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The map label for this gene is uvrA [H]

Identifier: 126208260

GI number: 126208260

Start: 899489

End: 902317

Strand: Reverse

Name: uvrA [H]

Synonym: APL_0782

Alternate gene names: 126208260

Gene position: 902317-899489 (Counterclockwise)

Preceding gene: 126208262

Following gene: 126208259

Centisome position: 39.67

GC content: 45.03

Gene sequence:

>2829_bases
ATGCAGTACATTGATGTTCGTGGTGCGCGAACCCACAACCTTAAAAATATCAATTTAATTCTTCCTCGAGATAAATTTAT
TGTAATTACCGGCTTATCCGGATCGGGTAAGTCTTCTTTAGCTTTTGATACATTGTATGCGGAAGGGCAACGCCGTTATG
TCGAATCCCTTTCCGCTTATGCACGCCAATTCCTTTCATTGATGGAAAAACCGGATGTTGACCATATTGAAGGGCTTTCA
CCAGCAATTTCTATTGAGCAAAAATCCACTTCGCATAATCCTCGTTCCACGGTCGGGACGGTAACCGAAATTCACGACTA
TTTACGTCTATTGTTTGCCCGAGTGGGTGAGCCTCGTTGTCCGGATCACGATTTACCGTTGGCAGCACAAACTATTTCAC
AAATGGTGGATAGAGTAATGGAAGAACCGGAGGGCAAGCGTTTGATGCTACTTGCGCCGGTGGTTAAAGATCGTAAAGGC
GAACACGTAAAATTATTGGAAAATTTGACCGCTTCCGGCTATATCCGAGCCAGAATTGACGGCGAAATCTGTGATTTATC
TGATCCGCCGGCATTGGAATTACAGAAAAAGCACACAATTGAAGTGGTGGTCGATCGCTTTAAAGTGAGAAGTGATATTG
CAACTCGCCTAGCGGAATCTTTTGAAACGGCATTGGATTTATCCGGTTCGACAGCGATTATTGCCGATATGGATGACCCG
AGTGCAGACGAAATCATCTTTTCGTCTAGTTTCGCTTGCCCGCATTGCGGCTATTCGTTGCACGAATTAGAACCTCGTTT
GTTCTCATTTAATAACCCGGCCGGTGCTTGTCCGATGTGTGACGGCTTAGGGGTAGAGCAGTATTTTGACCCGAACAAAG
TGGTACAAAATCCGGATGTCTCGTTAGCAAGCGGCGCAATTAAAGGTTGGGATCGCCGTAGCTTTTACTATTTCGGTTTG
TTGAAATCGGTGGCGGATCATTACGATTTTTCACTGGATACGCCGTTTAAAGATCTGACTAAAAAACAACGTGAAATTAT
TCTGAACGGTTCAAAAGACGAAATCGAATTTGTTTATGTTAATGATCGCGGTGATAAAGTAAAACGCAAACATACCTTTG
AGGGTGTGCTAAATAATATGGCTCGCCGTTATAAAGAAACCGAGTCGAATTCGGTGCGTGAAGAATTAGCGAAATATATC
AATAGCCGCCCGTGTTTAGAGTGTGAAGGATCTCGTTTACGTCGTGAGGCACGTTATGTCTTTTTAGATAAAACCAATTT
GCCGATGGTGTCGGAAAAATCGATTGGCGAAGCGTTAGAGTTTTTTGAACGTTTAGATCTTTCCGGACAAAAAGCGAAGA
TTGCGGAGAAAATTTTAAAAGAAATTCGTGAACGTTTGCAGTTCTTGGTCAATGTCGGCTTGAATTACCTCTCGCTTTCT
CGTTCGGCGGAAACCTTATCCGGCGGTGAGGCGCAACGTATCCGTTTAGCCAGCCAAATCGGTGCAGGCTTGGTTGGGGT
GATGTATGTGCTGGATGAGCCGTCTATCGGATTGCACCAACGTGATAACGAACGTTTATTAAATACCTTAATTCATCTGC
GTAATTTGGGTAATACCGTAATTGTGGTGGAGCATGATGAAGATGCGATCCGTGCCGCAGATCATATTGTCGATATCGGC
CCGGGAGCCGGTGTGCACGGTGGTCAAGTTATTGCACAAGGTACAGCGGAAGAAATTATGCAGGTGGAAGATTCGATTAC
CGGACAATTCCTCTCCGGCAAGCAGAAGATTGAAATTCCGGCAAAACGAGTGTCTTATGACGCGGCTAAATTGCTAACCT
TAAAAGGGGCAAGCGGTAATAACTTAAAACAAGTACAGTTGGATATTCCGGTTGGTTTATTCACTTGTATTACCGGTGTC
TCGGGTTCGGGTAAATCGACTCTAATCAACGATACCTTGTTCCCATTAGCACAAAATGCGTTAAATCGTGCGGAACGTAC
CGATGTCGCACCTTATGAGTCAATTGACGGCTTATCGCATTTCGATAAAGTGATTGATATCGACCAAAGCCCGATTGGGC
GTACACCACGTTCAAACCCGGCAACCTATACCGGTTTATTTACGCCGATTCGTGAATTATTTGCCGGTACGCAAGAAGCG
AGAGCGAGAGGCTATAATGTCGGACGCTTTAGTTTTAATGTGCGTGGCGGACGTTGTGAAGCCTGTCAAGGCGATGGCGT
GATTAAAGTGGAAATGCACTTCCTACCAGATGTATATGTGCCGTGTGATCATTGCAAAGGTAAACGTTATAACCGAGAAA
CTTTGGAAATCCGTTATAAAGGCAAAACGATTCATCAAGTGTTGGATATGACGGTGGAAGAAGCGAGAGAATTTTTCGCA
CCGGTACCGGCGATTGCGCGTAAATTGCAAACCTTAATGGATGTCGGTTTATCGTATATTCGCTTAGGACAGTCCTCGAC
CACGCTTTCCGGCGGTGAAGCGCAGCGTGTTAAATTAGCGACCGAGCTTTCCAAACGTGATACCGGCAAAACGCTGTATA
TCTTAGACGAACCGACCACCGGTTTACATTTTGCCGATATTAAACAGCTACTTTCGGTGTTACACAAATTGCGTGACCAA
GGTAATACGATTGTGGTGATCGAGCATAATTTAGATGTGATTAAAACCGCCGACTGGATTGTGGACTTAGGCCCTGAAGG
CGGTTCGGGCGGCGGACAAATTATTGCGACCGGCACACCGGAAGAGGTAGCGAAAGACAAACGCTCGCACACGGCAAGAT
TTTTAAAAGAGATCTTAGCTAAAGGGTAA

Upstream 100 bases:

>100_bases
CCTGAAATTCAAAAAAATGCACGCATTAAAACTGATATTTTGTACAGTTACTTTAAAATATGCGATAATAAAAAACATTT
TTTAGTGAGAGCAACCGATT

Downstream 100 bases:

>100_bases
ATGCCAAACGGTGTTTAACAAGCGGTCTGATTTTGCAGGAAATTTGCAAATTTCTTAGAAAATCAGACCGCTAGTTTTTA
ATAATAGACGAGTAAAACGA

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 942; Mature: 942

Protein sequence:

>942_residues
MQYIDVRGARTHNLKNINLILPRDKFIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLS
PAISIEQKSTSHNPRSTVGTVTEIHDYLRLLFARVGEPRCPDHDLPLAAQTISQMVDRVMEEPEGKRLMLLAPVVKDRKG
EHVKLLENLTASGYIRARIDGEICDLSDPPALELQKKHTIEVVVDRFKVRSDIATRLAESFETALDLSGSTAIIADMDDP
SADEIIFSSSFACPHCGYSLHELEPRLFSFNNPAGACPMCDGLGVEQYFDPNKVVQNPDVSLASGAIKGWDRRSFYYFGL
LKSVADHYDFSLDTPFKDLTKKQREIILNGSKDEIEFVYVNDRGDKVKRKHTFEGVLNNMARRYKETESNSVREELAKYI
NSRPCLECEGSRLRREARYVFLDKTNLPMVSEKSIGEALEFFERLDLSGQKAKIAEKILKEIRERLQFLVNVGLNYLSLS
RSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLNTLIHLRNLGNTVIVVEHDEDAIRAADHIVDIG
PGAGVHGGQVIAQGTAEEIMQVEDSITGQFLSGKQKIEIPAKRVSYDAAKLLTLKGASGNNLKQVQLDIPVGLFTCITGV
SGSGKSTLINDTLFPLAQNALNRAERTDVAPYESIDGLSHFDKVIDIDQSPIGRTPRSNPATYTGLFTPIRELFAGTQEA
RARGYNVGRFSFNVRGGRCEACQGDGVIKVEMHFLPDVYVPCDHCKGKRYNRETLEIRYKGKTIHQVLDMTVEEAREFFA
PVPAIARKLQTLMDVGLSYIRLGQSSTTLSGGEAQRVKLATELSKRDTGKTLYILDEPTTGLHFADIKQLLSVLHKLRDQ
GNTIVVIEHNLDVIKTADWIVDLGPEGGSGGGQIIATGTPEEVAKDKRSHTARFLKEILAKG

Sequences:

>Translated_942_residues
MQYIDVRGARTHNLKNINLILPRDKFIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLS
PAISIEQKSTSHNPRSTVGTVTEIHDYLRLLFARVGEPRCPDHDLPLAAQTISQMVDRVMEEPEGKRLMLLAPVVKDRKG
EHVKLLENLTASGYIRARIDGEICDLSDPPALELQKKHTIEVVVDRFKVRSDIATRLAESFETALDLSGSTAIIADMDDP
SADEIIFSSSFACPHCGYSLHELEPRLFSFNNPAGACPMCDGLGVEQYFDPNKVVQNPDVSLASGAIKGWDRRSFYYFGL
LKSVADHYDFSLDTPFKDLTKKQREIILNGSKDEIEFVYVNDRGDKVKRKHTFEGVLNNMARRYKETESNSVREELAKYI
NSRPCLECEGSRLRREARYVFLDKTNLPMVSEKSIGEALEFFERLDLSGQKAKIAEKILKEIRERLQFLVNVGLNYLSLS
RSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLNTLIHLRNLGNTVIVVEHDEDAIRAADHIVDIG
PGAGVHGGQVIAQGTAEEIMQVEDSITGQFLSGKQKIEIPAKRVSYDAAKLLTLKGASGNNLKQVQLDIPVGLFTCITGV
SGSGKSTLINDTLFPLAQNALNRAERTDVAPYESIDGLSHFDKVIDIDQSPIGRTPRSNPATYTGLFTPIRELFAGTQEA
RARGYNVGRFSFNVRGGRCEACQGDGVIKVEMHFLPDVYVPCDHCKGKRYNRETLEIRYKGKTIHQVLDMTVEEAREFFA
PVPAIARKLQTLMDVGLSYIRLGQSSTTLSGGEAQRVKLATELSKRDTGKTLYILDEPTTGLHFADIKQLLSVLHKLRDQ
GNTIVVIEHNLDVIKTADWIVDLGPEGGSGGGQIIATGTPEEVAKDKRSHTARFLKEILAKG
>Mature_942_residues
MQYIDVRGARTHNLKNINLILPRDKFIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLS
PAISIEQKSTSHNPRSTVGTVTEIHDYLRLLFARVGEPRCPDHDLPLAAQTISQMVDRVMEEPEGKRLMLLAPVVKDRKG
EHVKLLENLTASGYIRARIDGEICDLSDPPALELQKKHTIEVVVDRFKVRSDIATRLAESFETALDLSGSTAIIADMDDP
SADEIIFSSSFACPHCGYSLHELEPRLFSFNNPAGACPMCDGLGVEQYFDPNKVVQNPDVSLASGAIKGWDRRSFYYFGL
LKSVADHYDFSLDTPFKDLTKKQREIILNGSKDEIEFVYVNDRGDKVKRKHTFEGVLNNMARRYKETESNSVREELAKYI
NSRPCLECEGSRLRREARYVFLDKTNLPMVSEKSIGEALEFFERLDLSGQKAKIAEKILKEIRERLQFLVNVGLNYLSLS
RSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLNTLIHLRNLGNTVIVVEHDEDAIRAADHIVDIG
PGAGVHGGQVIAQGTAEEIMQVEDSITGQFLSGKQKIEIPAKRVSYDAAKLLTLKGASGNNLKQVQLDIPVGLFTCITGV
SGSGKSTLINDTLFPLAQNALNRAERTDVAPYESIDGLSHFDKVIDIDQSPIGRTPRSNPATYTGLFTPIRELFAGTQEA
RARGYNVGRFSFNVRGGRCEACQGDGVIKVEMHFLPDVYVPCDHCKGKRYNRETLEIRYKGKTIHQVLDMTVEEAREFFA
PVPAIARKLQTLMDVGLSYIRLGQSSTTLSGGEAQRVKLATELSKRDTGKTLYILDEPTTGLHFADIKQLLSVLHKLRDQ
GNTIVVIEHNLDVIKTADWIVDLGPEGGSGGGQIIATGTPEEVAKDKRSHTARFLKEILAKG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=940, Percent_Identity=79.7872340425532, Blast_Score=1566, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 104458; Mature: 104458

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYIDVRGARTHNLKNINLILPRDKFIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAY
CCEEECCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHH
ARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTVTEIHDYLRLLFARVGEPRC
HHHHHHHHCCCCCCHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
PDHDLPLAAQTISQMVDRVMEEPEGKRLMLLAPVVKDRKGEHVKLLENLTASGYIRARID
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECHHHCCCCCHHHHHHCCCCCCEEEEEEC
GEICDLSDPPALELQKKHTIEVVVDRFKVRSDIATRLAESFETALDLSGSTAIIADMDDP
CCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
SADEIIFSSSFACPHCGYSLHELEPRLFSFNNPAGACPMCDGLGVEQYFDPNKVVQNPDV
CCCCEEEECCCCCCCCCCHHHHCCCHHEECCCCCCCCCCCCCCCCHHHCCCCHHCCCCCC
SLASGAIKGWDRRSFYYFGLLKSVADHYDFSLDTPFKDLTKKQREIILNGSKDEIEFVYV
CHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEECCCCCCEEEEEE
NDRGDKVKRKHTFEGVLNNMARRYKETESNSVREELAKYINSRPCLECEGSRLRREARYV
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEE
FLDKTNLPMVSEKSIGEALEFFERLDLSGQKAKIAEKILKEIRERLQFLVNVGLNYLSLS
EEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHEECC
RSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLNTLIHLRNLGNTV
CCCHHCCCCCHHHHHHHHHHCCCCEEHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCEE
IVVEHDEDAIRAADHIVDIGPGAGVHGGQVIAQGTAEEIMQVEDSITGQFLSGKQKIEIP
EEEECCCHHHHHHHHEEECCCCCCCCCCEEEECCCHHHHHHHHHHHCCHHHCCCCEEECC
AKRVSYDAAKLLTLKGASGNNLKQVQLDIPVGLFTCITGVSGSGKSTLINDTLFPLAQNA
HHHHCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHHHCCCCCCCCEEECHHHHHHHHHH
LNRAERTDVAPYESIDGLSHFDKVIDIDQSPIGRTPRSNPATYTGLFTPIRELFAGTQEA
HHHHHHCCCCCCHHHCHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCHHH
RARGYNVGRFSFNVRGGRCEACQGDGVIKVEMHFLPDVYVPCDHCKGKRYNRETLEIRYK
HHCCCCEEEEEEEECCCEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEC
GKTIHQVLDMTVEEAREFFAPVPAIARKLQTLMDVGLSYIRLGQSSTTLSGGEAQRVKLA
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHEEECCCCCCCCCCCCHHHHHH
TELSKRDTGKTLYILDEPTTGLHFADIKQLLSVLHKLRDQGNTIVVIEHNLDVIKTADWI
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCEE
VDLGPEGGSGGGQIIATGTPEEVAKDKRSHTARFLKEILAKG
EEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQYIDVRGARTHNLKNINLILPRDKFIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAY
CCEEECCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHH
ARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTVTEIHDYLRLLFARVGEPRC
HHHHHHHHCCCCCCHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
PDHDLPLAAQTISQMVDRVMEEPEGKRLMLLAPVVKDRKGEHVKLLENLTASGYIRARID
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECHHHCCCCCHHHHHHCCCCCCEEEEEEC
GEICDLSDPPALELQKKHTIEVVVDRFKVRSDIATRLAESFETALDLSGSTAIIADMDDP
CCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
SADEIIFSSSFACPHCGYSLHELEPRLFSFNNPAGACPMCDGLGVEQYFDPNKVVQNPDV
CCCCEEEECCCCCCCCCCHHHHCCCHHEECCCCCCCCCCCCCCCCHHHCCCCHHCCCCCC
SLASGAIKGWDRRSFYYFGLLKSVADHYDFSLDTPFKDLTKKQREIILNGSKDEIEFVYV
CHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEECCCCCCEEEEEE
NDRGDKVKRKHTFEGVLNNMARRYKETESNSVREELAKYINSRPCLECEGSRLRREARYV
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEE
FLDKTNLPMVSEKSIGEALEFFERLDLSGQKAKIAEKILKEIRERLQFLVNVGLNYLSLS
EEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHEECC
RSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLNTLIHLRNLGNTV
CCCHHCCCCCHHHHHHHHHHCCCCEEHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCEE
IVVEHDEDAIRAADHIVDIGPGAGVHGGQVIAQGTAEEIMQVEDSITGQFLSGKQKIEIP
EEEECCCHHHHHHHHEEECCCCCCCCCCEEEECCCHHHHHHHHHHHCCHHHCCCCEEECC
AKRVSYDAAKLLTLKGASGNNLKQVQLDIPVGLFTCITGVSGSGKSTLINDTLFPLAQNA
HHHHCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHHHCCCCCCCCEEECHHHHHHHHHH
LNRAERTDVAPYESIDGLSHFDKVIDIDQSPIGRTPRSNPATYTGLFTPIRELFAGTQEA
HHHHHHCCCCCCHHHCHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCHHH
RARGYNVGRFSFNVRGGRCEACQGDGVIKVEMHFLPDVYVPCDHCKGKRYNRETLEIRYK
HHCCCCEEEEEEEECCCEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEC
GKTIHQVLDMTVEEAREFFAPVPAIARKLQTLMDVGLSYIRLGQSSTTLSGGEAQRVKLA
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHEEECCCCCCCCCCCCHHHHHH
TELSKRDTGKTLYILDEPTTGLHFADIKQLLSVLHKLRDQGNTIVVIEHNLDVIKTADWI
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCEE
VDLGPEGGSGGGQIIATGTPEEVAKDKRSHTARFLKEILAKG
EEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA