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The map label for this gene is uvrB [H]

Identifier: 126208147

GI number: 126208147

Start: 760899

End: 762920

Strand: Reverse

Name: uvrB [H]

Synonym: APL_0667

Alternate gene names: 126208147

Gene position: 762920-760899 (Counterclockwise)

Preceding gene: 126208151

Following gene: 126208146

Centisome position: 33.54

GC content: 45.94

Gene sequence:

>2022_bases
ATGAGCAAGCAAGGCAAACCTTTTATTTTACACAGCCCGTTTAAACCGTCTGGTGATCAGCCGTCAGCGATTGCCAAATT
GACCGAAGGGCTAAATGACGGATTGGCGCATCAAACGTTACTGGGGGTAACCGGTTCGGGTAAAACCTTTACCATTGCTA
ATGTGATCGCTCAACTCAATCGTCCGGCAATGTTGCTTGCGCCGAATAAAACGCTTGCCGCTCAGCTGTATGCCGAGATG
AAAGCCTTCTTCCCAGAAAATGCGGTGGAATACTTTGTCTCTTACTATGACTATTACCAACCGGAAGCCTATGTGCCGAG
TAGCGATACTTTTATCGAAAAAGATGCGTCGATTAACGAACAAATCGAACAGATGCGACTGTCGGCAACCAAATCATTCC
TTGAACGCCGAGATACCATTGTAGTTGCTTCTGTTTCAGCCATTTACGGCTTGGGGGACGTGGACGCTTATATGCAAATG
ATGTTGCATTTACAACTGGGGGCGATTATCGATCAACGAGAGATTCTCGCTCGCCTTGCCGAATTGCAATATACTCGCAA
CGATCAAGCATTTCAGCGTTCGACTTTCCGTGTGCGTGGCGAAGTGATTGATATTTTCCCTGCCGAATCGGACGAAATTG
CATTACGTGTTGAATTGTTTGACGATGAAATCGAAAGCCTTTCGTTGTTTGATCCGCTTACCGGACATAGCTTGGGCAAA
GTGCCTCGCTATACCATTTATCCGAAAACGCACTACGTTACCCCTCGTGAACGCATTTTGAATGCGATTGAAGAAATTAA
ACAAGAGTTGGTGGAACGCCGTGAGTATTTCATCAAAGAAAATAAATTATTGGAAGAACAACGCATTACCCAACGCACGC
AATTCGATATTGAAATGATGAATGAGCTGGGCTATTGCTCGGGTATCGAAAACTATTCACGCTACCTGTCGGGCAGAAAA
GAGGGCGAACCGCCTCCGACATTATTCGATTATATGCCGGCGGACGGTTTGCTGATTATTGACGAAAGCCATGTTACCGT
GCCGCAAATCGGCGGTATGTATCGAGGCGACCGAGCCAGAAAAGAAACGCTGGTGCAATACGGTTTCCGTTTGCCTTCAG
CATTGGATAACCGCCCGTTACGCTTTGAAGAATTTGAACGCCTTGCACCACAGACAATTTATGTTTCGGCAACACCGGGC
AATTATGAATTAGAAAAATCAAACGGTGATGTGGTGGATCAAGTGGTTCGCCCAACGGGATTATTAGACCCGATCATAGA
AGTTCGCCCTGTGGCCACGCAAGTTGATGATGTGTTATCGGAAATCCATAAACGAGTGGCGGTTGATGAACGAGTGTTAA
TTACTACGCTAACCAAAAAAATGGCGGAAGATTTAACCGATTATCTCGATGAACACGGCGTGCGTGTGCGTTATTTGCAT
AGCGATATTGATACGGTTGAACGGGTGGAAATTATTCACGACTTGCGAATGGGGATGTTTGACGTATTGGTCGGCATCAA
CTTGTTACGTGAGGGCTTAGATATGCCGGAAGTATCGCTGGTGGCGATTTTAGATGCGGATAAAGAAGGCTTTTTACGTT
CCGAACGTTCATTAATTCAGACCATCGGACGTGCCGCTCGAAACCTCAACGGCAAAGCGATTCTCTACGGCGACCGCATT
ACCAATTCTATGCAAAAAGCGATTACCGAAACCGAACGCCGCCGAGAAAAACAACAAAAATACAACGAAGAACACGGTAT
TACTCCGCAAGCCCTCAACAAAAAAGTAGGCGAATTGCTCGACATCGGACAAACCGACAAGCCGAAACGAGGCAAACAAG
CGGTCAAAGTCGAAGAAAAATCTGCAAATACCTACAAACCAAAATCCCGCAAAGAGCTGGAAAAAGAACTTAAACAGCTC
GAGCAACAAATGCGAGATTTCGCTAAAGATCTCGAGTTTGAAAAAGCGGCAGCGGTAAGGGATAAAATTGGGCAGTTGAA
GGCTGTATTGTTGGAGGTTTAG

Upstream 100 bases:

>100_bases
TTTGTGATCTGATTCACATTTTAGTTTGTAAATTTTTTTAGAAAATTGACCGCTTGCTTGTGCTAAAATCCTATCCGAAA
TTTCTTGGATAGGATGTTAT

Downstream 100 bases:

>100_bases
TAAGCAGCGGTCAAATTTCTTGAAAACTTTGCAAATTGTAAAAAATCAAGCGAATTTGACCGCTTGCTTTGACATTGGTA
TCGTATAAGCATATATTAAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MSKQGKPFILHSPFKPSGDQPSAIAKLTEGLNDGLAHQTLLGVTGSGKTFTIANVIAQLNRPAMLLAPNKTLAAQLYAEM
KAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINEQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDVDAYMQM
MLHLQLGAIIDQREILARLAELQYTRNDQAFQRSTFRVRGEVIDIFPAESDEIALRVELFDDEIESLSLFDPLTGHSLGK
VPRYTIYPKTHYVTPRERILNAIEEIKQELVERREYFIKENKLLEEQRITQRTQFDIEMMNELGYCSGIENYSRYLSGRK
EGEPPPTLFDYMPADGLLIIDESHVTVPQIGGMYRGDRARKETLVQYGFRLPSALDNRPLRFEEFERLAPQTIYVSATPG
NYELEKSNGDVVDQVVRPTGLLDPIIEVRPVATQVDDVLSEIHKRVAVDERVLITTLTKKMAEDLTDYLDEHGVRVRYLH
SDIDTVERVEIIHDLRMGMFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYGDRI
TNSMQKAITETERRREKQQKYNEEHGITPQALNKKVGELLDIGQTDKPKRGKQAVKVEEKSANTYKPKSRKELEKELKQL
EQQMRDFAKDLEFEKAAAVRDKIGQLKAVLLEV

Sequences:

>Translated_673_residues
MSKQGKPFILHSPFKPSGDQPSAIAKLTEGLNDGLAHQTLLGVTGSGKTFTIANVIAQLNRPAMLLAPNKTLAAQLYAEM
KAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINEQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDVDAYMQM
MLHLQLGAIIDQREILARLAELQYTRNDQAFQRSTFRVRGEVIDIFPAESDEIALRVELFDDEIESLSLFDPLTGHSLGK
VPRYTIYPKTHYVTPRERILNAIEEIKQELVERREYFIKENKLLEEQRITQRTQFDIEMMNELGYCSGIENYSRYLSGRK
EGEPPPTLFDYMPADGLLIIDESHVTVPQIGGMYRGDRARKETLVQYGFRLPSALDNRPLRFEEFERLAPQTIYVSATPG
NYELEKSNGDVVDQVVRPTGLLDPIIEVRPVATQVDDVLSEIHKRVAVDERVLITTLTKKMAEDLTDYLDEHGVRVRYLH
SDIDTVERVEIIHDLRMGMFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYGDRI
TNSMQKAITETERRREKQQKYNEEHGITPQALNKKVGELLDIGQTDKPKRGKQAVKVEEKSANTYKPKSRKELEKELKQL
EQQMRDFAKDLEFEKAAAVRDKIGQLKAVLLEV
>Mature_672_residues
SKQGKPFILHSPFKPSGDQPSAIAKLTEGLNDGLAHQTLLGVTGSGKTFTIANVIAQLNRPAMLLAPNKTLAAQLYAEMK
AFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINEQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDVDAYMQMM
LHLQLGAIIDQREILARLAELQYTRNDQAFQRSTFRVRGEVIDIFPAESDEIALRVELFDDEIESLSLFDPLTGHSLGKV
PRYTIYPKTHYVTPRERILNAIEEIKQELVERREYFIKENKLLEEQRITQRTQFDIEMMNELGYCSGIENYSRYLSGRKE
GEPPPTLFDYMPADGLLIIDESHVTVPQIGGMYRGDRARKETLVQYGFRLPSALDNRPLRFEEFERLAPQTIYVSATPGN
YELEKSNGDVVDQVVRPTGLLDPIIEVRPVATQVDDVLSEIHKRVAVDERVLITTLTKKMAEDLTDYLDEHGVRVRYLHS
DIDTVERVEIIHDLRMGMFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYGDRIT
NSMQKAITETERRREKQQKYNEEHGITPQALNKKVGELLDIGQTDKPKRGKQAVKVEEKSANTYKPKSRKELEKELKQLE
QQMRDFAKDLEFEKAAAVRDKIGQLKAVLLEV

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=670, Percent_Identity=79.1044776119403, Blast_Score=1064, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=23.4527687296417, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76680; Mature: 76548

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQGKPFILHSPFKPSGDQPSAIAKLTEGLNDGLAHQTLLGVTGSGKTFTIANVIAQLN
CCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHEEECCCCCEEHHHHHHHHCC
RPAMLLAPNKTLAAQLYAEMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINE
CCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
QIEQMRLSATKSFLERRDTIVVASVSAIYGLGDVDAYMQMMLHLQLGAIIDQREILARLA
HHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELQYTRNDQAFQRSTFRVRGEVIDIFPAESDEIALRVELFDDEIESLSLFDPLTGHSLGK
HHHHCCCCHHHHHHHHEEECCEEEEECCCCCCEEEEEEEECCHHHHHHHCCCCCCCCCCC
VPRYTIYPKTHYVTPRERILNAIEEIKQELVERREYFIKENKLLEEQRITQRTQFDIEMM
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NELGYCSGIENYSRYLSGRKEGEPPPTLFDYMPADGLLIIDESHVTVPQIGGMYRGDRAR
HHCHHHCCHHHHHHHHCCCCCCCCCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHH
KETLVQYGFRLPSALDNRPLRFEEFERLAPQTIYVSATPGNYELEKSNGDVVDQVVRPTG
HHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHCCCC
LLDPIIEVRPVATQVDDVLSEIHKRVAVDERVLITTLTKKMAEDLTDYLDEHGVRVRYLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
SDIDTVERVEIIHDLRMGMFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHH
TIGRAARNLNGKAILYGDRITNSMQKAITETERRREKQQKYNEEHGITPQALNKKVGELL
HHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
DIGQTDKPKRGKQAVKVEEKSANTYKPKSRKELEKELKQLEQQMRDFAKDLEFEKAAAVR
CCCCCCCCCCCCHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DKIGQLKAVLLEV
HHHHHHHHHHHCC
>Mature Secondary Structure 
SKQGKPFILHSPFKPSGDQPSAIAKLTEGLNDGLAHQTLLGVTGSGKTFTIANVIAQLN
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHEEECCCCCEEHHHHHHHHCC
RPAMLLAPNKTLAAQLYAEMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINE
CCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
QIEQMRLSATKSFLERRDTIVVASVSAIYGLGDVDAYMQMMLHLQLGAIIDQREILARLA
HHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELQYTRNDQAFQRSTFRVRGEVIDIFPAESDEIALRVELFDDEIESLSLFDPLTGHSLGK
HHHHCCCCHHHHHHHHEEECCEEEEECCCCCCEEEEEEEECCHHHHHHHCCCCCCCCCCC
VPRYTIYPKTHYVTPRERILNAIEEIKQELVERREYFIKENKLLEEQRITQRTQFDIEMM
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NELGYCSGIENYSRYLSGRKEGEPPPTLFDYMPADGLLIIDESHVTVPQIGGMYRGDRAR
HHCHHHCCHHHHHHHHCCCCCCCCCCCHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHH
KETLVQYGFRLPSALDNRPLRFEEFERLAPQTIYVSATPGNYELEKSNGDVVDQVVRPTG
HHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHCCCC
LLDPIIEVRPVATQVDDVLSEIHKRVAVDERVLITTLTKKMAEDLTDYLDEHGVRVRYLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
SDIDTVERVEIIHDLRMGMFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHH
TIGRAARNLNGKAILYGDRITNSMQKAITETERRREKQQKYNEEHGITPQALNKKVGELL
HHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
DIGQTDKPKRGKQAVKVEEKSANTYKPKSRKELEKELKQLEQQMRDFAKDLEFEKAAAVR
CCCCCCCCCCCCHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DKIGQLKAVLLEV
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA