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The map label for this gene is lrp [H]

Identifier: 126208099

GI number: 126208099

Start: 703430

End: 703912

Strand: Direct

Name: lrp [H]

Synonym: APL_0617

Alternate gene names: 126208099

Gene position: 703430-703912 (Clockwise)

Preceding gene: 126208098

Following gene: 126208100

Centisome position: 30.93

GC content: 37.68

Gene sequence:

>483_bases
ATGGAACATAAAAAACTACCTAAAGCACTAGATGCTATTGACTTAAAAATCTTAAATGAGCTACAACGTAACGGAAAAAT
CTCTAATATTGAACTTTCTAAACGTGTCGGTTTATCGCCGACACCTTGTTTAGAACGAGTAAAGCGTTTAGAAAAGCAGA
ATGTGATTATGGGATACCGTGCATTACTGAATCCGGAATTGCTTGAAGCACCGCTATTAGTGATTGTGGAAATTACCTTA
GTCAGAGGTAAGCCGGACGTATTTGAGGAATTTAATCGTGCCGTTCAACAATTGGATGAAATTCAAGAATGTCATTTGGT
TTCGGGTGATTTCGATTATTTACTCAAAACAAGGGTAGCGGATATGGCGGCTTATCGAAAACTTTTAGGTACGACTTTAC
TGCGATTACCCGGTGTGAACGATACGCGAACCTATGTCGTAATGGAAGAAGTGAAACAAACCAATTATCTGTTATTAAAA
TAA

Upstream 100 bases:

>100_bases
TCTTTCGGTTTTGTAACCTTTCTTCAACCAACATCATTAGACCGAATAAGATAAAACTTGTAGAATTAAATATTAGTAAA
AAAACTGGGAAGACAGGCAA

Downstream 100 bases:

>100_bases
GGAGTTAATCGGTGATTGAACGATTAAAACCGCGATTAAAGGGTAAAGAGAATTTAATCAATCTGATGTTTATCTTACTG
GGATTACTCGGATTATATTT

Product: leucine-responsive transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MEHKKLPKALDAIDLKILNELQRNGKISNIELSKRVGLSPTPCLERVKRLEKQNVIMGYRALLNPELLEAPLLVIVEITL
VRGKPDVFEEFNRAVQQLDEIQECHLVSGDFDYLLKTRVADMAAYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNYLLLK

Sequences:

>Translated_160_residues
MEHKKLPKALDAIDLKILNELQRNGKISNIELSKRVGLSPTPCLERVKRLEKQNVIMGYRALLNPELLEAPLLVIVEITL
VRGKPDVFEEFNRAVQQLDEIQECHLVSGDFDYLLKTRVADMAAYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNYLLLK
>Mature_160_residues
MEHKKLPKALDAIDLKILNELQRNGKISNIELSKRVGLSPTPCLERVKRLEKQNVIMGYRALLNPELLEAPLLVIVEITL
VRGKPDVFEEFNRAVQQLDEIQECHLVSGDFDYLLKTRVADMAAYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNYLLLK

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=161, Percent_Identity=77.0186335403727, Blast_Score=249, Evalue=6e-68,
Organism=Escherichia coli, GI87081742, Length=148, Percent_Identity=33.1081081081081, Blast_Score=88, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18342; Mature: 18342

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHKKLPKALDAIDLKILNELQRNGKISNIELSKRVGLSPTPCLERVKRLEKQNVIMGYR
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ALLNPELLEAPLLVIVEITLVRGKPDVFEEFNRAVQQLDEIQECHLVSGDFDYLLKTRVA
HHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
DMAAYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNYLLLK
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEC
>Mature Secondary Structure
MEHKKLPKALDAIDLKILNELQRNGKISNIELSKRVGLSPTPCLERVKRLEKQNVIMGYR
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ALLNPELLEAPLLVIVEITLVRGKPDVFEEFNRAVQQLDEIQECHLVSGDFDYLLKTRVA
HHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
DMAAYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNYLLLK
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]