 21381

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS51464 SIS

Important sites: BINDING 65-65 BINDING 124-124 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLAQIKAELQEAADVLDKFMSDEKNIQLIQDAALLISNSFKQGGKVLSCGNGGSHCDAM
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHH
HFAEELTGRYRENRPGYPAIAISDVSHLSCVSNDFGYEYVFSRYLEAVGQKGDVLFGLST
HHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEC
SGNSKNVLNAIKVAKEKGMKVIAMTGKDGGQMAGLADVEIRVPHFRYADRTQEIHIKVIH
CCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
ILMMLIEFEMAKQA
HHHHHHHHHHHHCC
>Mature Secondary Structure
MYLAQIKAELQEAADVLDKFMSDEKNIQLIQDAALLISNSFKQGGKVLSCGNGGSHCDAM
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHH
HFAEELTGRYRENRPGYPAIAISDVSHLSCVSNDFGYEYVFSRYLEAVGQKGDVLFGLST
HHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEC
SGNSKNVLNAIKVAKEKGMKVIAMTGKDGGQMAGLADVEIRVPHFRYADRTQEIHIKVIH
CCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
ILMMLIEFEMAKQA
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA