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The map label for this gene is pepB [H]

Identifier: 126207872

GI number: 126207872

Start: 441099

End: 442391

Strand: Reverse

Name: pepB [H]

Synonym: APL_0388

Alternate gene names: 126207872

Gene position: 442391-441099 (Counterclockwise)

Preceding gene: 126207873

Following gene: 126207871

Centisome position: 19.45

GC content: 44.32

Gene sequence:

>1293_bases
ATGGTTACCATGAATATTACGCTTTCCCAAGATCCCGCTCCAGAACAATGGGGCAAAAATGCCATTCTGTCTGCCAATCA
ACAAGGTATGACGATTCACTTACAAAAAGATCCGCTAACGACGATTCAACGTGCCGCTCGTAAAATTAAAAATCAAGGCG
TTTTAAACGTTACGCTTAGCGGACAAGGTTGGACATTAGAAGAATGTTGGGCATTTCATCAAGGTTTTATCAGTGTTCGC
AATACCGGAACAGTAAGTTACCCCGACTTAGCCGAACAACAAGCGGAATTTGATGCACGTTTGCATTGTTCTGACTTTAC
ACGTGCTTTGATTAACGAATCTTCCGAAACGCTTACCCCTGAGCGTTTAGCGCAAAAAGCGGCGGAGTTTATTACTAAAC
AGTCTGAGCAATATCTCGGTAAAAATGTAGTCTCCGCCGAAATGATTAGCGGTGAAGTGTTAAAACAGCAAGGCTATCAC
GGTATTTGGACGGTAGGTAAAGGCTCTGCAAATAAACCGACATTGCTCAAATTGGATTTTAATCCGAGCGGTGATATTAA
TGCACCCGTGCTTGCTTGTTTAGTCGGTAAAGGCATTACTTTTGATACCGGCGGTTATAGCATTAAACCGAGTGATTCAA
TGAGTACTATGCGTACCGATATGGGCGGTGCCGCCTTATTAACCGGTGCATTAGGCTTTGCAATCAGTCGCGGCTTAACA
CAACGGGTAAAACTGTACCTATGCTGTGCGGAAAATATGGTAAGCAGTACCGCATTCAAATTAGGCGATATTATCGAATA
TCGCAACGGTGTTAGCGCAGAAGTGCTGAATACCGATGCGGAAGGTCGCTTAGTGTTAGCGGACGGCTTAATTGAAGCCA
GTGAGCAAAATGCGAAATTTCTTATTGATGCGGCAACCTTAACCGGCGCGGCAAAAGTGGCGGTCGGTAATGACTACCAT
TCAGTGCTATCAATGGATGATGAATTAACCGCTTGCTTATTTAATGCGGCAAAAGCGGAAAACGAACCCTTCTGGCGTTT
ACCGTTTGAAGAATTTCATCGTTCACAAATTTCGTCATCATTTGCAGATATTGCCAATATCGGATCAGTACCGGTTGGTG
CCGGTGCAAGCACGGCAACCGCCTTTTTATCGTACTTTGTGAAAGATTACGAAAAAAATTGGCTTCATATTGATGCTTCC
GCCACTTTCCGTAAAACGGCGAGTGATTTATGGGCGGCAGGTGCAACCGGTTTAGGGATGAAAACCCTCGCGAATCTGCT
TTTATCTCGATAA

Upstream 100 bases:

>100_bases
TTCACTTCCGAAGACCGCCACAAGCGGTCTTTTTTCTATCTCTCTTTACAAAATTTTGCTAGGATTGAACCGCTTATTTT
AACCTAACAAGGACATAACA

Downstream 100 bases:

>100_bases
ACGTTTTGTAAAATTTCCAAAAAATTTAACCGCTTGTTCCGCTAAAGTTCGCGTAAAACAAGCGGTTTTATTTTGCTTTG
TGTATAATATTGCGAATTGA

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MVTMNITLSQDPAPEQWGKNAILSANQQGMTIHLQKDPLTTIQRAARKIKNQGVLNVTLSGQGWTLEECWAFHQGFISVR
NTGTVSYPDLAEQQAEFDARLHCSDFTRALINESSETLTPERLAQKAAEFITKQSEQYLGKNVVSAEMISGEVLKQQGYH
GIWTVGKGSANKPTLLKLDFNPSGDINAPVLACLVGKGITFDTGGYSIKPSDSMSTMRTDMGGAALLTGALGFAISRGLT
QRVKLYLCCAENMVSSTAFKLGDIIEYRNGVSAEVLNTDAEGRLVLADGLIEASEQNAKFLIDAATLTGAAKVAVGNDYH
SVLSMDDELTACLFNAAKAENEPFWRLPFEEFHRSQISSSFADIANIGSVPVGAGASTATAFLSYFVKDYEKNWLHIDAS
ATFRKTASDLWAAGATGLGMKTLANLLLSR

Sequences:

>Translated_430_residues
MVTMNITLSQDPAPEQWGKNAILSANQQGMTIHLQKDPLTTIQRAARKIKNQGVLNVTLSGQGWTLEECWAFHQGFISVR
NTGTVSYPDLAEQQAEFDARLHCSDFTRALINESSETLTPERLAQKAAEFITKQSEQYLGKNVVSAEMISGEVLKQQGYH
GIWTVGKGSANKPTLLKLDFNPSGDINAPVLACLVGKGITFDTGGYSIKPSDSMSTMRTDMGGAALLTGALGFAISRGLT
QRVKLYLCCAENMVSSTAFKLGDIIEYRNGVSAEVLNTDAEGRLVLADGLIEASEQNAKFLIDAATLTGAAKVAVGNDYH
SVLSMDDELTACLFNAAKAENEPFWRLPFEEFHRSQISSSFADIANIGSVPVGAGASTATAFLSYFVKDYEKNWLHIDAS
ATFRKTASDLWAAGATGLGMKTLANLLLSR
>Mature_430_residues
MVTMNITLSQDPAPEQWGKNAILSANQQGMTIHLQKDPLTTIQRAARKIKNQGVLNVTLSGQGWTLEECWAFHQGFISVR
NTGTVSYPDLAEQQAEFDARLHCSDFTRALINESSETLTPERLAQKAAEFITKQSEQYLGKNVVSAEMISGEVLKQQGYH
GIWTVGKGSANKPTLLKLDFNPSGDINAPVLACLVGKGITFDTGGYSIKPSDSMSTMRTDMGGAALLTGALGFAISRGLT
QRVKLYLCCAENMVSSTAFKLGDIIEYRNGVSAEVLNTDAEGRLVLADGLIEASEQNAKFLIDAATLTGAAKVAVGNDYH
SVLSMDDELTACLFNAAKAENEPFWRLPFEEFHRSQISSSFADIANIGSVPVGAGASTATAFLSYFVKDYEKNWLHIDAS
ATFRKTASDLWAAGATGLGMKTLANLLLSR

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=326, Percent_Identity=37.7300613496933, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI47155554, Length=283, Percent_Identity=36.0424028268551, Blast_Score=142, Evalue=7e-34,
Organism=Escherichia coli, GI87082123, Length=426, Percent_Identity=56.8075117370892, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1790710, Length=307, Percent_Identity=37.785016286645, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=259, Percent_Identity=35.5212355212355, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=159, Percent_Identity=34.5911949685535, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221379063, Length=358, Percent_Identity=32.122905027933, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI221379062, Length=358, Percent_Identity=32.122905027933, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21357381, Length=358, Percent_Identity=32.122905027933, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21355725, Length=326, Percent_Identity=28.5276073619632, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24661038, Length=326, Percent_Identity=27.6073619631902, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI20129969, Length=374, Percent_Identity=25.4010695187166, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24662227, Length=329, Percent_Identity=26.7477203647416, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI161077148, Length=300, Percent_Identity=26.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI20130057, Length=300, Percent_Identity=26.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21355645, Length=300, Percent_Identity=24.3333333333333, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24662223, Length=300, Percent_Identity=24.3333333333333, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129963, Length=296, Percent_Identity=25.6756756756757, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19922386, Length=300, Percent_Identity=24.3333333333333, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646701, Length=259, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646703, Length=259, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358201, Length=259, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 46401; Mature: 46401

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00631 CYTOSOL_AP ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTMNITLSQDPAPEQWGKNAILSANQQGMTIHLQKDPLTTIQRAARKIKNQGVLNVTLS
CEEEEEEECCCCCHHHHCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEC
GQGWTLEECWAFHQGFISVRNTGTVSYPDLAEQQAEFDARLHCSDFTRALINESSETLTP
CCCCCHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHCCEEEHHHHHHHHHCCCCCCCCH
ERLAQKAAEFITKQSEQYLGKNVVSAEMISGEVLKQQGYHGIWTVGKGSANKPTLLKLDF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEC
NPSGDINAPVLACLVGKGITFDTGGYSIKPSDSMSTMRTDMGGAALLTGALGFAISRGLT
CCCCCCCHHHHHHHHCCCCEECCCCEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHCHH
QRVKLYLCCAENMVSSTAFKLGDIIEYRNGVSAEVLNTDAEGRLVLADGLIEASEQNAKF
HHHEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHCCCCCCEE
LIDAATLTGAAKVAVGNDYHSVLSMDDELTACLFNAAKAENEPFWRLPFEEFHRSQISSS
EEEEEHHCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHH
FADIANIGSVPVGAGASTATAFLSYFVKDYEKNWLHIDASATFRKTASDLWAAGATGLGM
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCH
KTLANLLLSR
HHHHHHHHCC
>Mature Secondary Structure
MVTMNITLSQDPAPEQWGKNAILSANQQGMTIHLQKDPLTTIQRAARKIKNQGVLNVTLS
CEEEEEEECCCCCHHHHCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEC
GQGWTLEECWAFHQGFISVRNTGTVSYPDLAEQQAEFDARLHCSDFTRALINESSETLTP
CCCCCHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHCCEEEHHHHHHHHHCCCCCCCCH
ERLAQKAAEFITKQSEQYLGKNVVSAEMISGEVLKQQGYHGIWTVGKGSANKPTLLKLDF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEC
NPSGDINAPVLACLVGKGITFDTGGYSIKPSDSMSTMRTDMGGAALLTGALGFAISRGLT
CCCCCCCHHHHHHHHCCCCEECCCCEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHCHH
QRVKLYLCCAENMVSSTAFKLGDIIEYRNGVSAEVLNTDAEGRLVLADGLIEASEQNAKF
HHHEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHCCCCCCEE
LIDAATLTGAAKVAVGNDYHSVLSMDDELTACLFNAAKAENEPFWRLPFEEFHRSQISSS
EEEEEHHCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHH
FADIANIGSVPVGAGASTATAFLSYFVKDYEKNWLHIDASATFRKTASDLWAAGATGLGM
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCH
KTLANLLLSR
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA