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The map label for this gene is ilvD [H]

Identifier: 126176215

GI number: 126176215

Start: 4728856

End: 4730730

Strand: Reverse

Name: ilvD [H]

Synonym: Sbal_4029

Alternate gene names: 126176215

Gene position: 4730730-4728856 (Counterclockwise)

Preceding gene: 126176216

Following gene: 126176214

Centisome position: 92.26

GC content: 53.55

Gene sequence:

>1875_bases
ATGCCAAAGTTACGATCAGCTACCAGTACCGAAGGCCGCAATATGGCGGGTGCACGTGCGTTATGGCGTGCCACAGGGGT
GAAAGACAATGATTTTGGTAAGCCAATTATCGCCATTGCTAACTCCTTTACTCAATTTGTACCGGGCCACGTGCACTTAA
AAGACATGGGCTCACTCGTCGCGAGCGCCATCGAAGAAGCGGGCGGTATCGCAAAAGAATTCAATACGATCGCCGTCGAT
GACGGTATCGCCATGGGCCACGGCGGCATGCTGTACAGTCTGCCATCGCGTGAACTTATCGCCGACAGTGTGGAATACAT
GGTTAACGCCCACTGCGCCGATGCCTTAGTGTGTATCTCCAACTGCGACAAGATCACCCCCGGCATGTTGATGGCGGCGC
TGCGCCTCAATATTCCCGTAGTGTTTGTGTCTGGTGGACCGATGGAAGCGGGTAAAACTAAGTTGTCGGACAAACTCATC
AAACTCGATTTAGTCGATGCTATGGTGGCGGGCGCCGACTCGAACGTGAGCGATGAAGACAGTGCCAAAATCGAGCGTAG
CGCGTGCCCAACCTGCGGTTCTTGCTCTGGTATGTTTACCGCCAACTCAATGAACTGTTTAACCGAAGCTCTAGGATTAT
CGCTGCCGGGTAACGGCTCTATGCTGGCAACCCACGCCGATCGCCGCGAGCTGTTTTTAGAAGCGGGTCGTCGCGTGATG
GCGCTGGCAAAACGGTATTATCATCAAGATGATGAATCGGCATTGCCACGTAATATCGCCAACTTTAAAGCCTTCGAAAA
TGCTATGACCTTAGATATCGCCATGGGCGGTTCATCTAACACCGTATTGCATTTATTAGCCGCTGCGCAGGAAGCCGATG
TTGATTTTACCATGGCGGATATCGACCGTATGTCGCGCCTTGTGCCGCACCTTTGTAAGGTTGCACCATCGACGCCTAAA
TACCATATGGAAGACGTGCACCGTGCTGGCGGCGTGATGGGGATTTTGGGCGAGCTCGACAGAACCGGATTACTGCATAC
CGATGTGTTCCATGTGGCGGCCGACAATGACGGCACGCCGGGCAGCGGGACCTTGAAATCGGTATTGGCCCAGTACGATG
TGATGCAGACGCAAGATGAAAAAGTAAAACACTTCTTTATGGCGGGACCTGCGGGCATTCCGACCACTAAAGCCTTTAGC
CAAGATTGTCGCTGGCCGTCACTGGATAATGACAGGCAAGAAGGCTGTATCCGTAGCCGCGAGTTTGCCTTCAGCCAAGA
GGGCGGTCTTGCCGTATTGTCGGGCAACGTGGCCGAAAATGGCTGTATCGTTAAAACGGCGGGCGTGGATGAATCGAATC
TGACCTTTGTTGGCTCGGCGCGCGTCTATGAAAGCCAAGATGACGCCGTGGCGGGCATTTTAGGCGGCGAAGTGGTGGCG
GGGGATGTGGTTGTTATCCGTTATGAAGGCCCAAAAGGCGGCCCGGGTATGCAAGAAATGTTGTACCCAACCAGTTACTT
AAAATCTCGTGGCTTAGGCAAGGCCTGTGCGCTGATCACCGACGGTCGTTTCTCAGGTGGCACTTCAGGTTTATCTATCG
GTCACGTTTCACCCGAAGCGGCTGCGGGTGGCACAATCGCCTTGATTGAAAATGGCGATCGCATCGAAATTGATATACCC
AAGCGCAGCATCAAGTTGGCAGTAAGTGATGTTGAACTCAATGCTCGCCGCGAAAAAATGCACAGTCTTGGCCCAATGGC
GTGGAAACCTATCGGTCGCCAACGTTATGTATCACTCGCGCTTAAGGCCTACGCCATGCTCGCCACCAGTGCCGACAAGG
GCGCGGTGCGCGATCGCAGTAAACTGGAGGACTAA

Upstream 100 bases:

>100_bases
GTGACTATGAGTGCCAGATATTGAGGCGAATGCGGCAAGTGCAGCATTCGCCATGTGAATTAAGAATACGATTTTCGATT
TGAGATAAAGGATACAGTCA

Downstream 100 bases:

>100_bases
TATGTTGCCACTTGCATCGCAAGCTCGGACGGATTTAGCACATTTTCAGTTGGCACAAAGCTATCTGCAAAAAATCCTGT
TGTCATCTGTGTATGACATA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVASAIEEAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLI
KLDLVDAMVAGADSNVSDEDSAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
ALAKRYYHQDDESALPRNIANFKAFENAMTLDIAMGGSSNTVLHLLAAAQEADVDFTMADIDRMSRLVPHLCKVAPSTPK
YHMEDVHRAGGVMGILGELDRTGLLHTDVFHVAADNDGTPGSGTLKSVLAQYDVMQTQDEKVKHFFMAGPAGIPTTKAFS
QDCRWPSLDNDRQEGCIRSREFAFSQEGGLAVLSGNVAENGCIVKTAGVDESNLTFVGSARVYESQDDAVAGILGGEVVA
GDVVVIRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIALIENGDRIEIDIP
KRSIKLAVSDVELNARREKMHSLGPMAWKPIGRQRYVSLALKAYAMLATSADKGAVRDRSKLED

Sequences:

>Translated_624_residues
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVASAIEEAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLI
KLDLVDAMVAGADSNVSDEDSAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
ALAKRYYHQDDESALPRNIANFKAFENAMTLDIAMGGSSNTVLHLLAAAQEADVDFTMADIDRMSRLVPHLCKVAPSTPK
YHMEDVHRAGGVMGILGELDRTGLLHTDVFHVAADNDGTPGSGTLKSVLAQYDVMQTQDEKVKHFFMAGPAGIPTTKAFS
QDCRWPSLDNDRQEGCIRSREFAFSQEGGLAVLSGNVAENGCIVKTAGVDESNLTFVGSARVYESQDDAVAGILGGEVVA
GDVVVIRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIALIENGDRIEIDIP
KRSIKLAVSDVELNARREKMHSLGPMAWKPIGRQRYVSLALKAYAMLATSADKGAVRDRSKLED
>Mature_623_residues
PKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVASAIEEAGGIAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIK
LDLVDAMVAGADSNVSDEDSAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVMA
LAKRYYHQDDESALPRNIANFKAFENAMTLDIAMGGSSNTVLHLLAAAQEADVDFTMADIDRMSRLVPHLCKVAPSTPKY
HMEDVHRAGGVMGILGELDRTGLLHTDVFHVAADNDGTPGSGTLKSVLAQYDVMQTQDEKVKHFFMAGPAGIPTTKAFSQ
DCRWPSLDNDRQEGCIRSREFAFSQEGGLAVLSGNVAENGCIVKTAGVDESNLTFVGSARVYESQDDAVAGILGGEVVAG
DVVVIRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIALIENGDRIEIDIPK
RSIKLAVSDVELNARREKMHSLGPMAWKPIGRQRYVSLALKAYAMLATSADKGAVRDRSKLED

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=622, Percent_Identity=78.6173633440515, Blast_Score=1009, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=555, Percent_Identity=30.2702702702703, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI2367371, Length=518, Percent_Identity=30.6949806949807, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1786464, Length=538, Percent_Identity=29.7397769516729, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322476, Length=619, Percent_Identity=36.0258481421648, Blast_Score=330, Evalue=5e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 66298; Mature: 66167

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
ASAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIKLDLVDAMVAGADSNVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHEEHHHHHHHHHCCCCCCCCCH
SAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHCHHHH
ALAKRYYHQDDESALPRNIANFKAFENAMTLDIAMGGSSNTVLHLLAAAQEADVDFTMAD
HHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEHHH
IDRMSRLVPHLCKVAPSTPKYHMEDVHRAGGVMGILGELDRTGLLHTDVFHVAADNDGTP
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEHHHCCCCCCCEEEEEEEEEECCCCCC
GSGTLKSVLAQYDVMQTQDEKVKHFFMAGPAGIPTTKAFSQDCRWPSLDNDRQEGCIRSR
CCHHHHHHHHHHHHHCCCHHHHHEEEEECCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
EFAFSQEGGLAVLSGNVAENGCIVKTAGVDESNLTFVGSARVYESQDDAVAGILGGEVVA
HCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCEEECCCCCCEEEEECCCEEE
GDVVVIRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEA
CCEEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCC
AAGGTIALIENGDRIEIDIPKRSIKLAVSDVELNARREKMHSLGPMAWKPIGRQRYVSLA
CCCCEEEEEECCCEEEEECCCCEEEEEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LKAYAMLATSADKGAVRDRSKLED
HHHHHHHHCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
ASAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIKLDLVDAMVAGADSNVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHEEHHHHHHHHHCCCCCCCCCH
SAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHCHHHH
ALAKRYYHQDDESALPRNIANFKAFENAMTLDIAMGGSSNTVLHLLAAAQEADVDFTMAD
HHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEHHH
IDRMSRLVPHLCKVAPSTPKYHMEDVHRAGGVMGILGELDRTGLLHTDVFHVAADNDGTP
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEHHHCCCCCCCEEEEEEEEEECCCCCC
GSGTLKSVLAQYDVMQTQDEKVKHFFMAGPAGIPTTKAFSQDCRWPSLDNDRQEGCIRSR
CCHHHHHHHHHHHHHCCCHHHHHEEEEECCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
EFAFSQEGGLAVLSGNVAENGCIVKTAGVDESNLTFVGSARVYESQDDAVAGILGGEVVA
HCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCEEECCCCCCEEEEECCCEEE
GDVVVIRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEA
CCEEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCC
AAGGTIALIENGDRIEIDIPKRSIKLAVSDVELNARREKMHSLGPMAWKPIGRQRYVSLA
CCCCEEEEEECCCEEEEECCCCEEEEEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LKAYAMLATSADKGAVRDRSKLED
HHHHHHHHCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA