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The map label for this gene is gltP [H]

Identifier: 126176396

GI number: 126176396

Start: 4932443

End: 4933693

Strand: Direct

Name: gltP [H]

Synonym: Sbal_4211

Alternate gene names: 126176396

Gene position: 4932443-4933693 (Clockwise)

Preceding gene: 126176395

Following gene: 126176397

Centisome position: 96.2

GC content: 49.32

Gene sequence:

>1251_bases
ATGAAGAGCAAGAGTTTATTAGGCAACATTGGTGTGCAAGTGGTTATTGCCATGATTATCGGCGCGCTAGTCGGTTTTAT
CATGGGCGAGAGTGCAAGCGTGTTTGCACCACTCGGAACCATTTTTATCCATTTAATCAAAATGCTAGTGATCCCACTAG
TGTTAGTTTCTATCATCAGCGGTGCCGCGAGTTTAGGCGATAGCCCATCGGCGGGTAAGATTGGCATCGGCACTTTCGGC
TTCTTTATCGTGACATCTGGCATCGCCGTGGTGCTGGCGTTGGTGATGGGAAATCTGTTCCAACCGGGCGCGGGTGTGGA
TTTCACAGCCCACAGCAGCTCAGATTTGATGGAAGTAACCAAGGAACACGGCGCATTGCCTGGGGTGATGGATACCTTTA
TCGGTATGATCCCAACCAATGTGTTCGAATCGCTGAACGGCGGTAACATCTTACAAATCTTAGTCTTTAGTATCTTTTTT
GGTATCGCGCTGACGAAGGTTAAAGGCGATGGCGCTAAGCCTATTTTGGCTGCACTCAACACTGTCGTCGATGCCTTTGT
GTGGATGATCAACTGCGTGATGATCATTGCGCCTATCGGTGTATTTGGTTTGATGGCCGATTCCGTGGGCACCTTCGGTT
TCGATGCGTTAGAAGTGGTATTTAAGTTATTCGCCGTGTTTGTAGCCGCGATTCTGATCTACGGTTTTATCTTCTTCCCA
TTGGTGGTGCAGCTCTTCTCAAGAGTGTCGGCGCGCCAGTTTATTTCGGCAATGAAGAAACCACAGGTGATGGCGTTATC
GACCGCCTCGTCAATGGCGACGCTGCCGGTGAATATGGAAACCTGCGAGGAAGATCTTAAAGTCTCTAAGGCAACCACAG
CCTTCGTGCTGCCGTTAGGCGCCACGATCAATATGAGCGGCAACGCGATTTATTATGGTTTAGTGGCCATGTTCTTCGCT
CAAATGTATAACGTCGACCTGTCGATGACGGCCTATGCAGCCATTATCTTCACTTCGACCTTAGGCGCAATTGGTCAAGC
GGGTGTGCCCGGTCCGTCTTTCTTAGTGGTGGCAGTGCTGTTAGCGGCTGGCATTCCTATCGATGGCTTACCTTTGCTAT
TTGCCTTAGATCGAGTGTTTGACATGATCCGCACCGCACTTAATATCACTGGCGATGCGGCTTGTGCCTTGATCATGGAT
AAGTACACAGAAGTTGAAGTTAAAGCGGATAGCGAGCACAGCTTAAGCTAG

Upstream 100 bases:

>100_bases
TTTAGCCTAGAGTAAGCCTTAATCACTAAGGTTTACGGCGTCTAGATTCAAATCGCCTACATCACACAAAATGCTGCGGC
AACTGGGGAGTTTCGCAAGA

Downstream 100 bases:

>100_bases
CAAATACAGTCACTCAACGCTTCAAATACCGGCTTGAATAGGCAACCCTTATTCAAGCCTTTTTTATGCCTGCTGCACGG
CATAACAACCCGCTTCTGCA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKSKSLLGNIGVQVVIAMIIGALVGFIMGESASVFAPLGTIFIHLIKMLVIPLVLVSIISGAASLGDSPSAGKIGIGTFG
FFIVTSGIAVVLALVMGNLFQPGAGVDFTAHSSSDLMEVTKEHGALPGVMDTFIGMIPTNVFESLNGGNILQILVFSIFF
GIALTKVKGDGAKPILAALNTVVDAFVWMINCVMIIAPIGVFGLMADSVGTFGFDALEVVFKLFAVFVAAILIYGFIFFP
LVVQLFSRVSARQFISAMKKPQVMALSTASSMATLPVNMETCEEDLKVSKATTAFVLPLGATINMSGNAIYYGLVAMFFA
QMYNVDLSMTAYAAIIFTSTLGAIGQAGVPGPSFLVVAVLLAAGIPIDGLPLLFALDRVFDMIRTALNITGDAACALIMD
KYTEVEVKADSEHSLS

Sequences:

>Translated_416_residues
MKSKSLLGNIGVQVVIAMIIGALVGFIMGESASVFAPLGTIFIHLIKMLVIPLVLVSIISGAASLGDSPSAGKIGIGTFG
FFIVTSGIAVVLALVMGNLFQPGAGVDFTAHSSSDLMEVTKEHGALPGVMDTFIGMIPTNVFESLNGGNILQILVFSIFF
GIALTKVKGDGAKPILAALNTVVDAFVWMINCVMIIAPIGVFGLMADSVGTFGFDALEVVFKLFAVFVAAILIYGFIFFP
LVVQLFSRVSARQFISAMKKPQVMALSTASSMATLPVNMETCEEDLKVSKATTAFVLPLGATINMSGNAIYYGLVAMFFA
QMYNVDLSMTAYAAIIFTSTLGAIGQAGVPGPSFLVVAVLLAAGIPIDGLPLLFALDRVFDMIRTALNITGDAACALIMD
KYTEVEVKADSEHSLS
>Mature_416_residues
MKSKSLLGNIGVQVVIAMIIGALVGFIMGESASVFAPLGTIFIHLIKMLVIPLVLVSIISGAASLGDSPSAGKIGIGTFG
FFIVTSGIAVVLALVMGNLFQPGAGVDFTAHSSSDLMEVTKEHGALPGVMDTFIGMIPTNVFESLNGGNILQILVFSIFF
GIALTKVKGDGAKPILAALNTVVDAFVWMINCVMIIAPIGVFGLMADSVGTFGFDALEVVFKLFAVFVAAILIYGFIFFP
LVVQLFSRVSARQFISAMKKPQVMALSTASSMATLPVNMETCEEDLKVSKATTAFVLPLGATINMSGNAIYYGLVAMFFA
QMYNVDLSMTAYAAIIFTSTLGAIGQAGVPGPSFLVVAVLLAAGIPIDGLPLLFALDRVFDMIRTALNITGDAACALIMD
KYTEVEVKADSEHSLS

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=455, Percent_Identity=29.4505494505495, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI21314632, Length=414, Percent_Identity=29.2270531400966, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI40254478, Length=464, Percent_Identity=27.801724137931, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI5032093, Length=402, Percent_Identity=31.0945273631841, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI66773030, Length=470, Percent_Identity=27.6595744680851, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI223468566, Length=278, Percent_Identity=31.294964028777, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI223468564, Length=272, Percent_Identity=31.6176470588235, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI4827012, Length=324, Percent_Identity=31.1728395061728, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI262359914, Length=374, Percent_Identity=28.6096256684492, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI194239697, Length=271, Percent_Identity=30.2583025830258, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI301601644, Length=188, Percent_Identity=32.9787234042553, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1790514, Length=426, Percent_Identity=34.037558685446, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1789947, Length=414, Percent_Identity=29.4685990338164, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1788024, Length=411, Percent_Identity=26.5206812652068, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1789473, Length=396, Percent_Identity=26.7676767676768, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71996953, Length=457, Percent_Identity=28.0087527352298, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI193206654, Length=419, Percent_Identity=29.5942720763723, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71983106, Length=454, Percent_Identity=27.9735682819383, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71983099, Length=455, Percent_Identity=27.6923076923077, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI193206505, Length=421, Percent_Identity=28.0285035629454, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17541374, Length=423, Percent_Identity=29.7872340425532, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17537407, Length=419, Percent_Identity=26.9689737470167, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24583025, Length=433, Percent_Identity=24.2494226327945, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI17137668, Length=433, Percent_Identity=24.2494226327945, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24583023, Length=433, Percent_Identity=24.2494226327945, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI281360483, Length=440, Percent_Identity=26.3636363636364, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17137666, Length=440, Percent_Identity=26.3636363636364, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281360481, Length=440, Percent_Identity=26.3636363636364, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43604; Mature: 43604

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKSLLGNIGVQVVIAMIIGALVGFIMGESASVFAPLGTIFIHLIKMLVIPLVLVSIIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAASLGDSPSAGKIGIGTFGFFIVTSGIAVVLALVMGNLFQPGAGVDFTAHSSSDLMEVT
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHH
KEHGALPGVMDTFIGMIPTNVFESLNGGNILQILVFSIFFGIALTKVKGDGAKPILAALN
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TVVDAFVWMINCVMIIAPIGVFGLMADSVGTFGFDALEVVFKLFAVFVAAILIYGFIFFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVVQLFSRVSARQFISAMKKPQVMALSTASSMATLPVNMETCEEDLKVSKATTAFVLPLG
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCHHHHHHHHHHHHHHHEEEEECC
ATINMSGNAIYYGLVAMFFAQMYNVDLSMTAYAAIIFTSTLGAIGQAGVPGPSFLVVAVL
CEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LAAGIPIDGLPLLFALDRVFDMIRTALNITGDAACALIMDKYTEVEVKADSEHSLS
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCCCCCC
>Mature Secondary Structure
MKSKSLLGNIGVQVVIAMIIGALVGFIMGESASVFAPLGTIFIHLIKMLVIPLVLVSIIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAASLGDSPSAGKIGIGTFGFFIVTSGIAVVLALVMGNLFQPGAGVDFTAHSSSDLMEVT
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHH
KEHGALPGVMDTFIGMIPTNVFESLNGGNILQILVFSIFFGIALTKVKGDGAKPILAALN
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TVVDAFVWMINCVMIIAPIGVFGLMADSVGTFGFDALEVVFKLFAVFVAAILIYGFIFFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVVQLFSRVSARQFISAMKKPQVMALSTASSMATLPVNMETCEEDLKVSKATTAFVLPLG
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCHHHHHHHHHHHHHHHEEEEECC
ATINMSGNAIYYGLVAMFFAQMYNVDLSMTAYAAIIFTSTLGAIGQAGVPGPSFLVVAVL
CEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LAAGIPIDGLPLLFALDRVFDMIRTALNITGDAACALIMDKYTEVEVKADSEHSLS
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]