Click here to switch to the map view.

The map label for this gene is mscM [H]

Identifier: 126176422

GI number: 126176422

Start: 4963937

End: 4965202

Strand: Reverse

Name: mscM [H]

Synonym: Sbal_4237

Alternate gene names: 126176422

Gene position: 4965202-4963937 (Counterclockwise)

Preceding gene: 126176424

Following gene: 126176419

Centisome position: 96.84

GC content: 48.5

Gene sequence:

>1266_bases
GTGGATCAGGAAATAAGGCTCGAAATTTCGGCATGGTTAGCGGGCTTTGGGATTGATAGCCAACCCTCGGACGGCATATC
AACCAGCATCATGATCATTGCCTGCTTACTGCTTGCAGGCATCGCTTATTTCATTGTTCGACGCGTGGTCATACGTGCGG
TCAACATGGTGATCCTCCGCTCCAAAGTCACTTGGGACGATGTGTTCATGCGTTACAAGGTGCTTGAAAAGCTGGCCATG
CTAGTGCCTGCAATCGTGCTCAATCTATTAGTGCCCATCGCCTTAACCGAACATCAAATCTTAAGTAGTTTAGTCGATAG
GCTGCTGAGTATTTGGCTGGTGGTGCTGATGATCCGCGCTATTTATGCGGGTTTAGATGCGGTCGATGAAATTTCAGATG
TGAATCTGGTGAGTCGGCGTTTACCCGTTAAAAGCTTTGTGCAGTTAACTAAGCTGTTTTTATTCTTTGTCGGTATTATC
GTTTCTATCTCAATCTTGGCCGATCAGTCCCCTGTGTACTTCCTCAGCGGCTTAGGTGTGGCGACGGGTTTTGTGATGTT
AGTGTTCCGCGACACTATCTTAGGTTTCGTGGCGGGCATTCAGTTAGCGGCTAACCGTATGGTGAGCAAGGGCGATTGGA
TCCAGATGGACAAATACGGCGCCGACGGTGCGGTAGAAGAGGTCTCGCTGACCACAGTTAAAGTGCGCAACTGGGACAAA
ACCATCACTATGATCCCAGCCTATGCCTTAGTGTCGGATGCGTTTCGTAACTGGCGGGGTATGTCTGAGTCGGGTGGTCG
TAGGATCAAACGCGCCATCAATATTGATATCAACAGCATTAAGTTTTTGAGCGAGGAAGAGCGCGAGCGTCTGAGTAAGA
TCAATTGCTTAAAAGAATATTTTCCCGCCAAAATCAACGAAATCCGTGAGTCGAACGCCAGAGTGTCTGACCTCGACATG
AAAGTGAACGGTCGCCATCTGACTAATGTCGGCACCTTCCGTGCTTACCTGCAGGAATACCTACAGCGTCACGATAAAAT
CCATAAGGAAATGACCTTAATGGTGCGCCAATTAGCGCCGACCACTGAGGGATTGCCGATCGAGGTTTATATCTTCACCA
ACGATACCCGCTGGGCATTTTATGAGGCGATACAAGCGGATATCTTCGACCATATTTTTGCGATATTGCCTGAGTTTGGT
CTGCAGGCATTCCAAGCGCCAACGGGCAACGATATTCGTAGCTTAAAGTCGGTTAAGGTTGACTAG

Upstream 100 bases:

>100_bases
TTTGGATATCAGTATTTTCTAGGGTGACATTAACCGAGGTCAACTCGGCGGTTACCTTTGTATGGGTTTGTTGCGCTAGC
GCCTACGTTGGAGTGGAATT

Downstream 100 bases:

>100_bases
TGTTAATGACTGTCGACGATTATTGATTTAATTTCGAGAGATAAGAATCGCGGCTAAGGTAAGAAAGACACCGCCGCTGG
TTCTGTCAAACCAATGCAGC

Product: mechanosensitive ion channel protein MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDQEIRLEISAWLAGFGIDSQPSDGISTSIMIIACLLLAGIAYFIVRRVVIRAVNMVILRSKVTWDDVFMRYKVLEKLAM
LVPAIVLNLLVPIALTEHQILSSLVDRLLSIWLVVLMIRAIYAGLDAVDEISDVNLVSRRLPVKSFVQLTKLFLFFVGII
VSISILADQSPVYFLSGLGVATGFVMLVFRDTILGFVAGIQLAANRMVSKGDWIQMDKYGADGAVEEVSLTTVKVRNWDK
TITMIPAYALVSDAFRNWRGMSESGGRRIKRAINIDINSIKFLSEEERERLSKINCLKEYFPAKINEIRESNARVSDLDM
KVNGRHLTNVGTFRAYLQEYLQRHDKIHKEMTLMVRQLAPTTEGLPIEVYIFTNDTRWAFYEAIQADIFDHIFAILPEFG
LQAFQAPTGNDIRSLKSVKVD

Sequences:

>Translated_421_residues
MDQEIRLEISAWLAGFGIDSQPSDGISTSIMIIACLLLAGIAYFIVRRVVIRAVNMVILRSKVTWDDVFMRYKVLEKLAM
LVPAIVLNLLVPIALTEHQILSSLVDRLLSIWLVVLMIRAIYAGLDAVDEISDVNLVSRRLPVKSFVQLTKLFLFFVGII
VSISILADQSPVYFLSGLGVATGFVMLVFRDTILGFVAGIQLAANRMVSKGDWIQMDKYGADGAVEEVSLTTVKVRNWDK
TITMIPAYALVSDAFRNWRGMSESGGRRIKRAINIDINSIKFLSEEERERLSKINCLKEYFPAKINEIRESNARVSDLDM
KVNGRHLTNVGTFRAYLQEYLQRHDKIHKEMTLMVRQLAPTTEGLPIEVYIFTNDTRWAFYEAIQADIFDHIFAILPEFG
LQAFQAPTGNDIRSLKSVKVD
>Mature_421_residues
MDQEIRLEISAWLAGFGIDSQPSDGISTSIMIIACLLLAGIAYFIVRRVVIRAVNMVILRSKVTWDDVFMRYKVLEKLAM
LVPAIVLNLLVPIALTEHQILSSLVDRLLSIWLVVLMIRAIYAGLDAVDEISDVNLVSRRLPVKSFVQLTKLFLFFVGII
VSISILADQSPVYFLSGLGVATGFVMLVFRDTILGFVAGIQLAANRMVSKGDWIQMDKYGADGAVEEVSLTTVKVRNWDK
TITMIPAYALVSDAFRNWRGMSESGGRRIKRAINIDINSIKFLSEEERERLSKINCLKEYFPAKINEIRESNARVSDLDM
KVNGRHLTNVGTFRAYLQEYLQRHDKIHKEMTLMVRQLAPTTEGLPIEVYIFTNDTRWAFYEAIQADIFDHIFAILPEFG
LQAFQAPTGNDIRSLKSVKVD

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=405, Percent_Identity=46.6666666666667, Blast_Score=362, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 47575; Mature: 47575

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQEIRLEISAWLAGFGIDSQPSDGISTSIMIIACLLLAGIAYFIVRRVVIRAVNMVILR
CCCCEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKVTWDDVFMRYKVLEKLAMLVPAIVLNLLVPIALTEHQILSSLVDRLLSIWLVVLMIRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYAGLDAVDEISDVNLVSRRLPVKSFVQLTKLFLFFVGIIVSISILADQSPVYFLSGLGV
HHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ATGFVMLVFRDTILGFVAGIQLAANRMVSKGDWIQMDKYGADGAVEEVSLTTVKVRNWDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHEEEEEEEEECCCC
TITMIPAYALVSDAFRNWRGMSESGGRRIKRAINIDINSIKFLSEEERERLSKINCLKEY
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
FPAKINEIRESNARVSDLDMKVNGRHLTNVGTFRAYLQEYLQRHDKIHKEMTLMVRQLAP
CCHHHHHHHHCCCCEEECEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TTEGLPIEVYIFTNDTRWAFYEAIQADIFDHIFAILPEFGLQAFQAPTGNDIRSLKSVKV
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
D
C
>Mature Secondary Structure
MDQEIRLEISAWLAGFGIDSQPSDGISTSIMIIACLLLAGIAYFIVRRVVIRAVNMVILR
CCCCEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKVTWDDVFMRYKVLEKLAMLVPAIVLNLLVPIALTEHQILSSLVDRLLSIWLVVLMIRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYAGLDAVDEISDVNLVSRRLPVKSFVQLTKLFLFFVGIIVSISILADQSPVYFLSGLGV
HHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ATGFVMLVFRDTILGFVAGIQLAANRMVSKGDWIQMDKYGADGAVEEVSLTTVKVRNWDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHEEEEEEEEECCCC
TITMIPAYALVSDAFRNWRGMSESGGRRIKRAINIDINSIKFLSEEERERLSKINCLKEY
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
FPAKINEIRESNARVSDLDMKVNGRHLTNVGTFRAYLQEYLQRHDKIHKEMTLMVRQLAP
CCHHHHHHHHCCCCEEECEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TTEGLPIEVYIFTNDTRWAFYEAIQADIFDHIFAILPEFGLQAFQAPTGNDIRSLKSVKV
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]