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The map label for this gene is fhs

Identifier: 126207950

GI number: 126207950

Start: 537209

End: 538879

Strand: Reverse

Name: fhs

Synonym: APL_0466

Alternate gene names: 126207950

Gene position: 538879-537209 (Counterclockwise)

Preceding gene: 126207955

Following gene: 126207940

Centisome position: 23.69

GC content: 43.45

Gene sequence:

>1671_bases
ATGAAAAGCGATGTAGAAATTGCTCAGGCGGCGACTATGCAGCCGATTCACAAAATTGCTGAAAAGCTAGGTTTAAATGC
CGATCAAATTGAACAATACGGCAAATATAAAGCAAAAATTAACCCTACAGATGCGTTTAAATTACCGGCTAAAAACGGTA
AATTAATTTTAGTGACTGCGATTAACCCGACGCCGGCAGGCGAAGGCAAAACGACCGTCACTATCGGTTTAACCGATGCG
TTAAATCAACTTGGTAAAAATGCTGTGGTTGCGGCACGTGAGCCGTCGTTAGGTCCGGTATTCGGCGTGAAAGGCGGTGC
GGCCGGCGGCGGTTATGCACAAGTATTGCCAATGGAAGATATCAACCTACACTTTACCGGCGATTTCCACGCCATTACCA
GTGCCAATAACCTCTTAGCAGCGTTATTGGATAACCATATCTACCAAGGCAATGCGTTAAATATTGATACCAAACGTGTG
TTATGGCGACGTGTTATTGATATGAATGATCGTCAATTACGTAACGTATTGGGGGGGTTAGGCAATCCGACCGATGGCGT
GATTCGTCCGGACGGTTTCGATATTACCGTAGCTTCAGAAGTGATGGCAATTTTCTGTTTAGCGAAAGATCTTGCTGATT
TAAAAACGCGTTTAGGTAATATCTTAGTCGCTTACACTAAAGATAAACAGCCGGTTTATGCGAAAGATTTAAATGCGCAT
GGGGCAATGGCGGCATTATTAAAAGATGCGATTAAACCGAATTTAGTACAAACGATTGAAGGCAGCCCTGCCTTTATTCA
CGGTGGCCCGTTTGCCAATATCGCTCACGGTTGTAACTCGGTTACCGCAACACGTTTAGCATTACATTTAGGTGATTATG
CAGTAACAGAAGCCGGTTTCGGTGCGGACTTAGGTGCAGAAAAATTCTGTGATATTAAATGCCGTTTAGCTGATCTTAAA
CCGGATGTAGCTGTGGTCGTTGCCACGGTAAAAGCGCTGAAATATAACGGCGGTGTTGAAAAAGCGAATTTAGCTGAAGA
AAATTTAACCGCTTTACAACAAGGTTTACCGAATCTGCTTAAACATATCAGTAACCTCAAAAATGTATTCGGCTTACCGG
TTGTGGTCGCATTAAACCGCTTTGTGTCAGATACTGATGCAGAATTAGCCCTAATTCAGACCGCTTGTGCGAAACAAGGC
GTGGAAGTATCGCTCACTGAAGTTTGGGGTAAAGGCGGCGCCGGTGGTGTGGACTTAGCACAAAAAGTGTTAAAAGCGAT
TGATGAACAAGAGAACCGTTTTAATTTCGTCTATGACGTAAATGAAAGCGTGCAAAACAAGATCAAAGCGATCGCACAAA
AAATCTATGGTGCGGATGATGTGAATTTTAGTGCCGAAGCCTTAGCGGAAATTAAAAATCTGGAAAAATTAGGTTTAGAT
AAATTACCGATTTGTATGGCGAAAACACAATATTCATTAAGCGATAATGCCAAATTACTCGGTTGCCCAAGCGGTTTTAC
CGTTACCGTACGTAGTATTAGCGTCTCTGCCGGTGCCGGCTTTATCGTTGCGATTTGCGGTAGCATTATGCGTATGCCGG
GCTTACCGAAAGTGCCGGCGGCAAATCGTATTGATGTGGATGAAAACGGTTTGATTACCGGTTTATTCTAA

Upstream 100 bases:

>100_bases
TTAAATAGCCGTTACAGTTCTTTATTTTAAATGTATTTTAGCATATTCTAGCGGGGTTTTAAAAAAGCAAACGTTTGCGC
TTATTTTTTTGGAGGAACGC

Downstream 100 bases:

>100_bases
CCATAACGCTTACAAAAATCCCCGCCAAATGCGGGGATTTTTTATAGGATAATTTGCAAAAAAGCAGTGAAAAATGACCG
CTTGGATGCGTGCAATCTGT

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MKSDVEIAQAATMQPIHKIAEKLGLNADQIEQYGKYKAKINPTDAFKLPAKNGKLILVTAINPTPAGEGKTTVTIGLTDA
LNQLGKNAVVAAREPSLGPVFGVKGGAAGGGYAQVLPMEDINLHFTGDFHAITSANNLLAALLDNHIYQGNALNIDTKRV
LWRRVIDMNDRQLRNVLGGLGNPTDGVIRPDGFDITVASEVMAIFCLAKDLADLKTRLGNILVAYTKDKQPVYAKDLNAH
GAMAALLKDAIKPNLVQTIEGSPAFIHGGPFANIAHGCNSVTATRLALHLGDYAVTEAGFGADLGAEKFCDIKCRLADLK
PDVAVVVATVKALKYNGGVEKANLAEENLTALQQGLPNLLKHISNLKNVFGLPVVVALNRFVSDTDAELALIQTACAKQG
VEVSLTEVWGKGGAGGVDLAQKVLKAIDEQENRFNFVYDVNESVQNKIKAIAQKIYGADDVNFSAEALAEIKNLEKLGLD
KLPICMAKTQYSLSDNAKLLGCPSGFTVTVRSISVSAGAGFIVAICGSIMRMPGLPKVPAANRIDVDENGLITGLF

Sequences:

>Translated_556_residues
MKSDVEIAQAATMQPIHKIAEKLGLNADQIEQYGKYKAKINPTDAFKLPAKNGKLILVTAINPTPAGEGKTTVTIGLTDA
LNQLGKNAVVAAREPSLGPVFGVKGGAAGGGYAQVLPMEDINLHFTGDFHAITSANNLLAALLDNHIYQGNALNIDTKRV
LWRRVIDMNDRQLRNVLGGLGNPTDGVIRPDGFDITVASEVMAIFCLAKDLADLKTRLGNILVAYTKDKQPVYAKDLNAH
GAMAALLKDAIKPNLVQTIEGSPAFIHGGPFANIAHGCNSVTATRLALHLGDYAVTEAGFGADLGAEKFCDIKCRLADLK
PDVAVVVATVKALKYNGGVEKANLAEENLTALQQGLPNLLKHISNLKNVFGLPVVVALNRFVSDTDAELALIQTACAKQG
VEVSLTEVWGKGGAGGVDLAQKVLKAIDEQENRFNFVYDVNESVQNKIKAIAQKIYGADDVNFSAEALAEIKNLEKLGLD
KLPICMAKTQYSLSDNAKLLGCPSGFTVTVRSISVSAGAGFIVAICGSIMRMPGLPKVPAANRIDVDENGLITGLF
>Mature_556_residues
MKSDVEIAQAATMQPIHKIAEKLGLNADQIEQYGKYKAKINPTDAFKLPAKNGKLILVTAINPTPAGEGKTTVTIGLTDA
LNQLGKNAVVAAREPSLGPVFGVKGGAAGGGYAQVLPMEDINLHFTGDFHAITSANNLLAALLDNHIYQGNALNIDTKRV
LWRRVIDMNDRQLRNVLGGLGNPTDGVIRPDGFDITVASEVMAIFCLAKDLADLKTRLGNILVAYTKDKQPVYAKDLNAH
GAMAALLKDAIKPNLVQTIEGSPAFIHGGPFANIAHGCNSVTATRLALHLGDYAVTEAGFGADLGAEKFCDIKCRLADLK
PDVAVVVATVKALKYNGGVEKANLAEENLTALQQGLPNLLKHISNLKNVFGLPVVVALNRFVSDTDAELALIQTACAKQG
VEVSLTEVWGKGGAGGVDLAQKVLKAIDEQENRFNFVYDVNESVQNKIKAIAQKIYGADDVNFSAEALAEIKNLEKLGLD
KLPICMAKTQYSLSDNAKLLGCPSGFTVTVRSISVSAGAGFIVAICGSIMRMPGLPKVPAANRIDVDENGLITGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=622, Percent_Identity=43.0868167202572, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI36796743, Length=620, Percent_Identity=45.3225806451613, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI310124614, Length=85, Percent_Identity=41.1764705882353, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568737, Length=623, Percent_Identity=40.6099518459069, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17568739, Length=623, Percent_Identity=40.6099518459069, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319558, Length=632, Percent_Identity=42.879746835443, Blast_Score=463, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6321643, Length=627, Percent_Identity=42.1052631578947, Blast_Score=450, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=43.7096774193548, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=43.7096774193548, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=43.7096774193548, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=43.7096774193548, Blast_Score=469, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_ACTP2 (A3MZI4)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053175.1
- ProteinModelPortal:   A3MZI4
- SMR:   A3MZI4
- STRING:   A3MZI4
- GeneID:   4850530
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0466
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   KMPGLPK
- PhylomeDB:   A3MZI4
- ProtClustDB:   PRK13505
- BioCyc:   APLE416269:APL_0466-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 58956; Mature: 58956

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDVEIAQAATMQPIHKIAEKLGLNADQIEQYGKYKAKINPTDAFKLPAKNGKLILVTA
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEEEECCCCCEECCCCCCCEEEEEE
INPTPAGEGKTTVTIGLTDALNQLGKNAVVAAREPSLGPVFGVKGGAAGGGYAQVLPMED
ECCCCCCCCCEEEEEEEHHHHHHCCCCCEEEECCCCCCCEEECCCCCCCCCCEEEEEECC
INLHFTGDFHAITSANNLLAALLDNHIYQGNALNIDTKRVLWRRVIDMNDRQLRNVLGGL
CEEEEECCCCEECCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHCCCHHHHHHHHCCC
GNPTDGVIRPDGFDITVASEVMAIFCLAKDLADLKTRLGNILVAYTKDKQPVYAKDLNAH
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHCCCCC
GAMAALLKDAIKPNLVQTIEGSPAFIHGGPFANIAHGCNSVTATRLALHLGDYAVTEAGF
HHHHHHHHHHCCCCHHHHCCCCCCEEECCCCHHHHHCCCHHHHHHHHHHHCCHHEECCCC
GADLGAEKFCDIKCRLADLKPDVAVVVATVKALKYNGGVEKANLAEENLTALQQGLPNLL
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
KHISNLKNVFGLPVVVALNRFVSDTDAELALIQTACAKQGVEVSLTEVWGKGGAGGVDLA
HHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEHHCCCCCCCHHHHH
QKVLKAIDEQENRFNFVYDVNESVQNKIKAIAQKIYGADDVNFSAEALAEIKNLEKLGLD
HHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
KLPICMAKTQYSLSDNAKLLGCPSGFTVTVRSISVSAGAGFIVAICGSIMRMPGLPKVPA
CCCEEEECCCCCCCCCCEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCC
ANRIDVDENGLITGLF
CCCCCCCCCCCEEECC
>Mature Secondary Structure
MKSDVEIAQAATMQPIHKIAEKLGLNADQIEQYGKYKAKINPTDAFKLPAKNGKLILVTA
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEEEECCCCCEECCCCCCCEEEEEE
INPTPAGEGKTTVTIGLTDALNQLGKNAVVAAREPSLGPVFGVKGGAAGGGYAQVLPMED
ECCCCCCCCCEEEEEEEHHHHHHCCCCCEEEECCCCCCCEEECCCCCCCCCCEEEEEECC
INLHFTGDFHAITSANNLLAALLDNHIYQGNALNIDTKRVLWRRVIDMNDRQLRNVLGGL
CEEEEECCCCEECCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHCCCHHHHHHHHCCC
GNPTDGVIRPDGFDITVASEVMAIFCLAKDLADLKTRLGNILVAYTKDKQPVYAKDLNAH
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHCCCCC
GAMAALLKDAIKPNLVQTIEGSPAFIHGGPFANIAHGCNSVTATRLALHLGDYAVTEAGF
HHHHHHHHHHCCCCHHHHCCCCCCEEECCCCHHHHHCCCHHHHHHHHHHHCCHHEECCCC
GADLGAEKFCDIKCRLADLKPDVAVVVATVKALKYNGGVEKANLAEENLTALQQGLPNLL
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
KHISNLKNVFGLPVVVALNRFVSDTDAELALIQTACAKQGVEVSLTEVWGKGGAGGVDLA
HHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEHHCCCCCCCHHHHH
QKVLKAIDEQENRFNFVYDVNESVQNKIKAIAQKIYGADDVNFSAEALAEIKNLEKLGLD
HHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
KLPICMAKTQYSLSDNAKLLGCPSGFTVTVRSISVSAGAGFIVAICGSIMRMPGLPKVPA
CCCEEEECCCCCCCCCCEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCC
ANRIDVDENGLITGLF
CCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA