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The map label for this gene is folC [H]

Identifier: 126208114

GI number: 126208114

Start: 719517

End: 720821

Strand: Direct

Name: folC [H]

Synonym: APL_0632

Alternate gene names: 126208114

Gene position: 719517-720821 (Clockwise)

Preceding gene: 126208113

Following gene: 126208115

Centisome position: 31.63

GC content: 41.53

Gene sequence:

>1305_bases
ATGATGAATACTTTAACTGTTCCGACTATTAATGATTGCCTCGCCATATGGTTGGATTACTTAGAAAAATCACATTTTAA
GCCGATTGATATGGGCTTAGAGCGCATTAAAGGCATAGCACAAGAATTAGACTTACTTCAACCGGCGCCTTATGTTATCA
CCGTTGCCGGTACTAATGGTAAGGGTTCAACTTGTCGTTTATTAGAAGTAGCTTTGCTAAAAGCCGGTTATCGAGTCGGC
GTCTATTCATCGCCTCACCTAATTCGTTATAACGAACGGGTAAGAATTCAAGGCGACTTACTCAATGACGAAGCGCACGT
GCAATCATTTGTAAAAATCCAACAAAAAAAGACCGCTTCTTTAACTTATTTTGAGTTTAGTACGCTTTCGGCATTACAAC
TTTTTAAAGATGCAAATTTAGATATTGTGATTTTAGAAGTTGGACTTGGAGGACGTTTAGATGCAACCAATATTGTTGAT
CCGAATTTAGCTGTCATCACATCTATTGATATTGATCACGTTGAGTTTCTTGGTGATAACCGAGAAGATATCGGTCGAGA
AAAAGCAGGCATTTTCCGTGAAAATATACCGGTGATTATCGGTGAACCGGATTGTCCGAGGAGCATTTTACAGCAAGCGA
AAGCACTTAATTGCCAAGTGGTTAGACGCAATATAAATTGGAAATATTCCGTAGAAAATAACCACTTCCACTGGCAATCG
GAATCTATTGATTGGCAAGATTTACCGATGCCGCAAATTCCGATTCCGAATGCCGGTACCGCTTTAGCCGCGTTGGCTCA
ACTTCCGTTTGAAATTAATGAACAAGTGGTTAGAGCCGCACTGCAAGAAGCGCAAATGACCGCTCGTTTCCAAACGCTAA
ACGAACAAAATTTTGCAAACTTTTCCGGAAAACGACCGCTTGCTCAAGTAATCATTGATGTCGGACACAATCCGCATGCG
GCAAAATATTTGGCAGAGCGACTAACGTCACTGAAACAGCCGAACCAAAAGATTTATGCGGTATTTAGCGCATTAGTTGA
TAAAGACTTAAGCGGCATCGTAGAGCCATTAGAAAATGTGATTGACGAATGGCATTGTGCCGGTTTAGCCGGATACCGCG
GGCAATCGGGTGAAGAGGTTTATCAAAAACTTGCAAAAGTTTTACCAAATTCGACCGCTTGTTATTACCGAACCGTTCCC
GAAGCGGCCGAATCATTATTCGCCAAAACGAGCAAAACCGACATTATCCTGATTTTCGGCTCATTCCACACTGTGAGCGA
TTTTTTGGTTTGGATTGGGAAATAA

Upstream 100 bases:

>100_bases
CAACGCCTTTTAAAACGGCAGAATTAATTGTTGAAGAAGCCTAATTTTATTTAAGCATAACTTAAGCCACGTAATACGTG
GCTTTCTTTTTGAGAACGAT

Downstream 100 bases:

>100_bases
TTCTATAAATAGATATCAGTAAAATGGATACAAATTATAATTTTTTACTGATATCTATTTTATAGTTGCTTTAATATTTA
CTAAAACTTATATAAAATCC

Product: folylpolyglutamate synthase/dihydrofolate synthase

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MMNTLTVPTINDCLAIWLDYLEKSHFKPIDMGLERIKGIAQELDLLQPAPYVITVAGTNGKGSTCRLLEVALLKAGYRVG
VYSSPHLIRYNERVRIQGDLLNDEAHVQSFVKIQQKKTASLTYFEFSTLSALQLFKDANLDIVILEVGLGGRLDATNIVD
PNLAVITSIDIDHVEFLGDNREDIGREKAGIFRENIPVIIGEPDCPRSILQQAKALNCQVVRRNINWKYSVENNHFHWQS
ESIDWQDLPMPQIPIPNAGTALAALAQLPFEINEQVVRAALQEAQMTARFQTLNEQNFANFSGKRPLAQVIIDVGHNPHA
AKYLAERLTSLKQPNQKIYAVFSALVDKDLSGIVEPLENVIDEWHCAGLAGYRGQSGEEVYQKLAKVLPNSTACYYRTVP
EAAESLFAKTSKTDIILIFGSFHTVSDFLVWIGK

Sequences:

>Translated_434_residues
MMNTLTVPTINDCLAIWLDYLEKSHFKPIDMGLERIKGIAQELDLLQPAPYVITVAGTNGKGSTCRLLEVALLKAGYRVG
VYSSPHLIRYNERVRIQGDLLNDEAHVQSFVKIQQKKTASLTYFEFSTLSALQLFKDANLDIVILEVGLGGRLDATNIVD
PNLAVITSIDIDHVEFLGDNREDIGREKAGIFRENIPVIIGEPDCPRSILQQAKALNCQVVRRNINWKYSVENNHFHWQS
ESIDWQDLPMPQIPIPNAGTALAALAQLPFEINEQVVRAALQEAQMTARFQTLNEQNFANFSGKRPLAQVIIDVGHNPHA
AKYLAERLTSLKQPNQKIYAVFSALVDKDLSGIVEPLENVIDEWHCAGLAGYRGQSGEEVYQKLAKVLPNSTACYYRTVP
EAAESLFAKTSKTDIILIFGSFHTVSDFLVWIGK
>Mature_434_residues
MMNTLTVPTINDCLAIWLDYLEKSHFKPIDMGLERIKGIAQELDLLQPAPYVITVAGTNGKGSTCRLLEVALLKAGYRVG
VYSSPHLIRYNERVRIQGDLLNDEAHVQSFVKIQQKKTASLTYFEFSTLSALQLFKDANLDIVILEVGLGGRLDATNIVD
PNLAVITSIDIDHVEFLGDNREDIGREKAGIFRENIPVIIGEPDCPRSILQQAKALNCQVVRRNINWKYSVENNHFHWQS
ESIDWQDLPMPQIPIPNAGTALAALAQLPFEINEQVVRAALQEAQMTARFQTLNEQNFANFSGKRPLAQVIIDVGHNPHA
AKYLAERLTSLKQPNQKIYAVFSALVDKDLSGIVEPLENVIDEWHCAGLAGYRGQSGEEVYQKLAKVLPNSTACYYRTVP
EAAESLFAKTSKTDIILIFGSFHTVSDFLVWIGK

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=207, Percent_Identity=33.8164251207729, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI66932990, Length=207, Percent_Identity=33.8164251207729, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1788654, Length=423, Percent_Identity=47.2813238770686, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17553150, Length=171, Percent_Identity=37.4269005847953, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71984923, Length=171, Percent_Identity=37.4269005847953, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17553148, Length=171, Percent_Identity=37.4269005847953, Blast_Score=125, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323760, Length=351, Percent_Identity=27.9202279202279, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6324815, Length=177, Percent_Identity=32.7683615819209, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24641571, Length=172, Percent_Identity=40.1162790697674, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24581568, Length=177, Percent_Identity=35.5932203389831, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 48473; Mature: 48473

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS01012 FOLYLPOLYGLU_SYNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNTLTVPTINDCLAIWLDYLEKSHFKPIDMGLERIKGIAQELDLLQPAPYVITVAGTNG
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
KGSTCRLLEVALLKAGYRVGVYSSPHLIRYNERVRIQGDLLNDEAHVQSFVKIQQKKTAS
CCCHHHHHHHHHHHCCCEEEECCCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCE
LTYFEFSTLSALQLFKDANLDIVILEVGLGGRLDATNIVDPNLAVITSIDIDHVEFLGDN
EEEEEHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEECCHHHHHHCCCC
REDIGREKAGIFRENIPVIIGEPDCPRSILQQAKALNCQVVRRNINWKYSVENNHFHWQS
HHHHCHHHHCHHHCCCCEEECCCCCCHHHHHHHHHCCCEEEEECCCEEEEECCCEEEECC
ESIDWQDLPMPQIPIPNAGTALAALAQLPFEINEQVVRAALQEAQMTARFQTLNEQNFAN
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FSGKRPLAQVIIDVGHNPHAAKYLAERLTSLKQPNQKIYAVFSALVDKDLSGIVEPLENV
CCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IDEWHCAGLAGYRGQSGEEVYQKLAKVLPNSTACYYRTVPEAAESLFAKTSKTDIILIFG
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEEEEEE
SFHTVSDFLVWIGK
CHHHHHHHHHEECC
>Mature Secondary Structure
MMNTLTVPTINDCLAIWLDYLEKSHFKPIDMGLERIKGIAQELDLLQPAPYVITVAGTNG
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
KGSTCRLLEVALLKAGYRVGVYSSPHLIRYNERVRIQGDLLNDEAHVQSFVKIQQKKTAS
CCCHHHHHHHHHHHCCCEEEECCCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCE
LTYFEFSTLSALQLFKDANLDIVILEVGLGGRLDATNIVDPNLAVITSIDIDHVEFLGDN
EEEEEHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEECCHHHHHHCCCC
REDIGREKAGIFRENIPVIIGEPDCPRSILQQAKALNCQVVRRNINWKYSVENNHFHWQS
HHHHCHHHHCHHHCCCCEEECCCCCCHHHHHHHHHCCCEEEEECCCEEEEECCCEEEECC
ESIDWQDLPMPQIPIPNAGTALAALAQLPFEINEQVVRAALQEAQMTARFQTLNEQNFAN
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FSGKRPLAQVIIDVGHNPHAAKYLAERLTSLKQPNQKIYAVFSALVDKDLSGIVEPLENV
CCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IDEWHCAGLAGYRGQSGEEVYQKLAKVLPNSTACYYRTVPEAAESLFAKTSKTDIILIFG
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEEEEEE
SFHTVSDFLVWIGK
CHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]